SG67408A1 - Synthesis of analogs of pth and pthrp - Google Patents

Synthesis of analogs of pth and pthrp

Info

Publication number
SG67408A1
SG67408A1 SG1997002618A SG1997002618A SG67408A1 SG 67408 A1 SG67408 A1 SG 67408A1 SG 1997002618 A SG1997002618 A SG 1997002618A SG 1997002618 A SG1997002618 A SG 1997002618A SG 67408 A1 SG67408 A1 SG 67408A1
Authority
SG
Singapore
Prior art keywords
pthrp
pth
analogs
synthesis
Prior art date
Application number
SG1997002618A
Other languages
English (en)
Inventor
Humberto Bartolome Arzeno
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of SG67408A1 publication Critical patent/SG67408A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/061—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using protecting groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG1997002618A 1996-07-30 1997-07-23 Synthesis of analogs of pth and pthrp SG67408A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2332296P 1996-07-30 1996-07-30

Publications (1)

Publication Number Publication Date
SG67408A1 true SG67408A1 (en) 1999-09-21

Family

ID=21814418

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1997002618A SG67408A1 (en) 1996-07-30 1997-07-23 Synthesis of analogs of pth and pthrp

Country Status (30)

Country Link
US (1) US6849710B1 (fr)
EP (1) EP0822200B1 (fr)
JP (1) JP4229992B2 (fr)
KR (1) KR100518982B1 (fr)
CN (1) CN1293096C (fr)
AR (2) AR008094A1 (fr)
AT (1) ATE277080T1 (fr)
AU (1) AU731160B2 (fr)
BR (1) BR9704138A (fr)
CA (1) CA2206008C (fr)
CO (1) CO4650046A1 (fr)
CZ (1) CZ239697A3 (fr)
DE (1) DE69730787T2 (fr)
DK (1) DK0822200T3 (fr)
ES (1) ES2227639T3 (fr)
HR (1) HRP970416A2 (fr)
HU (1) HUP9701277A3 (fr)
IL (1) IL121391A0 (fr)
MA (1) MA24353A1 (fr)
MX (1) MX9705719A (fr)
NO (1) NO973482L (fr)
NZ (1) NZ328411A (fr)
PE (1) PE91998A1 (fr)
PL (1) PL321391A1 (fr)
SG (1) SG67408A1 (fr)
TR (1) TR199700714A2 (fr)
TW (1) TW505654B (fr)
UY (1) UY24651A1 (fr)
YU (1) YU32197A (fr)
ZA (1) ZA976555B (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1531855A4 (fr) * 2002-01-10 2009-07-22 Osteotrophin Llc Traitement des affections osseuses avec des medicaments anabolisants du squelette
US7378495B2 (en) * 2002-10-21 2008-05-27 Pevion Biotech, Ltd. PTH-rP related peptide cancer therapeutics
CA2628945A1 (fr) * 2005-11-10 2007-05-24 Board Of Control Of Michigan Technological University Parathormone de l'ours noir et procedes d'utilisation de la parathormone de l'ours noir
BRPI0706400A2 (pt) * 2006-01-17 2011-03-29 Organon Nv processos para a hidrólise enzimática seletiva de terc-butil ésteres c-terminais de substratos de peptìdeo, para a sìntese convergente de um peptìdeo de dois ou mais fragmentos de peptìdeo, para a sìntese enzimática por etapas de um peptìdeo na direção do terminal c, e para a sìntese de peptìdeo
US7803770B2 (en) * 2006-10-03 2010-09-28 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
USRE49444E1 (en) 2006-10-03 2023-03-07 Radius Health, Inc. Method of treating osteoporosis comprising administration of PTHrP analog
BRPI0719821B8 (pt) 2006-10-03 2021-05-25 Ipsen Pharma Sas composição estável na armazenagem apropriada para administração a pacientes
WO2010111617A2 (fr) 2009-03-27 2010-09-30 Van Andel Research Institute Peptides de l'hormone parathyroïdienne et peptides de la protéine apparentée à l'hormone parathyroïdienne ainsi que des procédés d'utilisation
BR112012013725A2 (pt) 2009-12-07 2017-01-10 Univ Michigan Tech paratormônio de urso preto e métodos de usar o paratormônio de uso preto.
CN102731643A (zh) * 2012-06-26 2012-10-17 深圳翰宇药业股份有限公司 一种治疗骨质疏松多肽的制备方法
CN102993293B (zh) * 2012-12-05 2014-05-07 深圳翰宇药业股份有限公司 一种特立帕肽醋酸盐的纯化方法
CA2907454C (fr) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthese de produits peptidiques contenant de l'hydantoine
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
ES3055185T3 (en) 2014-03-28 2026-02-10 Univ Duke Treatment of an estrogen receptor positive breast cancer using a selective estrogen receptor modulator
CN104530198B (zh) * 2014-12-09 2017-09-15 兰州大学 一种片段缩合制备醋酸去氨加压素的方法
KR20250152679A (ko) 2015-04-29 2025-10-23 래디어스 파마슈티컬스, 인코포레이티드 암을 치료하는 방법
JP7481115B2 (ja) 2017-01-05 2024-05-10 ラジウス ファーマシューティカルズ，インコーポレイテッド Ｒａｄ１９０１－２ｈｃｌの多形性形態
US10996208B2 (en) 2017-04-28 2021-05-04 Radius Health, Inc. Abaloparatide formulations and methods of testing, storing, modifying, and using same
EP3765488A1 (fr) * 2018-03-12 2021-01-20 Fresenius Kabi iPSUM S.r.l. Procédé de fabrication d'analogue de pthrp
MX2020013713A (es) 2018-07-04 2021-03-02 Radius Pharmaceuticals Inc Formas polimorficas de rad1901-2hcl.
CN111057139B (zh) * 2018-10-17 2023-12-22 南京华威医药科技集团有限公司 一种制备特立帕肽的新工艺
EP3924328A1 (fr) 2019-02-12 2021-12-22 Radius Pharmaceuticals, Inc. Procédés et composés

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3886132A (en) * 1972-12-21 1975-05-27 Us Health Human parathyroid hormone
FR2550204B1 (fr) * 1983-08-05 1987-11-13 Toyo Jozo Kk Derives peptidiques de (nle8,nle1b, tyr34)-h-pth
AU667662B2 (en) * 1990-07-13 1996-04-04 Regents Of The University Of California, The Parathyroid hormone analogues modified at positions 3, 6 or 9
GB9020544D0 (en) * 1990-09-20 1990-10-31 Sandoz Ltd Improvements in or relating to organic compounds
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
WO1995002610A1 (fr) * 1993-07-13 1995-01-26 Syntex (U.S.A.) Inc. Analogues de la parathormone et peptide apparente a la parathormone: synthese et utilisation pour le traitement de l'osteoporose
CO4410206A1 (es) * 1994-07-28 1997-01-09 Sandoz Ag DERIVADOS DE PTH o PTHrP, SU PREPARACION Y COMPOSICIONES FARMACEUTICAS QUE LAS COMPRENDEN

Also Published As

Publication number Publication date
JP4229992B2 (ja) 2009-02-25
MX9705719A (es) 1998-02-28
PL321391A1 (en) 1998-02-02
ZA976555B (en) 1998-01-30
BR9704138A (pt) 1998-12-29
DK0822200T3 (da) 2005-01-31
TW505654B (en) 2002-10-11
JPH1077295A (ja) 1998-03-24
KR100518982B1 (ko) 2006-05-29
AR016981A2 (es) 2001-08-01
TR199700714A2 (xx) 1998-02-21
CO4650046A1 (es) 1998-09-03
DE69730787T2 (de) 2005-10-13
HRP970416A2 (en) 1998-08-31
US6849710B1 (en) 2005-02-01
NO973482L (no) 1998-02-02
ATE277080T1 (de) 2004-10-15
CN1174845A (zh) 1998-03-04
AR008094A1 (es) 1999-12-09
YU32197A (sh) 1999-07-28
AU3236297A (en) 1998-02-05
EP0822200B1 (fr) 2004-09-22
KR980009282A (ko) 1998-04-30
EP0822200A1 (fr) 1998-02-04
UY24651A1 (es) 2000-12-29
PE91998A1 (es) 1998-12-31
CA2206008A1 (fr) 1998-01-30
HU9701277D0 (en) 1997-09-29
CN1293096C (zh) 2007-01-03
CA2206008C (fr) 2008-09-23
CZ239697A3 (cs) 1998-04-15
NO973482D0 (no) 1997-07-29
NZ328411A (en) 1998-12-23
HUP9701277A3 (en) 2001-02-28
HUP9701277A2 (hu) 1998-11-30
ES2227639T3 (es) 2005-04-01
DE69730787D1 (de) 2004-10-28
MA24353A1 (fr) 1998-07-01
IL121391A0 (en) 1998-01-04
AU731160B2 (en) 2001-03-22

Similar Documents

Publication Publication Date Title
SG67408A1 (en) Synthesis of analogs of pth and pthrp
SI0948541T1 (sl) PTHrP analogi
GB9526560D0 (en) Use of 2-Amino-Heterocycles
AU1513397A (en) Cyclic analogs of PTH and PTHrP
GB9512290D0 (en) Uses of polyhexanide
EP1021407A4 (fr) Synthese de clasto-lactacystine beta-lactone et de ses analogues
IL116924A0 (en) Preparation of n-aryl- and n-hetarylhydroxylamines
IL126272A0 (en) Synthesis of indolylmaleimides
SG42329A1 (en) Use of phenylcyclohexylcarboxamides
ZA931259B (en) Synthesis of desflurane
EP1098659A4 (fr) Banques de polyhydroxamates et leurs analogues
IL128376A0 (en) Synthesis of bisindolylmalimides
IL125637A0 (en) Synthesis of carboxyalkylthiosuccinic acids
IL117786A (en) Preparation of alpha-bisoximes
AU7267298A (en) Synthesis of discodermolide and analogs
HU9602125D0 (en) P-hidroxy-acetic acid for reduction of repellent of insecticids
EP0923519A4 (fr) Synthese de l'haloalkynol
IL118238A0 (en) Synthesis of benzoquinolinones
AP9600787A0 (en) Inhibiting photodecomposition of 3-substituted-2-oxindoles
GB9411032D0 (en) Synthesis of substituted diaminophthalimides and analogues
TW312301U (en) Improved structure of earmask
TW319017U (en) Improved structure of mousetraps
ZA962440B (en) Destressing of railtracks
TW320942U (en) Improved structure of mouthpiece
TW313856U (en) Improved structure of mouth mask