SK282944B6 - Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie - Google Patents

Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie Download PDF

Info

Publication number: SK282944B6
Authority: SK; Slovakia
Prior art keywords: dichlorophenyl; azatricyclo; alkyl; tricyclo; decan
Prior art date: 1995-11-02

Application number

SK422-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK42298A3 (en

Inventor

Jorgen Scheel-Kr�Ger

Gunnar M. Olsen

Elsebet Ostergaard Nielsen

Bjarne Hugo Dahl

Leif Helh Jensen

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-11-02

Filing date

1996-11-04

Publication date

2003-01-09

1996-11-04 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

1998-10-07 Publication of SK42298A3 publication Critical patent/SK42298A3/sk

2003-01-09 Publication of SK282944B6 publication Critical patent/SK282944B6/sk

Links

150000003813 tropane derivatives Chemical class 0.000 title claims description 7
239000003901 neurotransmitter uptake inhibitor Substances 0.000 title description 3
150000001875 compounds Chemical class 0.000 claims abstract description 75
239000000203 mixture Substances 0.000 claims abstract description 31
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 18
239000001257 hydrogen Substances 0.000 claims abstract description 18
125000000217 alkyl group Chemical group 0.000 claims abstract description 17
150000003839 salts Chemical class 0.000 claims abstract description 16
239000002858 neurotransmitter agent Substances 0.000 claims abstract description 13
150000002431 hydrogen Chemical class 0.000 claims abstract description 9
229910052736 halogen Inorganic materials 0.000 claims abstract description 8
150000002367 halogens Chemical class 0.000 claims abstract description 8
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 7
229910052760 oxygen Inorganic materials 0.000 claims abstract description 6
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 5
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 5
125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
150000001204 N-oxides Chemical class 0.000 claims abstract description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 3
125000001424 substituent group Chemical group 0.000 claims abstract description 3
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125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 2
125000004189 3,4-dichlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(Cl)C([H])=C1* 0.000 claims description 106
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125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 33
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
JDPQWHLMBJZURR-UHFFFAOYSA-N decan-5-one Chemical compound CCCCCC(=O)CCCC JDPQWHLMBJZURR-UHFFFAOYSA-N 0.000 claims description 20
238000002360 preparation method Methods 0.000 claims description 19
208000035475 disorder Diseases 0.000 claims description 16
SZMNDOUFZGODBR-UHFFFAOYSA-N decan-5-ol Chemical compound CCCCCC(O)CCCC SZMNDOUFZGODBR-UHFFFAOYSA-N 0.000 claims description 15
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract description 2
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125000000304 alkynyl group Chemical group 0.000 abstract 6
125000003710 aryl alkyl group Chemical group 0.000 abstract 4
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QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 1
PRQICMQRAXJOCP-ZHZAVPAVSA-N methyl (1r,3s,5r)-3-(4-chlorophenyl)-8-azabicyclo[3.2.1]octane-4-carboxylate Chemical compound C1([C@@H]2C([C@@]3([H])CC[C@@](N3)(C2)[H])C(=O)OC)=CC=C(Cl)C=C1 PRQICMQRAXJOCP-ZHZAVPAVSA-N 0.000 description 1
FZXFNVPTYNGFCH-DODZYUBVSA-N methyl (1s,3s,4r,5r)-3-(4-chlorophenyl)-8-(3-ethoxy-3-oxopropyl)-8-azabicyclo[3.2.1]octane-4-carboxylate Chemical compound C1([C@@H]2[C@H]([C@]3(CC[C@@](C2)(N3CCC(=O)OCC)[H])[H])C(=O)OC)=CC=C(Cl)C=C1 FZXFNVPTYNGFCH-DODZYUBVSA-N 0.000 description 1
206010027599 migraine Diseases 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
235000019426 modified starch Nutrition 0.000 description 1
230000000407 monoamine reuptake Effects 0.000 description 1
239000002324 mouth wash Substances 0.000 description 1
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
KVBGVZZKJNLNJU-UHFFFAOYSA-N naphthalene-2-sulfonic acid Chemical compound C1=CC=CC2=CC(S(=O)(=O)O)=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-N 0.000 description 1
201000003631 narcolepsy Diseases 0.000 description 1
235000021096 natural sweeteners Nutrition 0.000 description 1
210000001640 nerve ending Anatomy 0.000 description 1
230000007372 neural signaling Effects 0.000 description 1
230000001722 neurochemical effect Effects 0.000 description 1
239000006186 oral dosage form Substances 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000006408 oxalic acid Nutrition 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000006201 parenteral dosage form Substances 0.000 description 1
229960002296 paroxetine Drugs 0.000 description 1
239000006072 paste Substances 0.000 description 1
235000010603 pastilles Nutrition 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-M perchlorate Inorganic materials [O-]Cl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-M 0.000 description 1
VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
230000001242 postsynaptic effect Effects 0.000 description 1
206010036596 premature ejaculation Diseases 0.000 description 1
230000002335 preservative effect Effects 0.000 description 1
230000003518 presynaptic effect Effects 0.000 description 1
239000003380 propellant Substances 0.000 description 1
230000000069 prophylactic effect Effects 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
238000006798 ring closing metathesis reaction Methods 0.000 description 1
YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
229960001860 salicylate Drugs 0.000 description 1
230000000862 serotonergic effect Effects 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
208000019116 sleep disease Diseases 0.000 description 1
235000015424 sodium Nutrition 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
208000011117 substance-related disease Diseases 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
GGUBFICZYGKNTD-UHFFFAOYSA-N triethyl phosphonoacetate Chemical compound CCOC(=O)CP(=O)(OCC)OCC GGUBFICZYGKNTD-UHFFFAOYSA-N 0.000 description 1
WENNKWXPAWNIOO-UHFFFAOYSA-N undecan-5-one Chemical compound CCCCCCC(=O)CCCC WENNKWXPAWNIOO-UHFFFAOYSA-N 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
239000011345 viscous material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Ultra Sonic Daignosis Equipment (AREA)
Exhaust Gas After Treatment (AREA)

SK422-98A 1995-11-02 1996-11-04 Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie SK282944B6 (sk)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK122395		1995-11-02
DK14696		1996-02-13
PCT/EP1996/004793 WO1997016451A1 (en)	1995-11-02	1996-11-04	Fused tropane-derivatives as neurotransmitter reuptake inhibitors

Publications (2)

Publication Number	Publication Date
SK42298A3 SK42298A3 (en)	1998-10-07
SK282944B6 true SK282944B6 (sk)	2003-01-09

Family

ID=26063395

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK422-98A SK282944B6 (sk)	1995-11-02	1996-11-04	Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie

Country Status (24)

Country	Link
US (1)	US5998405A (et)
EP (1)	EP0858461B1 (et)
JP (1)	JP3157839B2 (et)
KR (1)	KR100277482B1 (et)
CN (1)	CN1060775C (et)
AT (1)	ATE224392T1 (et)
AU (1)	AU702720B2 (et)
BR (1)	BR9611300A (et)
CA (1)	CA2236707C (et)
CZ (1)	CZ285571B6 (et)
DE (1)	DE69623799T2 (et)
DK (1)	DK0858461T3 (et)
EE (1)	EE03566B1 (et)
HU (1)	HUP9802534A3 (et)
IL (1)	IL123898A (et)
IS (1)	IS4708A (et)
NO (1)	NO309569B1 (et)
NZ (1)	NZ321970A (et)
PL (1)	PL184843B1 (et)
RU (1)	RU2162469C2 (et)
SK (1)	SK282944B6 (et)
TR (1)	TR199800780T2 (et)
UA (1)	UA47442C2 (et)
WO (1)	WO1997016451A1 (et)

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US6329520B1 (en) *	1990-08-09	2001-12-11	Research Triangle Institute	Cocaine receptor binding ligands
US6706880B2 (en)	1990-08-09	2004-03-16	Research Triangle Institute	Cocaine receptor binding ligands
US6150376A (en) *	1998-08-05	2000-11-21	Georgetown University	Bi- and tri-cyclic aza compounds and their uses
TR200100462T2 (tr) *	1998-08-18	2001-09-21	Ucb, S.A.	Muskarinik agonistleri ve antagonistleri
CA2384692A1 (en)	1999-09-27	2001-04-05	Alan P. Kozikowski	Novel tropane analogs
US6479509B1 (en)	2000-05-22	2002-11-12	Research Triangle Institute	Method of promoting smoking cessation
WO2002002559A1 (en) *	2000-07-04	2002-01-10	Neurosearch A/S	Steric isomers of fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
MXPA03009185A (es)	2001-04-09	2004-02-17	Neurosearch As	Antagonistas de receptor a2a de adenosina combinados con compuestos de actividad neurotrofica en el tratamiento de la enfermedad de parkinson.
WO2002094827A1 (en) *	2001-05-23	2002-11-28	Neurosearch A/S	Fused tropane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
TW589312B (en)	2001-05-25	2004-06-01	Wyeth Corp	Aryl-8-azabicyclo[3.2.1]octanes for the treatment of depression
WO2003045388A1 (en) *	2001-11-30	2003-06-05	Neurosearch A/S	Tropane derivatives having dopamine reuptake inhibitor activity for the treatment of ischemic diseases
JP2006517567A (ja)	2003-02-12	2006-07-27	ニューロサーチ、アクティーゼルスカブ	新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
JP2006517568A (ja)	2003-02-12	2006-07-27	ニューロサーチ、アクティーゼルスカブ	８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
CN100356940C (zh) *	2004-12-01	2007-12-26	蒋毅	制备大叶蒟提取物的方法、提取物及其应用
US20090137625A1 (en)	2005-04-08	2009-05-28	Dan Peters	Novel Enantiomers and Their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors
EP1917264B1 (en)	2005-06-28	2010-11-17	NeuroSearch A/S	Novel 3,9-diaza-spiro[5.5]undecane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
US8093388B2 (en)	2005-06-28	2012-01-10	Neurosearch A/S	3-aza spiro[5,5]undec-8-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
BRPI0614944A2 (pt) *	2005-08-19	2011-04-26	Elan Pharm Inc	inibidores sulfonamido n-bicìclicos ponte de gama-secretase
TW200800980A (en)	2006-02-17	2008-01-01	Neurosearch As	Novel compounds
US8697721B2 (en)	2009-05-15	2014-04-15	Aniona Aps	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
PE20121066A1 (es) *	2009-06-19	2012-09-13	Abbvie Inc	Derivados de diazahomoadamantano y metodos para usarlos
WO2011032903A1 (en)	2009-09-21	2011-03-24	Neurosearch A/S	Piperazinyl-alkyl-benzoimidazol-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011092061A1 (en)	2010-01-29	2011-08-04	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2011117289A1 (en)	2010-03-25	2011-09-29	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neuro-transmitter re-uptake inhibitors
WO2012000881A1 (en)	2010-07-02	2012-01-05	Neurosearch A/S	Chromen-2-one derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
JP6052524B1 (ja) *	2015-07-30	2016-12-27	秋夫湯田	持ち運び設置が容易な手提げハンドルの付いた薪ストーブ。
AU2023303077A1 (en)	2022-07-08	2025-02-06	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction
JP2026512649A (ja)	2022-10-28	2026-04-20	イニシエーターファーマエー／エス	疼痛の治療用化合物
TW202440106A (zh)	2023-01-03	2024-10-16	丹麥商創始人製藥股份有限公司	用於治療勃起障礙之化合物
WO2025051846A1 (en)	2023-09-05	2025-03-13	Initiator Pharma A/S	Compound for treatment of female sexual dysfunction
KR20250050681A (ko)	2023-10-08	2025-04-15	임종완	이중관형멀티커넥터

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AU672644B2 (en) *	1992-12-23	1996-10-10	Neurosearch A/S	Aryl substituted heterocyclic compounds
BR9507489A (pt) *	1994-04-19	1997-08-12	Neurosearch As	Derivados tropano sua preparacão e uso

1996
- 1996-11-04 EE EE9800100A patent/EE03566B1/et not_active IP Right Cessation
- 1996-11-04 AU AU75631/96A patent/AU702720B2/en not_active Ceased
- 1996-11-04 RU RU98110007/04A patent/RU2162469C2/ru not_active IP Right Cessation
- 1996-11-04 EP EP96938064A patent/EP0858461B1/en not_active Expired - Lifetime
- 1996-11-04 CA CA002236707A patent/CA2236707C/en not_active Expired - Fee Related
- 1996-11-04 JP JP51708397A patent/JP3157839B2/ja not_active Expired - Fee Related
- 1996-11-04 SK SK422-98A patent/SK282944B6/sk unknown
- 1996-11-04 BR BR9611300A patent/BR9611300A/pt not_active Application Discontinuation
- 1996-11-04 AT AT96938064T patent/ATE224392T1/de not_active IP Right Cessation
- 1996-11-04 KR KR1019980702592A patent/KR100277482B1/ko not_active Expired - Fee Related
- 1996-11-04 CN CN96198012A patent/CN1060775C/zh not_active Expired - Fee Related
- 1996-11-04 UA UA98041933A patent/UA47442C2/uk unknown
- 1996-11-04 HU HU9802534A patent/HUP9802534A3/hu unknown
- 1996-11-04 NZ NZ321970A patent/NZ321970A/en unknown
- 1996-11-04 IL IL12389896A patent/IL123898A/en not_active IP Right Cessation
- 1996-11-04 CZ CZ981138A patent/CZ285571B6/cs not_active IP Right Cessation
- 1996-11-04 WO PCT/EP1996/004793 patent/WO1997016451A1/en not_active Ceased
- 1996-11-04 US US09/051,107 patent/US5998405A/en not_active Expired - Lifetime
- 1996-11-04 DK DK96938064T patent/DK0858461T3/da active
- 1996-11-04 TR TR1998/00780T patent/TR199800780T2/xx unknown
- 1996-11-04 PL PL96326448A patent/PL184843B1/pl unknown
- 1996-11-04 DE DE69623799T patent/DE69623799T2/de not_active Expired - Lifetime
1998
- 1998-03-31 IS IS4708A patent/IS4708A/is unknown
- 1998-04-07 NO NO981609A patent/NO309569B1/no unknown

Also Published As

Publication number	Publication date
EE9800100A (et)	1998-10-15
HUP9802534A3 (en)	1999-06-28
NO981609L (no)	1998-06-26
AU7563196A (en)	1997-05-22
AU702720B2 (en)	1999-03-04
US5998405A (en)	1999-12-07
RU2162469C2 (ru)	2001-01-27
NZ321970A (en)	2000-02-28
JPH11514638A (ja)	1999-12-14
IL123898A (en)	2001-08-08
CN1060775C (zh)	2001-01-17
PL326448A1 (en)	1998-09-28
CZ285571B6 (cs)	1999-09-15
IS4708A (is)	1998-03-31
CA2236707A1 (en)	1997-05-09
DE69623799T2 (de)	2003-01-30
WO1997016451A1 (en)	1997-05-09
IL123898A0 (en)	1998-10-30
PL184843B1 (pl)	2002-12-31
NO981609D0 (no)	1998-04-07
KR19990064111A (ko)	1999-07-26
SK42298A3 (en)	1998-10-07
EP0858461B1 (en)	2002-09-18
KR100277482B1 (ko)	2001-01-15
EP0858461A1 (en)	1998-08-19
ATE224392T1 (de)	2002-10-15
HK1016984A1 (en)	1999-11-12
NO309569B1 (no)	2001-02-19
JP3157839B2 (ja)	2001-04-16
CA2236707C (en)	2002-08-06
DE69623799D1 (de)	2002-10-24
CN1201461A (zh)	1998-12-09
BR9611300A (pt)	1999-06-15
TR199800780T2 (xx)	1998-07-21
UA47442C2 (uk)	2002-07-15
EE03566B1 (et)	2001-12-17
MX9803554A (es)	1998-09-30
HUP9802534A2 (hu)	1999-04-28
DK0858461T3 (da)	2003-01-27
CZ113898A3 (cs)	1998-07-15

Publication	Publication Date	Title
SK282944B6 (sk)	2003-01-09	Tavené tropánové deriváty, spôsob ich výroby, farmaceutický prostriedok s ich obsahom a ich použitie
US6395748B2 (en)	2002-05-28	Tropane-derivatives, their preparation and use
US6100275A (en)	2000-08-08	8-azabicyclo[3.2.1.]oct-2-ene derivatives, their preparation and use
EP0981515B1 (en)	2003-08-27	Piperidine derivatives as neurotransmitter re-uptake inhibitors
JP4588444B2 (ja)	2010-12-01	ジアザビシクロノナン及び−デカン誘導体並びにこれをオピオイドレセプターリガンドとして使用する方法
JP2006517567A (ja)	2006-07-27	新規８−アザ−ビシクロ［３．２．１］オクタン誘導体及びこれをモノアミン神経伝達物質再取り込み阻害薬として使用する方法
MXPA98003554A (en)	1998-11-16	Frozen tropan derivatives, its preparation and
EP2272847A1 (en)	2011-01-12	Enantiomers and their use as monoamine neurotransmitter re-uptake inhibitors
JP2010501624A (ja)	2010-01-21	新規なピペリジン誘導体及びモノアミン神経伝達物質再取込み阻害剤としてのその使用
JP2011513461A (ja)	2011-04-28	ニコチン性アセチルコリン受容体モジュレーターとして有用な新規な１，４−ジアザ−ビシクロ［３．２．１］オクタン誘導体