SG163610A1 - Macrocyclic inhibitors of hepatitis c virus - Google Patents

Macrocyclic inhibitors of hepatitis c virus

Info

Publication number: SG163610A1
Authority: SG; Singapore
Prior art keywords: inhibitors; hepatitis; virus; 6alkyl; hcv
Prior art date: 2005-07-29

Application number

SG201005076-3A

Other languages

English (en)

Inventor

Kock Herman Augustinus De

Pierre Jean-Marie Bernard Raboisson

Kenneth Alan Simmen

Mats Stefan Lindstroem

Pia Cecilia Kahnberg

Dmitry Antonov

Karl Magnus Nilsson

Bengt Bertil Samuelsson

Aasa Annica Kristina Rosenquist

Original Assignee

Tibotec Pharm Ltd

Medivir Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-07-29

Filing date

2006-07-28

Publication date

2010-08-30

2006-07-28 Application filed by Tibotec Pharm Ltd, Medivir Ab filed Critical Tibotec Pharm Ltd

2010-08-30 Publication of SG163610A1 publication Critical patent/SG163610A1/en

Links

239000003112 inhibitor Substances 0.000 title abstract 3
241000711549 Hepacivirus C Species 0.000 title 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 1
NCDNCNXCDXHOMX-UHFFFAOYSA-N Ritonavir Natural products C=1C=CC=CC=1CC(NC(=O)OCC=1SC=NC=1)C(O)CC(CC=1C=CC=CC=1)NC(=O)C(C(C)C)NC(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-UHFFFAOYSA-N 0.000 abstract 1
125000004429 atom Chemical group 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 abstract 1
229960000311 ritonavir Drugs 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/14—Quaternary ammonium compounds, e.g. edrophonium, choline
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Molecular Biology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biochemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SG201005076-3A 2005-07-29 2006-07-28 Macrocyclic inhibitors of hepatitis c virus SG163610A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP05107066		2005-07-29
EP06101278		2006-02-03

Publications (1)

Publication Number	Publication Date
SG163610A1 true SG163610A1 (en)	2010-08-30

Family

ID=37102945

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG201005076-3A SG163610A1 (en)	2005-07-29	2006-07-28	Macrocyclic inhibitors of hepatitis c virus

Country Status (31)

Country	Link
US (1)	US8008251B2 (fr)
EP (1)	EP1913014B1 (fr)
JP (1)	JP5508713B2 (fr)
KR (1)	KR101321392B1 (fr)
CN (1)	CN101233147B (fr)
AR (1)	AR054881A1 (fr)
AT (1)	ATE496934T1 (fr)
AU (1)	AU2006274857B2 (fr)
BR (1)	BRPI0614515A2 (fr)
CA (1)	CA2616954C (fr)
CY (1)	CY1112001T1 (fr)
DE (1)	DE602006019879D1 (fr)
DK (1)	DK1913014T3 (fr)
EA (1)	EA200800485A1 (fr)
GT (1)	GT200600340A (fr)
HR (1)	HRP20110289T1 (fr)
IL (1)	IL188281A (fr)
ME (1)	ME01233B (fr)
MX (1)	MX2008001394A (fr)
MY (1)	MY139987A (fr)
NO (1)	NO20081074L (fr)
NZ (1)	NZ564542A (fr)
PE (1)	PE20070210A1 (fr)
PL (1)	PL1913014T3 (fr)
PT (1)	PT1913014E (fr)
RS (1)	RS51776B (fr)
SG (1)	SG163610A1 (fr)
SI (1)	SI1913014T1 (fr)
TW (1)	TWI437993B (fr)
UY (1)	UY29702A1 (fr)
WO (1)	WO2007014918A1 (fr)

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ES2336009T3 (es)	2004-01-30	2010-04-07	Medivir Ab	Inhibidores de la ns-3 serina proteasa del vhc.
US20090074815A1 (en) *	2005-04-22	2009-03-19	Sciclone Pharmaceuticals, Inc.	Immunomodulator Compounds as Vaccine Enhancers
PE20070211A1 (es)	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
US7741281B2 (en)	2005-11-03	2010-06-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2008008776A2 (fr)	2006-07-11	2008-01-17	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
US8343477B2 (en)	2006-11-01	2013-01-01	Bristol-Myers Squibb Company	Inhibitors of hepatitis C virus
US7772180B2 (en)	2006-11-09	2010-08-10	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8003604B2 (en)	2006-11-16	2011-08-23	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7888464B2 (en)	2006-11-16	2011-02-15	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7763584B2 (en)	2006-11-16	2010-07-27	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
WO2008059046A1 (fr) *	2006-11-17	2008-05-22	Tibotec Pharmaceuticals Ltd.	Inhibiteurs macrocycliques du virus de l'hépatite c
US8383583B2 (en)	2007-10-26	2013-02-26	Enanta Pharmaceuticals, Inc.	Macrocyclic, pyridazinone-containing hepatitis C serine protease inhibitors
US8202996B2 (en)	2007-12-21	2012-06-19	Bristol-Myers Squibb Company	Crystalline forms of N-(tert-butoxycarbonyl)-3-methyl-L-valyl-(4R)-4-((7-chloro-4-methoxy-1-isoquinolinyl)oxy)-N- ((1R,2S)-1-((cyclopropylsulfonyl)carbamoyl)-2-vinylcyclopropyl)-L-prolinamide
RU2490272C2 (ru)	2008-02-04	2013-08-20	Айденикс Фармасьютикалз, Инк.	Макроциклические ингибиторы серинпротеазы
CA2719008A1 (fr)	2008-03-20	2009-09-24	Enanta Pharmaceuticals, Inc.	Composes macrocycliques fluores en tant qu'inhibiteurs du virus de l'hepatite c
US8163921B2 (en)	2008-04-16	2012-04-24	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US7964560B2 (en)	2008-05-29	2011-06-21	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
CN102046648A (zh)	2008-05-29	2011-05-04	百时美施贵宝公司	丙型肝炎病毒抑制剂
US8207341B2 (en)	2008-09-04	2012-06-26	Bristol-Myers Squibb Company	Process or synthesizing substituted isoquinolines
US8044087B2 (en)	2008-09-29	2011-10-25	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8563505B2 (en)	2008-09-29	2013-10-22	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8283310B2 (en)	2008-12-15	2012-10-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
TW201040181A (en)	2009-04-08	2010-11-16	Idenix Pharmaceuticals Inc	Macrocyclic serine protease inhibitors
AR077712A1 (es)	2009-08-05	2011-09-14	Idenix Pharmaceuticals Inc	Inhibidores de serina proteasa macrociclica
TW201309690A (zh)	2011-02-10	2013-03-01	Idenix Pharmaceuticals Inc	巨環絲胺酸蛋白酶抑制劑，其醫藥組合物及其於治療ｈｃｖ感染之用途
US8957203B2 (en)	2011-05-05	2015-02-17	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US8691757B2 (en)	2011-06-15	2014-04-08	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
US9207002B2 (en)	2011-10-12	2015-12-08	International Business Machines Corporation	Contaminant separator for a vapor-compression refrigeration apparatus
JP6154474B2 (ja)	2012-10-19	2017-06-28	ブリストル−マイヤーズスクイブカンパニーＢｒｉｓｔｏｌ−ＭｙｅｒｓＳｑｕｉｂｂＣｏｍｐａｎｙ	Ｃ型肝炎ウイルス阻害剤
US9643999B2 (en)	2012-11-02	2017-05-09	Bristol-Myers Squibb Company	Hepatitis C virus inhibitors
EP2914613B1 (fr)	2012-11-02	2017-11-22	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
WO2014071007A1 (fr)	2012-11-02	2014-05-08	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
EP2914614B1 (fr)	2012-11-05	2017-08-16	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
EP2964664B1 (fr)	2013-03-07	2017-01-11	Bristol-Myers Squibb Company	Inhibiteurs du virus de l'hépatite c
CN117186000B (zh) *	2023-08-16	2026-06-02	上海凌凯科技股份有限公司	一种喹啉类化合物的制备方法

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EP1673385B1 (fr) *	2003-09-22	2011-03-02	Boehringer Ingelheim International GmbH	Peptides macrocycliques actifs contre le virus de l'hepatite c
ES2336009T3 (es) *	2004-01-30	2010-04-07	Medivir Ab	Inhibidores de la ns-3 serina proteasa del vhc.
PE20070211A1 (es) *	2005-07-29	2007-05-12	Medivir Ab	Compuestos macrociclicos como inhibidores del virus de hepatitis c
EP1910347A2 (fr) *	2005-07-29	2008-04-16	Medivir Ab	Inhibiteurs macrocycliques du virus de l'hepatite c
EP1919904B1 (fr) *	2005-07-29	2014-01-08	Janssen R&D Ireland	Inhibiteurs macrocycliques du virus de l'hépatite c
AR055105A1 (es) *	2005-07-29	2007-08-08	Tibotec Pharm Ltd	Inhibidores macrociclicos del virus de la hepatitis c

2006
- 2006-07-26 PE PE2006000905A patent/PE20070210A1/es not_active Application Discontinuation
- 2006-07-28 CN CN2006800275421A patent/CN101233147B/zh not_active Expired - Fee Related
- 2006-07-28 ME MEP-2011-73A patent/ME01233B/fr unknown
- 2006-07-28 EP EP06764263A patent/EP1913014B1/fr not_active Expired - Lifetime
- 2006-07-28 JP JP2008523374A patent/JP5508713B2/ja not_active Expired - Fee Related
- 2006-07-28 CA CA2616954A patent/CA2616954C/fr not_active Expired - Fee Related
- 2006-07-28 PT PT06764263T patent/PT1913014E/pt unknown
- 2006-07-28 MX MX2008001394A patent/MX2008001394A/es active IP Right Grant
- 2006-07-28 EA EA200800485A patent/EA200800485A1/ru unknown
- 2006-07-28 SI SI200630993T patent/SI1913014T1/sl unknown
- 2006-07-28 US US11/995,888 patent/US8008251B2/en not_active Expired - Fee Related
- 2006-07-28 UY UY29702A patent/UY29702A1/es unknown
- 2006-07-28 TW TW095127583A patent/TWI437993B/zh not_active IP Right Cessation
- 2006-07-28 AU AU2006274857A patent/AU2006274857B2/en not_active Ceased
- 2006-07-28 DK DK06764263.7T patent/DK1913014T3/da active
- 2006-07-28 WO PCT/EP2006/064812 patent/WO2007014918A1/fr not_active Ceased
- 2006-07-28 AT AT06764263T patent/ATE496934T1/de active
- 2006-07-28 DE DE602006019879T patent/DE602006019879D1/de not_active Expired - Lifetime
- 2006-07-28 HR HR20110289T patent/HRP20110289T1/hr unknown
- 2006-07-28 KR KR1020087004157A patent/KR101321392B1/ko not_active Expired - Fee Related
- 2006-07-28 SG SG201005076-3A patent/SG163610A1/en unknown
- 2006-07-28 MY MYPI20063667A patent/MY139987A/en unknown
- 2006-07-28 BR BRPI0614515-9A patent/BRPI0614515A2/pt not_active IP Right Cessation
- 2006-07-28 GT GT200600340A patent/GT200600340A/es unknown
- 2006-07-28 AR ARP060103302A patent/AR054881A1/es unknown
- 2006-07-28 RS RS20110174A patent/RS51776B/sr unknown
- 2006-07-28 PL PL06764263T patent/PL1913014T3/pl unknown
- 2006-07-28 NZ NZ564542A patent/NZ564542A/en not_active IP Right Cessation
2007
- 2007-12-20 IL IL188281A patent/IL188281A/en not_active IP Right Cessation
2008
- 2008-02-29 NO NO20081074A patent/NO20081074L/no not_active Application Discontinuation
2011
- 2011-04-26 CY CY20111100415T patent/CY1112001T1/el unknown

Also Published As

Publication number	Publication date
UY29702A1 (es)	2007-05-31
WO2007014918A1 (fr)	2007-02-08
PL1913014T3 (pl)	2011-06-30
AU2006274857A1 (en)	2007-02-08
HK1116503A1 (en)	2008-12-24
EP1913014A1 (fr)	2008-04-23
BRPI0614515A2 (pt)	2011-03-29
TWI437993B (zh)	2014-05-21
IL188281A (en)	2015-01-29
HRP20110289T1 (hr)	2011-05-31
JP2009502881A (ja)	2009-01-29
IL188281A0 (en)	2008-04-13
NZ564542A (en)	2010-03-26
KR101321392B1 (ko)	2013-10-30
PT1913014E (pt)	2011-04-20
GT200600340A (es)	2007-02-26
CA2616954A1 (fr)	2007-02-08
US20080200503A1 (en)	2008-08-21
CY1112001T1 (el)	2015-11-04
ATE496934T1 (de)	2011-02-15
JP5508713B2 (ja)	2014-06-04
TW200801044A (en)	2008-01-01
AR054881A1 (es)	2007-07-25
EA200800485A1 (ru)	2009-04-28
RS51776B (sr)	2011-12-31
CN101233147B (zh)	2012-06-20
EP1913014B1 (fr)	2011-01-26
ME01233B (fr)	2013-06-20
PE20070210A1 (es)	2007-04-16
DK1913014T3 (da)	2011-08-01
CN101233147A (zh)	2008-07-30
DE602006019879D1 (de)	2011-03-10
MX2008001394A (es)	2008-04-08
CA2616954C (fr)	2013-12-24
KR20080039430A (ko)	2008-05-07
MY139987A (en)	2009-11-30
AU2006274857B2 (en)	2012-11-29
US8008251B2 (en)	2011-08-30
SI1913014T1 (sl)	2011-06-30
NO20081074L (no)	2008-04-29

Publication	Publication Date	Title
TW200801044A (en)	2008-01-01	Macrocylic inhibitors of hepatitis C virus
SG163617A1 (en)	2010-08-30	Macrocyclic inhibitors of hepatitis c virus
TW200745118A (en)	2007-12-16	Macrocylic inhibitors of hepatitis C virus
MX2009005219A (es)	2009-05-27	Inhibidores macrociclicos del virus de hepatitis c.
MY144607A (en)	2011-10-14	Macrocylic inhibitors of hepatitis c virus
TW200800949A (en)	2008-01-01	Macrocylic inhibitors of hepatitis C virus
SG164376A1 (en)	2010-09-29	Hcv ns3 protease inhibitors
ATE388958T1 (de)	2008-03-15	4'-c-substituierte 2-haloadenosinderivate
MY152153A (en)	2014-08-15	Macrocylic inhibitors of hepatitis c virus
MY164469A (en)	2017-12-15	Hcv ns3 protease inhibitors
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