SG48315A1 - Novel compounds - Google Patents

Novel compounds

Info

Publication number: SG48315A1
Authority: SG; Singapore
Prior art keywords: group; alkyl; novel compounds; chem; integer
Prior art date: 1989-04-13

Application number

SG1996008858A

Other languages

English (en)

Inventor

Barry Sidney Orlek

Steven Dabbs

Steven Mark Bromidge

Original Assignee

Beecham Group Plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-04-13

Filing date

1990-04-10

Publication date

1998-04-17

1989-04-13 Priority claimed from GB898908365A external-priority patent/GB8908365D0/en

1989-10-16 Priority claimed from GB898923299A external-priority patent/GB8923299D0/en

1990-04-10 Application filed by Beecham Group Plc filed Critical Beecham Group Plc

1998-04-17 Publication of SG48315A1 publication Critical patent/SG48315A1/en

Links

150000001875 compounds Chemical class 0.000 title abstract 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
125000006656 (C2-C4) alkenyl group Chemical group 0.000 abstract 1
125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 1
101100516563 Caenorhabditis elegans nhr-6 gene Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
-1 chloro, fluoro, bromo, cyclopropyl Chemical group 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
125000002816 methylsulfanyl group Chemical group [H]C([H])([H])S[*] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SG1996008858A 1989-04-13 1990-04-10 Novel compounds SG48315A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB898908365A GB8908365D0 (en)	1989-04-13	1989-04-13	Novel compounds
GB898923299A GB8923299D0 (en)	1989-10-16	1989-10-16	Novel compounds

Publications (1)

Publication Number	Publication Date
SG48315A1 true SG48315A1 (en)	1998-04-17

Family

ID=26295213

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996008858A SG48315A1 (en)	1989-04-13	1990-04-10	Novel compounds

Country Status (12)

Country	Link
US (1)	USRE35593E (de)
EP (1)	EP0392803B1 (de)
JP (3)	JP2665818B2 (de)
KR (1)	KR0185378B1 (de)
AT (1)	ATE269330T1 (de)
CA (1)	CA2014379C (de)
DE (1)	DE69034146T2 (de)
DK (1)	DK0392803T3 (de)
ES (1)	ES2219636T3 (de)
NZ (1)	NZ233290A (de)
PT (1)	PT93753B (de)
SG (1)	SG48315A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1992003435A1 (en) *	1990-08-24	1992-03-05	Beecham Group Plc	Azabicyclic compounds, process and intermediates for their preparation and pharmaceutical compositions containing them
GB9019095D0 (en) *	1990-09-01	1990-10-17	Beecham Group Plc	Novel compounds
CA2093823A1 (en) *	1990-10-12	1992-04-13	Steven M. Bromidge	1,2,5,6-tetrahydropyridine oxime derivatives
WO1992011261A1 (en) *	1990-12-21	1992-07-09	Merck Sharp & Dohme Limited	4-azatricyclo[2.2.1.02,6]heptanes and pharmaceutical compositions
MX9300875A (es) *	1992-02-20	1993-08-31	Smithkline Beecham Plc	Procedimiento para la preparacion de compuestos azabiciclicos.
GB9409705D0 (en) *	1994-05-14	1994-07-06	Smithkline Beecham Plc	Novel compounds
GB9409718D0 (en) *	1994-05-14	1994-07-06	Smithkline Beecham Plc	Novel compounds
GB9421472D0 (en) *	1994-10-25	1994-12-07	Smithkline Beecham Plc	Novel methods
AU751607B2 (en) *	1995-07-29	2002-08-22	Smithkline Beecham Plc	Method of treatment of dementia
AR004178A1 (es) *	1995-07-29	1998-11-04	Smithkline Beecham Plc	Procedimiento para la formulacion de un farmaco, una composicion farmaceutica obtenible mediante este procedimiento y el uso de la misma.
EA001422B1 (ru) *	1996-05-13	2001-02-26	Зенека Лимитед	Бициклические амины в качестве инсектицидов
GB9615628D0 (en) *	1996-07-25	1996-09-04	Smithkline Beecham Plc	Formulation
US20010003588A1 (en) *	1996-09-12	2001-06-14	Smithkline Beecham Corporation	Controlled release dosage form of [R-(Z)]-alpha-(methoxyimino)-alpha-(1-azabicyclo[2.2.2.]oct-3-yl)acetonitrile monohydrochloride
GB9619074D0 (en) *	1996-09-12	1996-10-23	Smithkline Beecham Plc	Composition
EP1009403A4 (de) *	1997-04-11	2002-08-28	Lilly Co Eli	Verfahren zur behandlung von schizophrenie
GB9815383D0 (en) *	1998-07-15	1998-09-16	Smithkline Beecham Plc	Novel method of treatment
KR20030021641A (ko) *	2001-09-07	2003-03-15	안병로	투명비누 자가제조용 키트 및 상기 키트를 이용한투명비누 자가제조방법
EP2258359A3 (de)	2005-08-26	2011-04-06	Braincells, Inc.	Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin
JP2009506069A (ja)	2005-08-26	2009-02-12	ブレインセルス，インコーポレイティド	ムスカリン性受容体調節による神経発生
US7985756B2 (en)	2005-10-21	2011-07-26	Braincells Inc.	Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en)	2005-10-31	2007-05-10	Braincells, Inc.	Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en)	2006-03-08	2010-08-26	Braincells, Inc.	Modulation of neurogenesis by nootropic agents
GB0607946D0 (en) *	2006-04-21	2006-05-31	Minster Res The Ltd	Mono and combination therapy
GB0607952D0 (en) *	2006-04-21	2006-05-31	Minster Res Ltd	Novel treatment
WO2007134077A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	5 ht receptor mediated neurogenesis
WO2007134136A2 (en)	2006-05-09	2007-11-22	Braincells, Inc.	Neurogenesis by modulating angiotensin
EP2068872A1 (de)	2006-09-08	2009-06-17	Braincells, Inc.	Kombinationen mit einem 4-acylaminopyridin-derivat
US20100184806A1 (en)	2006-09-19	2010-07-22	Braincells, Inc.	Modulation of neurogenesis by ppar agents
WO2010099217A1 (en)	2009-02-25	2010-09-02	Braincells, Inc.	Modulation of neurogenesis using d-cycloserine combinations
KR102287645B1 (ko)	2018-12-18	2021-08-06	한화솔루션 주식회사	실리카계 촉매를 이용한 배위-음이온 개환 중합에 의한 폴리아마이드의 제조방법 및 이에 의해 제조된 폴리아마이드
WO2026013563A1 (en)	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013570A1 (en)	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013573A1 (en)	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026013566A1 (en)	2024-07-09	2026-01-15	Syremis Therapeutics Ltd.	New salt forms of sabcomeline
WO2026018154A1 (en)	2024-07-16	2026-01-22	Syremis Therapeutics Ltd.	Combinations of sabcomeline with non-cns penetrant muscarinic antagonists
WO2026018155A1 (en)	2024-07-16	2026-01-22	Syremis Therapeutics Ltd.	Combinations of sabcomeline with long-acting non-cns penetrant muscarinic antagonists

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE56226B1 (en) *	1982-04-14	1991-05-22	Beecham Group Plc	Substituted azabicyclo compounds,process for their preparation and pharmaceutical compositions containing them
FR2531955A1 (fr) *	1982-08-17	1984-02-24	Pharmuka Lab	Nouveau procede de preparation de derives de la quinuclidine substitues en position 3
IL81610A (en) *	1986-02-27	1990-12-23	Roussel Uclaf	Derivatives of 1,2,5,6-tetrahydropyridin-3-carboxaldehyde oxime,their preparation and pharmaceutical compositions containing them
GB8615785D0 (en) *	1986-06-27	1986-08-06	Beecham Group Plc	Compounds
EP0261763B1 (de) *	1986-06-27	1994-02-09	Beecham Group Plc	Verbrückte bicyclische N-heterocyclische Verbindungen
US4786648A (en) *	1986-12-08	1988-11-22	Warner-Lambert Company	O-substituted tetrahydropyridine oxime cholinergic agents
US4710508A (en) *	1986-12-08	1987-12-01	Warner-Lambert Company	O-substituted tetrahydropyridine oxime cholinergic agents
US4798841A (en) *	1987-03-31	1989-01-17	Warner-Lambert Company	Tetrahydropyridine oxime cholinergic agents and method of treatment
EP0287356B1 (de) *	1987-04-15	1996-01-24	Beecham Group Plc	Am Brückenkopf substituierte Azabicyclenderivate
IT1203971B (it) *	1987-04-24	1989-02-23	Roussel Maestretti Spa	Derivati di 1,2,5,6-tetraidropiridina, loro procedimento di preparazione e loro applicazione come medicamenti
IT1222526B (it) *	1987-08-21	1990-09-05	Roussel Maestretti Spa	Derivati dell' ossima della 1,2,5,6-tetraidropiridin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
IT1222529B (it) *	1987-08-21	1990-09-05	Roussel Maestretti Spa	Derivati dell' ossima della 1,2,5,6-tetraidropirdin-3-carbossaldeide,loro procedimento di preparazione e loro impiego come sostanze medicinali
DE3738521C1 (de) *	1987-11-13	1988-12-01	Delta Getriebe Gmbh	Planetengetriebe
IE63906B1 (en) *	1987-11-13	1995-06-14	Novo Nordisk As	Azabicyclic compounds and their preparation and use
IT1233446B (it) *	1987-12-30	1992-04-01	Roussel Maestretti Spa	Derivati della 3 piperidinocarbaldeide ossima, loro procedimento di preparazione e loro applicazione come farmaci
PT90266B (pt) *	1988-04-15	1994-07-29	Beecham Group Plc	Processo para a preparacao de compostos azabiciclicos
IT1227436B (it) *	1988-10-28	1991-04-11	Roussel Maestretti Spa	Derivati di 1-azabicicloalcani, loro procedimento di preparazione e loro applicazione come farmaci
US4937239A (en) *	1989-02-13	1990-06-26	Warner-Lambert Company	Azabicycloalkane oxime & azabicycloalkene oxime muscarinic agents
EP0402056A3 (de) *	1989-06-06	1991-09-04	Beecham Group p.l.c.	Azabicyclische Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen

1990
- 1990-04-10 SG SG1996008858A patent/SG48315A1/en unknown
- 1990-04-10 EP EP90303852A patent/EP0392803B1/de not_active Expired - Lifetime
- 1990-04-10 ES ES90303852T patent/ES2219636T3/es not_active Expired - Lifetime
- 1990-04-10 AT AT90303852T patent/ATE269330T1/de not_active IP Right Cessation
- 1990-04-10 DK DK90303852T patent/DK0392803T3/da active
- 1990-04-10 DE DE69034146T patent/DE69034146T2/de not_active Expired - Lifetime
- 1990-04-11 NZ NZ233290A patent/NZ233290A/en unknown
- 1990-04-11 CA CA002014379A patent/CA2014379C/en not_active Expired - Lifetime
- 1990-04-12 PT PT93753A patent/PT93753B/pt not_active IP Right Cessation
- 1990-04-13 JP JP2096587A patent/JP2665818B2/ja not_active Expired - Lifetime
- 1990-04-13 KR KR1019900005136A patent/KR0185378B1/ko not_active Expired - Lifetime
1996
- 1996-01-11 US US08/585,113 patent/USRE35593E/en not_active Expired - Lifetime
1997
- 1997-01-23 JP JP9023113A patent/JP2913466B2/ja not_active Expired - Lifetime
- 1997-01-23 JP JP9023114A patent/JP2913467B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE269330T1 (de)	2004-07-15
HK1012365A1 (en)	1999-07-30
JPH09188678A (ja)	1997-07-22
JP2913466B2 (ja)	1999-06-28
USRE35593E (en)	1997-08-19
PT93753A (pt)	1990-11-20
CA2014379C (en)	2000-02-08
DE69034146T2 (de)	2005-07-14
DK0392803T3 (da)	2004-10-18
JPH037285A (ja)	1991-01-14
NZ233290A (en)	1992-06-25
PT93753B (pt)	1996-08-30
CA2014379A1 (en)	1990-10-13
JP2913467B2 (ja)	1999-06-28
AU619969B2 (en)	1992-02-06
EP0392803B1 (de)	2004-06-16
JP2665818B2 (ja)	1997-10-22
AU5315990A (en)	1990-10-18
DE69034146D1 (de)	2004-07-22
ES2219636T3 (es)	2004-12-01
KR900016211A (ko)	1990-11-12
EP0392803A1 (de)	1990-10-17
JPH09188679A (ja)	1997-07-22
KR0185378B1 (ko)	1999-05-01

Publication	Publication Date	Title
DK0392803T3 (da)	2004-10-18	Hidtil ukendte forbindelser
PT84896A (en)	1987-06-01	Process for the preparation of distamycin a analogs useful as antineoplastic and antiviral agents and of pharmaceutical compositions containing the same
DE69033935D1 (de)	2002-04-18	Bis(3,4-Dialkylbenzyliden)sorbitolacetale und diese enthaltende Zusammensetzungen
JPS57146777A (en)	1982-09-10	Manufacture of 2-penem compounds, novel compounds manufactured thereby and pharmaceutic compositions containing them
EP0287356A3 (en)	1989-09-20	Novel compounds
HU904785D0 (en)	1992-03-30	Process for the production of medicaments
EP0632031A4 (de)	1995-02-08
ATE35137T1 (de)	1988-07-15	Thieno(2,3-d)pyrimidin-derivate und deren salze.
SE8604950D0 (sv)	1986-11-19	Dementia-improving and therapeutic agents
ES8507090A1 (es)	1985-09-16	Procedimiento para la obtencion de nuevas 1, 5-benzotiacepinas
SG106091G (en)	1992-03-20	Aromatic compounds
ATE96446T1 (de)	1993-11-15	Estramustin-ester.
IL101087A0 (en)	1992-11-15	Derivatives of substituted imidazol-2-one,their preparation and pharmaceutical compositions containing them
FI870090A0 (fi)	1987-01-12	Laongkedjade alkylresorcinolfosfiter.
HU900840D0 (en)	1990-04-28	Process for preparation of aralkyl-amine-derivatives and compositions containing them
GR3002594T3 (en)	1993-01-25	Aromatic thioethers
DE3470882D1 (en)	1988-06-09	N-substituted tetrahydrothiazines, process for their preparation, and their use as pesticides
ZA896121B (en)	1991-04-24	Antiinflammatory carbinoloimidazoles