ES474849A1 - Mejoras en un proceso para la produccion de un producto que comprende un polipeptido especifico - Google Patents

Mejoras en un proceso para la produccion de un producto que comprende un polipeptido especifico

Info

Publication number
ES474849A1
ES474849A1 ES474849A ES474849A ES474849A1 ES 474849 A1 ES474849 A1 ES 474849A1 ES 474849 A ES474849 A ES 474849A ES 474849 A ES474849 A ES 474849A ES 474849 A1 ES474849 A1 ES 474849A1
Authority
ES
Spain
Prior art keywords
product
polypeptide
dna sequence
additional
hapten
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES474849A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25306071&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES474849(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of ES474849A1 publication Critical patent/ES474849A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Diabetes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Mejoras en un proceso para la producción de un producto que comprende un polipéptido específico que comprende la expresión de un gen estructural heterólogo para el mismo en un vehículo de clonación microbiano recombinante, cuya mejora consiste en que el gen estructural está en fase de lectura, con una codificación de secuencia de ADN para una proteína distinta del polipéptido, de manera que la expresión produzca una proteína precursora que comprenda tanto la secuencia de aminoácidos del polipéptido como de una proteína adicional que contiene una sitio de ruptura selectivo adyacente a la secuencia de aminoácidos del poliéptido deseado.
ES474849A 1977-11-08 1978-11-06 Mejoras en un proceso para la produccion de un producto que comprende un polipeptido especifico Expired ES474849A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84959177A 1977-11-08 1977-11-08

Publications (1)

Publication Number Publication Date
ES474849A1 true ES474849A1 (es) 1979-12-01

Family

ID=25306071

Family Applications (1)

Application Number Title Priority Date Filing Date
ES474849A Expired ES474849A1 (es) 1977-11-08 1978-11-06 Mejoras en un proceso para la produccion de un producto que comprende un polipeptido especifico

Country Status (28)

Country Link
EP (1) EP0001930B1 (es)
JP (2) JPS54145289A (es)
AT (1) AT373280B (es)
BE (1) BE871782A (es)
BG (1) BG38166A3 (es)
CA (2) CA1166983A (es)
CH (1) CH656640A5 (es)
DD (1) DD145928A5 (es)
DE (2) DE2862496D1 (es)
DK (1) DK493878A (es)
ES (1) ES474849A1 (es)
FI (1) FI783366A7 (es)
GB (1) GB2008123B (es)
GR (1) GR72861B (es)
HK (1) HK87284A (es)
IE (1) IE47890B1 (es)
IL (1) IL55890A (es)
IT (1) IT1100089B (es)
KE (1) KE3449A (es)
MY (1) MY8500760A (es)
NL (1) NL7811041A (es)
NO (2) NO158880C (es)
NZ (1) NZ188837A (es)
PH (1) PH20642A (es)
PL (1) PL210784A1 (es)
PT (1) PT68756A (es)
SE (1) SE7811458L (es)
ZA (1) ZA786305B (es)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411994A (en) * 1978-06-08 1983-10-25 The President And Fellows Of Harvard College Protein synthesis
US4565785A (en) * 1978-06-08 1986-01-21 The President And Fellows Of Harvard College Recombinant DNA molecule
IE48385B1 (en) * 1978-08-11 1984-12-26 Univ California Synthesis of a eucaryotic protein by a microorganism
US6270955B1 (en) 1978-12-22 2001-08-07 Biogen, Inc. Pharmaceutical compositions and methods for producing antibodies to hepatitis b virus and kits and methods for detecting antibodies to hepatitis b virus
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
DE3001928A1 (de) * 1980-01-19 1981-08-06 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enthaltenden mikroorganismus
US6455275B1 (en) 1980-02-25 2002-09-24 The Trustees Of Columbia University In The City Of New York DNA construct for producing proteinaceous materials in eucaryotic cells
CA1200773A (en) * 1980-02-29 1986-02-18 William J. Rutter Expression linkers
US4350764A (en) * 1980-03-10 1982-09-21 The Regents Of The University Of California Microbiological synthesis of beta endorphin
SE8101665L (sv) * 1980-03-17 1981-09-18 Harvard College Polypeptidframstellning
EP0041313B1 (en) 1980-04-03 1990-09-12 Biogen, Inc. Dna sequences, recombinant dna molecules and processes for producing human fibroblast interferon
FI83662C (fi) * 1980-07-17 1991-08-12 Scripps Clinic Res Diagnostik antikropp och foerfarande foer dess framstaellning.
IE52122B1 (en) * 1980-08-25 1987-06-24 Univ California Somatostatin or somatostatin precursors
US6692941B1 (en) 1980-08-26 2004-02-17 The Regents Of The University Of California Bovine growth hormone
US5525484A (en) * 1981-01-16 1996-06-11 Genome Therapeutics Corp. Recombinant DNA means and method for producing rennin, prorenin and pre-prorennin
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
US5137721A (en) * 1981-03-09 1992-08-11 Cetus Corporation Employing strains of E. coli expressing non-indigenous adhesins and toxoids of E. coli
NZ199866A (en) * 1981-03-09 1984-11-09 Cetus Corp Vaccine for prevention of gastroenteric disease:non-pathogenic strain genetically engineered to comprise genes for adhesin and/or toxoids
US5254463A (en) * 1981-09-18 1993-10-19 Genentech, Inc. Method for expression of bovine growth hormone
JPS5863395A (ja) * 1981-10-13 1983-04-15 Suntory Ltd アルフア・ネオ・エンドルフインの製造法
CA1338705C (en) * 1981-10-22 1996-11-12 Roy Curtiss Iii Vaccines obtained from antigenic gene products of recombinant genes
US4880911A (en) * 1982-03-19 1989-11-14 G. D. Searle & Co. Fused polypeptides and methods for their detection
US4532207A (en) * 1982-03-19 1985-07-30 G. D. Searle & Co. Process for the preparation of polypeptides utilizing a charged amino acid polymer and exopeptidase
IE55244B1 (en) * 1982-05-25 1990-07-18 Lilly Co Eli Cloning vectors for expression of exogenous protein
SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
EP0123928A3 (en) * 1983-03-31 1986-02-05 Codon Genetic Engineering Laboratories Recombinant dna coding for a polypeptide displaying milk clotting activity
DE3314812A1 (de) * 1983-04-23 1984-10-25 Battelle-Institut E.V., 6000 Frankfurt Mittel zum antigen/antikoerper-nachweis
US4703004A (en) * 1984-01-24 1987-10-27 Immunex Corporation Synthesis of protein with an identification peptide
US5082775A (en) * 1984-05-11 1992-01-21 Berlex Laboratories, Inc. Efficient process for isolating insoluble heterologous protein using non-ionic detergents
US5489529A (en) * 1984-07-19 1996-02-06 De Boer; Herman A. DNA for expression of bovine growth hormone
GB8422238D0 (en) * 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
EP0195680A3 (en) * 1985-03-21 1987-06-10 Immunex Corporation The synthesis of protein with an identification peptide
GB8509289D0 (en) * 1985-04-11 1985-05-15 Fujisawa Pharmaceutical Co Production of somatostatin
IL75553A (en) * 1985-06-18 1993-07-08 Yeda Res & Dev Dna sequence coding for a cholinesterase-like peptide, peptides produced by cells containing said dna and antibodies thereto
DE3686365T3 (de) * 1985-06-20 2000-07-27 Fujisawa Pharmaceutical Co., Ltd. Herstellungsverfahren für humanes atriales natriuretisches Polypeptid.
GB8515686D0 (en) * 1985-06-20 1985-07-24 Fujisawa Pharmaceutical Co Production of-human atrial natriuretic polypeptide
FR2599380A1 (fr) * 1986-05-29 1987-12-04 Centre Nat Rech Scient Vecteur d'exportation de proteines chez escherichiacoli, bacteries transformees et procede pour la preparation de proteines
US4987070A (en) * 1987-03-04 1991-01-22 Suntory Limited Use of a 97 amino acid leader sequence from the E. coli B-galactosidase gene for the production of hanp and hptc as fusion proteins
DE3805150A1 (de) * 1987-04-11 1988-10-20 Hoechst Ag Gentechnologisches verfahren zur herstellung von polypeptiden
DE68928124T2 (de) 1988-09-02 1997-10-16 Chiron Corp., Emeryville, Calif. Makrophagenabgeleiteter entzündungsmediator(mip-2)
US5218093A (en) * 1989-03-01 1993-06-08 Allelix Biopharmaceuticals, Inc. EGF variants and pharmaceutical use thereof
JPH0436185A (ja) * 1990-03-28 1992-02-06 Kyowa Hakko Kogyo Co Ltd 融合抗原ポリペプチド
JPH07108232B2 (ja) * 1990-10-09 1995-11-22 エム・ディ・リサーチ株式会社 ペプチド又は蛋白質の製造方法
JPH04315084A (ja) * 1991-04-12 1992-11-06 Kawasaki Heavy Ind Ltd 航空機の対地衝突防止システム
EP0752853B1 (en) 1993-03-10 2005-09-21 Smithkline Beecham Corporation Human brain phosphodiesterase
US6316004B1 (en) * 1993-06-22 2001-11-13 T. Tikhonenko Chimeric somatostatin containing protein and encoding DNA, plasmids of expression, method for preparing chimeric protein, strain-producers, immunogenic composition, method for increasing the productivity of farm animals
US6087128A (en) 1998-02-12 2000-07-11 Ndsu Research Foundation DNA encoding an avian E. coli iss

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0513630A (ja) * 1991-07-05 1993-01-22 Furukawa Electric Co Ltd:The ヒートパイプ式半導体冷却器

Also Published As

Publication number Publication date
JPH0657154B2 (ja) 1994-08-03
NL7811041A (nl) 1979-05-10
IE782192L (en) 1979-05-08
ATA793578A (de) 1983-05-15
NO158880C (no) 1988-11-09
JPS6427480A (en) 1989-01-30
JPH0123118B2 (es) 1989-05-01
PT68756A (en) 1978-12-01
GB2008123A (en) 1979-05-31
CA1221324A (en) 1987-05-05
GR72861B (es) 1983-12-13
MY8500760A (en) 1985-12-31
DD145928A5 (de) 1981-01-14
BG38166A3 (bg) 1985-10-15
SE7811458L (sv) 1979-05-09
JPS54145289A (en) 1979-11-13
IT1100089B (it) 1985-09-28
BE871782A (fr) 1979-05-07
PH20642A (en) 1987-03-18
AT373280B (de) 1984-01-10
IE47890B1 (en) 1984-07-11
ZA786305B (en) 1979-10-31
HK87284A (en) 1984-11-16
FI783366A7 (fi) 1979-05-09
DE2848052A1 (de) 1979-05-10
NO855217L (no) 1979-05-09
EP0001930B1 (en) 1989-05-24
PL210784A1 (es) 1980-02-25
IL55890A (en) 1984-01-31
NO783723L (no) 1979-05-09
GB2008123B (en) 1982-09-08
DE2862496D1 (en) 1989-06-29
NO158880B (no) 1988-08-01
IL55890A0 (en) 1979-01-31
IT7829519A0 (it) 1978-11-07
DK493878A (da) 1979-05-09
CH656640A5 (de) 1986-07-15
CA1166983A (en) 1984-05-08
EP0001930A2 (en) 1979-05-16
NZ188837A (en) 1982-09-14
EP0001930A3 (en) 1979-06-13
KE3449A (en) 1984-10-05

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