SE7703236L - Forbettrat forfarande for framstellning av 14-hydroximorfinanderivat - Google Patents

Forbettrat forfarande for framstellning av 14-hydroximorfinanderivat

Info

Publication number: SE7703236L
Authority: SE; Sweden
Prior art keywords: derivatives; hydroximorfinand; preparation; cyclobutylmethyl; methoxybenzyl
Prior art date: 1976-03-23

Application number

SE7703236A

Other languages

English (en)

Other versions

SE431749B (sv

Inventor

I Monkovic

C Bachand

H Wong

G Lim

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1976-03-23

Filing date

1977-03-21

Publication date

1977-09-24

1976-03-23 Priority claimed from US05/669,795 external-priority patent/US4058531A/en

1977-02-17 Priority claimed from US05/769,808 external-priority patent/US4139534A/en

1977-03-21 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1977-09-24 Publication of SE7703236L publication Critical patent/SE7703236L/sv

1984-02-27 Publication of SE431749B publication Critical patent/SE431749B/sv

Links

238000000034 method Methods 0.000 title abstract 2
UORVGPXVDQYIDP-UHFFFAOYSA-N borane Chemical compound B UORVGPXVDQYIDP-UHFFFAOYSA-N 0.000 abstract 4
239000000556 agonist Substances 0.000 abstract 2
239000005557 antagonist Substances 0.000 abstract 2
229910000085 borane Inorganic materials 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
230000000694 effects Effects 0.000 abstract 2
230000003389 potentiating effect Effects 0.000 abstract 2
NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical compound C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 abstract 1
PSGXTMNRCXHWJR-UHFFFAOYSA-N 2-[(4-methoxyphenyl)methyl]-3,4,5,6,7,8-hexahydro-1h-isoquinoline Chemical compound C1=CC(OC)=CC=C1CN1CC(CCCC2)=C2CC1 PSGXTMNRCXHWJR-UHFFFAOYSA-N 0.000 abstract 1
-1 N-substituted -14-hydroxy-3-substituted-morphinan Chemical class 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000000730 antalgic agent Substances 0.000 abstract 1
125000004850 cyclobutylmethyl group Chemical group C1(CCC1)C* 0.000 abstract 1
230000003533 narcotic effect Effects 0.000 abstract 1
229940051807 opiod analgesics morphinan derivative Drugs 0.000 abstract 1
239000007858 starting material Substances 0.000 abstract 1
238000006257 total synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pain & Pain Management (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)

SE7703236A 1976-03-23 1977-03-21 Forfarande for framstellning av 14-hydroximorfinanderivat SE431749B (sv)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US05/669,795 US4058531A (en)	1976-03-23	1976-03-23	Process for the preparation of 14-hydroxymorphinan derivatives
US05/769,808 US4139534A (en)	1977-02-17	1977-02-17	Process for the preparation of 14-hydroxymorphinan derivatives

Publications (2)

Publication Number	Publication Date
SE7703236L true SE7703236L (sv)	1977-09-24
SE431749B SE431749B (sv)	1984-02-27

Family

ID=27100195

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE7703236A SE431749B (sv)	1976-03-23	1977-03-21	Forfarande for framstellning av 14-hydroximorfinanderivat

Country Status (8)

Country	Link
JP (1)	JPS52136176A (sv)
CA (1)	CA1086723A (sv)
CH (1)	CH629783A5 (sv)
DK (2)	DK155322C (sv)
FI (1)	FI61486C (sv)
LU (1)	LU77000A1 (sv)
NL (2)	NL189846C (sv)
SE (1)	SE431749B (sv)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0373510U (sv) *	1989-11-15	1991-07-24
AU2017242268A1 (en) *	2016-03-29	2018-10-25	Hikal Limited	An improved process for the preparation of butorphanol tartrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3634429A (en) *	1969-09-30	1972-01-11	Hoffmann La Roche	Morphinan derivatives and preparation thereof
CA919668A (en) *	1970-06-20	1973-01-23	Murakami Masuo	Morphinan derivatives
BE788478A (fr) *	1971-09-08	1973-03-06	Bristol Myers Co	Procede de preparation de composes analgesiques
US3775414A (en) *	1972-05-10	1973-11-27	Bristol Myers Co	Process for the preparation of 14-hydroxymorphinan derivatives

1977
- 1977-03-17 JP JP2871277A patent/JPS52136176A/ja active Granted
- 1977-03-18 CA CA274,241A patent/CA1086723A/en not_active Expired
- 1977-03-18 FI FI770865A patent/FI61486C/fi not_active IP Right Cessation
- 1977-03-18 NL NLAANVRAGE7703000,A patent/NL189846C/xx active Protection Beyond IP Right Term
- 1977-03-21 SE SE7703236A patent/SE431749B/sv not_active IP Right Cessation
- 1977-03-21 DK DK123877A patent/DK155322C/da not_active IP Right Cessation
- 1977-03-22 CH CH358077A patent/CH629783A5/de not_active IP Right Cessation
- 1977-03-23 LU LU77000A patent/LU77000A1/xx unknown
1988
- 1988-10-27 DK DK597188A patent/DK160987C/da active
1996
- 1996-09-16 NL NL960022C patent/NL960022I1/nl unknown

Also Published As

Publication number	Publication date
NL7703000A (nl)	1977-09-27
SE431749B (sv)	1984-02-27
DK597188A (da)	1988-10-27
FI61486B (fi)	1982-04-30
CA1086723A (en)	1980-09-30
JPS52136176A (en)	1977-11-14
DK160987B (da)	1991-05-13
JPS6139938B2 (sv)	1986-09-06
LU77000A1 (sv)	1977-10-03
FI61486C (fi)	1982-08-10
DK155322B (da)	1989-03-28
DK597188D0 (da)	1988-10-27
DK160987C (da)	1991-11-11
NL960022I1 (nl)	1996-12-02
NL189846C (nl)	1993-08-16
DK155322C (da)	1989-09-11
FI770865A7 (sv)	1977-09-24
NL189846B (nl)	1993-03-16
DK123877A (da)	1977-09-24
CH629783A5 (en)	1982-05-14

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1995-01-31

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1997-06-09

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