SK2082003A3 - Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative - Google Patents

Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative Download PDF

Info

Publication number: SK2082003A3
Authority: SK; Slovakia
Prior art keywords: dione; thiazolidine; metformin; ethyl; fluorophenoxy
Prior art date: 2000-08-04

Application number

SK208-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Gerard Moinet

Gerard Botton

Didier Mesangeau

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-04

Filing date

2001-07-24

Publication date

2003-07-01

2001-07-24 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-07-01 Publication of SK2082003A3 publication Critical patent/SK2082003A3/sk

Links

XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 title claims abstract description 42
229960003105 metformin Drugs 0.000 title claims abstract description 41
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 15
150000003839 salts Chemical class 0.000 claims abstract description 24
-1 β-naphthyl group Chemical group 0.000 claims description 28
150000001875 compounds Chemical class 0.000 claims description 24
LGSOKZOQANLOEU-UHFFFAOYSA-N 4-[2-(2,4-dioxo-1,3-thiazolidin-5-yl)ethoxy]benzonitrile Chemical compound S1C(=O)NC(=O)C1CCOC1=CC=C(C#N)C=C1 LGSOKZOQANLOEU-UHFFFAOYSA-N 0.000 claims description 19
238000011282 treatment Methods 0.000 claims description 14
208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 12
206010012601 diabetes mellitus Diseases 0.000 claims description 11
125000004432 carbon atom Chemical group C* 0.000 claims description 10
125000000217 alkyl group Chemical group 0.000 claims description 9
125000003118 aryl group Chemical group 0.000 claims description 9
QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims description 8
ZOBPZXTWZATXDG-UHFFFAOYSA-N 1,3-thiazolidine-2,4-dione Chemical compound O=C1CSC(=O)N1 ZOBPZXTWZATXDG-UHFFFAOYSA-N 0.000 claims description 7
238000002360 preparation method Methods 0.000 claims description 7
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 6
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
FBZWYFBNIGSUPS-UHFFFAOYSA-N (2-chlorophenyl) ethaneperoxoate Chemical compound CC(=O)OOC1=CC=CC=C1Cl FBZWYFBNIGSUPS-UHFFFAOYSA-N 0.000 claims description 5
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 5
229950005627 embonate Drugs 0.000 claims description 5
239000000546 pharmaceutical excipient Substances 0.000 claims description 5
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 5
125000003545 alkoxy group Chemical group 0.000 claims description 4
125000003710 aryl alkyl group Chemical group 0.000 claims description 4
125000002619 bicyclic group Chemical group 0.000 claims description 4
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 4
125000005842 heteroatom Chemical group 0.000 claims description 4
QRDBEMGPWFEMDC-UHFFFAOYSA-N 5-(2-naphthalen-2-yloxyethyl)-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CCOC1=CC=C(C=CC=C2)C2=C1 QRDBEMGPWFEMDC-UHFFFAOYSA-N 0.000 claims description 3
VVUWDCNUSNOQMQ-UHFFFAOYSA-N 5-[2-(2-fluorophenoxy)ethyl]-1,3-thiazolidine-2,4-dione Chemical compound FC1=CC=CC=C1OCCC1C(=O)NC(=O)S1 VVUWDCNUSNOQMQ-UHFFFAOYSA-N 0.000 claims description 3
229910052739 hydrogen Inorganic materials 0.000 claims description 3
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125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims description 3
230000001225 therapeutic effect Effects 0.000 claims description 3
STVPBRGHYXQBLZ-UHFFFAOYSA-N 5-(1-phenoxypropan-2-yl)-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1C(C)COC1=CC=CC=C1 STVPBRGHYXQBLZ-UHFFFAOYSA-N 0.000 claims description 2
DFDFPHUMCPMDNV-UHFFFAOYSA-N 5-[2-(4-fluorophenoxy)ethyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(F)=CC=C1OCCC1C(=O)NC(=O)S1 DFDFPHUMCPMDNV-UHFFFAOYSA-N 0.000 claims description 2
BHQFXPRIBXWDMI-UHFFFAOYSA-N 5-[3-(4-fluorophenoxy)propyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(F)=CC=C1OCCCC1C(=O)NC(=O)S1 BHQFXPRIBXWDMI-UHFFFAOYSA-N 0.000 claims description 2
125000004183 alkoxy alkyl group Chemical group 0.000 claims description 2
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YZTPAOFYMLONRV-UHFFFAOYSA-N 5-(2-phenoxyethyl)-1,3-thiazolidine-2,4-dione Chemical compound S1C(=O)NC(=O)C1CCOC1=CC=CC=C1 YZTPAOFYMLONRV-UHFFFAOYSA-N 0.000 claims 2
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ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
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DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 4
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102000004877 Insulin Human genes 0.000 description 3
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QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

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Health & Medical Sciences (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Obesity (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK208-2003A 2000-08-04 2001-07-24 Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative SK2082003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0010362A FR2812547B1 (fr)	2000-08-04	2000-08-04	Composition pharmaceutique comprenant une association metformine et derive de thiazolidinedione et son utilisation pour la preparation de medicaments destines a traiter le diabete
PCT/EP2001/008512 WO2002011721A1 (en)	2000-08-04	2001-07-24	Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative

Publications (1)

Publication Number	Publication Date
SK2082003A3 true SK2082003A3 (en)	2003-07-01

Family

ID=8853342

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK208-2003A SK2082003A3 (en)	2000-08-04	2001-07-24	Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative

Country Status (19)

Country	Link
US (1)	US20040014797A1 (pl)
EP (1)	EP1305025A1 (pl)
JP (1)	JP2004505915A (pl)
KR (1)	KR20030019470A (pl)
CN (1)	CN1446090A (pl)
AR (1)	AR030309A1 (pl)
AU (1)	AU2001282010A1 (pl)
BR (1)	BR0112915A (pl)
CA (1)	CA2417883A1 (pl)
CZ (1)	CZ2003476A3 (pl)
EC (1)	ECSP034463A (pl)
FR (1)	FR2812547B1 (pl)
HU (1)	HUP0303684A2 (pl)
MX (1)	MXPA03000975A (pl)
NO (1)	NO20030518L (pl)
PL (1)	PL358791A1 (pl)
RU (1)	RU2003105809A (pl)
SK (1)	SK2082003A3 (pl)
WO (1)	WO2002011721A1 (pl)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8911781B2 (en)	2002-06-17	2014-12-16	Inventia Healthcare Private Limited	Process of manufacture of novel drug delivery system: multilayer tablet composition of thiazolidinedione and biguanides
UA80991C2 (en)	2002-10-07	2007-11-26		Solid preparation containing an insulin resistance improving drug and an active ingredient useful as a remedy for diabetes
WO2008016729A1 (en) *	2006-08-04	2008-02-07	Nastech Pharmaceutical Company Inc.	Compositions for intranasal delivery of human insulin and uses thereof
CN105152983A (zh)	2007-01-29	2015-12-16	韩诺生物制药株式会社	N,n-二甲基亚氨基二碳亚氨酸二酰胺乙酸盐、其制备方法和包含其的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2749583B1 (fr) *	1996-06-07	1998-08-21	Lipha	Nouveaux derives de thiazolidine -2,4- dione substitues, leurs procedes d'obtention et les compositions pharmaceutiques en renfermant
KR20060105005A (ko) *	1997-06-18	2006-10-09	스미스클라인비이참피이엘시이	티아졸리딘디온 및 메트포르민을 사용한 당뇨병의 치료
GB9715295D0 (en) *	1997-07-18	1997-09-24	Smithkline Beecham Plc	Novel method of treatment

2000
- 2000-08-04 FR FR0010362A patent/FR2812547B1/fr not_active Expired - Fee Related
2001
- 2001-07-24 MX MXPA03000975A patent/MXPA03000975A/es unknown
- 2001-07-24 WO PCT/EP2001/008512 patent/WO2002011721A1/en not_active Ceased
- 2001-07-24 CA CA002417883A patent/CA2417883A1/en not_active Abandoned
- 2001-07-24 HU HU0303684A patent/HUP0303684A2/hu unknown
- 2001-07-24 SK SK208-2003A patent/SK2082003A3/sk unknown
- 2001-07-24 JP JP2002517057A patent/JP2004505915A/ja active Pending
- 2001-07-24 EP EP01960539A patent/EP1305025A1/en not_active Withdrawn
- 2001-07-24 RU RU2003105809/15A patent/RU2003105809A/ru not_active Application Discontinuation
- 2001-07-24 BR BR0112915-5A patent/BR0112915A/pt not_active Application Discontinuation
- 2001-07-24 AU AU2001282010A patent/AU2001282010A1/en not_active Abandoned
- 2001-07-24 CN CN01813685A patent/CN1446090A/zh active Pending
- 2001-07-24 KR KR1020027018026A patent/KR20030019470A/ko not_active Withdrawn
- 2001-07-24 US US10/343,609 patent/US20040014797A1/en not_active Abandoned
- 2001-07-24 PL PL01358791A patent/PL358791A1/pl unknown
- 2001-07-24 CZ CZ2003476A patent/CZ2003476A3/cs unknown
- 2001-08-03 AR ARP010103708A patent/AR030309A1/es unknown
2003
- 2003-02-03 NO NO20030518A patent/NO20030518L/no not_active Application Discontinuation
- 2003-02-03 EC EC2003004463A patent/ECSP034463A/es unknown

Also Published As

Publication number	Publication date
EP1305025A1 (en)	2003-05-02
HUP0303684A2 (hu)	2004-03-01
AU2001282010A1 (en)	2002-02-18
ECSP034463A (es)	2003-03-31
NO20030518D0 (no)	2003-02-03
JP2004505915A (ja)	2004-02-26
CZ2003476A3 (cs)	2003-06-18
WO2002011721A1 (en)	2002-02-14
MXPA03000975A (es)	2003-06-09
RU2003105809A (ru)	2004-08-27
KR20030019470A (ko)	2003-03-06
FR2812547B1 (fr)	2002-10-31
AR030309A1 (es)	2003-08-20
BR0112915A (pt)	2003-07-08
CA2417883A1 (en)	2002-02-14
NO20030518L (no)	2003-02-03
US20040014797A1 (en)	2004-01-22
FR2812547A1 (fr)	2002-02-08
PL358791A1 (pl)	2004-08-23
CN1446090A (zh)	2003-10-01

Publication	Publication Date	Title
DE69713890T2 (de)	2002-11-21	Pharmazeutische kombination enthaltend einen wirkstoff mit angiotensin-ii antagonistischer aktivität und einen wirkstoff der die insulin-sensitivität erhöht
DE69432644T2 (de)	2003-11-27	Kombination eines Angiotensin-II antagonistisch wirkendes Benzimidazols mit ein Diuretikum
JP4767411B2 (ja)	2011-09-07	メトホルミンおよびフィブラートとの組み合わせからなる医薬組成物と、高血糖症を緩和するための医薬品製造へのその使用
SK2082003A3 (en)	2003-07-01	Pharmaceutical composition comprising metformin and a 5-phenoxyalkyl-2,4-thiazolidinedione-type derivative
KR20140033498A (ko)	2014-03-18	트리아진 유도체 및 인슐린 감작제의 조합물
EP1448181B1 (en)	2006-05-31	Pharmaceutical composition comprising a combination of metformin and a 4-oxobutanoic acid, and the use thereof for treating diabetes
WO2003041706A1 (en)	2003-05-22	Pharmaceutical composition comprising a glitazone and a thiazolidinedione derivative, and use thereof for treating diabetes
WO2003047627A1 (en)	2003-06-12	Pharmaceutical composition comprising an alpha-glucosidase inhibitor and a thiazolidinedione derivative, and a use thereof for treating diabetes
CN109879839B (zh)	2023-04-25	6-哌嗪甲基-7-羟基苯并呋喃类化合物及其医药用途
JPS6216417A (ja)	1987-01-24	虚血性心疾患・不整脈治療・予防剤
KR20040075871A (ko)	2004-08-30	알파-글루코시다제 저해제 및 ４-옥소부탄산을 포함하여이루어지는 약제학적 조성물 및 당뇨병을 치료하기 위한이의 용도
KR20040078109A (ko)	2004-09-08	글리타존 및 ４-옥소부탄산을 포함하여 이루어지는약제학적 조성물, 및 당뇨병을 치료하기 위한 이의 용도
WO2003047574A1 (en)	2003-06-12	Pharmaceutical composition comprising a derivative of 5-phenoxyalkyl-2,4-thiazolidinedione type and a 4-oxobutanoic acid
US20040097567A1 (en)	2004-05-20	Pharmaceutical composition
WO2007037296A1 (ja)	2007-04-05	インスリン抵抗性改善剤を含有する薬剤
FR2838968A1 (fr)	2003-10-31	Association d'insuline et d'un derive de thiazolidinedione et son utilisation pour traiter le diabete
AU2002247755A1 (en)	2002-10-03	Pharmaceutical composition for the treatment of diabetes comprising a 5-phenoxyalkal-2,4-thiazolidinedione derivative and a compound that stimulates insulin secretion
AU2005209657A1 (en)	2005-09-29	Combination of at least two compounds selected from an AT1-Receptor antagonist or an ACE inhibitor or a HMG-CO-A reductase inhibitor group
JPH0418021A (ja)	1992-01-22	血清尿酸低下剤