SK279461B6 - Farmaceutický prípravok vo forme mikroguľôčok a sp - Google Patents

Farmaceutický prípravok vo forme mikroguľôčok a sp Download PDF

Info

Publication number: SK279461B6
Authority: SK; Slovakia
Prior art keywords: mixture; oil; fat; biologically active; wax
Prior art date: 1990-03-30

Application number

SK791-91A

Other languages

English (en)

Slovak (sk)

Inventor

William Steber

Original Assignee

American Cyanamid Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-03-30

Filing date

1991-03-25

Publication date

1998-11-04

1991-03-25 Application filed by American Cyanamid Company filed Critical American Cyanamid Company

1998-11-04 Publication of SK279461B6 publication Critical patent/SK279461B6/sk

Links

239000000825 pharmaceutical preparation Substances 0.000 title claims description 4
239000000203 mixture Substances 0.000 claims abstract description 101
239000004005 microsphere Substances 0.000 claims abstract description 49
108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 40
102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 32
102000004169 proteins and genes Human genes 0.000 claims abstract description 26
108090000623 proteins and genes Proteins 0.000 claims abstract description 26
229920001184 polypeptide Polymers 0.000 claims abstract description 20
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 15
238000007911 parenteral administration Methods 0.000 claims abstract description 12
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 12
229940088623 biologically active substance Drugs 0.000 claims abstract description 7
238000000034 method Methods 0.000 claims abstract description 6
150000005690 diesters Chemical class 0.000 claims abstract description 3
239000007787 solid Substances 0.000 claims description 31
238000004519 manufacturing process Methods 0.000 claims description 23
239000003981 vehicle Substances 0.000 claims description 20
239000000194 fatty acid Substances 0.000 claims description 16
239000007788 liquid Substances 0.000 claims description 16
235000014113 dietary fatty acids Nutrition 0.000 claims description 15
229930195729 fatty acid Natural products 0.000 claims description 15
241000283690 Bos taurus Species 0.000 claims description 11
239000000122 growth hormone Substances 0.000 claims description 10
230000007935 neutral effect Effects 0.000 claims description 10
238000012545 processing Methods 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 7
108010051696 Growth Hormone Proteins 0.000 claims description 5
102000018997 Growth Hormone Human genes 0.000 claims description 5
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 claims description 5
230000008569 process Effects 0.000 claims description 4
239000000155 melt Substances 0.000 claims description 3
241000271566 Aves Species 0.000 claims description 2
-1 triesters fatty acids Chemical class 0.000 claims 2
238000002844 melting Methods 0.000 claims 1
230000008018 melting Effects 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 11
239000000725 suspension Substances 0.000 abstract description 7
239000002253 acid Substances 0.000 abstract description 4
150000007513 acids Chemical class 0.000 abstract description 2
239000008135 aqueous vehicle Substances 0.000 abstract 1
230000004927 fusion Effects 0.000 abstract 1
150000005691 triesters Chemical class 0.000 abstract 1
239000003925 fat Substances 0.000 description 54
235000019197 fats Nutrition 0.000 description 54
239000003921 oil Substances 0.000 description 42
235000019198 oils Nutrition 0.000 description 42
239000001993 wax Substances 0.000 description 27
238000002360 preparation method Methods 0.000 description 25
238000009472 formulation Methods 0.000 description 24
235000013336 milk Nutrition 0.000 description 19
239000008267 milk Substances 0.000 description 19
210000004080 milk Anatomy 0.000 description 19
150000004665 fatty acids Chemical class 0.000 description 12
239000004480 active ingredient Substances 0.000 description 11
239000000546 pharmaceutical excipient Substances 0.000 description 10
241001465754 Metazoa Species 0.000 description 8
150000002148 esters Chemical class 0.000 description 8
238000003860 storage Methods 0.000 description 8
239000002245 particle Substances 0.000 description 7
239000008280 blood Substances 0.000 description 6
210000004369 blood Anatomy 0.000 description 6
150000003839 salts Chemical class 0.000 description 6
238000013268 sustained release Methods 0.000 description 6
239000012730 sustained-release form Substances 0.000 description 6
230000009466 transformation Effects 0.000 description 6
DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 6
239000013078 crystal Substances 0.000 description 5
238000002347 injection Methods 0.000 description 5
239000007924 injection Substances 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
150000001298 alcohols Chemical class 0.000 description 4
108010006025 bovine growth hormone Proteins 0.000 description 4
238000002474 experimental method Methods 0.000 description 4
239000005556 hormone Substances 0.000 description 4
229940088597 hormone Drugs 0.000 description 4
230000004584 weight gain Effects 0.000 description 4
235000019786 weight gain Nutrition 0.000 description 4
108010010803 Gelatin Proteins 0.000 description 3
108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
102000013275 Somatomedins Human genes 0.000 description 3
239000013543 active substance Substances 0.000 description 3
238000000889 atomisation Methods 0.000 description 3
239000000872 buffer Substances 0.000 description 3
239000003795 chemical substances by application Substances 0.000 description 3
238000004090 dissolution Methods 0.000 description 3
239000002552 dosage form Substances 0.000 description 3
HQPMKSGTIOYHJT-UHFFFAOYSA-N ethane-1,2-diol;propane-1,2-diol Chemical compound OCCO.CC(O)CO HQPMKSGTIOYHJT-UHFFFAOYSA-N 0.000 description 3
239000012634 fragment Substances 0.000 description 3
239000008273 gelatin Substances 0.000 description 3
229920000159 gelatin Polymers 0.000 description 3
235000019322 gelatine Nutrition 0.000 description 3
235000011852 gelatine desserts Nutrition 0.000 description 3
125000005908 glyceryl ester group Chemical group 0.000 description 3
239000003102 growth factor Substances 0.000 description 3
229940116364 hard fat Drugs 0.000 description 3
150000002430 hydrocarbons Chemical class 0.000 description 3
230000003993 interaction Effects 0.000 description 3
230000006651 lactation Effects 0.000 description 3
229920002521 macromolecule Polymers 0.000 description 3
235000013372 meat Nutrition 0.000 description 3
239000012188 paraffin wax Substances 0.000 description 3
229920001993 poloxamer 188 Polymers 0.000 description 3
239000003381 stabilizer Substances 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
235000013365 dairy product Nutrition 0.000 description 2
150000002170 ethers Chemical class 0.000 description 2
238000001879 gelation Methods 0.000 description 2
125000005456 glyceride group Chemical group 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
230000007774 longterm Effects 0.000 description 2
239000002674 ointment Substances 0.000 description 2
239000003960 organic solvent Substances 0.000 description 2
229940124531 pharmaceutical excipient Drugs 0.000 description 2
239000003755 preservative agent Substances 0.000 description 2
230000004044 response Effects 0.000 description 2
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 2
239000004299 sodium benzoate Substances 0.000 description 2
235000010234 sodium benzoate Nutrition 0.000 description 2
VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 description 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
239000007921 spray Substances 0.000 description 2
238000012360 testing method Methods 0.000 description 2
URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
150000003626 triacylglycerols Chemical class 0.000 description 2
PVNIQBQSYATKKL-UHFFFAOYSA-N tripalmitin Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCC PVNIQBQSYATKKL-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 description 1
CGYGETOMCSJHJU-UHFFFAOYSA-N 2-chloronaphthalene Chemical compound C1=CC=CC2=CC(Cl)=CC=C21 CGYGETOMCSJHJU-UHFFFAOYSA-N 0.000 description 1
241000251468 Actinopterygii Species 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
229920005682 EO-PO block copolymer Polymers 0.000 description 1
241000196324 Embryophyta Species 0.000 description 1
241000283073 Equus caballus Species 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
241001553290 Euphorbia antisyphilitica Species 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
244000147568 Laurus nobilis Species 0.000 description 1
235000017858 Laurus nobilis Nutrition 0.000 description 1
235000019482 Palm oil Nutrition 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
235000019483 Peanut oil Nutrition 0.000 description 1
GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
235000019484 Rapeseed oil Nutrition 0.000 description 1
235000019485 Safflower oil Nutrition 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
235000005212 Terminalia tomentosa Nutrition 0.000 description 1
238000005299 abrasion Methods 0.000 description 1
239000000654 additive Substances 0.000 description 1
210000000577 adipose tissue Anatomy 0.000 description 1
238000005054 agglomeration Methods 0.000 description 1
230000002776 aggregation Effects 0.000 description 1
239000010775 animal oil Substances 0.000 description 1
239000012164 animal wax Substances 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
235000013871 bee wax Nutrition 0.000 description 1
239000012166 beeswax Substances 0.000 description 1
229940092738 beeswax Drugs 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
229960004365 benzoic acid Drugs 0.000 description 1
235000021028 berry Nutrition 0.000 description 1
230000008512 biological response Effects 0.000 description 1
230000001851 biosynthetic effect Effects 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229920001400 block copolymer Polymers 0.000 description 1
230000036765 blood level Effects 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
229960002645 boric acid Drugs 0.000 description 1
235000010338 boric acid Nutrition 0.000 description 1
239000007853 buffer solution Substances 0.000 description 1
230000008859 change Effects 0.000 description 1
239000012174 chinese wax Substances 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000001816 cooling Methods 0.000 description 1
235000005687 corn oil Nutrition 0.000 description 1
239000002285 corn oil Substances 0.000 description 1
235000012343 cottonseed oil Nutrition 0.000 description 1
239000002385 cottonseed oil Substances 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000006866 deterioration Effects 0.000 description 1
238000011161 development Methods 0.000 description 1
238000000113 differential scanning calorimetry Methods 0.000 description 1
238000009826 distribution Methods 0.000 description 1
230000000694 effects Effects 0.000 description 1
238000004945 emulsification Methods 0.000 description 1
238000005516 engineering process Methods 0.000 description 1
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
229940013317 fish oils Drugs 0.000 description 1
239000000499 gel Substances 0.000 description 1
239000001087 glyceryl triacetate Substances 0.000 description 1
235000013773 glyceryl triacetate Nutrition 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
238000000227 grinding Methods 0.000 description 1
239000012943 hotmelt Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
230000002209 hydrophobic effect Effects 0.000 description 1
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
239000007943 implant Substances 0.000 description 1
230000006872 improvement Effects 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
230000002427 irreversible effect Effects 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
150000002605 large molecules Chemical class 0.000 description 1
239000003077 lignite Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000000463 material Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
150000002736 metal compounds Chemical class 0.000 description 1
150000002739 metals Chemical class 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
239000012184 mineral wax Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
150000002790 naphthalenes Chemical class 0.000 description 1
239000005445 natural material Substances 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
231100000956 nontoxicity Toxicity 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000002540 palm oil Substances 0.000 description 1
239000006072 paste Substances 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
238000005453 pelletization Methods 0.000 description 1
239000012169 petroleum derived wax Substances 0.000 description 1
235000019381 petroleum wax Nutrition 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
229920000053 polysorbate 80 Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
WKEDVNSFRWHDNR-UHFFFAOYSA-N salicylanilide Chemical compound OC1=CC=CC=C1C(=O)NC1=CC=CC=C1 WKEDVNSFRWHDNR-UHFFFAOYSA-N 0.000 description 1
229950000975 salicylanilide Drugs 0.000 description 1
239000012266 salt solution Substances 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
239000012176 shellac wax Substances 0.000 description 1
235000002639 sodium chloride Nutrition 0.000 description 1
239000004317 sodium nitrate Substances 0.000 description 1
235000010344 sodium nitrate Nutrition 0.000 description 1
235000010288 sodium nitrite Nutrition 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
230000006641 stabilisation Effects 0.000 description 1
238000011105 stabilization Methods 0.000 description 1
238000007619 statistical method Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
238000003786 synthesis reaction Methods 0.000 description 1
239000003826 tablet Substances 0.000 description 1
239000003760 tallow Substances 0.000 description 1
238000010257 thawing Methods 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
229920001169 thermoplastic Polymers 0.000 description 1
239000004416 thermosoftening plastic Substances 0.000 description 1
230000036962 time dependent Effects 0.000 description 1
238000012546 transfer Methods 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
229960001947 tripalmitin Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/27—Growth hormone [GH], i.e. somatotropin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical & Material Sciences (AREA)
Epidemiology (AREA)
Endocrinology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Immunology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Manufacturing Of Micro-Capsules (AREA)

SK791-91A 1990-03-30 1991-03-25 Farmaceutický prípravok vo forme mikroguľôčok a sp SK279461B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/502,382 US5213810A (en)	1990-03-30	1990-03-30	Stable compositions for parenteral administration and method of making same

Publications (1)

Publication Number	Publication Date
SK279461B6 true SK279461B6 (sk)	1998-11-04

Family

ID=23997559

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK791-91A SK279461B6 (sk)	1990-03-30	1991-03-25	Farmaceutický prípravok vo forme mikroguľôčok a sp

Country Status (28)

Country	Link
US (1)	US5213810A (da)
EP (1)	EP0448930B1 (da)
JP (1)	JP2966564B2 (da)
KR (1)	KR0159778B1 (da)
CN (1)	CN1063941C (da)
AR (1)	AR248085A1 (da)
AT (1)	ATE106240T1 (da)
AU (1)	AU641994B2 (da)
BG (1)	BG60850B1 (da)
CA (1)	CA2039491C (da)
CZ (1)	CZ283053B6 (da)
DE (1)	DE69102176T2 (da)
DK (1)	DK0448930T3 (da)
ES (1)	ES2054380T3 (da)
FI (1)	FI101676B1 (da)
HU (1)	HU219584B (da)
IE (1)	IE65970B1 (da)
IL (1)	IL97145A (da)
MX (1)	MX172602B (da)
NO (1)	NO300717B1 (da)
NZ (1)	NZ237509A (da)
PL (1)	PL167692B1 (da)
PT (1)	PT97160B (da)
RO (1)	RO106191B1 (da)
RU (1)	RU2011377C1 (da)
SK (1)	SK279461B6 (da)
YU (1)	YU47650B (da)
ZA (1)	ZA912398B (da)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2086022T3 (es) *	1991-07-23	1996-06-16	American Cyanamid Co	Composiciones estables para administracion parenteral y su uso.
AU6029694A (en) *	1993-01-19	1994-08-15	Pharmacia P-L Biochemicals, Inc.	Storage and delivery of purified protein reagents with carrier wax
US5599660A (en) *	1993-01-19	1997-02-04	Pharmacia Biotech Inc.	Method and preparation for sequential delivery of wax-embedded, inactivated biological and chemical reagents
US5683720A (en) *	1994-10-28	1997-11-04	Fuisz Technologies Ltd.	Liquiflash particles and method of making same
US6083430A (en) *	1994-10-28	2000-07-04	Fuisz Technologies Ltd.	Method of preparing a dosage unit by direct tableting and product therefrom
DE69616167T2 (de) *	1995-06-29	2002-06-20	Societe Des Produits Nestle S.A., Vevey	Verfahren zur Verkapselung eines Kernmaterials mit einem Polymer durch Hochdruckbehandlung
WO1999013864A2 (en) *	1997-09-19	1999-03-25	Shire Laboratories, Inc.	Solid solution beadlet
AU2002300572B2 (en) *	1997-09-19	2004-11-25	Shire Laboratories, Inc.	Solid Solution Beadlet
US6117452A (en) *	1998-08-12	2000-09-12	Fuisz Technologies Ltd.	Fatty ester combinations
MXPA01011343A (es) *	1999-05-07	2002-06-04	Pharmasol Gmbh	Particulas de lipidos a base de mezclas de lipidos liquidos y solidos asi como procedimiento para su produccion.
KR20020011985A (ko) *	1999-05-07	2002-02-09	파르마솔 게엠베하	액상 및 고체상 지질 혼합물에 기초한 지질입자들 및 그의제조방법
CA2376202C (en) *	1999-06-07	2008-11-18	Byk Gulden Lomberg Chemische Fabrik Gmbh	Novel preparation and administration form comprising an acid-labile active compound
CN1164334C (zh) *	1999-08-18	2004-09-01	研究及应用科学协会股份有限公司	肽的缓释制剂
IES990700A2 (en) *	1999-08-18	2001-08-22	Kinerton Ltd	Process to make a sustained release formulation
CA2407154A1 (en)	2000-04-27	2001-11-01	Verion, Inc	Zero order release and temperature-controlled microcapsules and process for the preparation thereof
AU2001273028B2 (en) *	2000-06-26	2006-11-16	Dsm Ip Assets B.V.	Improved methods of incorporating polyunsaturated fatty acids in milk
JP2004509739A (ja)	2000-09-27	2004-04-02	ベリオン　インコーポレイテッド	即時水溶解性カプセルおよびその製法
EP1197207B1 (en) *	2000-10-10	2008-04-23	Wyeth Holdings Corporation	Stable compositions for parenteral administration
FR2852843B1 (fr)	2003-03-24	2008-05-23	Karim Ioualalen	Systeme galenique permettant le masquage du gout
ATE399536T1 (de) *	2003-12-04	2008-07-15	Pfizer Prod Inc	Verfahren zur herstellung von pharmazeutischen multiteilchenförmigen produkten
US6984403B2 (en) *	2003-12-04	2006-01-10	Pfizer Inc.	Azithromycin dosage forms with reduced side effects
CA2549225A1 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Spray-congeal process using an extruder for preparing multiparticulate crystalline drug compositions containing preferably a poloxamer and a glyceride
WO2005053639A2 (en) *	2003-12-04	2005-06-16	Pfizer Products Inc.	Controlled release multiparticulates formed with dissolution enhancers
CN1889931A (zh) *	2003-12-04	2007-01-03	辉瑞产品公司	利用挤压器制备优选含泊洛沙姆和甘油酯的多重粒子阿奇霉素组合物的喷雾－冻凝方法
EP1694304A2 (en) *	2003-12-04	2006-08-30	Pfizer Products Inc.	Azithromycin multiparticulate dosage forms by liquid-based processes
WO2005053652A1 (en)	2003-12-04	2005-06-16	Pfizer Products Inc.	Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0416534A (pt) *	2003-12-04	2007-01-09	Pfizer Prod Inc	composições multiparticuladas com estabilidade melhorada
US11246913B2 (en)	2005-02-03	2022-02-15	Intarcia Therapeutics, Inc.	Suspension formulation comprising an insulinotropic peptide
US8221809B2 (en) *	2006-06-22	2012-07-17	Martek Biosciences Corporation	Encapsulated labile compound compositions and methods of making the same
EP2049081B1 (en)	2006-08-09	2012-11-14	Intarcia Therapeutics, Inc.	Osmotic delivery systems and piston assemblies
HRP20130259T1 (hr)	2007-04-23	2013-04-30	Intarcia Therapeutics, Inc.	Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
DK2240155T3 (da)	2008-02-13	2012-09-17	Intarcia Therapeutics Inc	Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
KR101760953B1 (ko) *	2008-09-04	2017-07-24	아밀린 파마슈티칼스, 엘엘씨.	비-수성 담체를 이용한 서방성 제형물
JP5494957B2 (ja)	2009-06-11	2014-05-21	株式会社リコー	静電荷像現像用トナー、現像剤、画像形成方法及び画像形成装置
SMT201700583T1 (it)	2009-09-28	2018-01-11	Intarcia Therapeutics Inc	Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
US20120208755A1 (en)	2011-02-16	2012-08-16	Intarcia Therapeutics, Inc.	Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
US9364549B2 (en) *	2011-11-30	2016-06-14	Andreas Voigt	Hydrophobic drug-delivery material, method for manufacturing thereof and methods for delivery of a drug-delivery composition
US20160151286A1 (en) *	2013-05-29	2016-06-02	Therakine Biodelivery Gmbh	Hydrophilic Microparticles, Drug-Delivery Material, Method For Manufacturing Thereof And Methods For Delivery of A Drug-Delivery Composition
US9889085B1 (en)	2014-09-30	2018-02-13	Intarcia Therapeutics, Inc.	Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en)	2015-06-03	2021-02-23	Intarcia Therapeutics, Inc.	Implant placement and removal systems
RU2760007C2 (ru)	2016-05-16	2021-11-22	Интарсия Терапьютикс, Инк.	Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD860451S1 (en)	2016-06-02	2019-09-17	Intarcia Therapeutics, Inc.	Implant removal tool
USD840030S1 (en)	2016-06-02	2019-02-05	Intarcia Therapeutics, Inc.	Implant placement guide
CN110225762A (zh)	2017-01-03	2019-09-10	因塔西亚制药公司	包括glp-1受体激动剂的连续施用和药物的共同施用的方法
EP3927715A4 (en)	2019-02-21	2023-03-01	Chromadex, Inc.	Use of nicotinamide riboside, nicotinic acid riboside, reduced nicotinyl riboside compounds, and nicotinyl riboside compound derivatives in formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3147187A (en) *	1962-09-10	1964-09-01	Don Hall Lab	Sustained release pharmaceutical
CH637297A5 (fr) *	1978-12-05	1983-07-29	Nestle Sa	Microbille comprenant un microorganisme et son procede de fabrication.
JPS56140915A (en) *	1980-04-07	1981-11-04	Yamanouchi Pharmaceut Co Ltd	Pharmaceutical preparation for solid drug
US4331654A (en) *	1980-06-13	1982-05-25	Eli Lilly And Company	Magnetically-localizable, biodegradable lipid microspheres
DE3024416C2 (de) *	1980-06-28	1982-04-15	Gödecke AG, 1000 Berlin	Verfahren zur Herstellung von Arzneimitteln mit retardierter Wirkstoff-Freisetzung
US4666839A (en) *	1982-12-01	1987-05-19	Amgen	Methods and materials for obtaining microbial expression of polypeptides including bovine prolactin
US4452775A (en) *	1982-12-03	1984-06-05	Syntex (U.S.A.) Inc.	Cholesterol matrix delivery system for sustained release of macromolecules
US4603044A (en) *	1983-01-06	1986-07-29	Technology Unlimited, Inc.	Hepatocyte Directed Vesicle delivery system
US4568559A (en) *	1984-02-06	1986-02-04	Biotek, Inc.	Composite core coated microparticles and process of preparing same
US4568536A (en) *	1985-02-08	1986-02-04	Ethicon, Inc.	Controlled release of pharmacologically active agents from an absorbable biologically compatible putty-like composition
US4755387A (en) *	1985-03-21	1988-07-05	The Procter & Gamble Company	Therapeutic particles
DE3527356A1 (de) *	1985-07-31	1987-02-05	Degussa	Verfahren zur verbesserung der fruchtbarkeit von haustieren
SE462894B (sv) *	1985-10-28	1990-09-17	Biogram Ab	Mikrokapslar, foerfarande foer framstaellning daerav samt anvaendning
US4837381A (en) *	1986-08-11	1989-06-06	American Cyanamid Company	Compositions for parenteral administration and their use
US4911928A (en) *	1987-03-13	1990-03-27	Micro-Pak, Inc.	Paucilamellar lipid vesicles

1990
- 1990-03-30 US US07/502,382 patent/US5213810A/en not_active Expired - Lifetime
1991
- 1991-01-21 DK DK91100650.0T patent/DK0448930T3/da active
- 1991-01-21 DE DE69102176T patent/DE69102176T2/de not_active Expired - Fee Related
- 1991-01-21 EP EP91100650A patent/EP0448930B1/en not_active Expired - Lifetime
- 1991-01-21 AT AT91100650T patent/ATE106240T1/de not_active IP Right Cessation
- 1991-01-21 ES ES91100650T patent/ES2054380T3/es not_active Expired - Lifetime
- 1991-02-04 IL IL9714591A patent/IL97145A/en not_active IP Right Cessation
- 1991-02-20 MX MX024617A patent/MX172602B/es unknown
- 1991-02-26 BG BG93923A patent/BG60850B1/bg unknown
- 1991-02-27 RO RO147010A patent/RO106191B1/ro unknown
- 1991-02-28 CN CN91101315A patent/CN1063941C/zh not_active Expired - Fee Related
- 1991-03-20 NZ NZ237509A patent/NZ237509A/xx unknown
- 1991-03-25 RU SU914894793A patent/RU2011377C1/ru active
- 1991-03-25 CZ CS91791A patent/CZ283053B6/cs not_active IP Right Cessation
- 1991-03-25 SK SK791-91A patent/SK279461B6/sk not_active IP Right Cessation
- 1991-03-26 NO NO911228A patent/NO300717B1/no not_active IP Right Cessation
- 1991-03-27 AR AR91319349A patent/AR248085A1/es active
- 1991-03-27 PT PT97160A patent/PT97160B/pt active IP Right Grant
- 1991-03-27 JP JP3085921A patent/JP2966564B2/ja not_active Expired - Fee Related
- 1991-03-28 ZA ZA912398A patent/ZA912398B/xx unknown
- 1991-03-28 CA CA002039491A patent/CA2039491C/en not_active Expired - Lifetime
- 1991-03-28 FI FI911531A patent/FI101676B1/fi active
- 1991-03-28 AU AU73972/91A patent/AU641994B2/en not_active Ceased
- 1991-03-28 IE IE104191A patent/IE65970B1/en not_active IP Right Cessation
- 1991-03-28 PL PL91289657A patent/PL167692B1/pl not_active IP Right Cessation
- 1991-03-29 KR KR1019910005051A patent/KR0159778B1/ko not_active Expired - Fee Related
- 1991-03-29 HU HU054/91A patent/HU219584B/hu not_active IP Right Cessation
- 1991-03-29 YU YU57091A patent/YU47650B/sh unknown

Also Published As

Publication number	Publication date
FI101676B (fi)	1998-08-14
IL97145A0 (en)	1992-05-25
CZ283053B6 (cs)	1997-12-17
EP0448930B1 (en)	1994-06-01
FI911531A0 (fi)	1991-03-28
HK1000004A1 (en)	1997-10-03
EP0448930A1 (en)	1991-10-02
HU219584B (hu)	2001-05-28
KR910016322A (ko)	1991-11-05
YU47650B (sh)	1995-12-04
US5213810A (en)	1993-05-25
BG93923A (bg)	1993-12-24
DE69102176D1 (de)	1994-07-07
FI911531L (fi)	1991-10-01
HUT59834A (en)	1992-07-28
FI101676B1 (fi)	1998-08-14
KR0159778B1 (ko)	1998-12-01
AU641994B2 (en)	1993-10-07
IE65970B1 (en)	1995-11-29
RO106191B1 (ro)	1993-03-31
CN1063941C (zh)	2001-04-04
YU57091A (sh)	1994-01-20
DE69102176T2 (de)	1995-01-05
HU911054D0 (en)	1991-10-28
PL167692B1 (en)	1995-10-31
PT97160B (pt)	1998-07-31
MX172602B (es)	1993-01-03
NO911228L (no)	1991-10-01
BG60850B1 (bg)	1996-05-31
ES2054380T3 (es)	1994-08-01
ZA912398B (en)	1992-01-29
PT97160A (pt)	1991-11-29
JPH04221319A (ja)	1992-08-11
NO300717B1 (no)	1997-07-14
AU7397291A (en)	1991-10-03
NZ237509A (en)	1993-04-28
CA2039491A1 (en)	1991-10-01
CN1055293A (zh)	1991-10-16
NO911228D0 (no)	1991-03-26
IL97145A (en)	1996-06-18
AR248085A1 (es)	1995-06-30
RU2011377C1 (ru)	1994-04-30
CA2039491C (en)	2001-09-04
IE911041A1 (en)	1991-10-09
JP2966564B2 (ja)	1999-10-25
ATE106240T1 (de)	1994-06-15
PL289657A1 (en)	1992-01-13
DK0448930T3 (da)	1994-06-20

Legal Events

Date	Code	Title	Description
2010-12-07	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20101029

Publication	Publication Date	Title
SK279461B6 (sk)	1998-11-04	Farmaceutický prípravok vo forme mikroguľôčok a sp
US4837381A (en)	1989-06-06	Compositions for parenteral administration and their use
JP2571790B2 (ja)	1997-01-16	非経口投与のための組成物及びその使用
JP4642946B2 (ja)	2011-03-02	ゲル組成物および方法
JP3756512B2 (ja)	2006-03-15	徐放性タンパク質製剤
EP0278103B1 (en)	1992-10-28	Sustained release growth hormone compositions for parenteral administration and their use
HU196714B (en)	1989-01-30	Process for producing non-aqueous composition comprising somatotropin
SI9300468A (en)	1994-06-30	Injectable composition for the sustained release of biologically active compounds
KR20030023878A (ko)	2003-03-20	소마토트로핀의 지속적인 방출을 위한 계면활성제 함유비수성 제제들
AU596806B2 (en)	1990-05-17	Injectable semi-solid formulations
HK1000004B (en)	1997-10-03	Stable compositions for parenteral administration and method of making same
KR100329336B1 (ko)	2002-03-22	히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형
CN106456704A (zh)	2017-02-22	兽药组合物和其应用
JPH101440A (ja)	1998-01-06	徐放性非経口投与製剤およびその製造方法