SE503424C2 - Process för rening av rekombinant koagulationsfaktor VIII - Google Patents

Process för rening av rekombinant koagulationsfaktor VIII

Info

Publication number
SE503424C2
SE503424C2 SE9403914A SE9403914A SE503424C2 SE 503424 C2 SE503424 C2 SE 503424C2 SE 9403914 A SE9403914 A SE 9403914A SE 9403914 A SE9403914 A SE 9403914A SE 503424 C2 SE503424 C2 SE 503424C2
Authority
SE
Sweden
Prior art keywords
factor viii
gel
process according
aqueous solution
surfactant
Prior art date
Application number
SE9403914A
Other languages
English (en)
Swedish (sv)
Other versions
SE9403914D0 (sv
SE9403914L (sv
Inventor
Anna-Lisa Smeds
Original Assignee
Pharmacia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Ab filed Critical Pharmacia Ab
Priority to SE9403914A priority Critical patent/SE503424C2/sv
Publication of SE9403914D0 publication Critical patent/SE9403914D0/xx
Priority to DK95937285T priority patent/DK0792281T3/da
Priority to EP95937285A priority patent/EP0792281B1/de
Priority to NZ295810A priority patent/NZ295810A/en
Priority to AT95937285T priority patent/ATE225368T1/de
Priority to US08/809,698 priority patent/US6005082A/en
Priority to CA2202873A priority patent/CA2202873C/en
Priority to ES95937285T priority patent/ES2182915T3/es
Priority to JP51599296A priority patent/JP3871710B2/ja
Priority to AU39438/95A priority patent/AU691993B2/en
Priority to DE69528471T priority patent/DE69528471T2/de
Priority to PCT/SE1995/001350 priority patent/WO1996015140A1/en
Priority to PT95937285T priority patent/PT792281E/pt
Publication of SE9403914L publication Critical patent/SE9403914L/
Publication of SE503424C2 publication Critical patent/SE503424C2/sv
Priority to MXPA/A/1997/003470A priority patent/MXPA97003470A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Liquid Crystal Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
SE9403914A 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII SE503424C2 (sv)

Priority Applications (14)

Application Number Priority Date Filing Date Title
SE9403914A SE503424C2 (sv) 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII
PT95937285T PT792281E (pt) 1994-11-14 1995-11-14 Processo para a purificacao de factor viii
CA2202873A CA2202873C (en) 1994-11-14 1995-11-14 Process for purification of factor viii
JP51599296A JP3871710B2 (ja) 1994-11-14 1995-11-14 Ｖｉｉｉ因子の精製方法
NZ295810A NZ295810A (en) 1994-11-14 1995-11-14 Method of purifying factor viii using hydrophobic interaction chromatography gel with at least one surfactant in the chromatography solution
AT95937285T ATE225368T1 (de) 1994-11-14 1995-11-14 Verfahren zur reinigung von faktor viii
US08/809,698 US6005082A (en) 1994-11-14 1995-11-14 Process for purification of factor VIII
DK95937285T DK0792281T3 (da) 1994-11-14 1995-11-14 Proces til oprensning af faktor VIII
ES95937285T ES2182915T3 (es) 1994-11-14 1995-11-14 Procedimiento de purificacion del factor viii
EP95937285A EP0792281B1 (de) 1994-11-14 1995-11-14 Verfahren zur reinigung von faktor viii
AU39438/95A AU691993B2 (en) 1994-11-14 1995-11-14 Process for purification of factor VIII
DE69528471T DE69528471T2 (de) 1994-11-14 1995-11-14 Verfahren zur reinigung von faktor viii
PCT/SE1995/001350 WO1996015140A1 (en) 1994-11-14 1995-11-14 Process for purification of factor viii
MXPA/A/1997/003470A MXPA97003470A (en) 1994-11-14 1997-05-12 Factor v purification process

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9403914A SE503424C2 (sv) 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII

Publications (3)

Publication Number Publication Date
SE9403914D0 SE9403914D0 (sv) 1994-11-14
SE9403914L SE9403914L (sv) 1996-05-15
SE503424C2 true SE503424C2 (sv) 1996-06-10

Family

ID=20395963

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9403914A SE503424C2 (sv) 1994-11-14 1994-11-14 Process för rening av rekombinant koagulationsfaktor VIII

Country Status (13)

Country Link
US (1) US6005082A (de)
EP (1) EP0792281B1 (de)
JP (1) JP3871710B2 (de)
AT (1) ATE225368T1 (de)
AU (1) AU691993B2 (de)
CA (1) CA2202873C (de)
DE (1) DE69528471T2 (de)
DK (1) DK0792281T3 (de)
ES (1) ES2182915T3 (de)
NZ (1) NZ295810A (de)
PT (1) PT792281E (de)
SE (1) SE503424C2 (de)
WO (1) WO1996015140A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1820516T3 (da) 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
US6822081B2 (en) * 2000-01-13 2004-11-23 Max-Planck Gesellschaft zur Förderung der Wissenschaften e.V. Process for the isolation and/or purification of a proteinaceous material
AU4951501A (en) 2000-03-27 2001-10-08 Genetics Inst Methods for purifying highly anionic proteins
ES2321539T3 (es) * 2001-06-05 2009-06-08 Genetics Institute, Llc Procedimientos relativos a la purificacion de proteinas altamente anionicas.
US7427659B2 (en) * 2003-10-24 2008-09-23 Amgen Inc. Process for purifying proteins in a hydrophobic interaction chromatography flow-through fraction
CN101730707B (zh) * 2007-07-11 2014-12-17 诺沃-诺迪斯克有限公司 使用混合式或多模式树脂来纯化因子ⅷ
MX339060B (es) 2008-11-07 2016-05-09 Baxter Int Formulaciones del factor viii.
CA2771999A1 (en) 2009-08-24 2011-03-10 Amunix Operating Inc. Coagulation factor vii compositions and methods of making and using same
RU2012151132A (ru) 2010-05-19 2014-06-27 Ф. Хоффманн-Ля Рош Аг Хроматография с гиброфобным взаимодействием
SG191186A1 (en) 2010-12-15 2013-07-31 Baxter Int Eluate collection using conductivity gradient
BRPI1105317A2 (pt) 2011-01-24 2013-04-30 Fundacco Hemoct De Ribeirco Preto produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
EP2822577B1 (de) 2012-02-15 2019-02-06 Bioverativ Therapeutics Inc. Rekombinante faktor-viii-proteine
JP6256882B2 (ja) 2012-02-15 2018-01-10 アムニクス オペレーティング インコーポレイテッド 第ｖｉｉｉ因子組成物、ならびに組成物の作製方法および用途
WO2013158273A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Methods to modulate c-terminal lysine variant distribution
WO2013158279A1 (en) 2012-04-20 2013-10-24 Abbvie Inc. Protein purification methods to reduce acidic species
US9067990B2 (en) 2013-03-14 2015-06-30 Abbvie, Inc. Protein purification using displacement chromatography
US9512214B2 (en) 2012-09-02 2016-12-06 Abbvie, Inc. Methods to control protein heterogeneity
HK1207960A1 (en) 2013-03-12 2016-02-19 Abbvie Inc. Human antibodies that bind human tnf-alpha and methods of preparing the same
US10023608B1 (en) 2013-03-13 2018-07-17 Amgen Inc. Protein purification methods to remove impurities
US9017687B1 (en) 2013-10-18 2015-04-28 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same using displacement chromatography
US9499614B2 (en) 2013-03-14 2016-11-22 Abbvie Inc. Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides
TW202003554A (zh) 2013-08-14 2020-01-16 美商百歐維拉提夫治療公司 因子ｖｉｉｉ－ｘｔｅｎ融合物及其用途
US9598667B2 (en) 2013-10-04 2017-03-21 Abbvie Inc. Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
US9181337B2 (en) 2013-10-18 2015-11-10 Abbvie, Inc. Modulated lysine variant species compositions and methods for producing and using the same
US9085618B2 (en) 2013-10-18 2015-07-21 Abbvie, Inc. Low acidic species compositions and methods for producing and using the same
US20150139988A1 (en) 2013-11-15 2015-05-21 Abbvie, Inc. Glycoengineered binding protein compositions
EA201890423A1 (ru) 2015-08-03 2018-07-31 Биовератив Терапьютикс Инк. Слитые белки фактора ix, способы их получения и применения
MX2019006444A (es) 2016-12-02 2019-10-30 Bioverativ Therapeutics Inc Métodos de tratamiento de artropatía hemofílica utilizando factores de coagulación quiméricos.
US11299533B2 (en) 2017-06-23 2022-04-12 Takeda Pharmaceutical Company Limited Purification of factor VIII subspecies
PL3793588T3 (pl) 2018-05-18 2025-09-01 Bioverativ Therapeutics Inc. Sposoby leczenia hemofilii a

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI86885C (fi) * 1984-04-20 1992-10-26 Genentech Inc Foerfarande foer framstaellning av human rekombinantfaktor viii och nukleinsyrasekvenser och vektorer anvaend daertill
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
SE8501050D0 (sv) * 1985-03-05 1985-03-05 Kabivitrum Ab Biologically active fragments of human antihemophilic factor and method for preparation thereof
US4758657A (en) * 1985-07-11 1988-07-19 Armour Pharmaceutical Company Method of purifying Factor VIII:C
US5595886A (en) * 1986-01-27 1997-01-21 Chiron Corporation Protein complexes having Factor VIII:C activity and production thereof
CA1339946C (en) * 1987-03-31 1998-07-07 Michael J. Griffith Ultrapurification process for polypeptides
SE465222C5 (sv) * 1989-12-15 1998-02-10 Pharmacia & Upjohn Ab Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning
FR2662166A1 (fr) * 1990-05-18 1991-11-22 Fondation Nale Transfusion San Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption.
GB9211538D0 (en) * 1992-06-01 1992-07-15 Blake David R Antiinflammatory agent
CA2124690C (en) * 1992-10-02 2007-09-11 Thomas Osterberg Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
AU6653094A (en) * 1992-12-16 1994-07-04 Immuno Aktiengesellschaft Process for preparing a virus-safe biological composition

Also Published As

Publication number Publication date
SE9403914D0 (sv) 1994-11-14
AU3943895A (en) 1996-06-06
PT792281E (pt) 2003-02-28
EP0792281B1 (de) 2002-10-02
SE9403914L (sv) 1996-05-15
CA2202873C (en) 2011-06-21
DK0792281T3 (da) 2003-02-03
ATE225368T1 (de) 2002-10-15
WO1996015140A1 (en) 1996-05-23
JP3871710B2 (ja) 2007-01-24
US6005082A (en) 1999-12-21
MX9703470A (es) 1997-07-31
EP0792281A1 (de) 1997-09-03
ES2182915T3 (es) 2003-03-16
JPH10508841A (ja) 1998-09-02
AU691993B2 (en) 1998-05-28
NZ295810A (en) 1998-08-26
DE69528471D1 (de) 2002-11-07
CA2202873A1 (en) 1996-05-23
DE69528471T2 (de) 2003-07-10

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