SK18052000A3 - Amidínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Amidínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

Info

Publication number: SK18052000A3
Authority: SK; Slovakia
Prior art keywords: tert; formula; cysteine; iminoethylamino; butyl
Prior art date: 1998-05-30

Application number

SK1805-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Paul John Beswick

Savvas Kleanthous

Robert John Young

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-30

Filing date

1999-05-27

Publication date

2001-06-11

1999-05-27 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2001-06-11 Publication of SK18052000A3 publication Critical patent/SK18052000A3/sk

Links

239000000236 nitric oxide synthase inhibitor Substances 0.000 title claims 3
CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1
150000003839 salts Chemical class 0.000 claims abstract description 48
239000012453 solvate Substances 0.000 claims abstract description 32
238000000034 method Methods 0.000 claims abstract description 24
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 19
238000004519 manufacturing process Methods 0.000 claims abstract description 6
230000008569 process Effects 0.000 claims abstract description 4
238000002560 therapeutic procedure Methods 0.000 claims abstract description 4
125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims abstract description 3
125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 claims abstract description 3
125000002853 C1-C4 hydroxyalkyl group Chemical group 0.000 claims abstract description 3
150000001875 compounds Chemical class 0.000 claims description 65
-1 1-Iminoethylamino Chemical group 0.000 claims description 64
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 19
239000004201 L-cysteine Substances 0.000 claims description 17
150000001409 amidines Chemical class 0.000 claims description 16
239000004480 active ingredient Substances 0.000 claims description 15
238000011282 treatment Methods 0.000 claims description 14
239000000203 mixture Substances 0.000 claims description 12
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 10
238000011321 prophylaxis Methods 0.000 claims description 9
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 5
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 4
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 4
KAXFOSOXUNYWRV-CAHLUQPWSA-N (2s)-2-amino-3-[(2s)-2-(1-aminoethylideneamino)propyl]sulfanylpropanoic acid Chemical compound CC(=N)N[C@@H](C)CSC[C@@H](N)C(O)=O KAXFOSOXUNYWRV-CAHLUQPWSA-N 0.000 claims description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK1805-2000A 1998-05-30 1999-05-27 Amidínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie SK18052000A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9811599.1A GB9811599D0 (en)	1998-05-30	1998-05-30	Nitric oxide synthase inhibitors
PCT/EP1999/003583 WO1999062875A1 (en)	1998-05-30	1999-05-27	Nitric oxide synthase inhibitors

Publications (1)

Publication Number	Publication Date
SK18052000A3 true SK18052000A3 (sk)	2001-06-11

Family

ID=10832929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1805-2000A SK18052000A3 (sk)	1998-05-30	1999-05-27	Amidínové deriváty, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (30)

Country	Link
US (2)	US6355689B1 (et)
EP (1)	EP1084104B1 (et)
JP (1)	JP3839256B2 (et)
KR (1)	KR20010043920A (et)
CN (1)	CN1218940C (et)
AP (1)	AP1382A (et)
AT (1)	ATE245142T1 (et)
AU (1)	AU757042B2 (et)
BR (1)	BR9910849A (et)
CA (1)	CA2333322C (et)
CZ (1)	CZ297473B6 (et)
DE (1)	DE69909625T2 (et)
DK (1)	DK1084104T3 (et)
EA (1)	EA003026B1 (et)
EE (1)	EE04149B1 (et)
ES (1)	ES2203147T3 (et)
GB (1)	GB9811599D0 (et)
HU (1)	HUP0102472A3 (et)
ID (1)	ID26790A (et)
IL (1)	IL139697A (et)
IS (1)	IS2442B (et)
NO (1)	NO20006044L (et)
NZ (1)	NZ508222A (et)
PL (1)	PL194784B1 (et)
PT (1)	PT1084104E (et)
RS (1)	RS49984B (et)
SK (1)	SK18052000A3 (et)
TR (1)	TR200003539T2 (et)
WO (1)	WO1999062875A1 (et)
ZA (1)	ZA200006847B (et)

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1998
- 1998-05-30 GB GBGB9811599.1A patent/GB9811599D0/en not_active Ceased
1999
- 1999-05-27 AU AU43671/99A patent/AU757042B2/en not_active Ceased
- 1999-05-27 DK DK99926397T patent/DK1084104T3/da active
- 1999-05-27 PT PT99926397T patent/PT1084104E/pt unknown
- 1999-05-27 RS YUP-746/00A patent/RS49984B/sr unknown
- 1999-05-27 AP APAP/P/2000/001998A patent/AP1382A/en active
- 1999-05-27 KR KR1020007013451A patent/KR20010043920A/ko not_active Ceased
- 1999-05-27 WO PCT/EP1999/003583 patent/WO1999062875A1/en not_active Ceased
- 1999-05-27 EP EP99926397A patent/EP1084104B1/en not_active Expired - Lifetime
- 1999-05-27 JP JP2000552087A patent/JP3839256B2/ja not_active Expired - Fee Related
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- 1999-05-27 DE DE69909625T patent/DE69909625T2/de not_active Expired - Lifetime
- 1999-05-27 SK SK1805-2000A patent/SK18052000A3/sk unknown
- 1999-05-27 BR BR9910849-6A patent/BR9910849A/pt not_active Application Discontinuation
- 1999-05-27 AT AT99926397T patent/ATE245142T1/de not_active IP Right Cessation
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- 1999-05-27 CZ CZ20004450A patent/CZ297473B6/cs not_active IP Right Cessation
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- 1999-05-27 PL PL344368A patent/PL194784B1/pl unknown
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- 1999-05-27 ES ES99926397T patent/ES2203147T3/es not_active Expired - Lifetime
2000
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- 2000-11-22 ZA ZA200006847A patent/ZA200006847B/en unknown
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Also Published As

Publication number	Publication date
WO1999062875A1 (en)	1999-12-09
AP2000001998A0 (en)	2000-12-31
AU4367199A (en)	1999-12-20
YU74600A (sh)	2002-12-10
PT1084104E (pt)	2003-11-28
IS2442B (is)	2008-11-15
EA003026B1 (ru)	2002-12-26
ID26790A (id)	2001-02-08
US6355689B1 (en)	2002-03-12
DE69909625T2 (de)	2004-06-24
HUP0102472A3 (en)	2002-12-28
ES2203147T3 (es)	2004-04-01
JP3839256B2 (ja)	2006-11-01
TR200003539T2 (tr)	2001-06-21
CA2333322A1 (en)	1999-12-09
EE04149B1 (et)	2003-10-15
EP1084104A1 (en)	2001-03-21
NZ508222A (en)	2003-02-28
KR20010043920A (ko)	2001-05-25
CA2333322C (en)	2008-01-22
NO20006044D0 (no)	2000-11-29
US6495606B1 (en)	2002-12-17
PL344368A1 (en)	2001-11-05
CN1303367A (zh)	2001-07-11
HUP0102472A2 (hu)	2002-03-28
CZ297473B6 (cs)	2006-12-13
IL139697A (en)	2005-12-18
EE200000716A (et)	2002-04-15
NO20006044L (no)	2001-01-29
ATE245142T1 (de)	2003-08-15
GB9811599D0 (en)	1998-07-29
BR9910849A (pt)	2001-02-20
RS49984B (sr)	2008-09-29
AU757042B2 (en)	2003-01-30
EP1084104B1 (en)	2003-07-16
JP2002516901A (ja)	2002-06-11
EA200001122A1 (ru)	2001-06-25
IS5723A (is)	2000-11-21
ZA200006847B (en)	2001-11-22
HK1034241A1 (en)	2001-10-19
AP1382A (en)	2005-04-01
IL139697A0 (en)	2002-02-10
CN1218940C (zh)	2005-09-14
PL194784B1 (pl)	2007-07-31
DE69909625D1 (en)	2003-08-21
DK1084104T3 (da)	2003-10-27
CZ20004450A3 (en)	2001-05-16

Publication	Publication Date	Title
CZ20004450A3 (en)	2001-05-16	Amidine derivatives
SK283201B6 (sk)	2003-03-04	Amidínové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukt
KR100853049B1 (ko)	2008-08-19	산화질소 신타제 억제제 포스페이트염
US6620848B2 (en)	2003-09-16	Nitric oxide synthase inhibitors
US6369272B1 (en)	2002-04-09	Nitric oxide synthase inhibitors
HK1034241B (en)	2003-10-31	Nitric oxide synthase inhibitors
MXPA00011528A (en)	2001-11-21	Nitric oxide synthase inhibitors
MXPA99006172A (en)	2000-02-02	Nitric oxide synthase inhibitors