SG108208A1 - Connective tissue growth factor - Google Patents

Connective tissue growth factor

Info

Publication number: SG108208A1
Authority: SG; Singapore
Prior art keywords: ctgf; growth factor; connective tissue; tissue growth; provides
Prior art date: 1995-06-02

Application number

SG9806251A

Other languages

English (en)

Inventor

R Grotendorst Gary

M Bradham Douglass Jr

Original Assignee

Univ South Florida

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-06-02

Filing date

1996-05-31

Publication date

2005-01-28

1996-05-31 Application filed by Univ South Florida filed Critical Univ South Florida

2005-01-28 Publication of SG108208A1 publication Critical patent/SG108208A1/en

Links

108010039419 Connective Tissue Growth Factor Proteins 0.000 title abstract 9
102000015225 Connective Tissue Growth Factor Human genes 0.000 title abstract 9
239000002157 polynucleotide Substances 0.000 abstract 3
102000040430 polynucleotide Human genes 0.000 abstract 3
108091033319 polynucleotide Proteins 0.000 abstract 3
238000003556 assay Methods 0.000 abstract 1
238000002405 diagnostic procedure Methods 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
239000002773 nucleotide Substances 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
229920001184 polypeptide Polymers 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1
102000004196 processed proteins & peptides Human genes 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1
238000011144 upstream manufacturing Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1841—Transforming growth factor [TGF]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0655—Chondrocytes; Cartilage
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Zoology (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Genetics & Genomics (AREA)
Rheumatology (AREA)
Wood Science & Technology (AREA)
Epidemiology (AREA)
Biotechnology (AREA)
Immunology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Urology & Nephrology (AREA)
Ophthalmology & Optometry (AREA)
Cell Biology (AREA)
General Engineering & Computer Science (AREA)
Toxicology (AREA)
Microbiology (AREA)
Molecular Biology (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Dermatology (AREA)
Pulmonology (AREA)

SG9806251A 1995-06-02 1996-05-31 Connective tissue growth factor SG108208A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US08/459,717 US5770209A (en)	1991-08-30	1995-06-02	Acceleration of wound healing using connective tissue growth factor

Publications (1)

Publication Number	Publication Date
SG108208A1 true SG108208A1 (en)	2005-01-28

Family

ID=23825885

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG9806251A SG108208A1 (en)	1995-06-02	1996-05-31	Connective tissue growth factor

Country Status (11)

Country	Link
US (4)	US5770209A (de)
EP (2)	EP0831885A4 (de)
JP (4)	JPH11506449A (de)
CN (2)	CN1191491A (de)
AT (1)	ATE464067T1 (de)
AU (2)	AU722919B2 (de)
BR (2)	BR9609521A (de)
CA (2)	CA2222609A1 (de)
DE (1)	DE69638162D1 (de)
SG (1)	SG108208A1 (de)
WO (2)	WO1996038168A1 (de)

Families Citing this family (76)

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US7384634B2 (en)	1991-08-30	2008-06-10	University Of South Florida	Connective tissue growth factor
US5408040A (en) *	1991-08-30	1995-04-18	University Of South Florida	Connective tissue growth factor(CTGF)
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US6638912B2 (en) *	1995-05-01	2003-10-28	The Regents Of The University Of California	Peptide compositions mimicking TGF-β activity
AU763649B2 (en) *	1995-06-02	2003-07-31	University Of South Florida	Connective tissue growth factor
US6790606B1 (en)	1996-03-15	2004-09-14	Munin Corporation	Extracellular matrix signaling molecules
US7521540B2 (en) *	1996-03-15	2009-04-21	Munin Corporation	CYR61 compositions and methods
US6413735B1 (en)	1996-03-15	2002-07-02	Munin Corporation	Method of screening for a modulator of angiogenesis
US20090081228A1 (en) *	1996-03-15	2009-03-26	Munin Corporation	Cyr61 compositions and methods
US20040132987A1 (en)	1996-11-08	2004-07-08	Human Genome Sciences, Inc.	Connective tissue growth factor-3
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DE69734395T2 (de) *	1996-12-06	2006-07-27	Osiris Therapeutics, Inc.	Verbesserte chondrogene differenzierung von menschlichen mesenchym-stammzellen
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JP2002513294A (ja) *	1997-06-19	2002-05-08	ジェネティックス・インスチチュート・インコーポレーテッド	分泌蛋白およびそれらをコードするポリヌクレオチド
US5876730A (en)	1997-08-07	1999-03-02	Childrens Hospital Research Foundation	Heparin-binding growth factor (HBGF) polypeptides
JP4537507B2 (ja) *	1997-12-25	2010-09-01	アムジェンインコーポレイテッド	結合組織増殖因子に対するモノクローナル抗体及びその医薬用途
AU1682699A (en)	1997-12-25	1999-07-19	Japan Tobacco Inc.	Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
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US6348329B1 (en)	1998-11-06	2002-02-19	Fibrogen, Inc.	Nucleic acids encoding rat connective tissue growth factor (CTGF) and methods of use
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CN1170849C (zh) *	1998-12-14	2004-10-13	迈阿密大学	结缔组织生长因子片段及其方法和用途
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US6599526B2 (en) *	2000-08-18	2003-07-29	The University Of North Texas Health Science Center At Fort Worth	Pericardial anti-adhesion patch
WO2002042448A1 (fr)	2000-11-22	2002-05-30	Yamanouchi Pharmaceutical Co., Ltd.	Nouveau polypeptide
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JP4456796B2 (ja) *	2001-09-27	2010-04-28	株式会社林原生物化学研究所	コラーゲン産生増強剤の製造方法とその用途
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US20050191653A1 (en) *	2003-11-03	2005-09-01	Freier Susan M.	Modulation of SGLT2 expression
CN101884789A (zh)	2004-02-11	2010-11-17	法布罗根股份有限公司	Ctgf作为糖尿病肾病的治疗靶点
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US20110244006A1 (en) *	2007-11-29	2011-10-06	The Trustees Of Columbia University In The City Of New York	Microsphere skin treatment
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US8946172B2 (en)	2008-08-25	2015-02-03	Excaliard Pharmaceuticals, Inc.	Method for reducing scarring during wound healing using antisense compounds directed to CTGF
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JP5166360B2 (ja) *	2009-06-23	2013-03-21	株式会社島津製作所	マイクロ反応装置を用いた細胞運動評価方法
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US20120244169A1 (en)	2009-11-06	2012-09-27	Fibrogen, Inc.	Treatment for Radiation-Induced Disorders
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CN103200945B (zh)	2010-03-24	2016-07-06	雷克西制药公司	眼部症候中的rna干扰
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US20140134181A1 (en)	2010-11-05	2014-05-15	Kenneth E. Lipson	Treatment Method For Lung Remodeling Diseases
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CN104302780B (zh)	2011-08-05	2017-04-12	艾克斯-马赛大学	纤维变性易感性il22ra2基因及其用途
US9480449B2 (en)	2012-05-03	2016-11-01	Fibrogen, Inc.	Methods for treating idiopathic pulmonary fibrosis
US9631013B2 (en)	2014-01-28	2017-04-25	Fibrogen, Inc.	Therapeutic method for pancreatic cancer
KR102871263B1 (ko) *	2018-11-08	2025-10-16	이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디.	부착 비의존성 세포 및 그 용도
KR20220016890A (ko)	2019-06-04	2022-02-10	지앙수 헨그루이 메디슨 컴퍼니 리미티드	항-결합조직 성장인자 항체 및 이의 응용
MX2022003768A (es) *	2019-10-03	2022-08-19	Vitruvia Holdings Inc	Metodo de restauracion del tejido conectivo.
US12472234B2 (en)	2021-09-10	2025-11-18	Bjorn Eek	Treatment of connective tissue injuries
JP2023129339A (ja) *	2022-03-02	2023-09-14	イークビョルン	結合組織損傷の治療

Citations (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5408040A (en) *	1991-08-30	1995-04-18	University Of South Florida	Connective tissue growth factor(CTGF)

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1995
- 1995-06-02 US US08/459,717 patent/US5770209A/en not_active Expired - Lifetime
1996
- 1996-05-31 EP EP96920597A patent/EP0831885A4/de not_active Withdrawn
- 1996-05-31 BR BR9609521A patent/BR9609521A/pt not_active Application Discontinuation
- 1996-05-31 DE DE69638162T patent/DE69638162D1/de not_active Expired - Lifetime
- 1996-05-31 CN CN96195767A patent/CN1191491A/zh active Pending
- 1996-05-31 BR BR9608558-4A patent/BR9608558A/pt not_active Application Discontinuation
- 1996-05-31 JP JP8536723A patent/JPH11506449A/ja active Pending
- 1996-05-31 CA CA002222609A patent/CA2222609A1/en not_active Abandoned
- 1996-05-31 CN CN96195711A patent/CN1195295A/zh active Pending
- 1996-05-31 WO PCT/US1996/008210 patent/WO1996038168A1/en not_active Ceased
- 1996-05-31 AT AT96916841T patent/ATE464067T1/de not_active IP Right Cessation
- 1996-05-31 JP JP8536688A patent/JPH11507332A/ja not_active Withdrawn
- 1996-05-31 WO PCT/US1996/008140 patent/WO1996038172A1/en not_active Ceased
- 1996-05-31 SG SG9806251A patent/SG108208A1/en unknown
- 1996-05-31 CA CA2222509A patent/CA2222509C/en not_active Expired - Lifetime
- 1996-05-31 EP EP96916841A patent/EP0831903B1/de not_active Expired - Lifetime
- 1996-05-31 AU AU58855/96A patent/AU722919B2/en not_active Ceased
- 1996-05-31 AU AU59582/96A patent/AU720268B2/en not_active Expired
1998
- 1998-03-30 US US09/056,704 patent/US6232064B1/en not_active Expired - Fee Related
- 1998-04-02 US US09/054,368 patent/US6069006A/en not_active Expired - Fee Related
- 1998-04-02 US US09/054,274 patent/US6150101A/en not_active Expired - Fee Related
2003
- 2003-09-11 JP JP2003320335A patent/JP2004132974A/ja active Pending
2006
- 2006-10-04 JP JP2006273122A patent/JP2007051150A/ja active Pending

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Also Published As

Publication number	Publication date
US6069006A (en)	2000-05-30
US6150101A (en)	2000-11-21
CA2222509A1 (en)	1996-12-05
EP0831903A4 (de)	2001-02-28
AU722919B2 (en)	2000-08-17
US5770209A (en)	1998-06-23
CN1191491A (zh)	1998-08-26
BR9608558A (pt)	1999-11-30
EP0831885A4 (de)	2000-11-29
DE69638162D1 (de)	2010-05-27
EP0831903A1 (de)	1998-04-01
CA2222609A1 (en)	1996-12-05
CN1195295A (zh)	1998-10-07
WO1996038172A1 (en)	1996-12-05
AU5958296A (en)	1996-12-18
ATE464067T1 (de)	2010-04-15
AU720268B2 (en)	2000-05-25
WO1996038168A1 (en)	1996-12-05
EP0831903B1 (de)	2010-04-14
MX9709294A (es)	1998-08-30
EP0831885A1 (de)	1998-04-01
CA2222509C (en)	2012-12-04
JPH11507332A (ja)	1999-06-29
JP2007051150A (ja)	2007-03-01
AU5885596A (en)	1996-12-18
US6232064B1 (en)	2001-05-15
JPH11506449A (ja)	1999-06-08
JP2004132974A (ja)	2004-04-30
BR9609521A (pt)	1999-06-15

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