EE200000716A - Lämmastikoksiidi süntaasi inhibiitorid - Google Patents

Lämmastikoksiidi süntaasi inhibiitorid

Info

Publication number: EE200000716A
Authority: EE; Estonia
Prior art keywords: nitric oxide; oxide synthase; synthase inhibitors; inhibitors; nitric
Prior art date: 1998-05-30

Application number

EEP200000716A

Other languages

English (en)

Inventor

John Beswick Paul

Kleanthous Savvas

John Young Robert

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-05-30

Filing date

1999-05-27

Publication date

2002-04-15

1999-05-27 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2002-04-15 Publication of EE200000716A publication Critical patent/EE200000716A/et

2003-10-15 Publication of EE04149B1 publication Critical patent/EE04149B1/et

Links

239000000236 nitric oxide synthase inhibitor Substances 0.000 title 1
CSYSULGPHGCBQD-UHFFFAOYSA-N s-ethylisothiouronium diethylphosphate Chemical compound CCSC(N)=N.CCOP(O)(=O)OCC CSYSULGPHGCBQD-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Oncology (AREA)
Heart & Thoracic Surgery (AREA)
Communicable Diseases (AREA)
Cardiology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Dermatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

EEP200000716A 1998-05-30 1999-05-27 Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine EE04149B1 (et)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9811599.1A GB9811599D0 (en)	1998-05-30	1998-05-30	Nitric oxide synthase inhibitors
PCT/EP1999/003583 WO1999062875A1 (en)	1998-05-30	1999-05-27	Nitric oxide synthase inhibitors

Publications (2)

Publication Number	Publication Date
EE200000716A true EE200000716A (et)	2002-04-15
EE04149B1 EE04149B1 (et)	2003-10-15

Family

ID=10832929

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200000716A EE04149B1 (et)	1998-05-30	1999-05-27	Lämmastikoksiidi süntaasi inhibiitorid, nende valmistamismeetod ja kasutamine

Country Status (30)

Country	Link
US (2)	US6355689B1 (et)
EP (1)	EP1084104B1 (et)
JP (1)	JP3839256B2 (et)
KR (1)	KR20010043920A (et)
CN (1)	CN1218940C (et)
AP (1)	AP1382A (et)
AT (1)	ATE245142T1 (et)
AU (1)	AU757042B2 (et)
BR (1)	BR9910849A (et)
CA (1)	CA2333322C (et)
CZ (1)	CZ297473B6 (et)
DE (1)	DE69909625T2 (et)
DK (1)	DK1084104T3 (et)
EA (1)	EA003026B1 (et)
EE (1)	EE04149B1 (et)
ES (1)	ES2203147T3 (et)
GB (1)	GB9811599D0 (et)
HU (1)	HUP0102472A3 (et)
ID (1)	ID26790A (et)
IL (1)	IL139697A (et)
IS (1)	IS2442B (et)
NO (1)	NO20006044L (et)
NZ (1)	NZ508222A (et)
PL (1)	PL194784B1 (et)
PT (1)	PT1084104E (et)
RS (1)	RS49984B (et)
SK (1)	SK18052000A3 (et)
TR (1)	TR200003539T2 (et)
WO (1)	WO1999062875A1 (et)
ZA (1)	ZA200006847B (et)

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1998
- 1998-05-30 GB GBGB9811599.1A patent/GB9811599D0/en not_active Ceased
1999
- 1999-05-27 AU AU43671/99A patent/AU757042B2/en not_active Ceased
- 1999-05-27 DK DK99926397T patent/DK1084104T3/da active
- 1999-05-27 PT PT99926397T patent/PT1084104E/pt unknown
- 1999-05-27 RS YUP-746/00A patent/RS49984B/sr unknown
- 1999-05-27 AP APAP/P/2000/001998A patent/AP1382A/en active
- 1999-05-27 KR KR1020007013451A patent/KR20010043920A/ko not_active Ceased
- 1999-05-27 WO PCT/EP1999/003583 patent/WO1999062875A1/en not_active Ceased
- 1999-05-27 EP EP99926397A patent/EP1084104B1/en not_active Expired - Lifetime
- 1999-05-27 JP JP2000552087A patent/JP3839256B2/ja not_active Expired - Fee Related
- 1999-05-27 EE EEP200000716A patent/EE04149B1/et not_active IP Right Cessation
- 1999-05-27 IL IL13969799A patent/IL139697A/xx not_active IP Right Cessation
- 1999-05-27 DE DE69909625T patent/DE69909625T2/de not_active Expired - Lifetime
- 1999-05-27 SK SK1805-2000A patent/SK18052000A3/sk unknown
- 1999-05-27 BR BR9910849-6A patent/BR9910849A/pt not_active Application Discontinuation
- 1999-05-27 AT AT99926397T patent/ATE245142T1/de not_active IP Right Cessation
- 1999-05-27 TR TR2000/03539T patent/TR200003539T2/xx unknown
- 1999-05-27 NZ NZ508222A patent/NZ508222A/xx unknown
- 1999-05-27 US US09/701,473 patent/US6355689B1/en not_active Expired - Lifetime
- 1999-05-27 CN CNB998068578A patent/CN1218940C/zh not_active Expired - Fee Related
- 1999-05-27 HU HU0102472A patent/HUP0102472A3/hu unknown
- 1999-05-27 CA CA002333322A patent/CA2333322C/en not_active Expired - Fee Related
- 1999-05-27 CZ CZ20004450A patent/CZ297473B6/cs not_active IP Right Cessation
- 1999-05-27 EA EA200001122A patent/EA003026B1/ru not_active IP Right Cessation
- 1999-05-27 PL PL344368A patent/PL194784B1/pl unknown
- 1999-05-27 ID IDW20002495A patent/ID26790A/id unknown
- 1999-05-27 ES ES99926397T patent/ES2203147T3/es not_active Expired - Lifetime
2000
- 2000-11-21 IS IS5723A patent/IS2442B/is unknown
- 2000-11-22 ZA ZA200006847A patent/ZA200006847B/en unknown
- 2000-11-29 NO NO20006044A patent/NO20006044L/no not_active Application Discontinuation
2001
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Also Published As

Publication number	Publication date
WO1999062875A1 (en)	1999-12-09
AP2000001998A0 (en)	2000-12-31
AU4367199A (en)	1999-12-20
YU74600A (sh)	2002-12-10
PT1084104E (pt)	2003-11-28
IS2442B (is)	2008-11-15
EA003026B1 (ru)	2002-12-26
ID26790A (id)	2001-02-08
US6355689B1 (en)	2002-03-12
DE69909625T2 (de)	2004-06-24
HUP0102472A3 (en)	2002-12-28
ES2203147T3 (es)	2004-04-01
SK18052000A3 (sk)	2001-06-11
JP3839256B2 (ja)	2006-11-01
TR200003539T2 (tr)	2001-06-21
CA2333322A1 (en)	1999-12-09
EE04149B1 (et)	2003-10-15
EP1084104A1 (en)	2001-03-21
NZ508222A (en)	2003-02-28
KR20010043920A (ko)	2001-05-25
CA2333322C (en)	2008-01-22
NO20006044D0 (no)	2000-11-29
US6495606B1 (en)	2002-12-17
PL344368A1 (en)	2001-11-05
CN1303367A (zh)	2001-07-11
HUP0102472A2 (hu)	2002-03-28
CZ297473B6 (cs)	2006-12-13
IL139697A (en)	2005-12-18
NO20006044L (no)	2001-01-29
ATE245142T1 (de)	2003-08-15
GB9811599D0 (en)	1998-07-29
BR9910849A (pt)	2001-02-20
RS49984B (sr)	2008-09-29
AU757042B2 (en)	2003-01-30
EP1084104B1 (en)	2003-07-16
JP2002516901A (ja)	2002-06-11
EA200001122A1 (ru)	2001-06-25
IS5723A (is)	2000-11-21
ZA200006847B (en)	2001-11-22
HK1034241A1 (en)	2001-10-19
AP1382A (en)	2005-04-01
IL139697A0 (en)	2002-02-10
CN1218940C (zh)	2005-09-14
PL194784B1 (pl)	2007-07-31
DE69909625D1 (en)	2003-08-21
DK1084104T3 (da)	2003-10-27
CZ20004450A3 (en)	2001-05-16

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2010-02-15	MM4A	Lapsed by not paying the annual fees	Effective date: 20090527

Publication	Publication Date	Title
NO20006044L (no)	2001-01-29	Nitrogenoksid-syntaseinhibitorer
EE04013B1 (et)	2003-04-15	Lämmastikoksiidi süntaasi inhibiitorid
GB0031179D0 (en)	2001-01-31	Nitric oxide synthase inhibitors
IS5053A (is)	1999-05-18	6-Fenýlpýridýl-2-amín afleiður nytsamlegar sem nituroxíð sýntasa tálmar
AU4430599A (en)	1999-12-30	Inhibitors of nitric oxide synthase
EE200000519A (et)	2002-02-15	Lämmastikoksiidi süntaasi inhibiitoritena toimivad halogeenitud amidinoaminohappederivaadid
NO20031140L (no)	2003-05-08	2-amino-2-alkyl-5-hepten- og heptynsyrederivater som er anvendbare som nitrogenoksydsyntase-inhibitorer
DK1272488T3 (da)	2006-07-17	Tri-aryl-substitueret ethan-PDE4-inhibitorer
ATE252547T1 (de)	2003-11-15	Matrixmetalloproteinaseinhibitoren
EE9900474A (et)	2000-06-15	Amidiini derivaadid lämmastikoksiidi süntaasi inhibiitoritena
MA24854A1 (fr)	1999-12-31	Inhibiteurs d'oxyde nitrique synthase
MA24877A1 (fr)	1999-12-31	INHIBITEURS DE PROTéASES
DK1130214T3 (da)	2005-08-29	Korrosionsinhibitorer
HRP980381B1 (en)	2002-02-28	Nitric oxide synthase inhibitors
SI1084104T1 (en)	2003-12-31	Nitric oxide synthase inhibitors
DE69930852D1 (de)	2006-05-24	Prenyltransferase-inhibitoren
GB0031177D0 (en)	2001-01-31	Nitric oxide synthase inhibitors
SI0958277T1 (en)	2002-06-30	Nitric oxide synthase inhibitors
GB9918076D0 (en)	1999-10-06	Microencapsulated nitric oxide synthase source
SE9802118D0 (sv)	1998-06-15	Mycobacterial inhibitors
GB0016172D0 (en)	2000-08-23	Microencapsulated nitric oxide synthase source
ZA971944B (en)	1998-03-06	Hydroxyamidino derivatives useful as nitric oxide synthase inhibitors.
NO20000477D0 (no)	2000-01-31	Klosettavsug