SE517168C2 - En komposition för ett injicerbart ersättningsmaterial för benmineral - Google Patents

En komposition för ett injicerbart ersättningsmaterial för benmineral

Info

Publication number: SE517168C2
Authority: SE; Sweden
Prior art keywords: composition according; phosphate; aqueous liquid; reactant; weight
Prior art date: 2000-07-17

Application number

SE0002676A

Other languages

English (en)

Swedish (sv)

Other versions

SE0002676D0 (sv

SE0002676L (sv

Inventor

Lars Lidgren

Original Assignee

Bone Support Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-07-17

Filing date

2000-07-17

Publication date

2002-04-23

2000-07-17 Application filed by Bone Support Ab filed Critical Bone Support Ab

2000-07-17 Priority to SE0002676A priority Critical patent/SE517168C2/sv

2000-07-17 Publication of SE0002676D0 publication Critical patent/SE0002676D0/xx

2001-07-16 Priority to AU7120901A priority patent/AU7120901A/xx

2001-07-16 Priority to EP01950184A priority patent/EP1301219B1/de

2001-07-16 Priority to AT01950184T priority patent/ATE313344T1/de

2001-07-16 Priority to AU2001271209A priority patent/AU2001271209B2/en

2001-07-16 Priority to JP2002511792A priority patent/JP5351369B2/ja

2001-07-16 Priority to US10/333,026 priority patent/US7417077B2/en

2001-07-16 Priority to PCT/SE2001/001627 priority patent/WO2002005861A1/en

2001-07-16 Priority to ES01950184T priority patent/ES2252254T3/es

2001-07-16 Priority to DE60116098T priority patent/DE60116098T2/de

2002-01-18 Publication of SE0002676L publication Critical patent/SE0002676L/xx

2002-04-23 Publication of SE517168C2 publication Critical patent/SE517168C2/sv

2008-05-19 Priority to US12/122,873 priority patent/US20080286331A1/en

2008-07-23 Priority to US12/219,543 priority patent/US20090192629A1/en

2008-07-23 Priority to US12/219,542 priority patent/US20090018667A1/en

Links

239000000463 material Substances 0.000 title claims abstract description 58
210000000988 bone and bone Anatomy 0.000 title claims abstract description 43
239000000203 mixture Substances 0.000 title claims abstract description 43
229910052500 inorganic mineral Inorganic materials 0.000 title claims abstract description 19
239000011707 mineral Substances 0.000 title claims abstract description 19
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims abstract description 71
239000001506 calcium phosphate Substances 0.000 claims abstract description 66
235000011010 calcium phosphates Nutrition 0.000 claims abstract description 55
229910000389 calcium phosphate Inorganic materials 0.000 claims abstract description 44
238000006243 chemical reaction Methods 0.000 claims abstract description 36
239000004568 cement Substances 0.000 claims abstract description 35
ZOMBKNNSYQHRCA-UHFFFAOYSA-J calcium sulfate hemihydrate Chemical compound O.[Ca+2].[Ca+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O ZOMBKNNSYQHRCA-UHFFFAOYSA-J 0.000 claims abstract description 26
239000007788 liquid Substances 0.000 claims abstract description 25
239000000843 powder Substances 0.000 claims abstract description 22
239000007972 injectable composition Substances 0.000 claims abstract description 19
238000002156 mixing Methods 0.000 claims abstract description 15
PASHVRUKOFIRIK-UHFFFAOYSA-L calcium sulfate dihydrate Chemical compound O.O.[Ca+2].[O-]S([O-])(=O)=O PASHVRUKOFIRIK-UHFFFAOYSA-L 0.000 claims abstract description 13
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 claims description 46
229910052588 hydroxylapatite Inorganic materials 0.000 claims description 39
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical group [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 39
239000002245 particle Substances 0.000 claims description 22
229910019142 PO4 Inorganic materials 0.000 claims description 20
239000011575 calcium Substances 0.000 claims description 18
235000011132 calcium sulphate Nutrition 0.000 claims description 16
239000000376 reactant Substances 0.000 claims description 12
239000001175 calcium sulphate Substances 0.000 claims description 11
239000010452 phosphate Substances 0.000 claims description 10
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 10
229910000391 tricalcium phosphate Inorganic materials 0.000 claims description 10
235000019731 tricalcium phosphate Nutrition 0.000 claims description 10
229940078499 tricalcium phosphate Drugs 0.000 claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
GBNXLQPMFAUCOI-UHFFFAOYSA-H tetracalcium;oxygen(2-);diphosphate Chemical compound [O-2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O GBNXLQPMFAUCOI-UHFFFAOYSA-H 0.000 claims description 8
238000001727 in vivo Methods 0.000 claims description 6
HECLRDQVFMWTQS-UHFFFAOYSA-N Dicyclopentadiene Chemical compound C1C2C3CC=CC3C1C=C2 HECLRDQVFMWTQS-UHFFFAOYSA-N 0.000 claims description 5
239000003242 anti bacterial agent Substances 0.000 claims description 3
229940088710 antibiotic agent Drugs 0.000 claims description 3
239000010839 body fluid Substances 0.000 claims description 3
210000001124 body fluid Anatomy 0.000 claims description 3
239000012153 distilled water Substances 0.000 claims description 3
101100283604 Caenorhabditis elegans pigk-1 gene Proteins 0.000 claims description 2
239000003963 antioxidant agent Substances 0.000 claims description 2
239000000824 cytostatic agent Substances 0.000 claims description 2
230000001085 cytostatic effect Effects 0.000 claims description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical group [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
239000003102 growth factor Substances 0.000 claims description 2
-1 (MCPM) Chemical compound 0.000 claims 1
235000019739 Dicalciumphosphate Nutrition 0.000 claims 1
239000013543 active substance Substances 0.000 claims 1
239000003855 balanced salt solution Substances 0.000 claims 1
VOAQDGKNFNLTHL-UHFFFAOYSA-L calcium phosphoric acid dihydroxide hydrate Chemical compound O.[OH-].[OH-].[Ca+2].OP(O)(O)=O VOAQDGKNFNLTHL-UHFFFAOYSA-L 0.000 claims 1
NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims 1
229910000390 dicalcium phosphate Inorganic materials 0.000 claims 1
229940038472 dicalcium phosphate Drugs 0.000 claims 1
150000004683 dihydrates Chemical class 0.000 claims 1
TWRPYHQZUAIUAL-UHFFFAOYSA-H heptacalcium diphosphate Chemical compound P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].P(=O)([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2] TWRPYHQZUAIUAL-UHFFFAOYSA-H 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
229910000392 octacalcium phosphate Inorganic materials 0.000 claims 1
YIGWVOWKHUSYER-UHFFFAOYSA-F tetracalcium;hydrogen phosphate;diphosphate Chemical compound [Ca+2].[Ca+2].[Ca+2].[Ca+2].OP([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O YIGWVOWKHUSYER-UHFFFAOYSA-F 0.000 claims 1
238000000034 method Methods 0.000 abstract description 11
238000001723 curing Methods 0.000 description 26
235000010755 mineral Nutrition 0.000 description 14
239000013078 crystal Substances 0.000 description 12
239000011507 gypsum plaster Substances 0.000 description 12
229910001868 water Inorganic materials 0.000 description 12
238000012360 testing method Methods 0.000 description 11
241000700159 Rattus Species 0.000 description 10
239000007943 implant Substances 0.000 description 10
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 8
235000021317 phosphate Nutrition 0.000 description 8
230000000694 effects Effects 0.000 description 7
238000002347 injection Methods 0.000 description 7
239000007924 injection Substances 0.000 description 7
208000010392 Bone Fractures Diseases 0.000 description 6
CGMRCMMOCQYHAD-UHFFFAOYSA-J dicalcium hydroxide phosphate Chemical compound [OH-].[Ca++].[Ca++].[O-]P([O-])([O-])=O CGMRCMMOCQYHAD-UHFFFAOYSA-J 0.000 description 6
210000003205 muscle Anatomy 0.000 description 6
210000001519 tissue Anatomy 0.000 description 6
230000036760 body temperature Effects 0.000 description 5
239000012890 simulated body fluid Substances 0.000 description 5
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 4
239000007864 aqueous solution Substances 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
229910000019 calcium carbonate Inorganic materials 0.000 description 4
235000010216 calcium carbonate Nutrition 0.000 description 4
230000007547 defect Effects 0.000 description 4
XLYOFNOQVPJJNP-ZSJDYOACSA-N heavy water Substances [2H]O[2H] XLYOFNOQVPJJNP-ZSJDYOACSA-N 0.000 description 4
238000000338 in vitro Methods 0.000 description 4
238000011534 incubation Methods 0.000 description 4
WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 4
238000001556 precipitation Methods 0.000 description 4
235000002639 sodium chloride Nutrition 0.000 description 4
239000000126 substance Substances 0.000 description 4
241001465754 Metazoa Species 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
239000002253 acid Chemical class 0.000 description 3
238000006065 biodegradation reaction Methods 0.000 description 3
239000002639 bone cement Substances 0.000 description 3
230000008468 bone growth Effects 0.000 description 3
239000000316 bone substitute Substances 0.000 description 3
229910052791 calcium Inorganic materials 0.000 description 3
XAAHAAMILDNBPS-UHFFFAOYSA-L calcium hydrogenphosphate dihydrate Chemical compound O.O.[Ca+2].OP([O-])([O-])=O XAAHAAMILDNBPS-UHFFFAOYSA-L 0.000 description 3
ZBZJARSYCHAEND-UHFFFAOYSA-L calcium;dihydrogen phosphate;hydrate Chemical compound O.[Ca+2].OP(O)([O-])=O.OP(O)([O-])=O ZBZJARSYCHAEND-UHFFFAOYSA-L 0.000 description 3
230000000052 comparative effect Effects 0.000 description 3
230000035876 healing Effects 0.000 description 3
230000007062 hydrolysis Effects 0.000 description 3
238000006460 hydrolysis reaction Methods 0.000 description 3
238000002513 implantation Methods 0.000 description 3
239000000047 product Substances 0.000 description 3
238000001356 surgical procedure Methods 0.000 description 3
GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
229910052925 anhydrite Inorganic materials 0.000 description 2
229910052586 apatite Inorganic materials 0.000 description 2
230000003115 biocidal effect Effects 0.000 description 2
239000006227 byproduct Substances 0.000 description 2
230000015556 catabolic process Effects 0.000 description 2
239000000919 ceramic Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
238000006731 degradation reaction Methods 0.000 description 2
239000000839 emulsion Substances 0.000 description 2
238000002474 experimental method Methods 0.000 description 2
230000012010 growth Effects 0.000 description 2
VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 description 2
229960001412 pentobarbital Drugs 0.000 description 2
235000011007 phosphoric acid Nutrition 0.000 description 2
239000002244 precipitate Substances 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
238000011084 recovery Methods 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000011780 sodium chloride Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
208000015976 Corneal dystrophy-perceptive deafness syndrome Diseases 0.000 description 1
239000012594 Earle’s Balanced Salt Solution Substances 0.000 description 1
239000012981 Hank's balanced salt solution Substances 0.000 description 1
241001484259 Lacuna Species 0.000 description 1
101100030263 Mus musculus Pogz gene Proteins 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
206010031252 Osteomyelitis Diseases 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
108010039811 Starch synthase Proteins 0.000 description 1
238000000692 Student's t-test Methods 0.000 description 1
229930003427 Vitamin E Natural products 0.000 description 1
ZQOMKIOQTCAGCM-UHFFFAOYSA-L [Na+].[Na+].OS(O)(=O)=O.[O-]S([O-])(=O)=O Chemical compound [Na+].[Na+].OS(O)(=O)=O.[O-]S([O-])(=O)=O ZQOMKIOQTCAGCM-UHFFFAOYSA-L 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
235000006708 antioxidants Nutrition 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
239000008280 blood Substances 0.000 description 1
210000004369 blood Anatomy 0.000 description 1
210000001185 bone marrow Anatomy 0.000 description 1
230000010478 bone regeneration Effects 0.000 description 1
239000007795 chemical reaction product Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000000576 coating method Methods 0.000 description 1
239000002131 composite material Substances 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
210000002808 connective tissue Anatomy 0.000 description 1
230000003247 decreasing effect Effects 0.000 description 1
230000001627 detrimental effect Effects 0.000 description 1
AAOVKJBEBIDNHE-UHFFFAOYSA-N diazepam Chemical compound N=1CC(=O)N(C)C2=CC=C(Cl)C=C2C=1C1=CC=CC=C1 AAOVKJBEBIDNHE-UHFFFAOYSA-N 0.000 description 1
229960003529 diazepam Drugs 0.000 description 1
235000005911 diet Nutrition 0.000 description 1
230000037213 diet Effects 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
208000002854 epidermolysis bullosa simplex superficialis Diseases 0.000 description 1
238000011049 filling Methods 0.000 description 1
239000012530 fluid Substances 0.000 description 1
239000011888 foil Substances 0.000 description 1
239000012634 fragment Substances 0.000 description 1
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
230000035784 germination Effects 0.000 description 1
159000000011 group IA salts Chemical class 0.000 description 1
229910052602 gypsum Inorganic materials 0.000 description 1
239000010440 gypsum Substances 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000001788 irregular Effects 0.000 description 1
150000002632 lipids Chemical class 0.000 description 1
238000005259 measurement Methods 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000013508 migration Methods 0.000 description 1
230000005012 migration Effects 0.000 description 1
231100000957 no side effect Toxicity 0.000 description 1
231100000252 nontoxic Toxicity 0.000 description 1
230000003000 nontoxic effect Effects 0.000 description 1
238000001543 one-way ANOVA Methods 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000000399 orthopedic effect Effects 0.000 description 1
230000011164 ossification Effects 0.000 description 1
150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
239000011148 porous material Substances 0.000 description 1
230000005855 radiation Effects 0.000 description 1
230000008929 regeneration Effects 0.000 description 1
238000011069 regeneration method Methods 0.000 description 1
238000011160 research Methods 0.000 description 1
238000002271 resection Methods 0.000 description 1
238000005245 sintering Methods 0.000 description 1
210000004872 soft tissue Anatomy 0.000 description 1
239000011343 solid material Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000012453 sprague-dawley rat model Methods 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
238000005728 strengthening Methods 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
235000019165 vitamin E Nutrition 0.000 description 1
229940046009 vitamin E Drugs 0.000 description 1
239000011709 vitamin E Substances 0.000 description 1
238000005303 weighing Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/0047—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L24/0052—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
- A61L24/0063—Phosphorus containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/02—Surgical adhesives or cements; Adhesives for colostomy devices containing inorganic materials
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/12—Phosphorus-containing materials, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
- A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
- A61L27/425—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Inorganic Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Transplantation (AREA)
Oral & Maxillofacial Surgery (AREA)
Dermatology (AREA)
Composite Materials (AREA)
Materials Engineering (AREA)
Surgery (AREA)
Pulmonology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Materials For Medical Uses (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

SE0002676A 2000-07-17 2000-07-17 En komposition för ett injicerbart ersättningsmaterial för benmineral SE517168C2 (sv)

Priority Applications (13)

Application Number	Priority Date	Filing Date	Title
SE0002676A SE517168C2 (sv)	2000-07-17	2000-07-17	En komposition för ett injicerbart ersättningsmaterial för benmineral
DE60116098T DE60116098T2 (de)	2000-07-17	2001-07-16	Zusammensetzung für einen injizierbaren knochenmineral ersatz
US10/333,026 US7417077B2 (en)	2000-07-17	2001-07-16	Composition for an injectable bone mineral substitute material
ES01950184T ES2252254T3 (es)	2000-07-17	2001-07-16	Una composicion para un material sustituto de mineral oseo inyectable.
AT01950184T ATE313344T1 (de)	2000-07-17	2001-07-16	Zusammensetzung für einen injizierbaren knochenmineral ersatz
AU2001271209A AU2001271209B2 (en)	2000-07-17	2001-07-16	A composition for an injectable bone mineral substitute material
JP2002511792A JP5351369B2 (ja)	2000-07-17	2001-07-16	注射用骨ミネラル代替物質用組成物
AU7120901A AU7120901A (en)	2000-07-17	2001-07-16	A composition for an injectable bone mineral substitute material
PCT/SE2001/001627 WO2002005861A1 (en)	2000-07-17	2001-07-16	A composition for an injectable bone mineral substitute material
EP01950184A EP1301219B1 (de)	2000-07-17	2001-07-16	Zusammensetzung für einen injizierbaren knochenmineral ersatz
US12/122,873 US20080286331A1 (en)	2000-07-17	2008-05-19	Composition for an injectable bone mineral substitute material
US12/219,543 US20090192629A1 (en)	2000-07-17	2008-07-23	Composition for an injectable bone mineral substitute material
US12/219,542 US20090018667A1 (en)	2000-07-17	2008-07-23	Composition for an injectable bone mineral substitute material

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE0002676A SE517168C2 (sv)	2000-07-17	2000-07-17	En komposition för ett injicerbart ersättningsmaterial för benmineral

Publications (3)

Publication Number	Publication Date
SE0002676D0 SE0002676D0 (sv)	2000-07-17
SE0002676L SE0002676L (sv)	2002-01-18
SE517168C2 true SE517168C2 (sv)	2002-04-23

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SE0002676A SE517168C2 (sv)	2000-07-17	2000-07-17	En komposition för ett injicerbart ersättningsmaterial för benmineral

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US (4)	US7417077B2 (de)
EP (1)	EP1301219B1 (de)
JP (1)	JP5351369B2 (de)
AT (1)	ATE313344T1 (de)
AU (2)	AU7120901A (de)
DE (1)	DE60116098T2 (de)
ES (1)	ES2252254T3 (de)
SE (1)	SE517168C2 (de)
WO (1)	WO2002005861A1 (de)

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2000
- 2000-07-17 SE SE0002676A patent/SE517168C2/sv not_active IP Right Cessation
2001
- 2001-07-16 ES ES01950184T patent/ES2252254T3/es not_active Expired - Lifetime
- 2001-07-16 JP JP2002511792A patent/JP5351369B2/ja not_active Expired - Fee Related
- 2001-07-16 AU AU7120901A patent/AU7120901A/xx active Pending
- 2001-07-16 EP EP01950184A patent/EP1301219B1/de not_active Expired - Lifetime
- 2001-07-16 DE DE60116098T patent/DE60116098T2/de not_active Expired - Lifetime
- 2001-07-16 AT AT01950184T patent/ATE313344T1/de not_active IP Right Cessation
- 2001-07-16 AU AU2001271209A patent/AU2001271209B2/en not_active Ceased
- 2001-07-16 US US10/333,026 patent/US7417077B2/en not_active Expired - Fee Related
- 2001-07-16 WO PCT/SE2001/001627 patent/WO2002005861A1/en not_active Ceased
2008
- 2008-05-19 US US12/122,873 patent/US20080286331A1/en not_active Abandoned
- 2008-07-23 US US12/219,543 patent/US20090192629A1/en not_active Abandoned
- 2008-07-23 US US12/219,542 patent/US20090018667A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20090018667A1 (en)	2009-01-15
US20090192629A1 (en)	2009-07-30
DE60116098D1 (de)	2006-01-26
DE60116098T2 (de)	2006-08-17
WO2002005861A1 (en)	2002-01-24
EP1301219A1 (de)	2003-04-16
US20040048947A1 (en)	2004-03-11
SE0002676D0 (sv)	2000-07-17
SE0002676L (sv)	2002-01-18
JP2004503332A (ja)	2004-02-05
ATE313344T1 (de)	2006-01-15
AU2001271209B2 (en)	2005-12-15
JP5351369B2 (ja)	2013-11-27
US7417077B2 (en)	2008-08-26
AU7120901A (en)	2002-01-30
EP1301219B1 (de)	2005-12-21
ES2252254T3 (es)	2006-05-16
US20080286331A1 (en)	2008-11-20

Legal Events

Date	Code	Title	Description
2020-03-03	NUG	Patent has lapsed

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