SK14982000A3 - Spôsob inhibície mrp1 - Google Patents

Spôsob inhibície mrp1 Download PDF

Info

Publication number: SK14982000A3
Authority: SK; Slovakia
Prior art keywords: methyl; compound; dihydro; isoxazolo; substituted
Prior art date: 1998-04-08

Application number

SK1498-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Joseph Michael Gruber

Bryan Hurst Norman

Julian Stanley Kroin

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

1999-04-07

Publication date

2001-05-10

1999-04-07 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

2001-05-10 Publication of SK14982000A3 publication Critical patent/SK14982000A3/sk

Links

230000002401 inhibitory effect Effects 0.000 title claims abstract description 12
238000000034 method Methods 0.000 title claims description 111
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102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims abstract 2
108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims abstract 2
-1 4-aminosulfonylbenzyl Chemical group 0.000 claims description 142
239000000203 mixture Substances 0.000 claims description 78
150000003839 salts Chemical class 0.000 claims description 55
229910052739 hydrogen Inorganic materials 0.000 claims description 44
239000001257 hydrogen Substances 0.000 claims description 43
238000009472 formulation Methods 0.000 claims description 42
230000000174 oncolytic effect Effects 0.000 claims description 38
239000012453 solvate Substances 0.000 claims description 32
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
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125000000623 heterocyclic group Chemical group 0.000 claims description 21
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YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
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238000007423 screening assay Methods 0.000 description 1
229940116351 sebacate Drugs 0.000 description 1
CXMXRPHRNRROMY-UHFFFAOYSA-L sebacate(2-) Chemical compound [O-]C(=O)CCCCCCCCC([O-])=O CXMXRPHRNRROMY-UHFFFAOYSA-L 0.000 description 1
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235000011182 sodium carbonates Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
229910000104 sodium hydride Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000011150 stannous chloride Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000012058 sterile packaged powder Substances 0.000 description 1
210000002784 stomach Anatomy 0.000 description 1
239000006190 sub-lingual tablet Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
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238000006467 substitution reaction Methods 0.000 description 1
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BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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ISIJQEHRDSCQIU-UHFFFAOYSA-N tert-butyl 2,7-diazaspiro[4.5]decane-7-carboxylate Chemical compound C1N(C(=O)OC(C)(C)C)CCCC11CNCC1 ISIJQEHRDSCQIU-UHFFFAOYSA-N 0.000 description 1
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208000013076 thyroid tumor Diseases 0.000 description 1
AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
229940044693 topoisomerase inhibitor Drugs 0.000 description 1
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239000000196 tragacanth Substances 0.000 description 1
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230000037317 transdermal delivery Effects 0.000 description 1
ZMCBYSBVJIMENC-UHFFFAOYSA-N tricaine Chemical compound CCOC(=O)C1=CC=CC(N)=C1 ZMCBYSBVJIMENC-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical class OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Control Of The Air-Fuel Ratio Of Carburetors (AREA)
Magnetically Actuated Valves (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK1498-2000A 1998-04-08 1999-04-07 Spôsob inhibície mrp1 SK14982000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8108098P	1998-04-08	1998-04-08
PCT/US1999/007613 WO1999051228A1 (en)	1998-04-08	1999-04-07	Methods for inhibiting mrp1

Publications (1)

Publication Number	Publication Date
SK14982000A3 true SK14982000A3 (sk)	2001-05-10

Family

ID=22161981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1498-2000A SK14982000A3 (sk)	1998-04-08	1999-04-07	Spôsob inhibície mrp1

Country Status (18)

Country	Link
US (1)	US6369070B1 (id)
EP (1)	EP1067928A4 (id)
JP (1)	JP2002510625A (id)
KR (1)	KR20010042471A (id)
CN (1)	CN1304306A (id)
AU (1)	AU3476999A (id)
BR (1)	BR9910112A (id)
CA (1)	CA2327617A1 (id)
EA (1)	EA200001034A1 (id)
HR (1)	HRP20000646A2 (id)
HU (1)	HUP0101508A3 (id)
ID (1)	ID27364A (id)
IL (1)	IL138389A0 (id)
NO (1)	NO20005023L (id)
PL (1)	PL343313A1 (id)
SK (1)	SK14982000A3 (id)
TR (1)	TR200002851T2 (id)
WO (1)	WO1999051228A1 (id)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60025744D1 (de) *	1999-10-07	2006-04-13	Lilly Co Eli	Kondensierte dihydrochinolinon-derivate zur hemmung von mrp1
US6743794B2 (en)	1999-12-22	2004-06-01	Eli Lilly And Company	Methods and compounds for inhibiting MRP1
WO2001046199A1 (en) *	1999-12-22	2001-06-28	Eli Lilly And Company	Methods and compounds for inhibiting mrp1
WO2001096346A1 (en) *	2000-06-14	2001-12-20	Eli Lilly And Company	Tricyclic compounds as mrp1-inhibitors
WO2002024705A1 (en) *	2000-09-22	2002-03-28	Eli Lilly And Company	Stereoselective process for preparing cyclohexyl amine derivatives
JP2004529919A (ja) *	2001-04-09	2004-09-30	イーライ・リリー・アンド・カンパニー	Ｍｒｐ１を阻害するための化合物および方法
US7101891B2 (en)	2001-04-09	2006-09-05	Eli Lilly And Company	Compounds and pharmaceutical compositions for inhibiting MRP1
CA2442530A1 (en) *	2001-04-09	2002-10-17	Rosanne Bonjouklian	Compounds and methods for inhibiting mrp1
EP1684762A4 (en) *	2003-11-13	2009-06-17	Ambit Biosciences Corp	UREA DERIVATIVES AS MODULATORS OF KINASE
WO2005113519A1 (en) *	2004-05-14	2005-12-01	Irm Llc	Compounds and compositions as ppar modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588731A (en) *	1985-06-21	1986-05-13	Roussel Uclaf	Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents
US5744485A (en)	1994-03-25	1998-04-28	Vertex Pharmaceuticals Incorporated	Carbamates and ureas as modifiers of multi-drug resistance
US5717092A (en)	1996-03-29	1998-02-10	Vertex Pharmaceuticals Inc.	Compounds with improved multi-drug resistance activity

1999
- 1999-04-07 PL PL99343313A patent/PL343313A1/xx not_active Application Discontinuation
- 1999-04-07 HR HR20000646A patent/HRP20000646A2/hr not_active Application Discontinuation
- 1999-04-07 CN CN99807009A patent/CN1304306A/zh active Pending
- 1999-04-07 TR TR2000/02851T patent/TR200002851T2/xx unknown
- 1999-04-07 AU AU34769/99A patent/AU3476999A/en not_active Abandoned
- 1999-04-07 CA CA002327617A patent/CA2327617A1/en not_active Abandoned
- 1999-04-07 EA EA200001034A patent/EA200001034A1/ru unknown
- 1999-04-07 KR KR1020007011088A patent/KR20010042471A/ko not_active Withdrawn
- 1999-04-07 BR BR9910112-2A patent/BR9910112A/pt not_active Application Discontinuation
- 1999-04-07 HU HU0101508A patent/HUP0101508A3/hu unknown
- 1999-04-07 EP EP99916456A patent/EP1067928A4/en not_active Withdrawn
- 1999-04-07 US US09/646,062 patent/US6369070B1/en not_active Expired - Fee Related
- 1999-04-07 JP JP2000541999A patent/JP2002510625A/ja not_active Withdrawn
- 1999-04-07 IL IL13838999A patent/IL138389A0/xx unknown
- 1999-04-07 ID IDW20002003A patent/ID27364A/id unknown
- 1999-04-07 WO PCT/US1999/007613 patent/WO1999051228A1/en not_active Ceased
- 1999-04-07 SK SK1498-2000A patent/SK14982000A3/sk unknown
2000
- 2000-10-05 NO NO20005023A patent/NO20005023L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
TR200002851T2 (tr)	2000-12-21
HUP0101508A2 (hu)	2001-10-28
EP1067928A1 (en)	2001-01-17
US6369070B1 (en)	2002-04-09
BR9910112A (pt)	2000-12-26
HRP20000646A2 (en)	2001-06-30
AU3476999A (en)	1999-10-25
CA2327617A1 (en)	1999-10-14
JP2002510625A (ja)	2002-04-09
NO20005023D0 (no)	2000-10-05
HUP0101508A3 (en)	2002-04-29
IL138389A0 (en)	2001-10-31
PL343313A1 (en)	2001-08-13
CN1304306A (zh)	2001-07-18
WO1999051228A1 (en)	1999-10-14
EP1067928A4 (en)	2001-11-14
NO20005023L (no)	2000-12-05
ID27364A (id)	2001-04-05
KR20010042471A (ko)	2001-05-25
EA200001034A1 (ru)	2001-04-23

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