SK14982000A3 - Spôsob inhibície mrp1 - Google Patents

Spôsob inhibície mrp1 Download PDF

Info

Publication number: SK14982000A3
Authority: SK; Slovakia
Prior art keywords: methyl; compound; dihydro; isoxazolo; substituted
Prior art date: 1998-04-08

Application number

SK1498-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Joseph Michael Gruber

Bryan Hurst Norman

Julian Stanley Kroin

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-08

Filing date

1999-04-07

Publication date

2001-05-10

1999-04-07 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

2001-05-10 Publication of SK14982000A3 publication Critical patent/SK14982000A3/sk

Links

230000002401 inhibitory effect Effects 0.000 title claims abstract description 12
238000000034 method Methods 0.000 title claims description 111
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102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 claims abstract 2
108010066052 multidrug resistance-associated protein 1 Proteins 0.000 claims abstract 2
-1 4-aminosulfonylbenzyl Chemical group 0.000 claims description 142
239000000203 mixture Substances 0.000 claims description 78
150000003839 salts Chemical class 0.000 claims description 55
229910052739 hydrogen Inorganic materials 0.000 claims description 44
239000001257 hydrogen Substances 0.000 claims description 43
238000009472 formulation Methods 0.000 claims description 42
230000000174 oncolytic effect Effects 0.000 claims description 38
239000012453 solvate Substances 0.000 claims description 32
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 28
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 24
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125000000623 heterocyclic group Chemical group 0.000 claims description 21
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238000007423 screening assay Methods 0.000 description 1
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239000007790 solid phase Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
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239000008117 stearic acid Substances 0.000 description 1
239000012058 sterile packaged powder Substances 0.000 description 1
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AXZWODMDQAVCJE-UHFFFAOYSA-L tin(II) chloride (anhydrous) Chemical compound [Cl-].[Cl-].[Sn+2] AXZWODMDQAVCJE-UHFFFAOYSA-L 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
239000012049 topical pharmaceutical composition Substances 0.000 description 1
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239000000196 tragacanth Substances 0.000 description 1
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230000037317 transdermal delivery Effects 0.000 description 1
ZMCBYSBVJIMENC-UHFFFAOYSA-N tricaine Chemical compound CCOC(=O)C1=CC=CC(N)=C1 ZMCBYSBVJIMENC-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
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125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Organic Chemistry (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Control Of The Air-Fuel Ratio Of Carburetors (AREA)
Magnetically Actuated Valves (AREA)

SK1498-2000A 1998-04-08 1999-04-07 Spôsob inhibície mrp1 SK14982000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8108098P	1998-04-08	1998-04-08
PCT/US1999/007613 WO1999051228A1 (en)	1998-04-08	1999-04-07	Methods for inhibiting mrp1

Publications (1)

Publication Number	Publication Date
SK14982000A3 true SK14982000A3 (sk)	2001-05-10

Family

ID=22161981

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1498-2000A SK14982000A3 (sk)	1998-04-08	1999-04-07	Spôsob inhibície mrp1

Country Status (18)

Country	Link
US (1)	US6369070B1 (no)
EP (1)	EP1067928A4 (no)
JP (1)	JP2002510625A (no)
KR (1)	KR20010042471A (no)
CN (1)	CN1304306A (no)
AU (1)	AU3476999A (no)
BR (1)	BR9910112A (no)
CA (1)	CA2327617A1 (no)
EA (1)	EA200001034A1 (no)
HR (1)	HRP20000646A2 (no)
HU (1)	HUP0101508A3 (no)
ID (1)	ID27364A (no)
IL (1)	IL138389A0 (no)
NO (1)	NO20005023L (no)
PL (1)	PL343313A1 (no)
SK (1)	SK14982000A3 (no)
TR (1)	TR200002851T2 (no)
WO (1)	WO1999051228A1 (no)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1224189B1 (en) *	1999-10-07	2006-01-25	Eli Lilly And Company	Condensed dihydroquinolinone derivatives for inhibiting mrp1
US6743794B2 (en)	1999-12-22	2004-06-01	Eli Lilly And Company	Methods and compounds for inhibiting MRP1
ES2233487T3 (es) *	1999-12-22	2005-06-16	Eli Lilly And Company	Procedimientos y compuestos para la inhibicion de mrp1.
EP1301518A1 (en)	2000-06-14	2003-04-16	Eli Lilly And Company	Tricyclic compounds as mrp1-inhibitors
JP2004509897A (ja) *	2000-09-22	2004-04-02	イーライ・リリー・アンド・カンパニー	シクロヘキシルアミン誘導体の立体選択的製造方法
JP2004525952A (ja) *	2001-04-09	2004-08-26	イーライ・リリー・アンド・カンパニー	Ｍｒｐ１を阻害するための化合物および医薬組成物
WO2002081482A1 (en) *	2001-04-09	2002-10-17	Eli Lilly And Company	Compounds and methods for inhibiting mrp1
US7064131B2 (en)	2001-04-09	2006-06-20	Eli Lilly And Company	Compounds and methods for inhibiting MRP1
WO2005048953A2 (en) *	2003-11-13	2005-06-02	Ambit Biosciences Corporation	Amide derivatives as kinase modulators
CA2564429A1 (en) *	2004-05-14	2005-12-01	Irm Llc	Compounds and compositions as ppar modulators

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4588731A (en) *	1985-06-21	1986-05-13	Roussel Uclaf	Derivatives of isoxazolo[4,5-c]quinoline(2H)-3-one and method of preparation and use as anxiolytic agents
US5744485A (en)	1994-03-25	1998-04-28	Vertex Pharmaceuticals Incorporated	Carbamates and ureas as modifiers of multi-drug resistance
US5717092A (en)	1996-03-29	1998-02-10	Vertex Pharmaceuticals Inc.	Compounds with improved multi-drug resistance activity

1999
- 1999-04-07 EA EA200001034A patent/EA200001034A1/ru unknown
- 1999-04-07 ID IDW20002003A patent/ID27364A/id unknown
- 1999-04-07 PL PL99343313A patent/PL343313A1/xx not_active Application Discontinuation
- 1999-04-07 HR HR20000646A patent/HRP20000646A2/hr not_active Application Discontinuation
- 1999-04-07 HU HU0101508A patent/HUP0101508A3/hu unknown
- 1999-04-07 IL IL13838999A patent/IL138389A0/xx unknown
- 1999-04-07 US US09/646,062 patent/US6369070B1/en not_active Expired - Fee Related
- 1999-04-07 AU AU34769/99A patent/AU3476999A/en not_active Abandoned
- 1999-04-07 BR BR9910112-2A patent/BR9910112A/pt not_active Application Discontinuation
- 1999-04-07 SK SK1498-2000A patent/SK14982000A3/sk unknown
- 1999-04-07 KR KR1020007011088A patent/KR20010042471A/ko not_active Withdrawn
- 1999-04-07 EP EP99916456A patent/EP1067928A4/en not_active Withdrawn
- 1999-04-07 WO PCT/US1999/007613 patent/WO1999051228A1/en not_active Ceased
- 1999-04-07 CN CN99807009A patent/CN1304306A/zh active Pending
- 1999-04-07 CA CA002327617A patent/CA2327617A1/en not_active Abandoned
- 1999-04-07 JP JP2000541999A patent/JP2002510625A/ja not_active Withdrawn
- 1999-04-07 TR TR2000/02851T patent/TR200002851T2/xx unknown
2000
- 2000-10-05 NO NO20005023A patent/NO20005023L/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0101508A3 (en)	2002-04-29
TR200002851T2 (tr)	2000-12-21
KR20010042471A (ko)	2001-05-25
CA2327617A1 (en)	1999-10-14
NO20005023D0 (no)	2000-10-05
CN1304306A (zh)	2001-07-18
EA200001034A1 (ru)	2001-04-23
NO20005023L (no)	2000-12-05
EP1067928A1 (en)	2001-01-17
AU3476999A (en)	1999-10-25
HUP0101508A2 (hu)	2001-10-28
US6369070B1 (en)	2002-04-09
BR9910112A (pt)	2000-12-26
EP1067928A4 (en)	2001-11-14
WO1999051228A1 (en)	1999-10-14
IL138389A0 (en)	2001-10-31
HRP20000646A2 (en)	2001-06-30
ID27364A (id)	2001-04-05
PL343313A1 (en)	2001-08-13
JP2002510625A (ja)	2002-04-09

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