SK279781B6 - Bolus s plynulým uvoľňovaním na orálne podanie pre - Google Patents

Bolus s plynulým uvoľňovaním na orálne podanie pre Download PDF

Info

Publication number: SK279781B6
Authority: SK; Slovakia
Prior art keywords: animals; bolus; methyloxime; weight; wax
Prior art date: 1989-02-28

Application number

SK904-90A

Other languages

English (en)

Slovak (sk)

Inventor

Irwin B. Wood

Richard B. Toothill

Joseph C. Dietz

Original Assignee

American Cyanamid Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-02-28

Filing date

1990-02-26

Publication date

1999-03-12

1990-02-26 Application filed by American Cyanamid Company filed Critical American Cyanamid Company

1999-03-12 Publication of SK279781B6 publication Critical patent/SK279781B6/sk

Links

238000013268 sustained release Methods 0.000 title claims abstract description 16
239000012730 sustained-release form Substances 0.000 title claims abstract description 16
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 claims abstract description 37
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims abstract description 22
239000010428 baryte Substances 0.000 claims abstract description 19
229910052601 baryte Inorganic materials 0.000 claims abstract description 19
206010061217 Infestation Diseases 0.000 claims abstract description 12
241000238631 Hexapoda Species 0.000 claims abstract description 11
241000282849 Ruminantia Species 0.000 claims abstract description 11
YQEMORVAKMFKLG-UHFFFAOYSA-N glycerine monostearate Natural products CCCCCCCCCCCCCCCCCC(=O)OC(CO)CO YQEMORVAKMFKLG-UHFFFAOYSA-N 0.000 claims abstract description 11
SVUQHVRAGMNPLW-UHFFFAOYSA-N glycerol monostearate Natural products CCCCCCCCCCCCCCCCC(=O)OCC(O)CO SVUQHVRAGMNPLW-UHFFFAOYSA-N 0.000 claims abstract description 11
244000000013 helminth Species 0.000 claims abstract description 8
230000002035 prolonged effect Effects 0.000 claims abstract description 5
241001465754 Metazoa Species 0.000 claims description 70
229910052788 barium Inorganic materials 0.000 claims description 5
DSAJWYNOEDNPEQ-UHFFFAOYSA-N barium atom Chemical compound [Ba] DSAJWYNOEDNPEQ-UHFFFAOYSA-N 0.000 claims description 5
239000010419 fine particle Substances 0.000 claims description 4
108010034145 Helminth Proteins Proteins 0.000 claims description 3
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
229910021653 sulphate ion Inorganic materials 0.000 claims 2
239000000203 mixture Substances 0.000 abstract description 35
239000004203 carnauba wax Substances 0.000 abstract description 2
235000013869 carnauba wax Nutrition 0.000 abstract description 2
230000000069 prophylactic effect Effects 0.000 abstract description 2
YNFMRVVYUVPIAN-AQUURSMBSA-N nemadectin Chemical compound C1[C@H](O)[C@H](C)[C@@H](C(/C)=C/C(C)C)O[C@]11O[C@H](C\C=C(C)\C[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 YNFMRVVYUVPIAN-AQUURSMBSA-N 0.000 abstract 2
YNFMRVVYUVPIAN-UHFFFAOYSA-N nemadectin alpha Natural products C1C(O)C(C)C(C(C)=CC(C)C)OC11OC(CC=C(C)CC(C)C=CC=C2C3(C(C(=O)O4)C=C(C)C(O)C3OC2)O)CC4C1 YNFMRVVYUVPIAN-UHFFFAOYSA-N 0.000 abstract 2
230000001418 larval effect Effects 0.000 abstract 1
230000003071 parasitic effect Effects 0.000 abstract 1
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 42
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 27
241000244206 Nematoda Species 0.000 description 22
238000011282 treatment Methods 0.000 description 18
239000001993 wax Substances 0.000 description 18
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 17
241000283690 Bos taurus Species 0.000 description 15
244000309466 calf Species 0.000 description 15
239000004480 active ingredient Substances 0.000 description 14
150000001875 compounds Chemical class 0.000 description 13
238000002347 injection Methods 0.000 description 13
239000007924 injection Substances 0.000 description 13
239000000463 material Substances 0.000 description 13
238000011156 evaluation Methods 0.000 description 12
238000000034 method Methods 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
241000238876 Acari Species 0.000 description 11
238000002360 preparation method Methods 0.000 description 11
LEHBURLTIWGHEM-UHFFFAOYSA-N pyridinium chlorochromate Chemical compound [O-][Cr](Cl)(=O)=O.C1=CC=[NH+]C=C1 LEHBURLTIWGHEM-UHFFFAOYSA-N 0.000 description 10
235000013601 eggs Nutrition 0.000 description 9
210000003608 fece Anatomy 0.000 description 8
238000003756 stirring Methods 0.000 description 8
PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 description 7
238000005266 casting Methods 0.000 description 7
235000019439 ethyl acetate Nutrition 0.000 description 7
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
HLFSDGLLUJUHTE-SNVBAGLBSA-N Levamisole Chemical compound C1([C@H]2CN3CCSC3=N2)=CC=CC=C1 HLFSDGLLUJUHTE-SNVBAGLBSA-N 0.000 description 6
241001674048 Phthiraptera Species 0.000 description 6
239000002054 inoculum Substances 0.000 description 6
239000010410 layer Substances 0.000 description 6
229960001614 levamisole Drugs 0.000 description 6
239000002245 particle Substances 0.000 description 6
238000005453 pelletization Methods 0.000 description 6
229910052938 sodium sulfate Inorganic materials 0.000 description 6
235000011152 sodium sulphate Nutrition 0.000 description 6
239000000725 suspension Substances 0.000 description 6
238000005481 NMR spectroscopy Methods 0.000 description 5
238000002474 experimental method Methods 0.000 description 5
238000004128 high performance liquid chromatography Methods 0.000 description 5
239000011159 matrix material Substances 0.000 description 5
238000002844 melting Methods 0.000 description 5
230000008018 melting Effects 0.000 description 5
238000011321 prophylaxis Methods 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
208000021017 Weight Gain Diseases 0.000 description 4
230000003628 erosive effect Effects 0.000 description 4
238000011049 filling Methods 0.000 description 4
238000004949 mass spectrometry Methods 0.000 description 4
238000002156 mixing Methods 0.000 description 4
229910052757 nitrogen Inorganic materials 0.000 description 4
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 4
239000008188 pellet Substances 0.000 description 4
239000006187 pill Substances 0.000 description 4
239000000047 product Substances 0.000 description 4
230000002829 reductive effect Effects 0.000 description 4
230000004584 weight gain Effects 0.000 description 4
235000019786 weight gain Nutrition 0.000 description 4
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
241000257176 Hypoderma <fly> Species 0.000 description 3
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
238000004458 analytical method Methods 0.000 description 3
238000006243 chemical reaction Methods 0.000 description 3
239000013058 crude material Substances 0.000 description 3
238000000855 fermentation Methods 0.000 description 3
230000004151 fermentation Effects 0.000 description 3
239000000945 filler Substances 0.000 description 3
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 3
239000004615 ingredient Substances 0.000 description 3
238000001746 injection moulding Methods 0.000 description 3
239000000155 melt Substances 0.000 description 3
239000000843 powder Substances 0.000 description 3
239000007787 solid Substances 0.000 description 3
239000000243 solution Substances 0.000 description 3
230000001629 suppression Effects 0.000 description 3
201000001064 tick infestation Diseases 0.000 description 3
RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
239000004375 Dextrin Substances 0.000 description 2
229920001353 Dextrin Polymers 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
241000047428 Halter Species 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
230000000507 anthelmentic effect Effects 0.000 description 2
230000005540 biological transmission Effects 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
239000004927 clay Substances 0.000 description 2
238000007906 compression Methods 0.000 description 2
230000006835 compression Effects 0.000 description 2
235000019425 dextrin Nutrition 0.000 description 2
238000009472 formulation Methods 0.000 description 2
230000002496 gastric effect Effects 0.000 description 2
244000045947 parasite Species 0.000 description 2
NQLVQOSNDJXLKG-UHFFFAOYSA-N prosulfocarb Chemical compound CCCN(CCC)C(=O)SCC1=CC=CC=C1 NQLVQOSNDJXLKG-UHFFFAOYSA-N 0.000 description 2
239000008247 solid mixture Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
BCNZYOJHNLTNEZ-UHFFFAOYSA-N tert-butyldimethylsilyl chloride Chemical compound CC(C)(C)[Si](C)(C)Cl BCNZYOJHNLTNEZ-UHFFFAOYSA-N 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
-1 7-8% Inorganic materials 0.000 description 1
206010063409 Acarodermatitis Diseases 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 1
229920001817 Agar Polymers 0.000 description 1
244000180278 Copernicia prunifera Species 0.000 description 1
235000010919 Copernicia prunifera Nutrition 0.000 description 1
229920000742 Cotton Polymers 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
239000004471 Glycine Substances 0.000 description 1
229910004373 HOAc Inorganic materials 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
238000011887 Necropsy Methods 0.000 description 1
241001237728 Precis Species 0.000 description 1
201000004681 Psoriasis Diseases 0.000 description 1
241001649230 Psoroptes ovis Species 0.000 description 1
206010039509 Scab Diseases 0.000 description 1
241000447727 Scabies Species 0.000 description 1
229910004298 SiO 2 Inorganic materials 0.000 description 1
241000970253 Streptomyces cyaneogriseus Species 0.000 description 1
239000002253 acid Substances 0.000 description 1
150000007513 acids Chemical class 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
239000008272 agar Substances 0.000 description 1
229910000323 aluminium silicate Inorganic materials 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
238000010171 animal model Methods 0.000 description 1
239000000921 anthelmintic agent Substances 0.000 description 1
239000010426 asphalt Substances 0.000 description 1
238000003556 assay Methods 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical class CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 1
230000003115 biocidal effect Effects 0.000 description 1
230000037396 body weight Effects 0.000 description 1
238000009395 breeding Methods 0.000 description 1
230000001488 breeding effect Effects 0.000 description 1
229940041514 candida albicans extract Drugs 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000013270 controlled release Methods 0.000 description 1
238000001816 cooling Methods 0.000 description 1
239000012043 crude product Substances 0.000 description 1
238000000354 decomposition reaction Methods 0.000 description 1
239000008121 dextrose Substances 0.000 description 1
AIUDWMLXCFRVDR-UHFFFAOYSA-N dimethyl 2-(3-ethyl-3-methylpentyl)propanedioate Chemical compound CCC(C)(CC)CCC(C(=O)OC)C(=O)OC AIUDWMLXCFRVDR-UHFFFAOYSA-N 0.000 description 1
HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
238000009826 distribution Methods 0.000 description 1
239000003814 drug Substances 0.000 description 1
229940079593 drug Drugs 0.000 description 1
210000005069 ears Anatomy 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
239000003480 eluent Substances 0.000 description 1
239000002024 ethyl acetate extract Substances 0.000 description 1
239000000284 extract Substances 0.000 description 1
239000000706 filtrate Substances 0.000 description 1
230000003311 flocculating effect Effects 0.000 description 1
235000013305 food Nutrition 0.000 description 1
239000008187 granular material Substances 0.000 description 1
238000000227 grinding Methods 0.000 description 1
230000005802 health problem Effects 0.000 description 1
244000309465 heifer Species 0.000 description 1
235000008216 herbs Nutrition 0.000 description 1
RCBVKBFIWMOMHF-UHFFFAOYSA-L hydroxy-(hydroxy(dioxo)chromio)oxy-dioxochromium;pyridine Chemical compound C1=CC=NC=C1.C1=CC=NC=C1.O[Cr](=O)(=O)O[Cr](O)(=O)=O RCBVKBFIWMOMHF-UHFFFAOYSA-L 0.000 description 1
239000005457 ice water Substances 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
229910052500 inorganic mineral Inorganic materials 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
238000002955 isolation Methods 0.000 description 1
230000002147 killing effect Effects 0.000 description 1
230000000670 limiting effect Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
239000000401 methanolic extract Substances 0.000 description 1
239000011707 mineral Substances 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
239000012044 organic layer Substances 0.000 description 1
238000002559 palpation Methods 0.000 description 1
238000002953 preparative HPLC Methods 0.000 description 1
230000002265 prevention Effects 0.000 description 1
230000003449 preventive effect Effects 0.000 description 1
238000004064 recycling Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
210000004767 rumen Anatomy 0.000 description 1
229920006395 saturated elastomer Polymers 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
208000005687 scabies Diseases 0.000 description 1
238000007790 scraping Methods 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000011877 solvent mixture Substances 0.000 description 1
241000894007 species Species 0.000 description 1
239000007858 starting material Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
238000005979 thermal decomposition reaction Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
230000000007 visual effect Effects 0.000 description 1
238000011179 visual inspection Methods 0.000 description 1
230000003442 weekly effect Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0068—Rumen, e.g. rumen bolus
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Bioinformatics & Cheminformatics (AREA)
Tropical Medicine & Parasitology (AREA)
Communicable Diseases (AREA)
Nutrition Science (AREA)
Physiology (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Fodder In General (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Control Of Positive-Displacement Air Blowers (AREA)
Supercharger (AREA)
Control Of Turbines (AREA)

SK904-90A 1989-02-28 1990-02-26 Bolus s plynulým uvoľňovaním na orálne podanie pre SK279781B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US31662589A	1989-02-28	1989-02-28

Publications (1)

Publication Number	Publication Date
SK279781B6 true SK279781B6 (sk)	1999-03-12

Family

ID=23229886

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK904-90A SK279781B6 (sk)	1989-02-28	1990-02-26	Bolus s plynulým uvoľňovaním na orálne podanie pre

Country Status (20)

Country	Link
EP (1)	EP0385106B1 (ja)
JP (2)	JP3033965B2 (ja)
KR (1)	KR0160976B1 (ja)
CN (1)	CN1035986C (ja)
AT (1)	ATE103173T1 (ja)
AU (1)	AU626992B2 (ja)
CA (1)	CA2010934C (ja)
CZ (1)	CZ283055B6 (ja)
DE (1)	DE69007515T2 (ja)
DK (1)	DK0385106T3 (ja)
ES (1)	ES2062118T3 (ja)
HU (1)	HU206180B (ja)
IE (1)	IE64562B1 (ja)
IL (1)	IL93226A (ja)
NZ (1)	NZ232607A (ja)
PL (1)	PL163922B1 (ja)
RU (1)	RU2014832C1 (ja)
SK (1)	SK279781B6 (ja)
UA (1)	UA37173C2 (ja)
ZA (1)	ZA901497B (ja)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4876552A (en) *	1988-04-27	1989-10-24	Motorola, Inc.	Internally mounted broadband antenna
MX9200339A (es) *	1991-01-28	1992-08-01	Hoechst Ag	Preparado para la liberacion controlada de sustancias activas, que son apropiadas como terapeuticos o para mejorar el crecimiento y el aprovechamiento de los piensos en rumiantes
ATE134873T1 (de) *	1991-07-23	1996-03-15	American Cyanamid Co	Stabile zusammensetzungen für parenterale verabrechung und ihre verwendung
EP0739198B1 (en) *	1994-01-20	2003-09-17	Agresearch Limited	Device for administration of beneficial materials to ruminants
AU2540495A (en) *	1994-06-10	1996-01-05	Fernz Corporation Limited	Biodegradable sustained release composition
CN1099283C (zh) *	1997-05-28	2003-01-22	内蒙古巴彦淖尔盟畜牧兽医科学研究所	缓释丸及其制剂
DE10032878A1 (de) *	2000-07-06	2002-01-17	Bayer Ag	Anthelmintika zur Verhinderung von parasitären Infektionen bei Mensch und Tier
KR100464592B1 (ko) *	2001-04-13	2004-12-31	주식회사 한국팜비오	포타슘시트레이트를 함유한 왁스 매트릭스 타입의 정제와그의 조성물
US6892127B2 (en) *	2003-02-28	2005-05-10	General Electric Company	Methods and apparatus for assessing gas turbine engine damage
CN104277050B (zh) *	2013-07-04	2016-05-04	北大方正集团有限公司	一种制备莫西克汀的方法
US11529310B2 (en)	2020-12-08	2022-12-20	Ruminant Biotech Corp Limited	Devices and methods for delivery of substances to animals

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ204074A (en) *	1982-05-10	1986-05-09	Merck & Co Inc	Synergistic compositions containing avermectins
DE3519834C2 (de) *	1984-06-05	1993-12-16	American Cyanamid Co	Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
ATE66600T1 (de) *	1986-03-10	1991-09-15	American Cyanamid Co	Verfahren zur herstellung einer bolusformulierung mit verzoegerter freisetzung.
DE3782481T2 (de) *	1986-09-12	1993-05-19	American Cyanamid Co	23-deoxy-derivate von ll-f28249-verbindungen.
ATE109783T1 (de) *	1986-09-12	1994-08-15	American Cyanamid Co	23-oxo(keto) und 23-imino-derivate von ll-f28249- verbindungen.
US4886829A (en) *	1987-03-06	1989-12-12	American Cyanamid Company	23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds

1990
- 1990-01-25 AT AT90101483T patent/ATE103173T1/de not_active IP Right Cessation
- 1990-01-25 DK DK90101483.7T patent/DK0385106T3/da active
- 1990-01-25 EP EP90101483A patent/EP0385106B1/en not_active Expired - Lifetime
- 1990-01-25 ES ES90101483T patent/ES2062118T3/es not_active Expired - Lifetime
- 1990-01-25 DE DE69007515T patent/DE69007515T2/de not_active Expired - Fee Related
- 1990-01-30 IL IL9322690A patent/IL93226A/en not_active IP Right Cessation
- 1990-02-20 NZ NZ232607A patent/NZ232607A/xx unknown
- 1990-02-21 CN CN90100954A patent/CN1035986C/zh not_active Expired - Fee Related
- 1990-02-26 CZ CS90904A patent/CZ283055B6/cs not_active IP Right Cessation
- 1990-02-26 CA CA002010934A patent/CA2010934C/en not_active Expired - Fee Related
- 1990-02-26 SK SK904-90A patent/SK279781B6/sk unknown
- 1990-02-26 AU AU50522/90A patent/AU626992B2/en not_active Expired
- 1990-02-27 RU SU904743484A patent/RU2014832C1/ru active
- 1990-02-27 ZA ZA901497A patent/ZA901497B/xx unknown
- 1990-02-27 IE IE69990A patent/IE64562B1/en not_active IP Right Cessation
- 1990-02-27 UA UA4743484A patent/UA37173C2/uk unknown
- 1990-02-27 KR KR1019900002534A patent/KR0160976B1/ko not_active Expired - Fee Related
- 1990-02-27 JP JP2047118A patent/JP3033965B2/ja not_active Expired - Lifetime
- 1990-02-27 JP JP2047096A patent/JP2563139B2/ja not_active Expired - Fee Related
- 1990-02-28 HU HU901185A patent/HU206180B/hu not_active IP Right Cessation
- 1990-02-28 PL PL90284064A patent/PL163922B1/pl unknown

Also Published As

Publication number	Publication date
HU206180B (en)	1992-09-28
JPH02267351A (ja)	1990-11-01
CN1035986C (zh)	1997-10-01
JP3033965B2 (ja)	2000-04-17
HU901185D0 (en)	1990-05-28
DK0385106T3 (da)	1994-04-11
EP0385106A1 (en)	1990-09-05
ATE103173T1 (de)	1994-04-15
AU5052290A (en)	1990-09-06
CN1045228A (zh)	1990-09-12
CA2010934C (en)	2001-03-13
RU2014832C1 (ru)	1994-06-30
KR910015289A (ko)	1991-09-30
CZ283055B6 (cs)	1997-12-17
NZ232607A (en)	1993-05-26
PL284064A1 (en)	1991-05-06
AU626992B2 (en)	1992-08-13
IL93226A (en)	1994-02-27
JP2563139B2 (ja)	1996-12-11
IE64562B1 (en)	1995-08-23
IE900699L (en)	1990-08-28
ZA901497B (en)	1990-11-28
PL163922B1 (pl)	1994-05-31
CS9000904A2 (en)	1991-08-13
EP0385106B1 (en)	1994-03-23
DE69007515D1 (de)	1994-04-28
ES2062118T3 (es)	1994-12-16
JPH02268115A (ja)	1990-11-01
HUT53287A (en)	1990-10-28
UA37173C2 (uk)	2001-05-15
CA2010934A1 (en)	1990-08-31
IL93226A0 (en)	1990-11-05
KR0160976B1 (ko)	1998-12-01
DE69007515T2 (de)	1994-11-03

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KR101687973B1 (ko)	2016-12-21	마이크로필름 코팅을 이용한 동물 사료용 프리믹스 제조방법
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KR20000022446A (ko)	2000-04-25	버지니아마이신 혼합물
DE2618269A1 (de)	1977-11-17	Mittel zur oralen verabreichung an haustiere ohne zellulose-verdauung im pansen
US3812255A (en)	1974-05-21	Methods and compositions for improving the feed intake of meat producing animals
CZ435198A3 (cs)	2000-01-12	Virginiamycinová směs, jádrové krmivo a způsob jeho ošetření
CA1217430A (en)	1987-02-03	Anthelmintics
DD247601A1 (de)	1987-07-15	Futtermittelmischung
Bosman	1966	A comparison of sheep worm dosing routines, as adjudged by wool production, and bodyweight changes
IE832793L (en)	1985-05-28	Synergistic anthelmintic composition.
EP0750846A1 (de)	1997-01-02	Verwendung von Balhimycin zur Leistungssteigerung bei Tieren sowie leistungssteigernde Mittel
HU217086B (hu)	2000-02-28	Mikroelemeket és féreghajtó benzimidazolszármazékot tartalmazó állatgyógyászati készítmény, és eljárás előállítására
BG97845A (bg)	1994-06-30	Медикаментозен премикс
CH657048A5 (en)	1986-08-15	Composition for controlling single-celled organisms which produce enzymes which cleave amino acids