SK282649B6 - Protilátka proti CD44v6, hybridómová bunková línia, molekula protilátky a jej použitie - Google Patents

Protilátka proti CD44v6, hybridómová bunková línia, molekula protilátky a jej použitie Download PDF

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Publication number
SK282649B6
SK282649B6 SK1548-96A SK154896A SK282649B6 SK 282649 B6 SK282649 B6 SK 282649B6 SK 154896 A SK154896 A SK 154896A SK 282649 B6 SK282649 B6 SK 282649B6
Authority
SK
Slovakia
Prior art keywords
antibody
vff
antibodies
binding
cell line
Prior art date
Application number
SK1548-96A
Other languages
English (en)
Slovak (sk)
Other versions
SK154896A3 (en
Inventor
G�Nther R. Adolf
Erik Patzelt
Original Assignee
Boehringer Ingelheim International Gmbh
Forschungszentrum Karlsruhe Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19944431297 external-priority patent/DE4431297A1/de
Application filed by Boehringer Ingelheim International Gmbh, Forschungszentrum Karlsruhe Gmbh filed Critical Boehringer Ingelheim International Gmbh
Publication of SK154896A3 publication Critical patent/SK154896A3/sk
Publication of SK282649B6 publication Critical patent/SK282649B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70585—CD44
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2884—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD44
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C12N5/12—Fused cells, e.g. hybridomas
    • C12N5/16—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SK1548-96A 1994-06-08 1995-06-02 Protilátka proti CD44v6, hybridómová bunková línia, molekula protilátky a jej použitie SK282649B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE4419913 1994-06-08
DE19944431297 DE4431297A1 (de) 1994-09-02 1994-09-02 Monoklonaler Antikörper gegen CD44v6
PCT/EP1995/002126 WO1995033771A1 (de) 1994-06-08 1995-06-02 MONOKLONALER ANTIKÖRPER GEGEN CD44v6

Publications (2)

Publication Number Publication Date
SK154896A3 SK154896A3 (en) 1997-08-06
SK282649B6 true SK282649B6 (sk) 2002-10-08

Family

ID=25937246

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1548-96A SK282649B6 (sk) 1994-06-08 1995-06-02 Protilátka proti CD44v6, hybridómová bunková línia, molekula protilátky a jej použitie

Country Status (27)

Country Link
US (1) US5916561A (cs)
EP (1) EP0765343B1 (cs)
JP (2) JP3387929B2 (cs)
KR (2) KR100379217B1 (cs)
CN (1) CN1125083C (cs)
AT (1) ATE197592T1 (cs)
BG (1) BG64181B1 (cs)
BR (1) BR9507964A (cs)
CA (1) CA2192370A1 (cs)
CO (1) CO4410258A1 (cs)
CZ (1) CZ291274B6 (cs)
DE (1) DE59508864D1 (cs)
DK (1) DK0765343T3 (cs)
ES (1) ES2151603T3 (cs)
FI (1) FI964845L (cs)
GR (1) GR3035388T3 (cs)
HU (1) HU220168B (cs)
NO (1) NO317948B1 (cs)
NZ (1) NZ288224A (cs)
PL (1) PL190897B1 (cs)
PT (1) PT765343E (cs)
RO (1) RO118753B1 (cs)
RU (1) RU2204606C2 (cs)
SI (1) SI0765343T1 (cs)
SK (1) SK282649B6 (cs)
UA (1) UA58482C2 (cs)
WO (1) WO1995033771A1 (cs)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY24389A1 (es) * 1995-12-06 2001-10-25 Karlsruhe Forschzent Composición farmacéutica para el tratamiento de carcinoma de epitelio plano
EP0881299A4 (en) 1996-02-15 2004-12-15 Chugai Seiyakukabushiki Kaisha MONOCLONAL ANTIBODY THAT RECOGNIZES ANTIGENS ON THE SURFACE OF ENDOTHEL CELLS FROM TUMOR SUPPLYING BLOOD VESSELS.
DE19648209A1 (de) * 1996-11-21 1998-05-28 Boehringer Ingelheim Int Verfahren zur Tumorzelldepletion CD34-positiver Zellen
DE19708713C2 (de) * 1997-03-04 2002-11-28 Boehringer Ingelheim Int Verwendung von anti-CD44 Antikörpern enthaltenden Präparationen zur Behandlung bestimmter Tumore und zur Unterdrückung von Immunreaktionen
ATE369425T1 (de) * 1998-06-08 2007-08-15 Fuso Pharmaceutical Ind Antikörper gegen eine lar-phosphatase untereinheit
DE69939742D1 (de) * 1998-07-10 2008-11-27 Fuso Pharmaceutical Ind Antikörper gegen intrazelluläre domänen der protein tyrosin phosphatase
US20080124327A1 (en) * 1999-10-08 2008-05-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7947496B2 (en) * 1999-10-08 2011-05-24 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20090004103A1 (en) * 1999-10-08 2009-01-01 Young David S F Cytotoxicity mediation of cells evidencing surface expression of CD44
US8071072B2 (en) * 1999-10-08 2011-12-06 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US7189397B2 (en) * 1999-10-08 2007-03-13 Arius Research Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US8048416B2 (en) 1999-10-08 2011-11-01 Hoffmann-La Roche Inc. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20050100542A1 (en) * 1999-10-08 2005-05-12 Young David S. Cytotoxicity mediation of cells evidencing surface expression of CD44
US20030103985A1 (en) * 2001-05-18 2003-06-05 Boehringer Ingelheim International Gmbh Cytotoxic CD44 antibody immunoconjugates
US6972324B2 (en) 2001-05-18 2005-12-06 Boehringer Ingelheim Pharmaceuticals, Inc. Antibodies specific for CD44v6
PL365735A1 (en) * 2001-05-18 2005-01-10 Boehringer Ingelheim International Gmbh Antibodies specific for cd44v6
JP4580646B2 (ja) * 2001-08-24 2010-11-17 アンギチア エービー 新薬
US20040126379A1 (en) * 2002-08-21 2004-07-01 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and chemotherapeutic agents
US20040110933A1 (en) * 2002-09-13 2004-06-10 Dyax Corporation CD44-binding ligands
US20040120949A1 (en) * 2002-11-08 2004-06-24 Boehringer Ingelheim International Gmbh Compositions and methods for treating cancer using cytotoxic CD44 antibody immunoconjugates and radiotherapy
US20060140963A1 (en) * 2003-04-14 2006-06-29 Arius Research, Inc. Cytotoxicity mediation of cells evidencing surface expression of CD59
EP1806365A1 (en) 2006-01-05 2007-07-11 Boehringer Ingelheim International GmbH Antibody molecules specific for fibroblast activation protein and immunoconjugates containing them
EP2266593A1 (en) 2009-06-24 2010-12-29 Karlsruher Institut für Technologie Use of CD44v6 in the treatment of ophthalmic diseases
EA032728B1 (ru) * 2009-08-19 2019-07-31 Мерк Патент Гмбх Антитела для выявления комплексов интегрина в ffpe материале
CN102337298B (zh) * 2011-08-19 2013-11-06 黄开红 一种输送siRNA的免疫纳米载体及其制备方法和应用
EP2886126B1 (en) 2013-12-23 2017-06-07 Exchange Imaging Technologies GmbH Nanoparticle conjugated to CD44 binding peptides
AU2018409898A1 (en) * 2018-02-22 2020-09-24 Multitude Inc. Therapeutic antibody and uses thereof
CN109593125A (zh) * 2018-12-12 2019-04-09 深圳市龙华区人民医院 基于前列腺癌干细胞标志物cd44的抗原表位多肽cd44-p1及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2149635A1 (en) * 1992-11-20 1994-06-09 David Tarin Peptide corresponding to cd44 exon 6, antibodies specific for said peptide and use of these antibodies for diagnosis of tumors
EP0703989B1 (en) * 1993-06-18 1997-11-05 Oy Biotie Therapies COMPOSITIONS AND DIAGNOSTIC METHODS USING MONOCLONAL ANTIBODIES AGAINST CD44v6
EP0767380A1 (de) * 1993-06-22 1997-04-09 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Verfahren zur Diagnose und Analyse von Zervixkarzinomen

Also Published As

Publication number Publication date
CN1125083C (zh) 2003-10-22
DK0765343T3 (da) 2000-12-27
NZ288224A (en) 1999-04-29
RO118753B1 (ro) 2003-10-30
JP3387929B2 (ja) 2003-03-17
NO965239D0 (no) 1996-12-06
EP0765343A1 (de) 1997-04-02
HU220168B (hu) 2001-11-28
GR3035388T3 (en) 2001-05-31
KR970703368A (ko) 1997-07-03
CA2192370A1 (en) 1995-12-14
BG64181B1 (bg) 2004-03-31
HK1011697A1 (en) 1999-07-16
FI964845A0 (fi) 1996-12-04
AU701885B2 (en) 1999-02-11
BR9507964A (pt) 1997-09-02
RU2204606C2 (ru) 2003-05-20
CN1152925A (zh) 1997-06-25
FI964845A7 (fi) 1996-12-04
HU9603387D0 (en) 1997-01-28
KR100379217B1 (ko) 2003-06-11
PL317536A1 (en) 1997-04-14
CZ359196A3 (en) 1997-11-12
BG101024A (bg) 1997-09-30
PT765343E (pt) 2001-02-28
CO4410258A1 (es) 1997-01-09
SI0765343T1 (en) 2001-02-28
ATE197592T1 (de) 2000-12-15
US5916561A (en) 1999-06-29
UA58482C2 (uk) 2003-08-15
NO965239L (no) 1996-12-06
WO1995033771A1 (de) 1995-12-14
DE59508864D1 (de) 2000-12-21
SK154896A3 (en) 1997-08-06
EP0765343B1 (de) 2000-11-15
JPH10501797A (ja) 1998-02-17
HUT76260A (en) 1997-07-28
ES2151603T3 (es) 2001-01-01
FI964845L (fi) 1996-12-04
CZ291274B6 (cs) 2003-01-15
NO317948B1 (no) 2005-01-10
AU2737095A (en) 1996-01-04
PL190897B1 (pl) 2006-02-28
JP2003034700A (ja) 2003-02-07

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