SE7610409L - PHARMACOLOGICALLY ACTIVE ASSOCIATIONS - Google Patents
PHARMACOLOGICALLY ACTIVE ASSOCIATIONSInfo
- Publication number
- SE7610409L SE7610409L SE7610409A SE7610409A SE7610409L SE 7610409 L SE7610409 L SE 7610409L SE 7610409 A SE7610409 A SE 7610409A SE 7610409 A SE7610409 A SE 7610409A SE 7610409 L SE7610409 L SE 7610409L
- Authority
- SE
- Sweden
- Prior art keywords
- ring
- sulphur
- bromine
- optionally substituted
- lower alkyl
- Prior art date
Links
- -1 4-imidazolyl ring Chemical group 0.000 abstract 5
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 4
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 4
- 239000005864 Sulphur Substances 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 4
- 229910052794 bromium Inorganic materials 0.000 abstract 4
- 229910052801 chlorine Inorganic materials 0.000 abstract 4
- 239000000460 chlorine Substances 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000005871 1,3-benzodioxolyl group Chemical group 0.000 abstract 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000001622 2-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C(*)C([H])=C([H])C2=C1[H] 0.000 abstract 1
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical group O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 1
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000005083 alkoxyalkoxy group Chemical group 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000002102 aryl alkyloxo group Chemical group 0.000 abstract 1
- 125000005059 halophenyl group Chemical group 0.000 abstract 1
- 239000000938 histamine H1 antagonist Substances 0.000 abstract 1
- 239000003485 histamine H2 receptor antagonist Substances 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
There is disclosed the preparation of compounds of the formula wherein Het' is a 2- or 4-imidazolyl ring optionally substituted by lower alkyl (preferably methyl), halogen (preferably chlorine or bromine), trifluoromethyl or hydroxymethyl, a 2-pyridyl ring optionally substituted by lower alkyl {preferably methyl), lower alkoxy (preferably methoxy), halogen (preferably chlorine or bromine), amino or hydroxy, a 2-thiazolyl ring, a 3-isothiazolyl ring optionally substituted by chlorine or bromine, a 3-(1,2,5) thiadiazolyl ring optionally substituted by chlorine or bromine, or a 2-(5-amino-1,3,4-thiadiazolyl) ring; Z is sulphur or a methylene group; X is oxygen or sulphur; W is methylene, oxygen or sulphur; m and n are such that their sum is from 1 to 4 when W is oxygen or sulphur, or from O to 4 when W is methylene; A is a 1- or 2-naphthyl ring, a 2,3-dihydro-1,4-benzodioxinyl or a 1,3-benzodioxolyl ring, a phenyl ring substituted with one or more lower alkyl, lower alkoxy, halogen, arylalkoxy, hydroxy, alkoxyalkoxy, trifluoromethyl, di(loweralkyl)amino, phenoxy, halophenoxy, alkoxyphenoxy, phenyl, halophenyl or alkoxyphenyl group and when is not a methylene group, A may also be phenyl; and Y3 is hydrogen or lower alkyl. The compounds have both histamine H1-antagonist and H2-antagonist activity.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4034175 | 1975-10-02 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SE7610409L true SE7610409L (en) | 1977-04-03 |
| SE431872B SE431872B (en) | 1984-03-05 |
Family
ID=10414412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7610409A SE431872B (en) | 1975-10-02 | 1976-09-20 | ANALOGY PROCEDURE FOR PREPARING DERIVATIVES OF 4-PYRIMIDON |
Country Status (36)
| Country | Link |
|---|---|
| JP (2) | JPS5246087A (en) |
| AR (1) | AR221682A1 (en) |
| AT (1) | AT358045B (en) |
| AU (1) | AU504897B2 (en) |
| BE (1) | BE846452A (en) |
| BG (1) | BG25224A3 (en) |
| CA (1) | CA1067076A (en) |
| CH (1) | CH625801A5 (en) |
| CS (1) | CS203003B2 (en) |
| DD (1) | DD126563A5 (en) |
| DE (1) | DE2643670C2 (en) |
| DK (1) | DK442476A (en) |
| ES (1) | ES452060A1 (en) |
| FI (1) | FI61701C (en) |
| FR (1) | FR2326192A1 (en) |
| GR (1) | GR61307B (en) |
| HU (1) | HU175537B (en) |
| IE (1) | IE44845B1 (en) |
| IL (1) | IL50503A (en) |
| IN (1) | IN146736B (en) |
| IT (2) | IT1070839B (en) |
| LU (1) | LU75922A1 (en) |
| MW (1) | MW3476A1 (en) |
| MX (1) | MX4614E (en) |
| NL (1) | NL7609917A (en) |
| NO (1) | NO145792C (en) |
| NZ (1) | NZ181959A (en) |
| OA (1) | OA05445A (en) |
| PH (1) | PH13921A (en) |
| PL (1) | PL105828B1 (en) |
| PT (1) | PT65590B (en) |
| RO (1) | RO73511A (en) |
| SE (1) | SE431872B (en) |
| YU (1) | YU237276A (en) |
| ZA (1) | ZA765498B (en) |
| ZM (1) | ZM12176A1 (en) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MW5076A1 (en) * | 1975-12-29 | 1978-02-08 | Smith Kline French Lab | Pharmacologicalle active compounds |
| NZ186511A (en) | 1977-03-19 | 1980-11-14 | Smith Kline French Lab | 3-substituted alkylamino-6-substituted alkyl-1,2,4-triazin-5-ones and pharmaceutical compositions 3-substituted thio-1,2,4-triazin-5-ones |
| US4165378A (en) | 1977-04-20 | 1979-08-21 | Ici Americas Inc. | Guanidine derivatives of imidazoles and thiazoles |
| NZ186965A (en) | 1977-04-20 | 1980-02-21 | Ici Ltd | Guanidino derivatives and pharmaceutical compositions |
| JPS54104816A (en) * | 1978-01-27 | 1979-08-17 | Memorex Corp | Magnetic recorder tape reel |
| IN151188B (en) * | 1978-02-13 | 1983-03-05 | Smith Kline French Lab | |
| PH16240A (en) * | 1978-04-11 | 1983-08-11 | Smith Kline French Lab | Process for making histamine antagonist |
| IL57416A (en) * | 1978-05-30 | 1983-03-31 | Smith Kline French Lab | Nitro compounds,processes for preparing them and compositions containing them |
| ZA793443B (en) * | 1978-07-26 | 1980-12-31 | Glaxo Group Ltd | Heterocyclic derivatives |
| US4374836A (en) | 1978-10-16 | 1983-02-22 | Imperial Chemical Industries Ltd. | Antisecretory heterocyclic derivatives, process for their manufacture and pharmaceutical compositions containing them |
| US4496567A (en) * | 1978-11-13 | 1985-01-29 | Smith Kline & French Laboratories Limited | Phenyl alkylaminopyrimidones |
| EP0014057B1 (en) | 1979-01-18 | 1985-01-02 | Imperial Chemical Industries Plc | Guanidine derivatives, processes for their manufacture and pharmaceutical compositions containing them |
| US4521418A (en) * | 1979-02-21 | 1985-06-04 | Smith Kline & French Laboratories Limited | Guanidinothiazolyl derivatives |
| JPS55145683A (en) * | 1979-04-26 | 1980-11-13 | Smith Kline French Lab | Pyrimidone derivative |
| CA1155842A (en) * | 1980-03-29 | 1983-10-25 | Thomas H. Brown | Compounds |
| ZW21281A1 (en) * | 1980-10-01 | 1981-11-18 | Smith Kline French Lab | Amine derivatives |
| IE53068B1 (en) * | 1981-06-15 | 1988-05-25 | Merck & Co Inc | Diamino isothiazole-1-oxides and -1,1-dioxides as gastic secretion inhibitors |
| PT75074B (en) * | 1981-06-27 | 1986-02-26 | Smith Kline French Lab | Process for preparing certain pyrimidone derivatives and compositions containing them |
| CA1206151A (en) * | 1981-12-28 | 1986-06-17 | Richard P. Pioch | Pyrimidone anti-ulcer agents |
| JPS5993074A (en) * | 1982-10-01 | 1984-05-29 | スミス・クライン・アンド・フレンチ・ラボラトリ−ス・リミテツド | Pyrimidone derivative |
| DE8309239U1 (en) * | 1983-03-29 | 1983-09-29 | Basf Ag, 6700 Ludwigshafen | TAPE REEL, IN PARTICULAR FOR MAGNETIC TAPES |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1397436A (en) * | 1972-09-05 | 1975-06-11 | Smith Kline French Lab | Heterocyclic n-cyanoguinidines |
| GB1419994A (en) * | 1973-05-03 | 1976-01-07 | Smith Kline French Lab | Heterocyclicalkylaminotheterocyclic compounds methods for their preparation and compositions comprising them |
-
1976
- 1976-09-06 IN IN1633/CAL/76A patent/IN146736B/en unknown
- 1976-09-07 NZ NZ181959A patent/NZ181959A/en unknown
- 1976-09-07 NL NL7609917A patent/NL7609917A/en unknown
- 1976-09-10 MW MW34/76A patent/MW3476A1/en unknown
- 1976-09-14 IT IT27192/76A patent/IT1070839B/en active
- 1976-09-14 PT PT65590A patent/PT65590B/en unknown
- 1976-09-14 ZA ZA765498A patent/ZA765498B/en unknown
- 1976-09-16 IL IL50503A patent/IL50503A/en unknown
- 1976-09-20 SE SE7610409A patent/SE431872B/en not_active IP Right Cessation
- 1976-09-22 BE BE170830A patent/BE846452A/en not_active IP Right Cessation
- 1976-09-24 PH PH18943A patent/PH13921A/en unknown
- 1976-09-24 AT AT711976A patent/AT358045B/en not_active IP Right Cessation
- 1976-09-24 FR FR7628824A patent/FR2326192A1/en active Granted
- 1976-09-27 CS CS766222A patent/CS203003B2/en unknown
- 1976-09-28 GR GR51794A patent/GR61307B/en unknown
- 1976-09-28 CA CA262,162A patent/CA1067076A/en not_active Expired
- 1976-09-28 DE DE2643670A patent/DE2643670C2/en not_active Expired
- 1976-09-28 YU YU02372/76A patent/YU237276A/en unknown
- 1976-09-29 OA OA55946A patent/OA05445A/en unknown
- 1976-09-29 IE IE2154/76A patent/IE44845B1/en unknown
- 1976-09-30 AR AR264926A patent/AR221682A1/en active
- 1976-09-30 AU AU18295/76A patent/AU504897B2/en not_active Expired
- 1976-09-30 DD DD195067A patent/DD126563A5/xx unknown
- 1976-10-01 NO NO763371A patent/NO145792C/en unknown
- 1976-10-01 ES ES452060A patent/ES452060A1/en not_active Expired
- 1976-10-01 CH CH1248276A patent/CH625801A5/en not_active IP Right Cessation
- 1976-10-01 JP JP51118904A patent/JPS5246087A/en active Granted
- 1976-10-01 HU HU76SI1543A patent/HU175537B/en unknown
- 1976-10-01 PL PL1976192809A patent/PL105828B1/en unknown
- 1976-10-01 DK DK442476A patent/DK442476A/en not_active Application Discontinuation
- 1976-10-01 MX MX764951U patent/MX4614E/en unknown
- 1976-10-01 BG BG034338A patent/BG25224A3/en unknown
- 1976-10-01 FI FI762803A patent/FI61701C/en not_active IP Right Cessation
- 1976-10-01 ZM ZM121/76A patent/ZM12176A1/en unknown
- 1976-10-01 LU LU75922A patent/LU75922A1/xx unknown
- 1976-10-02 RO RO7687887A patent/RO73511A/en unknown
-
1978
- 1978-12-11 IT IT7830708A patent/IT7830708A0/en unknown
-
1980
- 1980-12-09 JP JP55174447A patent/JPS609755B2/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NUG | Patent has lapsed |
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