SE462098B - Estrar baserade paa en polyol innehaallande minst tre hydroxylgrupper och mjoelksyra eller derivat daerav, foerfarande foer framstaellning av dessa estrar, depaamatrismaterial och depaaberedning innehaallande dessa estrar - Google Patents

Estrar baserade paa en polyol innehaallande minst tre hydroxylgrupper och mjoelksyra eller derivat daerav, foerfarande foer framstaellning av dessa estrar, depaamatrismaterial och depaaberedning innehaallande dessa estrar

Info

Publication number: SE462098B
Authority: SE; Sweden
Prior art keywords: polyol; molecular weight; active substance; hydroxyl groups; lactic acid
Prior art date: 1983-08-26

Application number

SE8404225A

Other languages

English (en)

Swedish (sv)

Other versions

SE8404225L (sv

SE8404225D0 (sv

Inventor

Z Brich

T Kissel

Original Assignee

Sandoz Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1983-08-26

Filing date

1984-08-24

Publication date

1990-05-07

1984-08-24 Application filed by Sandoz Ag filed Critical Sandoz Ag

1984-08-24 Publication of SE8404225D0 publication Critical patent/SE8404225D0/xx

1985-02-27 Publication of SE8404225L publication Critical patent/SE8404225L/xx

1990-05-07 Publication of SE462098B publication Critical patent/SE462098B/sv

Links

229920005862 polyol Polymers 0.000 title claims description 58
150000003077 polyols Chemical class 0.000 title claims description 34
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 title claims description 27
238000000034 method Methods 0.000 title claims description 13
239000004310 lactic acid Substances 0.000 title claims description 11
235000014655 lactic acid Nutrition 0.000 title claims description 10
238000002360 preparation method Methods 0.000 title claims description 6
-1 HYDROXYL GROUPS Chemical group 0.000 title description 32
239000000463 material Substances 0.000 title description 4
239000013543 active substance Substances 0.000 claims description 45
239000003094 microcapsule Substances 0.000 claims description 27
229920000642 polymer Polymers 0.000 claims description 27
239000000047 product Substances 0.000 claims description 24
239000011159 matrix material Substances 0.000 claims description 23
239000000203 mixture Substances 0.000 claims description 19
AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical group OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims description 13
239000003405 delayed action preparation Substances 0.000 claims description 13
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 13
OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 claims description 11
229960002802 bromocriptine Drugs 0.000 claims description 11
239000002253 acid Substances 0.000 claims description 10
150000002148 esters Chemical class 0.000 claims description 10
BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 9
239000007943 implant Substances 0.000 claims description 9
238000005227 gel permeation chromatography Methods 0.000 claims description 8
ZCVMWBYGMWKGHF-UHFFFAOYSA-N Ketotifene Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2CC(=O)C2=C1C=CS2 ZCVMWBYGMWKGHF-UHFFFAOYSA-N 0.000 claims description 5
125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims description 5
229960004958 ketotifen Drugs 0.000 claims description 5
238000009472 formulation Methods 0.000 claims description 3
229920000728 polyester Polymers 0.000 claims description 3
239000011149 active material Substances 0.000 claims description 2
239000007795 chemical reaction product Substances 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
229920001577 copolymer Polymers 0.000 claims description 2
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 32
JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 description 20
229960001031 glucose Drugs 0.000 description 13
239000008103 glucose Substances 0.000 description 13
RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 description 12
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
238000006243 chemical reaction Methods 0.000 description 10
239000000243 solution Substances 0.000 description 10
239000002904 solvent Substances 0.000 description 10
238000000338 in vitro Methods 0.000 description 7
238000003756 stirring Methods 0.000 description 7
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 6
238000001727 in vivo Methods 0.000 description 6
238000000746 purification Methods 0.000 description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
230000015556 catabolic process Effects 0.000 description 5
238000006731 degradation reaction Methods 0.000 description 5
238000001914 filtration Methods 0.000 description 5
238000005374 membrane filtration Methods 0.000 description 5
WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 5
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 4
238000002955 isolation Methods 0.000 description 4
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
229930195725 Mannitol Natural products 0.000 description 3
GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 3
238000009835 boiling Methods 0.000 description 3
239000003054 catalyst Substances 0.000 description 3
125000004122 cyclic group Chemical group 0.000 description 3
239000003814 drug Substances 0.000 description 3
230000002209 hydrophobic effect Effects 0.000 description 3
239000000594 mannitol Substances 0.000 description 3
235000010355 mannitol Nutrition 0.000 description 3
239000012074 organic phase Substances 0.000 description 3
229920000747 poly(lactic acid) Polymers 0.000 description 3
239000007921 spray Substances 0.000 description 3
JJTUDXZGHPGLLC-IMJSIDKUSA-N 4511-42-6 Chemical group C[C@@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-IMJSIDKUSA-N 0.000 description 2
229920002307 Dextran Polymers 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
239000001116 FEMA 4028 Substances 0.000 description 2
241000283973 Oryctolagus cuniculus Species 0.000 description 2
102000003946 Prolactin Human genes 0.000 description 2
108010057464 Prolactin Proteins 0.000 description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
239000008346 aqueous phase Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
235000011175 beta-cyclodextrine Nutrition 0.000 description 2
229960004853 betadex Drugs 0.000 description 2
230000036765 blood level Effects 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
239000007979 citrate buffer Substances 0.000 description 2
238000001816 cooling Methods 0.000 description 2
238000000354 decomposition reaction Methods 0.000 description 2
125000001142 dicarboxylic acid group Chemical group 0.000 description 2
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238000009413 insulation Methods 0.000 description 2
239000007788 liquid Substances 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 2
210000003205 muscle Anatomy 0.000 description 2
230000000144 pharmacologic effect Effects 0.000 description 2
229940097325 prolactin Drugs 0.000 description 2
230000028327 secretion Effects 0.000 description 2
238000007920 subcutaneous administration Methods 0.000 description 2
239000003826 tablet Substances 0.000 description 2
235000002906 tartaric acid Nutrition 0.000 description 2
239000011975 tartaric acid Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
HOSGXJWQVBHGLT-UHFFFAOYSA-N 6-hydroxy-3,4-dihydro-1h-quinolin-2-one Chemical group N1C(=O)CCC2=CC(O)=CC=C21 HOSGXJWQVBHGLT-UHFFFAOYSA-N 0.000 description 1
229920000858 Cyclodextrin Polymers 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
102000004190 Enzymes Human genes 0.000 description 1
108090000790 Enzymes Proteins 0.000 description 1
239000004386 Erythritol Substances 0.000 description 1
UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
241001077660 Molo Species 0.000 description 1
239000004793 Polystyrene Substances 0.000 description 1
241000700159 Rattus Species 0.000 description 1
JVWLUVNSQYXYBE-UHFFFAOYSA-N Ribitol Natural products OCC(C)C(O)C(O)CO JVWLUVNSQYXYBE-UHFFFAOYSA-N 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
238000009825 accumulation Methods 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
229940035676 analgesics Drugs 0.000 description 1
239000000730 antalgic agent Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
229940124599 anti-inflammatory drug Drugs 0.000 description 1
229940035678 anti-parkinson drug Drugs 0.000 description 1
239000000924 antiasthmatic agent Substances 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940125681 anticonvulsant agent Drugs 0.000 description 1
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239000000427 antigen Substances 0.000 description 1
102000036639 antigens Human genes 0.000 description 1
108091007433 antigens Proteins 0.000 description 1
239000003430 antimalarial agent Substances 0.000 description 1
229940124433 antimigraine drug Drugs 0.000 description 1
239000000164 antipsychotic agent Substances 0.000 description 1
229940005529 antipsychotics Drugs 0.000 description 1
239000012300 argon atmosphere Substances 0.000 description 1
208000006673 asthma Diseases 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
NOJMTMIRQRDZMT-GSPXQYRGSA-N bromocriptine methanesulfonate Chemical compound CS(O)(=O)=O.C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 NOJMTMIRQRDZMT-GSPXQYRGSA-N 0.000 description 1
229940124630 bronchodilator Drugs 0.000 description 1
239000000168 bronchodilator agent Substances 0.000 description 1
239000000872 buffer Substances 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
125000004432 carbon atom Chemical group C* 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
229940125692 cardiovascular agent Drugs 0.000 description 1
239000002327 cardiovascular agent Substances 0.000 description 1
230000003197 catalytic effect Effects 0.000 description 1
238000005119 centrifugation Methods 0.000 description 1
230000002490 cerebral effect Effects 0.000 description 1
238000009833 condensation Methods 0.000 description 1
230000005494 condensation Effects 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
WQZGKKKJIJFFOK-UKLRSMCWSA-N dextrose-2-13c Chemical compound OC[C@H]1OC(O)[13C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-UKLRSMCWSA-N 0.000 description 1
150000001991 dicarboxylic acids Chemical class 0.000 description 1
238000009792 diffusion process Methods 0.000 description 1
239000000539 dimer Substances 0.000 description 1
239000012153 distilled water Substances 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
229940088598 enzyme Drugs 0.000 description 1
UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
235000019414 erythritol Nutrition 0.000 description 1
229940009714 erythritol Drugs 0.000 description 1
230000032050 esterification Effects 0.000 description 1
238000005886 esterification reaction Methods 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
BJHIKXHVCXFQLS-UYFOZJQFSA-N fructose group Chemical group OCC(=O)[C@@H](O)[C@H](O)[C@H](O)CO BJHIKXHVCXFQLS-UYFOZJQFSA-N 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000002513 implantation Methods 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
208000030603 inherited susceptibility to asthma Diseases 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
150000002596 lactones Chemical class 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
239000012299 nitrogen atmosphere Substances 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
210000002381 plasma Anatomy 0.000 description 1
238000012667 polymer degradation Methods 0.000 description 1
229920002223 polystyrene Polymers 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
239000012264 purified product Substances 0.000 description 1
238000003127 radioimmunoassay Methods 0.000 description 1
230000007420 reactivation Effects 0.000 description 1
238000010992 reflux Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
238000007142 ring opening reaction Methods 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
238000007873 sieving Methods 0.000 description 1
150000003384 small molecules Chemical class 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
238000005507 spraying Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
239000000126 substance Substances 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
229960005486 vaccine Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/66—Polyesters containing oxygen in the form of ether groups
- C08G63/664—Polyesters containing oxygen in the form of ether groups derived from hydroxy carboxylic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
- A61K9/204—Polyesters, e.g. poly(lactide-co-glycolide)
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
- Y10S977/915—Therapeutic or pharmaceutical composition

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Polymers & Plastics (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Preparation (AREA)
Polyesters Or Polycarbonates (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SE8404225A 1983-08-26 1984-08-24 Estrar baserade paa en polyol innehaallande minst tre hydroxylgrupper och mjoelksyra eller derivat daerav, foerfarande foer framstaellning av dessa estrar, depaamatrismaterial och depaaberedning innehaallande dessa estrar SE462098B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CH4671/83A CH656884A5 (de)	1983-08-26	1983-08-26	Polyolester, deren herstellung und verwendung.

Publications (3)

Publication Number	Publication Date
SE8404225D0 SE8404225D0 (sv)	1984-08-24
SE8404225L SE8404225L (sv)	1985-02-27
SE462098B true SE462098B (sv)	1990-05-07

Family

ID=4280440

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8404225A SE462098B (sv)	1983-08-26	1984-08-24	Estrar baserade paa en polyol innehaallande minst tre hydroxylgrupper och mjoelksyra eller derivat daerav, foerfarande foer framstaellning av dessa estrar, depaamatrismaterial och depaaberedning innehaallande dessa estrar

Country Status (27)

Country	Link
US (2)	US5922682A (fr)
JP (1)	JPH0819226B2 (fr)
AT (1)	AT395584B (fr)
AU (1)	AU575066B2 (fr)
BE (1)	BE900406A (fr)
CH (1)	CH656884A5 (fr)
CY (1)	CY1556A (fr)
DE (1)	DE3430852C2 (fr)
DK (1)	DK173556B1 (fr)
ES (1)	ES8706750A1 (fr)
FR (1)	FR2551072B1 (fr)
GB (1)	GB2145422B (fr)
GR (1)	GR80184B (fr)
HK (1)	HK67390A (fr)
HU (1)	HU195426B (fr)
IE (1)	IE58818B1 (fr)
IL (1)	IL72763A (fr)
IT (1)	IT1176629B (fr)
LU (1)	LU85514A1 (fr)
MY (1)	MY101861A (fr)
NL (2)	NL190415C (fr)
NZ (1)	NZ209335A (fr)
PH (1)	PH23556A (fr)
PT (1)	PT79129B (fr)
SE (1)	SE462098B (fr)
SG (1)	SG53590G (fr)
ZA (1)	ZA846634B (fr)

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1983
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1984
- 1984-08-20 NL NLAANVRAGE8402547,A patent/NL190415C/xx not_active IP Right Cessation
- 1984-08-21 HU HU843146A patent/HU195426B/hu unknown
- 1984-08-21 FR FR8413111A patent/FR2551072B1/fr not_active Expired
- 1984-08-22 DE DE3430852A patent/DE3430852C2/de not_active Expired - Lifetime
- 1984-08-22 BE BE1/11073A patent/BE900406A/fr not_active IP Right Cessation
- 1984-08-22 GB GB08421273A patent/GB2145422B/en not_active Expired
- 1984-08-23 GR GR80184A patent/GR80184B/el unknown
- 1984-08-24 LU LU85514A patent/LU85514A1/fr unknown
- 1984-08-24 ZA ZA846634A patent/ZA846634B/xx unknown
- 1984-08-24 PH PH31143A patent/PH23556A/en unknown
- 1984-08-24 IE IE217184A patent/IE58818B1/xx not_active IP Right Cessation
- 1984-08-24 ES ES535399A patent/ES8706750A1/es not_active Expired
- 1984-08-24 IT IT22413/84A patent/IT1176629B/it active Protection Beyond IP Right Term
- 1984-08-24 JP JP59177375A patent/JPH0819226B2/ja not_active Expired - Lifetime
- 1984-08-24 DK DK198404072A patent/DK173556B1/da not_active IP Right Cessation
- 1984-08-24 NZ NZ209335A patent/NZ209335A/xx unknown
- 1984-08-24 PT PT79129A patent/PT79129B/pt unknown
- 1984-08-24 SE SE8404225A patent/SE462098B/sv not_active IP Right Cessation
- 1984-08-24 AT AT0271384A patent/AT395584B/de active
- 1984-08-24 IL IL72763A patent/IL72763A/xx not_active IP Right Cessation
- 1984-08-24 AU AU32348/84A patent/AU575066B2/en not_active Expired
1987
- 1987-09-24 MY MYPI87001920A patent/MY101861A/en unknown
1990
- 1990-07-11 SG SG535/90A patent/SG53590G/en unknown
- 1990-08-30 HK HK673/90A patent/HK67390A/xx not_active IP Right Cessation
1991
- 1991-03-22 CY CY1556A patent/CY1556A/en unknown
1992
- 1992-02-11 US US07/834,018 patent/US5922682A/en not_active Expired - Lifetime
1995
- 1995-06-06 US US08/471,304 patent/US5922338A/en not_active Expired - Lifetime
1996
- 1996-06-06 NL NL960014C patent/NL960014I1/nl unknown

Also Published As

Publication number	Publication date
PT79129B (en)	1986-07-17
GR80184B (en)	1985-01-02
NL190415C (nl)	1994-02-16
SE8404225L (sv)	1985-02-27
CY1556A (en)	1991-03-22
DK407284A (da)	1985-02-27
CH656884A5 (de)	1986-07-31
NL190415B (nl)	1993-09-16
JPS6076531A (ja)	1985-05-01
LU85514A1 (fr)	1985-04-24
DK407284D0 (da)	1984-08-24
SG53590G (en)	1990-10-26
IT1176629B (it)	1987-08-18
IL72763A (en)	1988-02-29
IE58818B1 (en)	1993-11-17
DK173556B1 (da)	2001-03-12
HUT38265A (en)	1986-05-28
US5922338A (en)	1999-07-13
NZ209335A (en)	1988-08-30
FR2551072A1 (fr)	1985-03-01
AT395584B (de)	1993-01-25
ZA846634B (en)	1986-04-30
HU195426B (en)	1988-05-30
AU575066B2 (en)	1988-07-21
IT8422413A0 (it)	1984-08-24
IL72763A0 (en)	1984-11-30
PH23556A (en)	1989-08-25
ATA271384A (de)	1992-06-15
NL960014I1 (nl)	1996-10-01
SE8404225D0 (sv)	1984-08-24
AU3234884A (en)	1985-02-28
FR2551072B1 (fr)	1988-01-15
ES535399A0 (es)	1987-06-16
PT79129A (en)	1984-09-01
IE842171L (en)	1985-02-26
MY101861A (en)	1992-01-31
DE3430852C2 (de)	2003-08-14
ES8706750A1 (es)	1987-06-16
NL8402547A (nl)	1985-03-18
JPH0819226B2 (ja)	1996-02-28
BE900406A (fr)	1985-02-22
DE3430852A1 (de)	1985-03-14
US5922682A (en)	1999-07-13
GB2145422B (en)	1987-08-26
GB2145422A (en)	1985-03-27
HK67390A (en)	1990-09-07
GB8421273D0 (en)	1984-09-26

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Publication	Publication Date	Title
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EP1716847B1 (fr)	2008-01-02	Composition pharmaceutique bioabsorbable contenant un copolymère de PLGA
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KR930002707B1 (ko)	1993-04-09	폴리올 에스테르의 제조방법
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JP3254449B2 (ja)	2002-02-04	生体内分解型高分子重合物
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Jameela	1997	Crosslinked chitosan as a carrier for controlled drug delivery.