SG48742A1 - Sulfonamides and derivatives thereof that modulate the activity of endothelin - Google Patents

Sulfonamides and derivatives thereof that modulate the activity of endothelin

Info

Publication number: SG48742A1
Authority: SG; Singapore
Prior art keywords: endothelin; activity; sulfonamides; modulate; derivatives
Prior art date: 1993-05-20

Application number

SG1996001101A

Other languages

English (en)

Inventor

Ming Fai Chan

Bore Gowda Raju

Adam Kois

Erik Joel Verner

Chengde Wu

Rosario Silvestre Castillo

Venkatachalapathi Yalamoori

Vitukudi Narayanaiyenga Balaji

Kalyanaraman Ramnarayan

Original Assignee

Immunopharmaceutics Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-20

Filing date

1994-05-20

Publication date

1998-05-18

1993-10-21 Priority claimed from US08/142,552 external-priority patent/US5514691A/en

1993-10-21 Priority claimed from US08/142,159 external-priority patent/US5464853A/en

1994-05-20 Application filed by Immunopharmaceutics Inc filed Critical Immunopharmaceutics Inc

1998-05-18 Publication of SG48742A1 publication Critical patent/SG48742A1/en

Links

102000002045 Endothelin Human genes 0.000 title abstract 2
108050009340 Endothelin Proteins 0.000 title abstract 2
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title abstract 2
229940124530 sulfonamide Drugs 0.000 title 1
150000003456 sulfonamides Chemical class 0.000 title 1
ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 abstract 2
235000010290 biphenyl Nutrition 0.000 abstract 1
239000004305 biphenyl Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
- C07D261/16—Benzene-sulfonamido isoxazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Ophthalmology & Optometry (AREA)
Urology & Nephrology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)

SG1996001101A 1993-05-20 1994-05-20 Sulfonamides and derivatives thereof that modulate the activity of endothelin SG48742A1 (en)

Applications Claiming Priority (7)

Application Number	Priority Date	Filing Date	Title
US6520293A	1993-05-20	1993-05-20
US10056593A	1993-07-30	1993-07-30
US10012593A	1993-07-30	1993-07-30
US14263193A	1993-10-21	1993-10-21
US08/142,552 US5514691A (en)	1993-05-20	1993-10-21	N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate the activity of endothelin
US08/142,159 US5464853A (en)	1993-05-20	1993-10-21	N-(5-isoxazolyl)biphenylsulfonamides, N-(3-isoxazolyl)biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
US08/222,287 US5591761A (en)	1993-05-20	1994-04-05	Thiophenyl-, furyl-and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin

Publications (1)

Publication Number	Publication Date
SG48742A1 true SG48742A1 (en)	1998-05-18

Family

ID=27568241

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996001101A SG48742A1 (en)	1993-05-20	1994-05-20	Sulfonamides and derivatives thereof that modulate the activity of endothelin

Country Status (13)

Country	Link
US (1)	US5591761A (fr)
EP (3)	EP1069114A3 (fr)
JP (1)	JP3135922B2 (fr)
AT (1)	ATE174592T1 (fr)
CA (1)	CA2161346C (fr)
CY (1)	CY2124B1 (fr)
DE (1)	DE69415316T2 (fr)
DK (1)	DK0699191T3 (fr)
ES (1)	ES2127397T3 (fr)
GB (1)	GB2285625B (fr)
RU (1)	RU2151144C1 (fr)
SG (1)	SG48742A1 (fr)
WO (1)	WO1994027979A1 (fr)

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1994
- 1994-04-05 US US08/222,287 patent/US5591761A/en not_active Expired - Lifetime
- 1994-05-20 GB GB9503693A patent/GB2285625B/en not_active Expired - Fee Related
- 1994-05-20 EP EP00119107A patent/EP1069114A3/fr not_active Withdrawn
- 1994-05-20 SG SG1996001101A patent/SG48742A1/en unknown
- 1994-05-20 EP EP98109339A patent/EP0870764A1/fr not_active Withdrawn
- 1994-05-20 WO PCT/US1994/005755 patent/WO1994027979A1/fr not_active Ceased
- 1994-05-20 CA CA002161346A patent/CA2161346C/fr not_active Expired - Fee Related
- 1994-05-20 AT AT94918081T patent/ATE174592T1/de not_active IP Right Cessation
- 1994-05-20 EP EP94918081A patent/EP0699191B1/fr not_active Expired - Lifetime
- 1994-05-20 JP JP07500856A patent/JP3135922B2/ja not_active Expired - Fee Related
- 1994-05-20 DE DE69415316T patent/DE69415316T2/de not_active Expired - Lifetime
- 1994-05-20 ES ES94918081T patent/ES2127397T3/es not_active Expired - Lifetime
- 1994-05-20 RU RU95121744/04A patent/RU2151144C1/ru not_active IP Right Cessation
- 1994-05-20 DK DK94918081T patent/DK0699191T3/da active
1998
- 1998-12-22 CY CY9800048A patent/CY2124B1/xx unknown

Also Published As

Publication number	Publication date
WO1994027979A1 (fr)	1994-12-08
EP1069114A3 (fr)	2001-01-31
JPH08510744A (ja)	1996-11-12
EP0870764A1 (fr)	1998-10-14
EP0699191A1 (fr)	1996-03-06
GB2285625B (en)	1997-12-10
DE69415316T2 (de)	1999-04-29
EP1069114A2 (fr)	2001-01-17
RU2151144C1 (ru)	2000-06-20
AU6964694A (en)	1994-12-20
GB9503693D0 (en)	1995-04-12
CA2161346A1 (fr)	1994-12-08
US5591761A (en)	1997-01-07
JP3135922B2 (ja)	2001-02-19
AU691813B2 (en)	1998-05-28
EP0699191B1 (fr)	1998-12-16
CA2161346C (fr)	2004-11-23
ATE174592T1 (de)	1999-01-15
CY2124B1 (en)	2002-06-21
DE69415316D1 (de)	1999-01-28
ES2127397T3 (es)	1999-04-16
GB2285625A (en)	1995-07-19
DK0699191T3 (da)	1999-08-23

Publication	Publication Date	Title
GB2285625B (en)	1997-12-10	Sulfonamides and derivatives thereof that modulate the activity of endothelin
AU8771591A (en)	1992-05-21	Retroviral protease inhibiting compounds
AU6858791A (en)	1991-07-25	Uracil derivatives and pesticides containing the same as active ingredient
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AU2415292A (en)	1993-03-02	Novel tetrapeptide derivative
AU4717189A (en)	1990-06-28	Low volatility amine salts of pesticides
AU645672B2 (en)	1994-01-20	Agents for preserving technical materials against insects
AU2722095A (en)	1996-02-15	Novel pyrrolocarbazoles
TW269687B (fr)	1996-02-01
AU3406993A (en)	1993-09-16	Improvements in or relating to organic compounds
AU583763B2 (en)	1989-05-04	Antiarrhythmic agents
AU657397B2 (en)	1995-03-09	3,4-diaryl-(5H)-furan-2-one based compounds with fungicidal activity
AU591892B2 (en)	1989-12-21	Peptides
AU6418698A (en)	1998-10-22	Antirheumatic agents
CA2183320A1 (fr)	1995-08-17	Nouveaux derives bisulfure de mercaptoacetylamides utiles comme inhibiteurs de l'enkephalinase et de l'enzyme de conversion de l'angiotensine (ace)
AU581914B2 (en)	1989-03-09	2,5-pyrrolidinedione derivatives useful as antiarrhythmic agents
ATE159253T1 (de)	1997-11-15	2-thiazolylpyrroleakrylate mit fungizider wirkung
AU2057392A (en)	1993-02-25	Polyglucosides obtained from hydroxyalkylsorbitol