SG11202004502SA - Anti-alpha-synuclein antibodies - Google Patents

Anti-alpha-synuclein antibodies

Info

Publication number
SG11202004502SA
SG11202004502SA SG11202004502SA SG11202004502SA SG11202004502SA SG 11202004502S A SG11202004502S A SG 11202004502SA SG 11202004502S A SG11202004502S A SG 11202004502SA SG 11202004502S A SG11202004502S A SG 11202004502SA SG 11202004502S A SG11202004502S A SG 11202004502SA
Authority
SG
Singapore
Prior art keywords
alpha
synuclein antibodies
synuclein
antibodies
Prior art date
Application number
SG11202004502SA
Other languages
English (en)
Inventor
Ralph Adams
Patrick Downey
Terence Seward Baker
Kerry Louise Tyson
Lichtervelde Lorenzo De
Daniel John Lightwood
David James Mcmillan
Original Assignee
UCB Biopharma SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by UCB Biopharma SRL filed Critical UCB Biopharma SRL
Publication of SG11202004502SA publication Critical patent/SG11202004502SA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896Neurological disorders, e.g. Alzheimer's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51Complete heavy chain or Fd fragment, i.e. VH + CH1
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515Complete light chain, i.e. VL + CL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567Framework region [FR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/28Neurological disorders
    • G01N2800/2835Movement disorders, e.g. Parkinson, Huntington, Tourette

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Psychology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202004502SA 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies SG11202004502SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1720975.0A GB201720975D0 (en) 2017-12-15 2017-12-15 Anti-alpha synuclein antibodies
PCT/EP2018/084697 WO2019115674A1 (fr) 2017-12-15 2018-12-13 Anticorps anti-alpha-synucléine

Publications (1)

Publication Number Publication Date
SG11202004502SA true SG11202004502SA (en) 2020-06-29

Family

ID=61009086

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202004502SA SG11202004502SA (en) 2017-12-15 2018-12-13 Anti-alpha-synuclein antibodies

Country Status (26)

Country Link
US (2) US11261242B2 (fr)
EP (1) EP3724224A1 (fr)
JP (2) JP7292279B2 (fr)
KR (1) KR102789446B1 (fr)
CN (1) CN111479826B (fr)
AR (1) AR115192A1 (fr)
AU (1) AU2018382530B2 (fr)
BR (1) BR112020010504A2 (fr)
CA (1) CA3083199A1 (fr)
CL (1) CL2020001605A1 (fr)
EA (1) EA202091478A1 (fr)
EC (1) ECSP20039623A (fr)
GB (1) GB201720975D0 (fr)
IL (1) IL275187B1 (fr)
MA (1) MA51135A (fr)
MX (2) MX2020005691A (fr)
MY (1) MY205948A (fr)
PE (1) PE20201061A1 (fr)
PH (1) PH12020551007A1 (fr)
SG (1) SG11202004502SA (fr)
TN (2) TN2020000069A1 (fr)
TW (2) TW202332692A (fr)
UA (1) UA126295C2 (fr)
UY (1) UY38010A (fr)
WO (1) WO2019115674A1 (fr)
ZA (2) ZA202003542B (fr)

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WO2018119142A1 (fr) 2016-12-21 2018-06-28 Amgen Inc. Formulations d'anticorps anti-tnf alpha
CN110506057B (zh) 2017-02-17 2023-09-29 百时美施贵宝公司 Alpha突触核蛋白抗体及其应用
GB201720975D0 (en) * 2017-12-15 2018-01-31 Ucb Biopharma Sprl Anti-alpha synuclein antibodies
GB201720970D0 (en) 2017-12-15 2018-01-31 Ucb Biopharma Sprl Antibodies
WO2020079113A1 (fr) * 2018-10-19 2020-04-23 Janssen Vaccines & Prevention B.V. Anticorps anti-synucléine
US20230074436A1 (en) * 2019-09-20 2023-03-09 Denali Therapeutics Inc. Anti-alpha-synuclein antibodies and methods of use thereof
WO2021113464A1 (fr) * 2019-12-04 2021-06-10 Friedman Simon Ensemble de blocage de protéines et procédés de fabrication et d'utilisation
KR20240176098A (ko) * 2023-06-14 2024-12-24 경상국립대학교산학협력단 알파 시누클레인 에피토프를 유효성분으로 포함하는 파킨슨병의 예방 또는 치료용 조성물

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Also Published As

Publication number Publication date
TW202332692A (zh) 2023-08-16
EA202091478A1 (ru) 2020-09-04
TN2020000069A1 (en) 2022-01-06
TWI801469B (zh) 2023-05-11
JP7627300B2 (ja) 2025-02-05
MA51135A (fr) 2021-03-24
US12545720B2 (en) 2026-02-10
JP2021509012A (ja) 2021-03-18
JP2023127585A (ja) 2023-09-13
MX2020005691A (es) 2020-08-20
AU2018382530B2 (en) 2025-04-17
RU2020123274A (ru) 2022-01-17
CL2020001605A1 (es) 2020-08-28
CA3083199A1 (fr) 2019-06-20
JP7292279B2 (ja) 2023-06-16
TW201930354A (zh) 2019-08-01
UY38010A (es) 2019-07-31
ECSP20039623A (es) 2020-08-31
UA126295C2 (uk) 2022-09-14
CN111479826A (zh) 2020-07-31
PE20201061A1 (es) 2020-10-16
TN2021000169A1 (en) 2023-04-04
US20210107971A1 (en) 2021-04-15
AR115192A1 (es) 2020-12-09
EP3724224A1 (fr) 2020-10-21
WO2019115674A1 (fr) 2019-06-20
MX2024013356A (es) 2024-12-06
KR20200099160A (ko) 2020-08-21
KR102789446B1 (ko) 2025-04-01
US20220220192A1 (en) 2022-07-14
CN111479826B (zh) 2024-10-29
ZA202103456B (en) 2023-01-25
US11261242B2 (en) 2022-03-01
IL275187A (en) 2020-07-30
RU2020123274A3 (fr) 2022-01-17
IL275187B1 (en) 2026-01-01
GB201720975D0 (en) 2018-01-31
PH12020551007A1 (en) 2021-08-16
ZA202003542B (en) 2022-12-21
AU2018382530A1 (en) 2020-06-18
BR112020010504A2 (pt) 2020-11-24
MY205948A (en) 2024-11-21

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