SK14492000A3 - Použitie 2-(alfa-(2-etoxyfenoxy)benzyl)-morfolínu - Google Patents

Použitie 2-(alfa-(2-etoxyfenoxy)benzyl)-morfolínu Download PDF

Info

Publication number: SK14492000A3
Authority: SK; Slovakia
Prior art keywords: disorders; reboxetine; treatment; use according; addiction
Prior art date: 1998-04-09

Application number

SK1449-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Fred Hassan

John Michael Mccall

Duncan Paul Taylor

Voigtlander Philip F. Von

Erik Ho Fong Wong

Original Assignee

Pharmacia And Upjohn Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-09

Filing date

1999-04-02

Publication date

2001-06-11

1999-04-02 Application filed by Pharmacia And Upjohn Company filed Critical Pharmacia And Upjohn Company

2001-06-11 Publication of SK14492000A3 publication Critical patent/SK14492000A3/sk

Links

CBQGYUDMJHNJBX-UHFFFAOYSA-N 2-[(2-ethoxyphenoxy)-phenylmethyl]morpholine Chemical compound CCOC1=CC=CC=C1OC(C=1C=CC=CC=1)C1OCCNC1 CBQGYUDMJHNJBX-UHFFFAOYSA-N 0.000 title claims description 5
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 33
235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract description 15
206010057852 Nicotine dependence Diseases 0.000 claims abstract description 9
208000025569 Tobacco Use disease Diseases 0.000 claims abstract description 9
150000003839 salts Chemical class 0.000 claims abstract description 8
230000035987 intoxication Effects 0.000 claims abstract description 6
231100000566 intoxication Toxicity 0.000 claims abstract description 6
206010012335 Dependence Diseases 0.000 claims abstract description 5
208000035475 disorder Diseases 0.000 claims abstract description 4
208000007848 Alcoholism Diseases 0.000 claims abstract description 3
241000208125 Nicotiana Species 0.000 claims description 14
SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 8
229960002715 nicotine Drugs 0.000 claims description 8
SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 8
208000011580 syndromic disease Diseases 0.000 claims description 8
230000006735 deficit Effects 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 7
208000013403 hyperactivity Diseases 0.000 claims description 7
230000000391 smoking effect Effects 0.000 claims description 7
208000024891 symptom Diseases 0.000 claims description 7
239000004480 active ingredient Substances 0.000 claims description 4
230000001055 chewing effect Effects 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 2
239000013543 active substance Substances 0.000 claims 1
230000036528 appetite Effects 0.000 claims 1
235000019789 appetite Nutrition 0.000 claims 1
230000001914 calming effect Effects 0.000 claims 1
229960003770 reboxetine Drugs 0.000 abstract description 31
CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 abstract description 30
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 abstract description 10
208000011117 substance-related disease Diseases 0.000 abstract description 3
231100000252 nontoxic Toxicity 0.000 abstract description 2
230000003000 nontoxic effect Effects 0.000 abstract description 2
244000061176 Nicotiana tabacum Species 0.000 abstract 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 11
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 description 9
229940123445 Tricyclic antidepressant Drugs 0.000 description 9
208000015802 attention deficit-hyperactivity disease Diseases 0.000 description 9
239000000126 substance Substances 0.000 description 9
239000003029 tricyclic antidepressant agent Substances 0.000 description 9
230000000694 effects Effects 0.000 description 8
SFLSHLFXELFNJZ-QMMMGPOBSA-N (-)-norepinephrine Chemical compound NC[C@H](O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-QMMMGPOBSA-N 0.000 description 7
239000000935 antidepressant agent Substances 0.000 description 7
229940005513 antidepressants Drugs 0.000 description 7
229960002748 norepinephrine Drugs 0.000 description 7
SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 7
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 6
VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 6
230000007420 reactivation Effects 0.000 description 6
CGTZMJIMMUNLQD-STYNFMPRSA-N (2r)-2-[(r)-(2-ethoxyphenoxy)-phenylmethyl]morpholine;methanesulfonic acid Chemical compound CS(O)(=O)=O.CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CGTZMJIMMUNLQD-STYNFMPRSA-N 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
239000003112 inhibitor Substances 0.000 description 5
201000010099 disease Diseases 0.000 description 4
238000000034 method Methods 0.000 description 4
229960003638 dopamine Drugs 0.000 description 3
229940079593 drug Drugs 0.000 description 3
229960001340 histamine Drugs 0.000 description 3
230000003551 muscarinic effect Effects 0.000 description 3
229940076279 serotonin Drugs 0.000 description 3
208000020401 Depressive disease Diseases 0.000 description 2
HCYAFALTSJYZDH-UHFFFAOYSA-N Desimpramine Chemical compound C1CC2=CC=CC=C2N(CCCNC)C2=CC=CC=C21 HCYAFALTSJYZDH-UHFFFAOYSA-N 0.000 description 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
230000001078 anti-cholinergic effect Effects 0.000 description 2
230000001430 anti-depressive effect Effects 0.000 description 2
239000003795 chemical substances by application Substances 0.000 description 2
229960003914 desipramine Drugs 0.000 description 2
239000012458 free base Substances 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
229960003269 reboxetine mesylate Drugs 0.000 description 2
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 description 2
239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
230000005062 synaptic transmission Effects 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
YWPHCCPCQOJSGZ-LLVKDONJSA-N (2r)-2-[(2-ethoxyphenoxy)methyl]morpholine Chemical compound CCOC1=CC=CC=C1OC[C@@H]1OCCNC1 YWPHCCPCQOJSGZ-LLVKDONJSA-N 0.000 description 1
TZJUVVIWVWFLCD-UHFFFAOYSA-N 1,1-dioxo-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-1,2-benzothiazol-3-one Chemical compound O=S1(=O)C2=CC=CC=C2C(=O)N1CCCCN(CC1)CCN1C1=NC=CC=N1 TZJUVVIWVWFLCD-UHFFFAOYSA-N 0.000 description 1
ASXGJMSKWNBENU-UHFFFAOYSA-N 8-OH-DPAT Chemical compound C1=CC(O)=C2CC(N(CCC)CCC)CCC2=C1 ASXGJMSKWNBENU-UHFFFAOYSA-N 0.000 description 1
208000028698 Cognitive impairment Diseases 0.000 description 1
DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 description 1
UEQUQVLFIPOEMF-UHFFFAOYSA-N Mianserin Chemical compound C1C2=CC=CC=C2N2CCN(C)CC2C2=CC=CC=C21 UEQUQVLFIPOEMF-UHFFFAOYSA-N 0.000 description 1
102000010909 Monoamine Oxidase Human genes 0.000 description 1
108010062431 Monoamine oxidase Proteins 0.000 description 1
208000012902 Nervous system disease Diseases 0.000 description 1
206010037180 Psychiatric symptoms Diseases 0.000 description 1
206010039897 Sedation Diseases 0.000 description 1
GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 description 1
229960004373 acetylcholine Drugs 0.000 description 1
230000009471 action Effects 0.000 description 1
208000012826 adjustment disease Diseases 0.000 description 1
230000002908 adrenolytic effect Effects 0.000 description 1
230000002411 adverse Effects 0.000 description 1
201000007930 alcohol dependence Diseases 0.000 description 1
238000010171 animal model Methods 0.000 description 1
230000001387 anti-histamine Effects 0.000 description 1
230000000891 anti-reserpine Effects 0.000 description 1
239000000739 antihistaminic agent Substances 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229960001058 bupropion Drugs 0.000 description 1
SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 description 1
150000003943 catecholamines Chemical class 0.000 description 1
230000001713 cholinergic effect Effects 0.000 description 1
208000010877 cognitive disease Diseases 0.000 description 1
239000000221 dopamine uptake inhibitor Substances 0.000 description 1
201000003104 endogenous depression Diseases 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000003517 fume Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
230000000147 hypnotic effect Effects 0.000 description 1
230000002631 hypothermal effect Effects 0.000 description 1
230000003993 interaction Effects 0.000 description 1
230000004410 intraocular pressure Effects 0.000 description 1
229950003599 ipsapirone Drugs 0.000 description 1
208000024714 major depressive disease Diseases 0.000 description 1
QSLMDECMDJKHMQ-GSXCWMCISA-N maprotiline Chemical compound C12=CC=CC=C2[C@@]2(CCCNC)C3=CC=CC=C3[C@@H]1CC2 QSLMDECMDJKHMQ-GSXCWMCISA-N 0.000 description 1
229960004090 maprotiline Drugs 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229960001344 methylphenidate Drugs 0.000 description 1
229960003955 mianserin Drugs 0.000 description 1
239000000203 mixture Substances 0.000 description 1
210000005036 nerve Anatomy 0.000 description 1
208000015238 neurotic disease Diseases 0.000 description 1
239000002767 noradrenalin uptake inhibitor Substances 0.000 description 1
230000002474 noradrenergic effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
230000008569 process Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
208000020016 psychiatric disease Diseases 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000036280 sedation Effects 0.000 description 1
230000013275 serotonin uptake Effects 0.000 description 1
238000002633 shock therapy Methods 0.000 description 1
239000000779 smoke Substances 0.000 description 1
201000009032 substance abuse Diseases 0.000 description 1
231100000736 substance abuse Toxicity 0.000 description 1
230000000946 synaptic effect Effects 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
229960003991 trazodone Drugs 0.000 description 1
PHLBKPHSAVXXEF-UHFFFAOYSA-N trazodone Chemical compound ClC1=CC=CC(N2CCN(CCCN3C(N4C=CC=CC4=N3)=O)CC2)=C1 PHLBKPHSAVXXEF-UHFFFAOYSA-N 0.000 description 1
230000000980 vagolytic effect Effects 0.000 description 1
229960001255 viloxazine Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse

Landscapes

Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Addiction (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Anesthesiology (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

SK1449-2000A 1998-04-09 1999-04-02 Použitie 2-(alfa-(2-etoxyfenoxy)benzyl)-morfolínu SK14492000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8123198P	1998-04-09	1998-04-09
PCT/US1999/004289 WO1999052531A1 (en)	1998-04-09	1999-04-02	New treatments for nervous disorders

Publications (1)

Publication Number	Publication Date
SK14492000A3 true SK14492000A3 (sk)	2001-06-11

Family

ID=22162900

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1449-2000A SK14492000A3 (sk)	1998-04-09	1999-04-02	Použitie 2-(alfa-(2-etoxyfenoxy)benzyl)-morfolínu

Country Status (24)

Country	Link
US (1)	US6352986B1 (no)
EP (1)	EP1069900B1 (no)
JP (1)	JP2002511414A (no)
KR (1)	KR20010034758A (no)
CN (1)	CN1301164A (no)
AT (1)	ATE301462T1 (no)
AU (1)	AU756373B2 (no)
BR (1)	BR9909478A (no)
CA (2)	CA2634698A1 (no)
CZ (1)	CZ297346B6 (no)
DE (1)	DE69926616T2 (no)
DK (1)	DK1069900T3 (no)
EA (1)	EA200001049A1 (no)
ES (1)	ES2244189T3 (no)
HU (1)	HUP0102436A3 (no)
IL (1)	IL138855A0 (no)
NO (1)	NO20005059L (no)
NZ (1)	NZ507398A (no)
PL (1)	PL193797B1 (no)
PT (1)	PT1069900E (no)
SK (1)	SK14492000A3 (no)
TR (1)	TR200002868T2 (no)
WO (1)	WO1999052531A1 (no)
ZA (1)	ZA200004454B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586427B2 (en) *	1998-04-09	2003-07-01	Pharmacia & Upjohn Company	Treatments for nervous disorders
SI1196172T1 (sl) *	1999-07-01	2006-06-30	Pharmacia & Upjohn Co Llc	(S,S)-reboksetin za zdravljenje kronicne bolecine
US6465458B1 (en) *	1999-07-01	2002-10-15	Pharmacia & Upjohn Company	Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor
AU4529101A (en) *	2000-03-07	2001-09-17	Eli Lilly And Company	Treatment of psoriasis
SE521512C2 (sv)	2001-06-25	2003-11-11	Niconovum Ab	Anordning för administrering av en substans till främre delen av en individs munhåla
US20040102440A1 (en) *	2002-07-01	2004-05-27	Wong Erik Ho Fong	Method of promoting smoking cessation
ES2285233T3 (es)	2002-12-20	2007-11-16	Niconovum Ab	Un material en particulas que contiene nicotina y celulosa microcristalina fisicamente y quimicamente estable.
UA95454C2 (uk)	2005-07-15	2011-08-10	Амр Текнолоджи, Інк.	Арил- і гетероарилзаміщені тетрагідробензазепіни і їх застосування для блокування зворотного захоплення норепінефрину, допаміну і серотоніну
US9402809B2 (en)	2006-03-16	2016-08-02	Niconovum Usa, Inc.	Snuff composition
US20100069389A1 (en) *	2008-09-06	2010-03-18	Bionevia Pharmaceuticals, Inc.	Novel forms of reboxetine
AU2010247763B2 (en)	2009-05-12	2015-12-24	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
WO2012024397A2 (en)	2010-08-17	2012-02-23	Albany Molecular Research, Inc.	2,5-methano-and 2,5-ethano-tetrahydrobenzazepine derivatives and use thereof to block reuptake of norepinephrine, dopamine, and serotonin

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL56369A (en)	1978-01-20	1984-05-31	Erba Farmitalia	Alpha-phenoxybenzyl propanolamine derivatives,their preparation and pharmaceutical compositions comprising them
EP0072177B1 (en) *	1981-08-07	1987-01-07	Holset Engineering Company Limited	Impeller for centrifugal compressor
GB8419683D0 (en)	1984-08-02	1984-09-05	Erba Farmitalia	3-substituted derivatives of 1-amino-2-hydroxy-propane
US5281624A (en) *	1991-09-27	1994-01-25	Eli Lilly And Company	N-alkyl-3-phenyl-3-(2-substituted phenoxy) propylamines and pharmaceutical use thereof
ZA958725B (en) *	1994-10-20	1997-04-16	Lilly Co Eli	Treatment of disorders with duloxetine
US5658590A (en) *	1995-01-11	1997-08-19	Eli Lilly And Company	Treatment of attention-deficit/hyperactivity disorder
NZ313076A (en) *	1995-07-24	1999-11-29	Lilly Co Eli	Medicament containing duloxetine for treating hyperactivity and attention deficiency disorders
AU9214498A (en) *	1997-09-23	1999-04-12	Eli Lilly And Company	Treatment of attention-deficit/hyperactivity disorder
UA56257C2 (uk)	1997-09-23	2003-05-15	Елі Ліллі Енд Компані	Спосіб лікування неадекватної визивної поведінки

1999
- 1999-04-02 IL IL13885599A patent/IL138855A0/xx unknown
- 1999-04-02 PL PL99346293A patent/PL193797B1/pl unknown
- 1999-04-02 TR TR2000/02868T patent/TR200002868T2/xx unknown
- 1999-04-02 CN CN99804011A patent/CN1301164A/zh active Pending
- 1999-04-02 WO PCT/US1999/004289 patent/WO1999052531A1/en not_active Ceased
- 1999-04-02 DK DK99916114T patent/DK1069900T3/da active
- 1999-04-02 CA CA002634698A patent/CA2634698A1/en not_active Abandoned
- 1999-04-02 AU AU34494/99A patent/AU756373B2/en not_active Ceased
- 1999-04-02 ES ES99916114T patent/ES2244189T3/es not_active Expired - Lifetime
- 1999-04-02 EA EA200001049A patent/EA200001049A1/ru unknown
- 1999-04-02 KR KR1020007011158A patent/KR20010034758A/ko not_active Ceased
- 1999-04-02 CZ CZ20003671A patent/CZ297346B6/cs not_active IP Right Cessation
- 1999-04-02 DE DE69926616T patent/DE69926616T2/de not_active Expired - Fee Related
- 1999-04-02 BR BR9909478-9A patent/BR9909478A/pt not_active Application Discontinuation
- 1999-04-02 SK SK1449-2000A patent/SK14492000A3/sk unknown
- 1999-04-02 JP JP2000543141A patent/JP2002511414A/ja not_active Withdrawn
- 1999-04-02 AT AT99916114T patent/ATE301462T1/de not_active IP Right Cessation
- 1999-04-02 CA CA002321157A patent/CA2321157A1/en not_active Abandoned
- 1999-04-02 PT PT99916114T patent/PT1069900E/pt unknown
- 1999-04-02 EP EP99916114A patent/EP1069900B1/en not_active Expired - Lifetime
- 1999-04-02 NZ NZ507398A patent/NZ507398A/en unknown
- 1999-04-02 HU HU0102436A patent/HUP0102436A3/hu unknown
2000
- 2000-05-05 US US09/565,780 patent/US6352986B1/en not_active Expired - Fee Related
- 2000-08-28 ZA ZA200004454A patent/ZA200004454B/en unknown
- 2000-10-06 NO NO20005059A patent/NO20005059L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
ES2244189T3 (es)	2005-12-01
EP1069900B1 (en)	2005-08-10
IL138855A0 (en)	2001-10-31
NO20005059D0 (no)	2000-10-06
AU3449499A (en)	1999-11-01
CZ20003671A3 (en)	2001-06-13
BR9909478A (pt)	2000-12-19
TR200002868T2 (tr)	2001-01-22
ATE301462T1 (de)	2005-08-15
HUP0102436A3 (en)	2002-01-28
EP1069900A1 (en)	2001-01-24
JP2002511414A (ja)	2002-04-16
DK1069900T3 (da)	2005-10-31
KR20010034758A (ko)	2001-04-25
CA2634698A1 (en)	1999-10-21
PL193797B1 (pl)	2007-03-30
PT1069900E (pt)	2005-10-31
EA200001049A1 (ru)	2001-04-23
CZ297346B6 (cs)	2006-11-15
DE69926616T2 (de)	2006-05-24
NO20005059L (no)	2000-10-06
HUP0102436A2 (hu)	2001-11-28
CA2321157A1 (en)	1999-10-21
PL346293A1 (en)	2002-01-28
WO1999052531A1 (en)	1999-10-21
AU756373B2 (en)	2003-01-09
US6352986B1 (en)	2002-03-05
NZ507398A (en)	2004-01-30
DE69926616D1 (de)	2005-09-15
CN1301164A (zh)	2001-06-27
ZA200004454B (en)	2002-04-24

Publication	Publication Date	Title
PL196996B1 (pl)	2008-02-29	Zastosowanie optycznie czystej (S,S)-reboksetyny lub jej dopuszczalnej farmaceutycznie soli do wytwarzania leku
SK14492000A3 (sk)	2001-06-11	Použitie 2-(alfa-(2-etoxyfenoxy)benzyl)-morfolínu
US20070149527A1 (en)	2007-06-28	New treatments for nervous disorders
US6500827B2 (en)	2002-12-31	Drug combinations
AU764579B2 (en)	2003-08-21	New drug combinations of a N.A.R.I., preferably reboxetine, and pindolol
SK14482000A3 (sk)	2001-08-06	Použitie reboxetínu
MXPA00009883A (en)	2001-07-09	New treatments for nervous disorders
CZ20003694A3 (cs)	2001-05-16	Použití reboxetinu
CZ20004067A3 (cs)	2001-03-14	Nové kombinace léků N.A.R.I.(inhibitory reaktivace noradrenalinu), s výhodou reboxetinu, a pinodolu
MXPA00010945A (en)	2001-07-31	New drug combinations of a n.a.r.i., preferably reboxetine, and pindolol
HK1036418A (en)	2002-01-04	New treatments for nervous disorders