SE385885B - Foerfarande foer framstaellning av 4-amino-6-arylpyrimidinderivat - Google Patents

Foerfarande foer framstaellning av 4-amino-6-arylpyrimidinderivat

Info

Publication number
SE385885B
SE385885B SE7112534-8A SE1253471A SE385885B SE 385885 B SE385885 B SE 385885B SE 1253471 A SE1253471 A SE 1253471A SE 385885 B SE385885 B SE 385885B
Authority
SE
Sweden
Prior art keywords
amino
procedure
preparation
arylpyrimidine derivatives
arylpyrimidine
Prior art date
Application number
SE7112534-8A
Other languages
English (en)
Swedish (sv)
Inventor
G G De Angelis
H-J E Hess
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of SE385885B publication Critical patent/SE385885B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SE7112534-8A 1970-10-05 1971-10-04 Foerfarande foer framstaellning av 4-amino-6-arylpyrimidinderivat SE385885B (sv)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7821670A 1970-10-05 1970-10-05

Publications (1)

Publication Number Publication Date
SE385885B true SE385885B (sv) 1976-07-26

Family

ID=22142671

Family Applications (2)

Application Number Title Priority Date Filing Date
SE7112534-8A SE385885B (sv) 1970-10-05 1971-10-04 Foerfarande foer framstaellning av 4-amino-6-arylpyrimidinderivat
SE7410488A SE390304B (sv) 1970-10-05 1971-10-04 Analogiforfarande for framstellning av 4-hydroxi-5-etyl-6-fonylpyrimidin

Family Applications After (1)

Application Number Title Priority Date Filing Date
SE7410488A SE390304B (sv) 1970-10-05 1971-10-04 Analogiforfarande for framstellning av 4-hydroxi-5-etyl-6-fonylpyrimidin

Country Status (16)

Country Link
US (1) US3707560A (de)
JP (2) JPS5648511B1 (de)
AT (4) AT315856B (de)
AU (1) AU465734B2 (de)
BE (1) BE773484A (de)
CA (1) CA988519A (de)
CH (4) CH554875A (de)
DE (2) DE2149249C3 (de)
DK (1) DK131858C (de)
ES (4) ES395676A1 (de)
FI (1) FI55502C (de)
FR (1) FR2110227B1 (de)
GB (2) GB1373535A (de)
NL (1) NL168511C (de)
SE (2) SE385885B (de)
ZA (1) ZA716615B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3908012A (en) * 1970-10-05 1975-09-23 Pfizer Arylpyrimidines-inhibitors of platelet aggregation and bronchodilators
US3895112A (en) * 1970-10-05 1975-07-15 Pfizer Arylpyrimidines in the relaxation of smooth muscle
US3859288A (en) * 1970-10-05 1975-01-07 Pfizer Arylpyrimidines - inhibitors of platelet aggregation and bronchodilators
US3835132A (en) * 1972-02-01 1974-09-10 Shell Oil Co Morpholino-piperazinyl pyrimidines
US3950525A (en) * 1973-06-19 1976-04-13 Pfizer Inc. Relaxation of smooth muscle in a mammal
DE2343419A1 (de) * 1973-08-29 1975-03-13 Gruenenthal Chemie Verfahren zur herstellung von pyrimidinderivaten
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
US4935516A (en) * 1988-01-29 1990-06-19 Ube Industries, Ltd. Process for preparing 4-hydroxypyrimidine
JPH0625157B2 (ja) * 1988-01-29 1994-04-06 宇部興産株式会社 ４―ヒドロキシピリミジン類の製造方法
DE3825647A1 (de) * 1988-07-28 1990-02-01 Geyer Gmbh & Co Christian Vorrichtung zur befestigung eines elektrischen schaltgeraetes
DE3905364A1 (de) * 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
ATE250053T1 (de) * 1999-07-15 2003-10-15 Pharmacopeia Inc Bradikinin b1 rezeptor antagonisten
AU2003214110A1 (en) * 2002-03-15 2003-09-29 Ciba Specialty Chemicals Holding Inc. 4-aminopyrimidines and their use for the antimicrobial treatment of surfaces
JP2005531574A (ja) * 2002-05-22 2005-10-20 アムジエン・インコーポレーテツド 痛みの治療にバニロイド受容体リガンドとして使用するためのアミノ−ピリジン、−ピリジンおよびピリダジン誘導体
JP2006521345A (ja) * 2003-03-28 2006-09-21 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ニコチン性アセチルコリン受容体の正のアロステリック調節剤
US20060235036A1 (en) * 2005-04-15 2006-10-19 Doherty Elizabeth M Vanilloid receptor ligands and their use in treatments
JP2009164373A (ja) * 2008-01-08 2009-07-23 Toshiba Corp 半導体装置
NZ601547A (en) * 2010-01-25 2014-04-30 Chdi Foundation Inc Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2013033068A1 (en) 2011-08-30 2013-03-07 Stephen Martin Courtney Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
SG2014012926A (en) 2011-08-30 2014-06-27 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
MX372995B (es) 2014-07-17 2020-04-13 Chdi Foundation Inc Metodos y composiciones para el tratamiento de trastornos relacionados con vih.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3047462A (en) * 1959-03-06 1962-07-31 Lab Jacques Logeais Soc D Expl Quinazolone anti-inflammatory composition

Also Published As

Publication number Publication date
SE7410488L (de) 1974-08-16
DE2165962C2 (de) 1982-05-13
NL7113670A (de) 1972-04-07
CH554876A (fr) 1974-10-15
GB1373535A (en) 1974-11-13
ES395676A1 (es) 1974-10-16
JPS578107B2 (de) 1982-02-15
ES420211A1 (es) 1976-03-16
SE390304B (sv) 1976-12-13
ZA716615B (en) 1972-06-28
DE2149249C3 (de) 1975-07-03
FI55502B (fi) 1979-04-30
ES420210A1 (es) 1976-06-01
JPS5636468A (en) 1981-04-09
US3707560A (en) 1972-12-26
CH554875A (fr) 1974-10-15
CH554346A (fr) 1974-09-30
JPS5648511B1 (de) 1981-11-16
AT315856B (de) 1974-05-15
GB1373536A (en) 1974-11-13
ES420209A1 (es) 1976-06-01
AU3425971A (en) 1973-04-12
AT317229B (de) 1974-08-26
CA988519A (en) 1976-05-04
AU465734B2 (en) 1975-10-09
FR2110227B1 (de) 1975-02-07
FI55502C (fi) 1979-08-10
AT316563B (de) 1974-06-15
NL168511C (nl) 1982-04-16
CH542218A (fr) 1973-11-15
DK131858B (da) 1975-09-15
DE2149249B2 (de) 1974-11-07
AT314540B (de) 1974-04-10
DE2149249A1 (de) 1972-04-13
BE773484A (fr) 1972-04-05
DK131858C (da) 1976-02-16
FR2110227A1 (de) 1972-06-02
DE2165962A1 (de) 1972-08-31
NL168511B (nl) 1981-11-16

Similar Documents

Publication Publication Date Title
BG19162A3 (bg) Метод за получаване на фенил-имидазолил-алканилови производни
SE398877B (sv) Forfarande for framstellning av 14-hydroxi-morfinanderivat
SE394678B (sv) Analogiforfarande for framstellning av pyridokinolinderivat
SE390304B (sv) Analogiforfarande for framstellning av 4-hydroxi-5-etyl-6-fonylpyrimidin
SE384368B (sv) Forfarande for framstellning av 6-substituerade - 4 - amino- 1,2 - dihydro - 1 - hydroxi - 2 - iminopyrimidiner
SE395149B (sv) Forfarande for framstellning av dibenso-tiepinylpiperazinderivat
NO138883C (no) Fremgangsmaate for fremstilling av oksiranforbindelser
SE401676B (sv) Forfarande for framstellning av dibensofuranderivat
SE399701B (sv) Forfarande for framstellning av hydroxyalkyldiamin
SE394436B (sv) Forfarande for framstellning av 7-halogen-linkomyciner
SE7511680L (sv) Forfarande for framstellning av furanderivat
SE380273B (sv) Forfarande for framstellning av tiopyrimidinderivat
SE392615B (sv) Forfarande for framstellning av 2-nitro-5-imidazolaldehydderivat
SE385011B (sv) Forfarande for framstellning av alfa-linkosaminider
SE384685B (sv) Forfarande for framstellning av linkomycinderivat
SE395897B (sv) Forfarande for framstellning av 7beta-acylamido-3-metyl-cef-3-em-4-karbonsyror
SE395699B (sv) Forfarande for framstellning av kinuklidin-kinolinderivat
SE408177B (sv) Forfarande for framstellning av 4-hydroximetyl-1-ftalazonderivat
SE408418B (sv) Forfarande for framstellning av 5-fluor-pyrimidiner
SE380528B (sv) Forfarande for framstellning av 2-klor-7-hydroxi-11-piperazinyldibensoxazepmderivat
SE380795B (sv) Forfarande for framstellning av tiokarbamider
SE411759B (sv) Forfarande for framstellning av erytromycyliminforeningar
SE397350B (sv) Forfarande for framstellning av tieno-diazepinderivat
RO70179A (ro) Procedeu pentru prepararea izoprenului
NO136409C (no) Fremgangsm}te for fremstilling av aryloksyalkyl-morfolinderivater