SE8300693L - Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta - Google Patents

Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta

Info

Publication number
SE8300693L
SE8300693L SE8300693A SE8300693A SE8300693L SE 8300693 L SE8300693 L SE 8300693L SE 8300693 A SE8300693 A SE 8300693A SE 8300693 A SE8300693 A SE 8300693A SE 8300693 L SE8300693 L SE 8300693L
Authority
SE
Sweden
Prior art keywords
polypeptide
protein
fusion protein
igg
host
Prior art date
Application number
SE8300693A
Other languages
Unknown language ( )
English (en)
Swedish (sv)
Other versions
SE8300693D0 (sv
Inventor
Sven Lofdahl
Mathias Uhlen
Martin Lindberg
John Sjoquist
Original Assignee
Sven Lofdahl
Mathias Uhlen
Martin Lindberg
John Sjoquist
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sven Lofdahl, Mathias Uhlen, Martin Lindberg, John Sjoquist filed Critical Sven Lofdahl
Priority to SE8300693A priority Critical patent/SE8300693L/
Publication of SE8300693D0 publication Critical patent/SE8300693D0/xx
Priority to EP84900773A priority patent/EP0135532B1/de
Priority to JP59500885A priority patent/JPH0634742B2/ja
Priority to DE8484900773T priority patent/DE3473298D1/de
Priority to AT84900773T priority patent/ATE36348T1/de
Priority to PCT/SE1984/000046 priority patent/WO1984003103A1/en
Publication of SE8300693L publication Critical patent/SE8300693L/
Priority to US07/196,846 priority patent/US5100788A/en
Priority to JP7117618A priority patent/JPH07265078A/ja

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/66—General methods for inserting a gene into a vector to form a recombinant vector using cleavage and ligation; Use of non-functional linkers or adaptors, e.g. linkers containing the sequence for a restriction endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SE8300693A 1983-02-09 1983-02-09 Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta SE8300693L (sv)

Priority Applications (8)

Application Number Priority Date Filing Date Title
SE8300693A SE8300693L (sv) 1983-02-09 1983-02-09 Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
EP84900773A EP0135532B1 (de) 1983-02-09 1984-02-09 Herstellungsverfahren und selektive isolierung von proteinen und polypeptiden, rekombinant und expressionsvektor dazu und schmelzprotein das zum konstanten teil von immoglobulinen binden kann
JP59500885A JPH0634742B2 (ja) 1983-02-09 1984-02-09 蛋白質とポリペプチドを製造及び分離する方法
DE8484900773T DE3473298D1 (en) 1983-02-09 1984-02-09 Method of producing and selectively isolating proteins and polypeptides, recombinant and expression vector therefor and fusion protein able to bind to the constant region of immunoglobulins
AT84900773T ATE36348T1 (de) 1983-02-09 1984-02-09 Herstellungsverfahren und selektive isolierung von proteinen und polypeptiden, rekombinant und expressionsvektor dazu und schmelzprotein das zum konstanten teil von immoglobulinen binden kann.
PCT/SE1984/000046 WO1984003103A1 (en) 1983-02-09 1984-02-09 Method of producing and selectively isolating proteins and polypeptides, recombinant and expression vector therefor and fusion protein able to bind to the constant region of immunoglobulins
US07/196,846 US5100788A (en) 1983-02-09 1988-05-09 Method of producing and isolating igg-binding protein a fusion peptides and a vector therefor
JP7117618A JPH07265078A (ja) 1983-02-09 1995-04-20 蛋白質とポリペプチドを製造するための組換えベクター

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE8300693A SE8300693L (sv) 1983-02-09 1983-02-09 Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta

Publications (2)

Publication Number Publication Date
SE8300693D0 SE8300693D0 (sv) 1983-02-09
SE8300693L true SE8300693L (sv) 1984-08-10

Family

ID=20349966

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8300693A SE8300693L (sv) 1983-02-09 1983-02-09 Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta

Country Status (6)

Country Link
US (1) US5100788A (de)
EP (1) EP0135532B1 (de)
JP (2) JPH0634742B2 (de)
DE (1) DE3473298D1 (de)
SE (1) SE8300693L (de)
WO (1) WO1984003103A1 (de)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3486491T2 (de) * 1983-04-25 2003-01-16 Chiron Corp., Emeryville Hybrid-DNS-Synthesis von reifen insulinähnlichen Wachstumsfaktoren
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
WO1985000831A1 (en) * 1983-08-10 1985-02-28 Amgen Microbial expression of insulin-like growth factor
US4708929A (en) * 1984-10-29 1987-11-24 Microgenics Corporation Methods for protein binding enzyme complementation assays
DK108685A (da) * 1984-03-19 1985-09-20 Fujisawa Pharmaceutical Co Vaekstfaktor i
US5248666A (en) * 1984-03-23 1993-09-28 Oncogen Methods for inhibiting neoplastic cell proliferation using platelet factor 4
US4745179A (en) * 1984-04-02 1988-05-17 Fujisawa Pharmaceutical Co., Ltd. 59 Valine insulin-like growth factor I and process for production thereof
GB8412517D0 (en) * 1984-05-16 1984-06-20 Nagai K Recombinant fusion proteins
US5028530A (en) * 1985-01-28 1991-07-02 Xoma Corporation AraB promoters and method of producing polypeptides, including cecropins, by microbiological techniques
EP0195680A3 (de) * 1985-03-21 1987-06-10 Immunex Corporation Proteinsynthese mit einem Identifizierungspeptid
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
US4751180A (en) * 1985-03-28 1988-06-14 Chiron Corporation Expression using fused genes providing for protein product
DE3679343D1 (de) * 1985-03-28 1991-06-27 Chiron Corp Expression durch verwendung von fusionsgenen fuer proteinproduktion.
US5342921A (en) * 1985-03-28 1994-08-30 Chiron Corporation Superoxide dismutase fusion polypeptides for expression of mammalian proteins
US5169939A (en) * 1985-05-21 1992-12-08 Massachusetts Institute Of Technology & Pres. & Fellows Of Harvard College Chimeric antibodies
SE8505921D0 (sv) * 1985-12-13 1985-12-13 Kabigen Ab A method to export gene products to the growth medium of gram negative bacteria
SE8505922D0 (sv) * 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering
DE3545568A1 (de) * 1985-12-21 1987-07-16 Hoechst Ag Gm-csf-protein, seine derivate, herstellung solcher proteine und ihre verwendung
SE459662B (sv) * 1986-03-21 1989-07-24 Pharmacia Ab Hybrid-dna-molekyl som kodar foer ett protein med samma igg specificitet som protein g, plasmid innehaallande densamma samt foerfarande foer framstaellning av proteinet
SE8601940D0 (sv) * 1986-04-25 1986-04-25 Kabigen Ab Preparation of fused proteins, antibodies and processes therefor
JPH01503513A (ja) * 1987-03-02 1989-11-30 オンコゲン 血小板関連増殖調節剤
US4987070A (en) * 1987-03-04 1991-01-22 Suntory Limited Use of a 97 amino acid leader sequence from the E. coli B-galactosidase gene for the production of hanp and hptc as fusion proteins
US5643758A (en) * 1987-03-10 1997-07-01 New England Biolabs, Inc. Production and purification of a protein fused to a binding protein
US5215896A (en) * 1987-03-20 1993-06-01 Creative Biomolecules, Inc. Leader sequences for the production of recombinant proteins
US5013653A (en) 1987-03-20 1991-05-07 Creative Biomolecules, Inc. Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage
JPH082315B2 (ja) * 1987-05-29 1996-01-17 財団法人相模中央化学研究所 リンホトキシンを含む融合蛋白質
US5212064A (en) * 1987-09-21 1993-05-18 Microgenics Corporation Solid phase non-separation enzyme complementation assay
US5243040A (en) * 1987-11-20 1993-09-07 Creative Biomolecules DNA encoding a protein which enables selective removal of immune complexes
US5084398A (en) * 1987-11-20 1992-01-28 Creative Biomolecules Selective removal of immune complexes
SE501169C2 (sv) * 1988-02-05 1994-11-28 Aake Nygren Framställning av serumalbuminbindande fusionsproteiner vilka innehåller protein G-domäner
SE8800981D0 (sv) * 1988-03-17 1988-03-17 Nygren Per Ake A recombinant fusion protein, its use and a recombinant vector
CA2005252C (en) * 1988-12-13 2001-07-17 Nahum Sonenberg Isolation of full-length cdna clones and capped mrna
US6267964B1 (en) * 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
US5620923A (en) * 1989-10-12 1997-04-15 The University Of Utah Synthesis of peptides as cloned ubiquitin extensions
US5624822A (en) * 1989-12-22 1997-04-29 Basf Aktiengesellschaft Hirudin fusion proteins and preparation of hirudin
DE3942580A1 (de) * 1989-12-22 1991-06-27 Basf Ag Verfahren zur herstellung von hirudin
JPH0740924B2 (ja) * 1990-08-22 1995-05-10 エム・ディ・リサーチ株式会社 形質転換体および融合蛋白質の製造方法
EP0548267A4 (en) * 1990-09-04 1994-11-23 Salk Inst Biotech Ind Production of insulin-like growth factor-1 in methylotrophic yeast cells
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
JPH0740926B2 (ja) * 1990-10-09 1995-05-10 エム・ディ・リサーチ株式会社 形質転換体およびペプチド前駆体タンパク質の製造方法
EP0499990B1 (de) * 1991-02-19 1996-05-15 Takeda Chemical Industries, Ltd. Verfahren zur Herstellung von cysteinfreien Peptiden
ATE220105T1 (de) * 1991-04-01 2002-07-15 Merck & Co Inc Gene, die die proteolytische aktivitaet von pichia beeinflussen und deren verwendung
US5665539A (en) * 1991-07-12 1997-09-09 The Regents Of The University Of California Immuno-polymerase chain reaction system for antigen detection
US5328985A (en) * 1991-07-12 1994-07-12 The Regents Of The University Of California Recombinant streptavidin-protein chimeras useful for conjugation of molecules in the immune system
US5763584A (en) * 1992-05-18 1998-06-09 Genentech, Inc. Receptor activation with hepatocyte growth factor agonists
DK0642585T3 (da) * 1992-05-18 2006-05-15 Genentech Inc Aktiviering af oligomeriserende receptorer ved anvendelse af fusionerede receptorligander
US5532142A (en) * 1993-02-12 1996-07-02 Board Of Regents, The University Of Texas System Method of isolation and purification of fusion polypeptides
GB9513967D0 (en) * 1995-07-08 1995-09-06 Univ Leicester Insulin
US6261787B1 (en) 1996-06-03 2001-07-17 Case Western Reserve University Bifunctional molecules for delivery of therapeutics
JP2001512306A (ja) 1997-01-08 2001-08-21 ライフ テクノロジーズ，インコーポレイテッド タンパク質の産生方法
EP1911841B1 (de) 1997-01-08 2015-06-03 Life Technologies Corporation Verfahren zur Herstellung von Proteinen
US6432699B1 (en) * 1997-03-28 2002-08-13 New York University Viral vectors having chimeric envelope proteins containing the IgG-binding domain of protein A
JP2002544237A (ja) * 1999-05-15 2002-12-24 ユニバーシティ オブ カリフォルニア，サン ディエゴ 望ましい活性を有するプロテインａに基づく結合ドメイン
US7163686B1 (en) 1999-05-15 2007-01-16 The Regents Of The University Of California Protein A based binding domains with desirable activities
US7259232B1 (en) 2000-10-27 2007-08-21 Nymox Pharmaceutical Corporation Preferred segments of neural thread protein
US20030211970A1 (en) * 2001-06-01 2003-11-13 Samuel Nochumson Processing of plasmid-containing fluids
US7270960B2 (en) 2001-08-29 2007-09-18 Pacific Northwest Research Institute Diagnosis of ovarian carcinomas
US7375188B2 (en) * 2005-07-29 2008-05-20 Mallinckrodt Baker, Inc. Vegetarian protein a preparation and methods thereof
PL2005185T3 (pl) 2006-03-22 2011-05-31 Viral Logic Systems Tech Corp Sposoby identyfikowania celów polipeptydowych
US8377448B2 (en) * 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
AU2007249709A1 (en) * 2006-05-15 2007-11-22 Viral Logic Systems Technology Corp. CD47 related compositions and methods for treating immunological diseases and disorders
US20090087873A1 (en) 2006-07-21 2009-04-02 Invitrogen Corporation Sharply resolving labeled protein molecular weight standards
EP2099932A4 (de) * 2006-12-06 2009-11-18 Repligen Corp Nukleinsäuren zur kodierung des rekombinanten proteins a
WO2008121757A1 (en) * 2007-03-30 2008-10-09 Centocor Inc High expression clones of mammalian cells with fluorescent protein a or g
CN112662676B (zh) * 2020-12-30 2023-12-29 南方科技大学 一种dna编码靶向水解蛋白的多肽或者蛋白的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2848051A1 (de) * 1977-11-08 1979-05-10 Genentech Inc Synthetische dna und verfahren zu ihrer herstellung
DE2862496D1 (en) * 1977-11-08 1989-06-29 Genentech Inc Method for polypeptide production involving expression of a heterologous gene, recombinant microbial cloning vehicle containing said gene and bacterial culture transformed by said cloning vehicle
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
FI792481A7 (fi) * 1978-08-11 1981-01-01 The Regents Of The Univ Of Enkaroyyttisen proteiinin synteesi mikro-organismia käyttäen.
US4336336A (en) * 1979-01-12 1982-06-22 President And Fellows Of Harvard College Fused gene and method of making and using same
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
GR76959B (de) * 1981-01-02 1984-09-04 Univ New York State Res Found
SE8204811L (sv) * 1982-08-23 1984-02-24 Sven Lofdahl Dna-fragment innefattande en signalsekvens
SE462046C (sv) * 1982-08-23 1998-04-27 Pharmacia Biotech Ab Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma
SE451596B (sv) * 1983-06-22 1987-10-19 Excorim Kb Forfarande for utvinning av protein g
US4801537A (en) * 1984-06-08 1989-01-31 Genex Corporation Vector for expression of polypeptides in bacilli
US4691009A (en) * 1984-12-26 1987-09-01 Repligen Corporation Hybrid proteins produced by an ultrahigh prokaryotic expression system
US4900660A (en) * 1985-11-25 1990-02-13 University Of Florida Streptococcal fc rc

Also Published As

Publication number Publication date
EP0135532B1 (de) 1988-08-10
DE3473298D1 (en) 1988-09-15
JPH0634742B2 (ja) 1994-05-11
WO1984003103A1 (en) 1984-08-16
EP0135532A1 (de) 1985-04-03
JPS60500480A (ja) 1985-04-11
JPH07265078A (ja) 1995-10-17
SE8300693D0 (sv) 1983-02-09
US5100788A (en) 1992-03-31

Similar Documents

Publication Publication Date Title
SE8300693L (sv) Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
ES474849A1 (es) Mejoras en un proceso para la produccion de un producto que comprende un polipeptido especifico
IE883612L (en) Vectors and compounds for direct expression of activated human protein c
ATE135403T1 (de) Herstellung und reinigung eines proteins, das mit einem bindungsprotein fusioniert ist
ATA192895A (de) Herstellung von proteinen aus pro-proteinen durch fusionsproteine abgeleitet von furin oder furinanalogen
AU2795989A (en) Production of gonorrheal pi proteins and vaccines
DE68925044D1 (de) Herstellung von Fusionsproteinen oder -polypeptiden
SE8802939D0 (sv) A method for the production and isolation of a fusion protein in eukaryotic cells
AU6839900A (en) Nucleic acid molecule comprising a nucleic acid sequence which codes for a haemocyanin, and comprising at least one intron sequence
WO2000043419A3 (en) Exocytosis pathway proteins and methods of use
SE0003573D0 (sv) Method and means for producing novel von Willebrand factor binding proteins and their use in biotechnology
WO2000055192A3 (de) Hämocyanin und dafür kodierende nukleinsäuresequenz
EP1241179A3 (de) Menschliches Cornichon-ähliches Protein und dafür kodierende Nukleinsäure
EP1241180A3 (de) Menschliches A33-Antigen-ähnliches Protein und dafür kodierende Nukleinsäure
EP1251139A3 (de) Menschliches mindin-ähliches Protein und dafür kodierende Nukleinsäure
PT1241251E (pt) Proteína semelhante a prostasina humana e ácidos nucleicos que a codificam
EP1659131A3 (de) Polypeptide und dafür kodierende Nukleinsäure
EP1241185A3 (de) Menschliches Protocadherin-ähnliches Protein und dafür kodierende Nukleinsäure
EP1247817A3 (de) Menschliches CD-23-ähliches Protein und dafür kodierende Nukleinsäure
PT1241184E (pt) Proteína semelhante a sinaptogirina e ácidos nucleicos que a codificam
PT1241183E (pt) Proteína semelhante a hcar humana e ácidos nucleicos que a codificam
ATE268819T1 (de) Pro241 polypeptide und dafür kodierende nukleinsäuren
ATE282047T1 (de) Polypeptide und dafür kodierende nukleinsäure
EP1249491A3 (de) Menschliches very long chain acyl-CoA synthase (VLCAS)-ähliches Protein und dafür codierende Nukleinsäure

Legal Events

Date Code Title Description
NAV Patent application has lapsed

Ref document number: 8300693-2

Effective date: 19880418

Format of ref document f/p: F