SE426548B - Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer - Google Patents
Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymerInfo
- Publication number
- SE426548B SE426548B SE7813245A SE7813245A SE426548B SE 426548 B SE426548 B SE 426548B SE 7813245 A SE7813245 A SE 7813245A SE 7813245 A SE7813245 A SE 7813245A SE 426548 B SE426548 B SE 426548B
- Authority
- SE
- Sweden
- Prior art keywords
- layer
- therapeutically effective
- polymer
- solid pharmaceutical
- core
- Prior art date
Links
- 229920000642 polymer Polymers 0.000 title claims description 13
- 239000000825 pharmaceutical preparation Substances 0.000 title claims description 7
- 239000007787 solid Substances 0.000 title claims description 6
- 229940097217 cardiac glycoside Drugs 0.000 claims description 12
- 239000002368 cardiac glycoside Substances 0.000 claims description 12
- 229930002534 steroid glycoside Natural products 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000009472 formulation Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 8
- LPMXVESGRSUGHW-HBYQJFLCSA-N ouabain Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C[C@@]2(O)CC[C@H]3[C@@]4(O)CC[C@H](C=5COC(=O)C=5)[C@@]4(C)C[C@@H](O)[C@@H]3[C@@]2(CO)[C@H](O)C1 LPMXVESGRSUGHW-HBYQJFLCSA-N 0.000 claims description 7
- 238000005507 spraying Methods 0.000 claims description 4
- 210000002784 stomach Anatomy 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 125000005456 glyceride group Chemical group 0.000 claims 2
- YBCVMFKXIKNREZ-UHFFFAOYSA-N acoh acetic acid Chemical compound CC(O)=O.CC(O)=O YBCVMFKXIKNREZ-UHFFFAOYSA-N 0.000 claims 1
- 229920002301 cellulose acetate Polymers 0.000 claims 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims 1
- 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
- 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 description 8
- 239000011162 core material Substances 0.000 description 8
- LTMHDMANZUZIPE-UHFFFAOYSA-N digoxine Natural products C1C(O)C(O)C(C)OC1OC1C(C)OC(OC2C(OC(OC3CC4C(C5C(C6(CCC(C6(C)C(O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)CC2O)C)CC1O LTMHDMANZUZIPE-UHFFFAOYSA-N 0.000 description 7
- LTMHDMANZUZIPE-AMTYYWEZSA-N Digoxin Natural products O([C@H]1[C@H](C)O[C@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@](C)([C@H](O)C4)[C@H](C4=CC(=O)OC4)CC5)CC3)CC2)C[C@@H]1O)[C@H]1O[C@H](C)[C@@H](O[C@H]2O[C@@H](C)[C@H](O)[C@@H](O)C2)[C@@H](O)C1 LTMHDMANZUZIPE-AMTYYWEZSA-N 0.000 description 5
- 229960005156 digoxin Drugs 0.000 description 5
- LTMHDMANZUZIPE-PUGKRICDSA-N digoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O LTMHDMANZUZIPE-PUGKRICDSA-N 0.000 description 5
- 150000008143 steroidal glycosides Chemical class 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- -1 Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Acetyl Chemical group 0.000 description 4
- 125000002252 acyl group Chemical group 0.000 description 4
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 3
- WDJUZGPOPHTGOT-OAXVISGBSA-N Digitoxin Natural products O([C@H]1[C@@H](C)O[C@@H](O[C@@H]2C[C@@H]3[C@@](C)([C@@H]4[C@H]([C@]5(O)[C@@](C)([C@H](C6=CC(=O)OC6)CC5)CC4)CC3)CC2)C[C@H]1O)[C@H]1O[C@@H](C)[C@H](O[C@H]2O[C@@H](C)[C@@H](O)[C@@H](O)C2)[C@@H](O)C1 WDJUZGPOPHTGOT-OAXVISGBSA-N 0.000 description 3
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 229960000648 digitoxin Drugs 0.000 description 3
- WDJUZGPOPHTGOT-XUDUSOBPSA-N digitoxin Chemical compound C1[C@H](O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)CC5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O WDJUZGPOPHTGOT-XUDUSOBPSA-N 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- JAYAGJDXJIDEKI-PTGWOZRBSA-N Lanatoside C Chemical compound O([C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(CC[C@@H]([C@@]4(C)[C@H](O)C3)C=3COC(=O)C=3)O)CC2)(C)CC1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O JAYAGJDXJIDEKI-PTGWOZRBSA-N 0.000 description 2
- JAYAGJDXJIDEKI-UHFFFAOYSA-N Lanatoside C Natural products CC1OC(OC2CC3C(C4C(C5(CCC(C5(C)C(O)C4)C=4COC(=O)C=4)O)CC3)(C)CC2)CC(O)C1OC(OC1C)CC(O)C1OC(OC1C)CC(OC(C)=O)C1OC1OC(CO)C(O)C(O)C1O JAYAGJDXJIDEKI-UHFFFAOYSA-N 0.000 description 2
- MYEJFUXQJGHEQK-ALRJYLEOSA-N Proscillaridin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@@H]1C=C2CC[C@H]3[C@@]4(O)CC[C@H](C5=COC(=O)C=C5)[C@@]4(C)CC[C@@H]3[C@@]2(C)CC1 MYEJFUXQJGHEQK-ALRJYLEOSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 2
- 239000007931 coated granule Substances 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000002552 dosage form Substances 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 229960002614 lanatoside c Drugs 0.000 description 2
- 230000036470 plasma concentration Effects 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000208011 Digitalis Species 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 206010028813 Nausea Diseases 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- XZTUSOXSLKTKJQ-UHFFFAOYSA-N Uzarigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C1(O)CCC2C1=CC(=O)OC1 XZTUSOXSLKTKJQ-UHFFFAOYSA-N 0.000 description 1
- JDYLJSDIEBHXPO-ALNZGLKXSA-N [(2r,3r,4s,6r)-3-[(2s,4s,5r,6r)-4-acetyloxy-5-[(2s,4s,5r,6r)-4,5-diacetyloxy-6-methyloxan-2-yl]oxy-6-methyloxan-2-yl]oxy-6-[[(3s,5r,8r,9s,10s,13r,14s,16s,17r)-16-acetyloxy-14-hydroxy-10,13-dimethyl-17-(5-oxo-2h-furan-3-yl)-1,2,3,4,5,6,7,8,9,11,12,15,16,17 Chemical compound O([C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@H]1[C@@H](OC(C)=O)C[C@@H](O[C@@H]1C)O[C@@H]1C[C@@H]2[C@]([C@@H]3[C@H]([C@]4(C[C@@H]([C@@H]([C@@]4(C)CC3)C=3COC(=O)C=3)OC(C)=O)O)CC2)(C)CC1)[C@H]1C[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](C)O1 JDYLJSDIEBHXPO-ALNZGLKXSA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 229960003304 acetyldigoxin Drugs 0.000 description 1
- HWKJSYYYURVNQU-DXJNJSHLSA-N acetyldigoxin Chemical compound C1[C@H](OC(C)=O)[C@H](O)[C@@H](C)O[C@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O HWKJSYYYURVNQU-DXJNJSHLSA-N 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- ACLJAFRNPZVVIW-ADFGDECNSA-N actodigin Chemical compound O([C@@H]1C[C@H]2CC[C@@H]3[C@@H]([C@]2(CC1)C)CC[C@]1([C@]3(O)CC[C@@H]1C=1C(OCC=1)=O)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O ACLJAFRNPZVVIW-ADFGDECNSA-N 0.000 description 1
- 229950004735 actodigin Drugs 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- MGVYFNHJWXJYBE-UHFFFAOYSA-N alpha-Acetyl-digoxin Natural products CC1OC(CC(O)C1O)OC2C(O)CC(OC3C(C)OC(CC3OC(=O)C)OC4CCC5(C)C(CCC6C5CCC7(C)C(C(O)CC67O)C8=CC(=O)OC8)C4)OC2C MGVYFNHJWXJYBE-UHFFFAOYSA-N 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 206010003119 arrhythmia Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 239000007853 buffer solution Substances 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 150000008280 chlorinated hydrocarbons Chemical class 0.000 description 1
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical class CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 1
- 125000004177 diethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 1
- 229940082657 digitalis glycosides Drugs 0.000 description 1
- XZTUSOXSLKTKJQ-CESUGQOBSA-N digitoxigenin Chemical compound C1([C@H]2CC[C@]3(O)[C@H]4[C@@H]([C@]5(CC[C@H](O)C[C@H]5CC4)C)CC[C@@]32C)=CC(=O)OC1 XZTUSOXSLKTKJQ-CESUGQOBSA-N 0.000 description 1
- QONQRTHLHBTMGP-UHFFFAOYSA-N digitoxigenin Natural products CC12CCC(C3(CCC(O)CC3CC3)C)C3C11OC1CC2C1=CC(=O)OC1 QONQRTHLHBTMGP-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000002702 enteric coating Substances 0.000 description 1
- 238000009505 enteric coating Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 210000004211 gastric acid Anatomy 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 229960003746 metildigoxin Drugs 0.000 description 1
- IYJMSDVSVHDVGT-PEQKVOOWSA-N metildigoxin Chemical compound O1[C@H](C)[C@@H](OC)[C@@H](O)C[C@@H]1O[C@@H]1[C@@H](C)O[C@@H](O[C@@H]2[C@H](O[C@@H](O[C@@H]3C[C@@H]4[C@]([C@@H]5[C@H]([C@]6(CC[C@@H]([C@@]6(C)[C@H](O)C5)C=5COC(=O)C=5)O)CC4)(C)CC3)C[C@@H]2O)C)C[C@@H]1O IYJMSDVSVHDVGT-PEQKVOOWSA-N 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 230000008693 nausea Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 229930190098 proscillaridin Natural products 0.000 description 1
- 229960003584 proscillaridin Drugs 0.000 description 1
- MYEJFUXQJGHEQK-UHFFFAOYSA-N proscillaridin A Natural products OC1C(O)C(O)C(C)OC1OC1C=C2CCC3C4(O)CCC(C5=COC(=O)C=C5)C4(C)CCC3C2(C)CC1 MYEJFUXQJGHEQK-UHFFFAOYSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 231100001274 therapeutic index Toxicity 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000001960 triggered effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3205—Apparatus for removing or disposing of used needles or syringes, e.g. containers; Means for protection against accidental injuries from used needles
- A61M5/3278—Apparatus for destroying used needles or syringes
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Anesthesiology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Environmental & Geological Engineering (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Accommodation For Nursing Or Treatment Tables (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Crushing And Grinding (AREA)
- Disintegrating Or Milling (AREA)
Priority Applications (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7813245A SE426548B (sv) | 1978-12-05 | 1978-12-22 | Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer |
| GB7941299A GB2044619A (en) | 1978-12-05 | 1979-11-29 | Improvements to destructors of disposable medical syringes |
| DE19792948632 DE2948632A1 (de) | 1978-12-05 | 1979-12-04 | Vorrichtung zum unbrauchbarmachen von spritzen |
| JP15693479A JPS55102443A (en) | 1978-12-05 | 1979-12-05 | Improvement of breaking device of injector for medical treatment which can be treated |
| ZA00796606A ZA796606B (en) | 1978-12-05 | 1979-12-05 | Improvements to destructors of disposable medical syringes |
| ZA00796683A ZA796683B (en) | 1978-12-05 | 1979-12-10 | A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer |
| DE7979850111T DE2966037D1 (en) | 1978-12-22 | 1979-12-13 | A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer, and a process for preparation thereof |
| AT79850111T ATE4371T1 (de) | 1978-12-05 | 1979-12-13 | Ein herzglykosid in kombination mit einem polymer enthaltendes pharmazeutisches praeparat und verfahren zu dessen herstellung. |
| EP79850111A EP0013263B1 (fr) | 1978-12-05 | 1979-12-13 | Préparation pharmaceutique comprenant un glycoside cardiaque combiné à un polymère et procédé pour sa fabrication |
| CA342,036A CA1133394A (fr) | 1978-12-05 | 1979-12-17 | Preparation pharmaceutique contenant un glycoside cardiaque combine a un polymere |
| US06/104,429 US4261971A (en) | 1978-12-05 | 1979-12-17 | Pharmaceutically preparation comprising a cardiac glycoside in combination with a polymer |
| AU53962/79A AU531279B2 (en) | 1978-12-05 | 1979-12-18 | Cardiac glycoside composition |
| IE245579A IE48717B1 (en) | 1978-12-22 | 1979-12-18 | A pharmaceutical preparation comprising a cardiac glycoside in combination with a polymer,and a process for preparation thereof |
| CH1127979A CH641358A5 (de) | 1978-12-05 | 1979-12-19 | Pharmazeutisches praeparat, enthaltend ein herzglykosid in kombination mit einem polymeren und verfahren zur herstellung desselben. |
| DK542379A DK542379A (da) | 1978-12-05 | 1979-12-19 | Farmaceutisk praeparat som indeholder et hjertestyrkende glykosid i konbination med en polymer |
| PT7061879A PT70618A (en) | 1978-12-22 | 1979-12-20 | Process for preparing pharmaceutical compositions comprising a cardiac glycoside in combination with a polymer |
| FI794006A FI794006A7 (fi) | 1978-12-22 | 1979-12-20 | Farmaseuttinen valmiste, joka käsittää sydänglykosidin yhdessä polymeerin kanssa. |
| GR60840A GR74016B (fr) | 1978-12-22 | 1979-12-21 | |
| ES487182A ES8101888A1 (es) | 1978-12-22 | 1979-12-21 | Procedimiento para obtener una preparacion farmaceutica, que comprende un glicorido cardiaco en combinacion con un poli-mero. |
| NO794251A NO152634C (no) | 1978-12-22 | 1979-12-21 | Fremgangsmaate for fremstilling av et farmasoeytisk preparat omfattende et hjerteglykosid i kombinasjon med en polymer |
| BE0/198690A BE880796A (fr) | 1978-12-05 | 1979-12-21 | Preparation pharmaceutique comprenant un glycoside cardiaque en combinaison avec un polymere |
| LU82025A LU82025A1 (fr) | 1978-12-05 | 1979-12-21 | Preparation pharmaceutique comprenant un glycoside cardiaque en combinaison avec un polymere |
| JP16632379A JPS5587717A (en) | 1978-12-05 | 1979-12-22 | Cardiotonic glycoside containing medicine |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPD700478 | 1978-12-05 | ||
| SE7813245A SE426548B (sv) | 1978-12-05 | 1978-12-22 | Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7813245L SE7813245L (sv) | 1980-06-23 |
| SE426548B true SE426548B (sv) | 1983-01-31 |
Family
ID=25642273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7813245A SE426548B (sv) | 1978-12-05 | 1978-12-22 | Fast farmaceutisk beredning innehallande en terapeutiskt effektiv hjertglykosid och en polymer |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US4261971A (fr) |
| EP (1) | EP0013263B1 (fr) |
| JP (2) | JPS55102443A (fr) |
| AU (1) | AU531279B2 (fr) |
| BE (1) | BE880796A (fr) |
| CA (1) | CA1133394A (fr) |
| CH (1) | CH641358A5 (fr) |
| DE (1) | DE2948632A1 (fr) |
| DK (1) | DK542379A (fr) |
| GB (1) | GB2044619A (fr) |
| LU (1) | LU82025A1 (fr) |
| SE (1) | SE426548B (fr) |
| ZA (2) | ZA796606B (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4539155A (en) * | 1978-11-14 | 1985-09-03 | Fuisawa Pharmaceutical Company, Ltd. | New peptide, process for preparation thereof and use thereof |
| US4458078A (en) * | 1978-11-14 | 1984-07-03 | Fujisawa Pharmaceutical Company, Ltd. | Oxazole derivatives |
| JPS5769913A (en) * | 1980-10-20 | 1982-04-30 | Toshiba Corp | Input buffer circuit for measuring device |
| DE3264867D1 (en) * | 1981-04-27 | 1985-08-29 | Haessle Ab | New pharmaceutical preparation |
| DK150008C (da) * | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
| JPS58116414A (ja) * | 1981-12-23 | 1983-07-11 | Yamanouchi Pharmaceut Co Ltd | ニカルジピン持続性製剤用球形顆粒およびその製造法 |
| US4758437A (en) * | 1981-12-23 | 1988-07-19 | Yamanouchi Pharmaceutical Co., Ltd. | Composition for long acting nicardipine preparation and process of producing the composition |
| IE55519B1 (en) * | 1982-05-14 | 1990-10-10 | Maroko Peter R | Use of a protoberberine alkaloid and composition containing same |
| SE457505B (sv) * | 1984-01-10 | 1989-01-09 | Lejus Medical Ab | Laminatbelagd oral farmaceutisk komposition och foerfarande foer dess framstaellning |
| SE450087B (sv) * | 1985-10-11 | 1987-06-09 | Haessle Ab | Korn med kontrollerad frisettning av farmaceutiskt aktiva emnen som anbringats teckande pa ett kompakt olosligt kernmaterial |
| SE455836B (sv) * | 1985-10-11 | 1988-08-15 | Haessle Ab | Beredning med kontrollerad frisettning innehallande ett salt av metoprolol samt metod for framstellning av denna beredning |
| FR2602423B1 (fr) * | 1986-08-08 | 1989-05-05 | Ethypharm Sa | Procede de preparation d'un medicament a base de fenofibrate, medicament obtenu par ce procede |
| DE3632092A1 (de) * | 1986-09-20 | 1988-03-24 | Hans Bauer | Entsorgungssystem fuer kanuelen |
| SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
| NZ230763A (en) * | 1988-09-27 | 1991-10-25 | Takeda Chemical Industries Ltd | Production of granules having a core by spraying the cores with a dispersion of hydroxypropylcellulose, optionally incorporating an active ingredient |
| US4996113A (en) * | 1989-04-24 | 1991-02-26 | Aluminum Company Of America | Brightness enhancement with textured roll |
| EP0452862B1 (fr) * | 1990-04-18 | 1995-07-19 | Asahi Kasei Kogyo Kabushiki Kaisha | Noyaux des germes sphériques, granules sphériques et procédé de leur préparation |
| TW212139B (fr) * | 1991-04-15 | 1993-09-01 | Yamanouchi Pharma Co Ltd | |
| GB2321597B (en) * | 1997-01-29 | 2000-01-26 | Elizabeth Margaret Rinfret | Syringe needle disposal device |
| ATE400251T1 (de) * | 1999-02-09 | 2008-07-15 | Pfizer Prod Inc | Zusammensetzungen basischer arzneistoffe mit verbesserter bioverfügbarkeit |
| US8906891B2 (en) * | 2006-01-31 | 2014-12-09 | The University Of Toledo | Na/K-ATPase ligand |
| WO2008054792A2 (fr) | 2006-10-31 | 2008-05-08 | University Of Toledo | Activateurs/inhibiteurs peptidiques spécifiques à la voie na+/k+-atpase des kinases src et des kinases de la famille src |
| CA2615137A1 (fr) * | 2007-12-17 | 2009-06-17 | Pharmascience Inc. | Dispositif therapeutique monocouche a liberation controlee |
| US20120302630A1 (en) | 2009-09-16 | 2012-11-29 | Chinese Academy Of Medical Sciences | Na/K-ATPase Ligands, Ouabain Antagonists, Assays and Uses Thereof |
| CN102811729B (zh) | 2010-01-13 | 2015-02-11 | 托莱多大学 | 钠/钾三磷酸腺苷酶及src相关的材料和方法 |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2455790A (en) * | 1945-06-09 | 1948-12-07 | Eastman Kodak Co | Enteric coatings |
| CH283585A (de) * | 1950-03-15 | 1952-06-15 | Hoffmann La Roche | Zur Herstellung von Tablettenüberzügen geeignetes Gemisch. |
| US2698822A (en) * | 1951-04-28 | 1955-01-04 | Fougera & Co Inc E | Cardiac glycoside buccal composition |
| GB742544A (en) * | 1952-02-23 | 1955-12-30 | Kodak Ltd | Enteric products |
| US2881085A (en) * | 1953-11-09 | 1959-04-07 | Abbott Lab | Thin film coating for tablets and the like |
| US2853420A (en) * | 1956-01-25 | 1958-09-23 | Lowey Hans | Ethyl cellulose coatings for shaped medicinal preparations |
| US2921883A (en) * | 1957-05-03 | 1960-01-19 | Smith Kline French Lab | Novel coating material for medicaments |
| US2928770A (en) * | 1958-11-28 | 1960-03-15 | Frank M Bardani | Sustained action pill |
| BE590276A (fr) * | 1959-04-30 | |||
| NL122039C (fr) * | 1960-10-20 | |||
| DE1228757B (de) * | 1962-06-28 | 1966-11-17 | Haessle Ab | Verfahren zur Herstellung eines in Wasser und Magensaft rasch zerfallenden UEberzuges auf festen Arzneiformen |
| US3247066A (en) * | 1962-09-12 | 1966-04-19 | Parke Davis & Co | Controlled release dosage form containing water-swellable beadlet |
| US3325365A (en) * | 1963-04-02 | 1967-06-13 | Ciba Geigy Corp | Enteric composition for tablet compression coating |
| NL297631A (fr) * | 1963-06-03 | |||
| US3400185A (en) * | 1965-04-08 | 1968-09-03 | Bristol Myers Co | Agglomeration of smaller pharmaceutical particles into larger microspherules and enteic-coating thereof |
| GB1276089A (en) * | 1968-08-23 | 1972-06-01 | Pfizer Ltd | Pharmaceutical preparations |
| US3538214A (en) * | 1969-04-22 | 1970-11-03 | Merck & Co Inc | Controlled release medicinal tablets |
| DE2010416B2 (de) * | 1970-03-05 | 1979-03-29 | Hoechst Ag, 6000 Frankfurt | Oral anwendbare Arzneiform mit Retardwirkung |
| DE2031871C3 (de) * | 1970-06-27 | 1974-06-27 | Roehm Gmbh, 6100 Darmstadt | Überzugsmasse für Arzneiformen |
| US3954959A (en) * | 1973-03-28 | 1976-05-04 | A/S Alfred Benzon | Oral drug preparations |
| IL42166A (en) * | 1973-05-02 | 1976-01-30 | Res Prod Rehovot Ltd | Drug releasing preparation |
| DE2336218C3 (de) * | 1973-07-17 | 1985-11-14 | Byk Gulden Lomberg Chemische Fabrik Gmbh, 7750 Konstanz | Orale Arzneiform |
| US3965255A (en) * | 1974-05-01 | 1976-06-22 | E. E. Eljim Ecology Ltd. | Controlled drug releasing preparations |
| US4151273A (en) * | 1974-10-31 | 1979-04-24 | The Regents Of The University Of California | Increasing the absorption rate of insoluble drugs |
| SE418247B (sv) | 1975-11-17 | 1981-05-18 | Haessle Ab | Sett att framstella kroppar med reglerad frigoring av en aktiv komponent |
| US4202888A (en) * | 1976-07-12 | 1980-05-13 | Kali-Chemie Pharma Gmbh. | Readily enterally absorbable pharmaceutical compositions of cardiac glycosides and preparation thereof |
| US4147768A (en) * | 1976-09-13 | 1979-04-03 | Interx Research Corporation | Enteric coated digoxin and therapeutic use thereof |
-
1978
- 1978-12-22 SE SE7813245A patent/SE426548B/sv unknown
-
1979
- 1979-11-29 GB GB7941299A patent/GB2044619A/en not_active Withdrawn
- 1979-12-04 DE DE19792948632 patent/DE2948632A1/de not_active Withdrawn
- 1979-12-05 ZA ZA00796606A patent/ZA796606B/xx unknown
- 1979-12-05 JP JP15693479A patent/JPS55102443A/ja active Pending
- 1979-12-10 ZA ZA00796683A patent/ZA796683B/xx unknown
- 1979-12-13 EP EP79850111A patent/EP0013263B1/fr not_active Expired
- 1979-12-17 CA CA342,036A patent/CA1133394A/fr not_active Expired
- 1979-12-17 US US06/104,429 patent/US4261971A/en not_active Expired - Lifetime
- 1979-12-18 AU AU53962/79A patent/AU531279B2/en not_active Ceased
- 1979-12-19 DK DK542379A patent/DK542379A/da not_active Application Discontinuation
- 1979-12-19 CH CH1127979A patent/CH641358A5/de not_active IP Right Cessation
- 1979-12-21 LU LU82025A patent/LU82025A1/fr unknown
- 1979-12-21 BE BE0/198690A patent/BE880796A/fr not_active IP Right Cessation
- 1979-12-22 JP JP16632379A patent/JPS5587717A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP0013263A2 (fr) | 1980-07-09 |
| US4261971A (en) | 1981-04-14 |
| SE7813245L (sv) | 1980-06-23 |
| CA1133394A (fr) | 1982-10-12 |
| BE880796A (fr) | 1980-06-23 |
| ZA796683B (en) | 1980-11-26 |
| DK542379A (da) | 1980-06-23 |
| EP0013263B1 (fr) | 1983-08-03 |
| AU531279B2 (en) | 1983-08-18 |
| DE2948632A1 (de) | 1980-06-19 |
| ZA796606B (en) | 1980-12-31 |
| GB2044619A (en) | 1980-10-22 |
| CH641358A5 (de) | 1984-02-29 |
| LU82025A1 (fr) | 1980-07-21 |
| JPS5587717A (en) | 1980-07-02 |
| JPS55102443A (en) | 1980-08-05 |
| EP0013263A3 (en) | 1981-05-27 |
| AU5396279A (en) | 1980-06-26 |
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