SE8603308L - Cefalosporinsalter och injicerbara beredningar - Google Patents

Cefalosporinsalter och injicerbara beredningar

Info

Publication number: SE8603308L
Authority: SE; Sweden
Prior art keywords: alpha; methyl; salts; crystalline; dilution
Prior art date: 1985-08-05

Application number

SE8603308A

Other languages

Unknown language ( )

English (en)

Other versions

SE469633B (sv

SE8603308D0 (sv

Inventor

M A Kaplan

T W Hudyma

R A Lipper

Original Assignee

Bristol Myers Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-08-05

Filing date

1986-08-04

Publication date

1987-02-06

1986-08-04 Application filed by Bristol Myers Co filed Critical Bristol Myers Co

1986-08-04 Publication of SE8603308D0 publication Critical patent/SE8603308D0/sv

1987-02-06 Publication of SE8603308L publication Critical patent/SE8603308L/sv

1993-08-09 Publication of SE469633B publication Critical patent/SE469633B/sv

Links

229930186147 Cephalosporin Natural products 0.000 title abstract 2
229940124587 cephalosporin Drugs 0.000 title abstract 2
150000001780 cephalosporins Chemical class 0.000 title 1
238000002360 preparation method Methods 0.000 title 1
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 5
-1 Cephalosporin Salts Chemical class 0.000 abstract 3
238000010790 dilution Methods 0.000 abstract 3
239000012895 dilution Substances 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
239000002253 acid Substances 0.000 abstract 2
239000013078 crystal Substances 0.000 abstract 2
238000002425 crystallisation Methods 0.000 abstract 2
230000008025 crystallization Effects 0.000 abstract 2
239000007972 injectable composition Substances 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
238000000862 absorption spectrum Methods 0.000 abstract 1
HVFLCNVBZFFHBT-ZKDACBOMSA-N cefepime Chemical compound S([C@@H]1[C@@H](C(N1C=1C([O-])=O)=O)NC(=O)\C(=N/OC)C=2N=C(N)SC=2)CC=1C[N+]1(C)CCCC1 HVFLCNVBZFFHBT-ZKDACBOMSA-N 0.000 abstract 1
238000001035 drying Methods 0.000 abstract 1
238000002329 infrared spectrum Methods 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical class [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
235000011149 sulphuric acid Nutrition 0.000 abstract 1
238000005406 washing Methods 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cephalosporin Compounds (AREA)
Medicinal Preparation (AREA)

SE8603308A 1985-08-05 1986-08-04 Fysikaliska blandningar av cefalosporinsalter, kristallina sulfatsalter och ett foerfarande foer framstaellning av dessa SE469633B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US76223585A	1985-08-05	1985-08-05

Publications (3)

Publication Number	Publication Date
SE8603308D0 SE8603308D0 (sv)	1986-08-04
SE8603308L true SE8603308L (sv)	1987-02-06
SE469633B SE469633B (sv)	1993-08-09

Family

ID=25064475

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8603308A SE469633B (sv)	1985-08-05	1986-08-04	Fysikaliska blandningar av cefalosporinsalter, kristallina sulfatsalter och ett foerfarande foer framstaellning av dessa

Country Status (34)

Country	Link
JP (1)	JPH0615548B2 (sv)
KR (1)	KR930003121B1 (sv)
AR (1)	AR243894A1 (sv)
AT (1)	AT390957B (sv)
AU (1)	AU597262B2 (sv)
BE (1)	BE905219A (sv)
CA (1)	CA1284994C (sv)
CH (1)	CH675581A5 (sv)
CS (2)	CS276849B6 (sv)
CY (1)	CY1614A (sv)
DD (2)	DD254941A5 (sv)
DE (1)	DE3626375A1 (sv)
DK (1)	DK162053C (sv)
EG (1)	EG18003A (sv)
ES (1)	ES2002112A6 (sv)
FI (1)	FI84484C (sv)
FR (1)	FR2585705B1 (sv)
GB (1)	GB2179936B (sv)
GR (1)	GR862055B (sv)
HK (1)	HK99691A (sv)
HU (1)	HU196602B (sv)
IE (1)	IE59222B1 (sv)
IL (1)	IL79608A (sv)
IT (1)	IT1197067B (sv)
LU (2)	LU88574I2 (sv)
MY (1)	MY102212A (sv)
NL (1)	NL8601991A (sv)
OA (1)	OA08672A (sv)
PT (1)	PT83134B (sv)
SE (1)	SE469633B (sv)
SG (1)	SG79791G (sv)
SU (1)	SU1516013A3 (sv)
YU (1)	YU45793B (sv)
ZA (1)	ZA865842B (sv)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4883868A (en) *	1984-12-27	1989-11-28	Banyu Pharmaceutical Co., Ltd.	7-amino-3-(substituted isoindolinium)methyl-3-cephem derivatives
US4959469A (en) *	1984-12-27	1990-09-25	Banyu Pharmaceutical Company, Ltd.	Crystalline cephalosporin compounds
US4910301A (en) *	1985-08-05	1990-03-20	Bristol-Myers Company	Cefepime cephalosporin salts
US5244891A (en) *	1985-08-05	1993-09-14	Bristol-Myers Squibb Company	Injectable compositions of cefepime dihydrochloride hydrate
US4808617A (en) *	1985-12-18	1989-02-28	Bristol-Myers Company	Lyophilized or precipitated cephalosporin zwitterion and salt combination
EP0321562B1 (en) *	1987-06-25	1993-11-24	Banyu Pharmaceutical Co., Ltd.	Crystalline cephalosporin compounds, process for their preparation, and intermediates for their preparation
JPH02101081A (ja) *	1988-10-08	1990-04-12	Meiji Seika Kaisha Ltd	セファロスポリン誘導体結晶性二塩酸塩及びその製造法
CA2011116C (en) *	1989-03-06	1999-11-16	Murray A. Kaplan	Lyophilized bmy-28142 dihydrochloride for parenteral use
CA2101571A1 (en) *	1992-09-08	1994-03-09	Elizabeth A. Garofalo	Crystalline dihydrate of a cephalosporin dihydrate salt and injectable compositions thereof
US5721359A (en) *	1993-03-12	1998-02-24	Pharmacia & Upjohn Company	Crystalline ceftiofur free acid
EP0638573A1 (en) *	1993-08-10	1995-02-15	Lucky Ltd.	Crystalline hydrates of cephalosporin and process for preparation thereof
WO2005063772A1 (en)	2003-12-23	2005-07-14	Sandoz Ag	Process for production of intermediates for use in cefalosporin synthesis
WO2008056221A2 (en) *	2006-11-06	2008-05-15	Orchid Chemicals & Pharmaceuticals Limited	Crystalline sulfate salt of cephalosporin antibiotic
DE102012101680A1 (de) *	2012-02-29	2013-08-29	Aicuris Gmbh & Co. Kg	Pharmazeutische Zubereitung enthaltend ein antiviral wirksames Dihydrochinazolinderivat

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS55151588A (en) *	1979-05-14	1980-11-26	Takeda Chem Ind Ltd	Preparation of cephalosporin salt crystal
CA1213882A (en) *	1982-03-04	1986-11-12	Jun Okumura	Cephalosporins
US4406899A (en) *	1982-03-04	1983-09-27	Bristol-Myers Company	Cephalosporins
US4525473A (en) *	1983-03-30	1985-06-25	Bristol-Myers Company	Cephalosporins
DE3419015A1 (de) *	1984-05-22	1985-11-28	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von cephalosporinen
GB2165245B (en) *	1984-10-01	1988-05-25	Glaxo Group Ltd	Chemical compounds
GB8424692D0 (en) *	1984-10-01	1984-11-07	Glaxo Group Ltd	Chemical compounds

1986
- 1986-07-28 FR FR8610892A patent/FR2585705B1/fr not_active Expired
- 1986-07-28 CA CA000514766A patent/CA1284994C/en not_active Expired - Lifetime
- 1986-07-29 AR AR86304717A patent/AR243894A1/es active
- 1986-07-30 AU AU60694/86A patent/AU597262B2/en not_active Expired
- 1986-07-31 YU YU137186A patent/YU45793B/sh unknown
- 1986-08-01 IE IE207886A patent/IE59222B1/en not_active IP Right Cessation
- 1986-08-01 FI FI863155A patent/FI84484C/sv not_active IP Right Cessation
- 1986-08-04 CS CS903570A patent/CS276849B6/cs unknown
- 1986-08-04 BE BE07217010A patent/BE905219A/fr not_active IP Right Cessation
- 1986-08-04 CS CS865827A patent/CS276717B6/cs unknown
- 1986-08-04 LU LU88574C patent/LU88574I2/fr unknown
- 1986-08-04 GB GB8618989A patent/GB2179936B/en not_active Expired
- 1986-08-04 NL NL8601991A patent/NL8601991A/nl not_active Application Discontinuation
- 1986-08-04 ZA ZA865842A patent/ZA865842B/xx unknown
- 1986-08-04 CH CH3117/86A patent/CH675581A5/de not_active IP Right Cessation
- 1986-08-04 IL IL79608A patent/IL79608A/xx not_active IP Right Cessation
- 1986-08-04 JP JP61183288A patent/JPH0615548B2/ja not_active Expired - Lifetime
- 1986-08-04 SU SU864027914A patent/SU1516013A3/ru active
- 1986-08-04 SE SE8603308A patent/SE469633B/sv not_active IP Right Cessation
- 1986-08-04 PT PT83134A patent/PT83134B/pt unknown
- 1986-08-04 DE DE19863626375 patent/DE3626375A1/de not_active Ceased
- 1986-08-04 IT IT21409/86A patent/IT1197067B/it active Protection Beyond IP Right Term
- 1986-08-04 DK DK371886A patent/DK162053C/da not_active IP Right Cessation
- 1986-08-04 GR GR862055A patent/GR862055B/el unknown
- 1986-08-04 LU LU86540A patent/LU86540A1/fr unknown
- 1986-08-05 HU HU863376A patent/HU196602B/hu unknown
- 1986-08-05 ES ES8600872A patent/ES2002112A6/es not_active Expired
- 1986-08-05 DD DD86293433A patent/DD254941A5/de unknown
- 1986-08-05 OA OA58918A patent/OA08672A/xx unknown
- 1986-08-05 KR KR1019860006445A patent/KR930003121B1/ko not_active Expired - Lifetime
- 1986-08-05 AT AT0211086A patent/AT390957B/de not_active IP Right Cessation
1987
- 1987-09-29 MY MYPI87002279A patent/MY102212A/en unknown
1988
- 1988-03-30 DD DD88314213A patent/DD268395A5/de unknown
1989
- 1989-08-04 EG EG489/86A patent/EG18003A/xx active
1991
- 1991-10-02 SG SG797/91A patent/SG79791G/en unknown
- 1991-12-05 HK HK996/91A patent/HK99691A/xx not_active IP Right Cessation
1992
- 1992-07-10 CY CY1614A patent/CY1614A/en unknown

Also Published As

Publication number	Publication date
SE469633B (sv)	1993-08-09
LU86540A1 (fr)	1987-03-06
DK162053B (da)	1991-09-09
FI863155A0 (fi)	1986-08-01
GB8618989D0 (en)	1986-09-17
HK99691A (en)	1991-12-13
FR2585705A1 (fr)	1987-02-06
PT83134B (pt)	1989-07-31
NL8601991A (nl)	1987-03-02
FI84484C (sv)	1991-12-10
DD268395A5 (de)	1989-05-31
AU6069486A (en)	1987-02-12
CS276717B6 (en)	1992-08-12
IT1197067B (it)	1988-11-25
PT83134A (en)	1986-09-01
IL79608A (en)	1991-07-18
IE59222B1 (en)	1994-01-26
EG18003A (en)	1991-08-30
ES2002112A6 (es)	1988-07-16
GB2179936A (en)	1987-03-18
GR862055B (en)	1986-12-24
ATA211086A (de)	1990-01-15
CA1284994C (en)	1991-06-18
MY102212A (en)	1992-05-15
JPH0615548B2 (ja)	1994-03-02
KR880002530A (ko)	1988-05-09
SG79791G (en)	1991-11-15
FI863155A7 (fi)	1987-02-06
AR243894A1 (es)	1993-09-30
IL79608A0 (en)	1986-11-30
FI84484B (fi)	1991-08-30
ZA865842B (en)	1987-04-29
YU137186A (en)	1987-12-31
BE905219A (fr)	1987-02-04
IE862078L (en)	1987-02-05
KR930003121B1 (ko)	1993-04-19
DE3626375A1 (de)	1987-02-12
CY1614A (en)	1992-07-10
LU88574I2 (fr)	1995-03-01
OA08672A (en)	1989-03-31
AU597262B2 (en)	1990-05-31
FR2585705B1 (fr)	1989-01-13
DK162053C (da)	1992-02-10
YU45793B (sh)	1992-07-20
HU196602B (en)	1988-12-28
DK371886D0 (da)	1986-08-04
IT8621409A1 (it)	1988-02-04
CH675581A5 (sv)	1990-10-15
IT8621409A0 (it)	1986-08-04
HUT41802A (en)	1987-05-28
JPS62103090A (ja)	1987-05-13
SE8603308D0 (sv)	1986-08-04
AT390957B (de)	1990-07-25
DK371886A (da)	1987-02-06
GB2179936B (en)	1989-04-26
DD254941A5 (de)	1988-03-16
SU1516013A3 (ru)	1989-10-15
CS276849B6 (en)	1992-08-12

Legal Events

Date	Code	Title	Description
1994-05-24	SPCF	Application for supplementary protection certificate filed	Free format text: 8603308
1994-05-30	SPCG	Supplementary protection certificate granted	Free format text: 8603308, EXPIRES: 20080628
1995-01-31	NAL	Patent in force	Ref document number: 8603308-1 Format of ref document f/p: F
2006-10-24	NUG	Patent has lapsed

Publication	Publication Date	Title
SE8603308L (sv)	1987-02-06	Cefalosporinsalter och injicerbara beredningar
ES2012948A6 (es)	1990-04-16	Procedimiento para la preparacion de sales de cefalosporina y composiciones inyectables
ES8605500A1 (es)	1986-03-16	Procedimiento para preparar derivados de acidos fenilaceticos.
SE8304045D0 (sv)	1983-07-19	Derivat av morfolinyl-daunorubicin och morfolinyl-doxorubicin, och analoger derav samt forfarande for framstellning derav
JPS54132592A (en)	1979-10-15	3,7-di-substituted-3-cephem-4-carboxylic acid derivative, its salt, and their preparation
FI830380A0 (fi)	1983-02-03	Pyridylfoereningar
DE69032733D1 (de)	1998-12-10	Lyophilisiertes Dihydrochloridsalz von 7-[alpha-(2-Aminothiazol-4-yl)-alpha-(Z)-methoxyiminoacetamid]-3-[(1-methyl-1-pyrrolidinium)-methyl]-3-cephem-4-carboxylsäure
ES8504790A1 (es)	1985-04-16	Un procedimiento para producir derivados de tiazol
SE8107524L (sv)	1982-06-17	Heterocykliska foreningar
JPS6440467A (en)	1989-02-10	Novel substituted diphenylimidazole derivative
MY116452A (en)	2004-02-28	Cephalosporin salts and injectable compositions
JPS5212141A (en)	1977-01-29	Novel amino benzoic acid derivatives, their preparation, and pharmaceu tical compositions therefrom
SE7901262L (sv)	1979-08-16	3,7-disubstituerade 3-cefem-4-karboxylsyraforeningar och forfarande for deras framstellning
DE3685942D1 (de)	1992-08-13	2-pyridylessigsaeurederivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
KR860005793A (ko)	1986-08-13	이미다졸 유도체와 그의 약학적 허용 가능한 에스테르, 아미드 및 염의 제조방법
US3088947A (en)	1963-05-07	Benzoylcarbinol-aminoacetates
IE38116L (en)	1973-12-01	Benzamide derivatives
ES406297A1 (es)	1975-09-16	Un procedimiento para la preparacion de un compuesto acilo-xialquilheterociclico.
GB942876A (en)	1963-11-27	Improvements in or relating to piperidylidene-thiaxanthene
JPS55151555A (en)	1980-11-26	Proline derivatives and their production
ES8104285A1 (es)	1981-04-16	Un procedimiento para la obtencion de un derivado del acido clarulanico.
ES369646A1 (es)	1971-06-01	Un procedimiento de preparacion de los derivados de acido 5-tiazol carboxilico.
KR920000787A (ko)	1992-01-29	결정성 폴리펩티드
JPS5547639A (en)	1980-04-04	Preparation of alkylanthraquinone
TH2766B (th)	1992-02-07	เกลือโมโนโซเดียมของกรดเซโฟนิซิค