SG69975A1 - Crystalline salt of 4-(d1-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¬cd¾ indole - Google Patents

Crystalline salt of 4-(d1-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¬cd¾ indole

Info

Publication number: SG69975A1
Authority: SG; Singapore
Prior art keywords: tetrahydrobenz; aminocarbonyl; propyl; amino; indole
Prior art date: 1990-02-26

Application number

SG1996007257A

Other languages

English (en)

Inventor

Thomas Joseph Kress

David Lee Varie

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-02-26

Filing date

1991-02-26

Publication date

2000-01-25

1991-02-26 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2000-01-25 Publication of SG69975A1 publication Critical patent/SG69975A1/en

Links

SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 2
PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 title 1
RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 title 1
YTOJFUORFUYGSV-UHFFFAOYSA-N 4-(dipropylamino)-1,3,4,5-tetrahydrobenzo[cd]indole-6-carboxamide Chemical compound C1=C(C(N)=O)C(CC(N(CCC)CCC)C2)=C3C2=CNC3=C1 YTOJFUORFUYGSV-UHFFFAOYSA-N 0.000 abstract 1
QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/90—Benzo [c, d] indoles; Hydrogenated benzo [c, d] indoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Addiction (AREA)
Obesity (AREA)
Hematology (AREA)
Diabetes (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Child & Adolescent Psychology (AREA)
Anesthesiology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

SG1996007257A 1990-02-26 1991-02-26 Crystalline salt of 4-(d1-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¬cd¾ indole SG69975A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US48518590A	1990-02-26	1990-02-26

Publications (1)

Publication Number	Publication Date
SG69975A1 true SG69975A1 (en)	2000-01-25

Family

ID=23927224

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996007257A SG69975A1 (en)	1990-02-26	1991-02-26	Crystalline salt of 4-(d1-n-propyl) amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz ¬cd¾ indole

Country Status (28)

Country	Link
US (1)	US5397799A (2)
EP (1)	EP0444852B1 (2)
JP (1)	JP3157007B2 (2)
KR (1)	KR100208114B1 (2)
CN (1)	CN1027503C (2)
AT (1)	ATE126506T1 (2)
AU (1)	AU629453B2 (2)
BR (1)	BR9100767A (2)
CA (1)	CA2037099C (2)
CY (1)	CY1887A (2)
DE (1)	DE69112099T2 (2)
DK (1)	DK0444852T3 (2)
ES (1)	ES2077796T3 (2)
FI (1)	FI95464C (2)
GR (1)	GR3017940T3 (2)
HK (1)	HK175495A (2)
HU (1)	HU217118B (2)
IE (1)	IE67801B1 (2)
IL (1)	IL97306A (2)
LV (1)	LV10251B (2)
NO (1)	NO174149C (2)
NZ (1)	NZ237181A (2)
PT (1)	PT96852B (2)
RU (2)	RU2034837C1 (2)
SG (1)	SG69975A1 (2)
TW (1)	TW219933B (2)
YU (1)	YU47594B (2)
ZA (1)	ZA911258B (2)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL97309A (en) *	1990-02-26	1996-11-14	Lilly Co Eli	Intermediates for hexahydrobenz Úcd¾ indoles and process for the preparation of pure enantiomers thereof
US5302612A (en) *	1990-02-26	1994-04-12	Eli Lilly And Company	6-substituted-hexahydrobenz[cd]indoles
IL97308A (en) *	1990-02-26	1996-10-31	Lilly Co Eli	6-Substituted-hexahydrobenz (cd) indoles process for their preparation and pharmaceutical compositions containing them
US5364856A (en) *	1991-03-28	1994-11-15	Eli Lilly And Company	6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz[CD]indoles
US5643934A (en) *	1991-03-28	1997-07-01	Eli Lilly And Company	6-heterocyclic-4-amino-1,2,2a,3,4,5-hexahydrobenz [CD]indoles
TW248556B (2) *	1993-01-18	1995-06-01	Takeda Pharm Industry Co
UA53205C2 (en) *	2002-04-03	2006-06-15	Pharmatech Close Joint Stock C	Antidepressant formulation and method for its manufacture
US7588924B2 (en)	2006-03-07	2009-09-15	Procter & Gamble Company	Crystal of hypoxia inducible factor 1 alpha prolyl hydroxylase
NZ601730A (en)	2006-06-26	2014-04-30	Akebia Therapeutics Inc	Prolyl hydroxylase inhibitors and methods of use
ES2782999T3 (es)	2009-11-06	2020-09-16	Aerpio Therapeutics Inc	Composiciones y métodos para tratar la colitis
NO2686520T3 (2)	2011-06-06	2018-03-17
EP3251671A1 (en)	2011-06-06	2017-12-06	Akebia Therapeutics Inc.	Compositions for stabilizing hypoxia inducible factor-2 alpha as a method for treating cancer
SMT202400092T1 (it)	2013-06-13	2024-05-14	Akebia Therapeutics Inc	Composizioni e metodi per il trattamento dell'anemia
EP3578546A1 (en)	2013-11-15	2019-12-11	Akebia Therapeutics Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof
HK1247201A1 (zh)	2015-01-23	2018-09-21	阿克比治疗有限公司	2-(5-(3-氟苯基)-3-羟基吡啶甲醯胺)乙酸的固体形式、其组合物及用途
PL3277270T3 (pl)	2015-04-01	2022-02-14	Akebia Therapeutics, Inc.	Kompozycje i sposoby leczenia niedokrwistości
CA3097219A1 (en)	2018-05-09	2019-11-14	Akebia Therapeutics, Inc.	Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino]acetic acid
US11524939B2 (en)	2019-11-13	2022-12-13	Akebia Therapeutics, Inc.	Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino} acetic acid
US12612367B2 (en)	2019-12-10	2026-04-28	Akebia Therapeutics, Inc.	Method for producing nitrogen-containing heteroarylcarboxamide acetic acid derivative

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4110339A (en) *	1977-11-25	1978-08-29	Eli Lilly And Company	4-(Di-n-propyl)amino-1,3,4,5-tetrahydrobenz[cd]indole
US4576959A (en) *	1984-02-06	1986-03-18	Eli Lilly And Company	6-Substituted-4-dialkylaminotetrahydrobenz[c,d]indoles
US4745126A (en) *	1987-03-12	1988-05-17	Eli Lilly And Company	Method of treating anxiety with tetrahydrobenz[c,d]indole-6-carboxamides
DE3809155A1 (de) *	1988-03-18	1989-09-28	Bayer Ag	1,3,4,5-tetrahydrobenz-(c,d)-indole
US5204340A (en) *	1989-04-11	1993-04-20	Eli Lilly And Company	Tetrahydrobenz(c,d)indole serotonin agonists
US5229409A (en) *	1990-08-15	1993-07-20	Eli Lilly And Company	6-substituted-tetrahydrobenz[cd]indoles

1990
- 1990-06-26 TW TW079105258A patent/TW219933B/zh active
1991
- 1991-02-20 IL IL9730691A patent/IL97306A/en not_active IP Right Cessation
- 1991-02-20 ZA ZA911258A patent/ZA911258B/xx unknown
- 1991-02-21 NZ NZ237181A patent/NZ237181A/en unknown
- 1991-02-22 PT PT96852A patent/PT96852B/pt not_active IP Right Cessation
- 1991-02-22 JP JP05064391A patent/JP3157007B2/ja not_active Expired - Fee Related
- 1991-02-25 NO NO910735A patent/NO174149C/no unknown
- 1991-02-25 IE IE62591A patent/IE67801B1/en not_active IP Right Cessation
- 1991-02-25 FI FI910895A patent/FI95464C/fi active
- 1991-02-25 AU AU71971/91A patent/AU629453B2/en not_active Ceased
- 1991-02-25 KR KR1019910003029A patent/KR100208114B1/ko not_active Expired - Fee Related
- 1991-02-25 RU SU914894699A patent/RU2034837C1/ru not_active IP Right Cessation
- 1991-02-25 YU YU32791A patent/YU47594B/sh unknown
- 1991-02-25 HU HU91629A patent/HU217118B/hu unknown
- 1991-02-26 ES ES91301501T patent/ES2077796T3/es not_active Expired - Lifetime
- 1991-02-26 AT AT91301501T patent/ATE126506T1/de not_active IP Right Cessation
- 1991-02-26 DE DE69112099T patent/DE69112099T2/de not_active Expired - Fee Related
- 1991-02-26 CA CA002037099A patent/CA2037099C/en not_active Expired - Fee Related
- 1991-02-26 BR BR919100767A patent/BR9100767A/pt not_active Application Discontinuation
- 1991-02-26 EP EP91301501A patent/EP0444852B1/en not_active Expired - Lifetime
- 1991-02-26 DK DK91301501.2T patent/DK0444852T3/da active
- 1991-02-26 CN CN91101296A patent/CN1027503C/zh not_active Expired - Fee Related
- 1991-02-26 SG SG1996007257A patent/SG69975A1/en unknown
1992
- 1992-12-03 RU RU9292004575A patent/RU2083561C1/ru not_active IP Right Cessation
1993
- 1993-05-19 US US08/064,539 patent/US5397799A/en not_active Expired - Lifetime
- 1993-06-08 LV LVP-93-509A patent/LV10251B/xx unknown
1995
- 1995-11-01 GR GR950403048T patent/GR3017940T3/el unknown
- 1995-11-16 HK HK175495A patent/HK175495A/en not_active IP Right Cessation
1996
- 1996-04-05 CY CY188796A patent/CY1887A/xx unknown

Also Published As

Publication number	Publication date
CN1027503C (zh)	1995-01-25
NO174149C (no)	1994-03-23
HUT56542A (en)	1991-09-30
DE69112099D1 (de)	1995-09-21
LV10251A (lv)	1994-10-20
IL97306A (en)	1996-10-16
HU217118B (hu)	1999-11-29
EP0444852B1 (en)	1995-08-16
US5397799A (en)	1995-03-14
CY1887A (en)	1996-04-05
FI910895L (fi)	1991-08-27
CA2037099A1 (en)	1991-08-27
LV10251B (en)	1995-04-20
JP3157007B2 (ja)	2001-04-16
DK0444852T3 (da)	1995-12-11
JPH04217662A (ja)	1992-08-07
YU47594B (sh)	1995-10-24
NO910735D0 (no)	1991-02-25
HK175495A (en)	1995-11-24
NZ237181A (en)	1992-06-25
ZA911258B (en)	1992-10-28
AU7197191A (en)	1991-08-29
DE69112099T2 (de)	1996-02-08
CN1054589A (zh)	1991-09-18
KR910021375A (ko)	1991-12-20
PT96852A (pt)	1991-10-31
GR3017940T3 (en)	1996-02-29
RU2083561C1 (ru)	1997-07-10
NO910735L (no)	1991-08-27
ES2077796T3 (es)	1995-12-01
AU629453B2 (en)	1992-10-01
IL97306A0 (en)	1992-05-25
EP0444852A3 (en)	1992-02-19
KR100208114B1 (ko)	1999-07-15
TW219933B (2)	1994-02-01
ATE126506T1 (de)	1995-09-15
IE910625A1 (en)	1991-08-28
PT96852B (pt)	1998-07-31
IE67801B1 (en)	1996-05-01
YU32791A (sh)	1994-01-20
EP0444852A2 (en)	1991-09-04
FI910895A0 (fi)	1991-02-25
BR9100767A (pt)	1991-10-29
CA2037099C (en)	2001-09-11
FI95464B (fi)	1995-10-31
RU2034837C1 (ru)	1995-05-10
FI95464C (fi)	1996-02-12
NO174149B (no)	1993-12-13

Publication	Publication Date	Title
GR3017940T3 (en)	1996-02-29	Crystalline salt of 4-(di-n-propyl)amino-6-aminocarbonyl-1,3,4,5-tetrahydrobenz[cd]indole.
IE782325L (en)	1979-05-25	TETRAHYDROBENZ £cd\| INDOLES
YU16989A (en)	1991-10-31	Amfiregulin - new bifunctional glicoprotein for growth modulation
AU3430689A (en)	1989-10-05	Prevention of lens-related tissue growth in the eye
AU2097788A (en)	1989-02-23	Permanent ligament prosthesis
AU6762687A (en)	1987-07-23	N,s and o-substituted indole derivatives
AU2867689A (en)	1989-07-20	Felt-like implant
RU92004575A (ru)	1995-09-27	Кристаллическая соль 4-(ди-н-пропил) амино-6-аминокарбонил-1,3,4,5-тетрагидробенз (cd) индола и ее 4p и 4s-изомеры
AU3481289A (en)	1989-11-30	Immunostimulating 7-deaza-7-oxa- and 7-deaza-7-thia- analogs of 8-substituted-guanine-9-(1'beta-d-aldoglycosidyl) derivatives, compositions and methods
EP0336318A3 (en)	1990-06-13	Hard intraocular lens, methods for its preparation and use thereof
AU625940B2 (en)	1992-07-16	Hybrid phase-locked loop
AU4046189A (en)	1990-02-19	Sterilising methods
AU6085890A (en)	1991-02-14	Human thrombomodulin derivatives
HU9302749D0 (en)	1993-12-28	6-heterocyclic-4-amino-1`,3,4,5-tetrahydrobenz/cd/indoles
AU4731389A (en)	1990-07-12	Suspension adjustment
AU6791790A (en)	1991-06-13	5-(2-methyl-4,4,4-trifluorobutyl-carbamoyl)indole derivatives
GB9021319D0 (en)	1990-11-14	Growing medium
AU3489889A (en)	1989-11-23	Tryptophan for treatment of coughing
AU2803689A (en)	1989-04-18	Certain 3-substituted 2- alkyl indole derivatives
AU3257793A (en)	1993-07-28	Archazolides, method of preparing them and agents containing them
YU48489A (en)	1991-10-31	Indole derivatives and process for preparing thereof
AU7291394A (en)	1994-11-24	Tetrahydroisoquinolinylcarbamates of 1,2,3,3A,8,8A-hexahydro-1,3A,8-trimethylpyrrolo(2,3-B)indole
ZA908041B (en)	1991-08-28	Indole derivatives,their preparation and use
ZA912473B (en)	1992-12-30	Epithelins:novel cysteine-rich growth modulating proteins
AU6147390A (en)	1992-03-02	Reconstructive surgery method and implant