SK282984B6 - Na kožu priľnavý farmaceutický prípravok a spôsob jeho prípravy - Google Patents

Na kožu priľnavý farmaceutický prípravok a spôsob jeho prípravy Download PDF

Info

Publication number: SK282984B6
Authority: SK; Slovakia
Prior art keywords: estradiol; skin; composition according; air; humidity
Prior art date: 1996-01-08

Application number

SK908-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK90898A3 (en

Inventor

Bodo Asmussen

Michael Horstmann

Original Assignee

Lts Lohmann Therapie - Systeme Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-08

Filing date

1996-12-23

Publication date

2003-01-09

1996-12-23 Application filed by Lts Lohmann Therapie - Systeme Gmbh filed Critical Lts Lohmann Therapie - Systeme Gmbh

1999-01-11 Publication of SK90898A3 publication Critical patent/SK90898A3/sk

2003-01-09 Publication of SK282984B6 publication Critical patent/SK282984B6/sk

Links

229960005309 estradiol Drugs 0.000 title claims abstract description 27
230000001225 therapeutic effect Effects 0.000 title claims abstract description 9
239000000825 pharmaceutical preparation Substances 0.000 title abstract description 6
VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims abstract description 36
239000010410 layer Substances 0.000 claims abstract description 13
229930182833 estradiol Natural products 0.000 claims abstract description 12
239000004480 active ingredient Substances 0.000 claims abstract description 10
239000011159 matrix material Substances 0.000 claims abstract description 8
239000012790 adhesive layer Substances 0.000 claims abstract description 7
238000002360 preparation method Methods 0.000 claims abstract description 5
239000013543 active substance Substances 0.000 claims description 14
239000000203 mixture Substances 0.000 claims description 9
229920001577 copolymer Polymers 0.000 claims description 5
239000000853 adhesive Substances 0.000 claims description 4
238000000034 method Methods 0.000 claims description 4
239000008194 pharmaceutical composition Substances 0.000 claims description 4
239000007787 solid Substances 0.000 claims description 4
230000001070 adhesive effect Effects 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 3
238000004806 packaging method and process Methods 0.000 claims description 3
239000006185 dispersion Substances 0.000 claims description 2
238000004090 dissolution Methods 0.000 claims description 2
239000007788 liquid Substances 0.000 claims description 2
239000011358 absorbing material Substances 0.000 claims 1
125000005396 acrylic acid ester group Chemical group 0.000 claims 1
230000001143 conditioned effect Effects 0.000 claims 1
238000005520 cutting process Methods 0.000 claims 1
239000002274 desiccant Substances 0.000 claims 1
239000003937 drug carrier Substances 0.000 claims 1
238000001035 drying Methods 0.000 claims 1
238000012432 intermediate storage Methods 0.000 claims 1
238000010030 laminating Methods 0.000 claims 1
239000000463 material Substances 0.000 claims 1
238000007493 shaping process Methods 0.000 claims 1
239000007792 gaseous phase Substances 0.000 abstract 2
239000005022 packaging material Substances 0.000 abstract 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
239000003814 drug Substances 0.000 description 6
229940079593 drug Drugs 0.000 description 5
239000003623 enhancer Substances 0.000 description 5
230000001965 increasing effect Effects 0.000 description 5
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
238000002425 crystallisation Methods 0.000 description 3
230000008025 crystallization Effects 0.000 description 3
MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
239000002674 ointment Substances 0.000 description 3
229920000728 polyester Polymers 0.000 description 3
238000003860 storage Methods 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
KBPLFHHGFOOTCA-UHFFFAOYSA-N 1-Octanol Chemical compound CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 2
KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical compound C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 description 2
229910000831 Steel Inorganic materials 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
239000006071 cream Substances 0.000 description 2
GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
235000014113 dietary fatty acids Nutrition 0.000 description 2
LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 2
POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
229930195729 fatty acid Natural products 0.000 description 2
239000000194 fatty acid Substances 0.000 description 2
-1 fatty acid sulphates Chemical class 0.000 description 2
230000006870 function Effects 0.000 description 2
239000011521 glass Substances 0.000 description 2
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
230000004048 modification Effects 0.000 description 2
238000012986 modification Methods 0.000 description 2
FBUKVWPVBMHYJY-UHFFFAOYSA-N nonanoic acid Chemical compound CCCCCCCCC(O)=O FBUKVWPVBMHYJY-UHFFFAOYSA-N 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
238000004080 punching Methods 0.000 description 2
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
239000010959 steel Substances 0.000 description 2
239000000126 substance Substances 0.000 description 2
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
DNIAPMSPPWPWGF-GSVOUGTGSA-N (R)-(-)-Propylene glycol Chemical compound C[C@@H](O)CO DNIAPMSPPWPWGF-GSVOUGTGSA-N 0.000 description 1
229940058015 1,3-butylene glycol Drugs 0.000 description 1
WEEGYLXZBRQIMU-UHFFFAOYSA-N 1,8-cineole Natural products C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 1
RZRNAYUHWVFMIP-KTKRTIGZSA-N 1-oleoylglycerol Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(O)CO RZRNAYUHWVFMIP-KTKRTIGZSA-N 0.000 description 1
LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
229920002126 Acrylic acid copolymer Polymers 0.000 description 1
208000024827 Alzheimer disease Diseases 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 1
WEEGYLXZBRQIMU-WAAGHKOSSA-N Eucalyptol Chemical compound C1C[C@H]2CC[C@]1(C)OC2(C)C WEEGYLXZBRQIMU-WAAGHKOSSA-N 0.000 description 1
206010020751 Hypersensitivity Diseases 0.000 description 1
239000005639 Lauric acid Substances 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
208000001132 Osteoporosis Diseases 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
239000005643 Pelargonic acid Substances 0.000 description 1
206010070834 Sensitisation Diseases 0.000 description 1
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000011054 acetic acid Nutrition 0.000 description 1
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
229920006243 acrylic copolymer Polymers 0.000 description 1
239000000654 additive Substances 0.000 description 1
239000001361 adipic acid Substances 0.000 description 1
235000011037 adipic acid Nutrition 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
208000026935 allergic disease Diseases 0.000 description 1
230000007815 allergy Effects 0.000 description 1
DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
235000020661 alpha-linolenic acid Nutrition 0.000 description 1
150000001408 amides Chemical class 0.000 description 1
229920005601 base polymer Polymers 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
235000019437 butane-1,3-diol Nutrition 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
238000006243 chemical reaction Methods 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229960005233 cineole Drugs 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
239000002537 cosmetic Substances 0.000 description 1
150000003950 cyclic amides Chemical class 0.000 description 1
229960002887 deanol Drugs 0.000 description 1
230000007423 decrease Effects 0.000 description 1
SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
230000000694 effects Effects 0.000 description 1
230000002708 enhancing effect Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
239000011888 foil Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
RZRNAYUHWVFMIP-HXUWFJFHSA-N glycerol monolinoleate Natural products CCCCCCCCC=CCCCCCCCC(=O)OC[C@H](O)CO RZRNAYUHWVFMIP-HXUWFJFHSA-N 0.000 description 1
150000002314 glycerols Chemical class 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
229960004488 linolenic acid Drugs 0.000 description 1
KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000012528 membrane Substances 0.000 description 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
239000003883 ointment base Substances 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
235000021313 oleic acid Nutrition 0.000 description 1
229940055577 oleyl alcohol Drugs 0.000 description 1
XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
229940101267 panthenol Drugs 0.000 description 1
235000020957 pantothenol Nutrition 0.000 description 1
239000011619 pantothenol Substances 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
239000002245 particle Substances 0.000 description 1
230000035515 penetration Effects 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
125000005498 phthalate group Chemical class 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920006267 polyester film Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001451 polypropylene glycol Polymers 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
230000002028 premature Effects 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
238000010526 radical polymerization reaction Methods 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
238000009877 rendering Methods 0.000 description 1
229920005989 resin Polymers 0.000 description 1
239000011347 resin Substances 0.000 description 1
230000029058 respiratory gaseous exchange Effects 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
230000008313 sensitization Effects 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000002356 single layer Substances 0.000 description 1
239000002904 solvent Substances 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000008961 swelling Effects 0.000 description 1
TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
230000007704 transition Effects 0.000 description 1
239000003981 vehicle Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Physical Education & Sports Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)
Materials For Medical Uses (AREA)

SK908-98A 1996-01-08 1996-12-23 Na kožu priľnavý farmaceutický prípravok a spôsob jeho prípravy SK282984B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19600347A DE19600347A1 (de)	1996-01-08	1996-01-08	Hauthaftende pharmazeutische Zubereitung, insbesondere TTS zur Abgabe von 17-beta-Estradiol an den menschlichen Organismus
PCT/EP1996/005822 WO1997025077A1 (fr)	1996-01-08	1996-12-23	PREPARATION PHARMACEUTIQUE ADHERANT A LA PEAU, NOTAMMENT SYSTEME THERAPEUTIQUE TRANSDERMIQUE POUR LA LIBERATION DE 17-β-ESTRADIOL DANS L'ORGANISME HUMAIN

Publications (2)

Publication Number	Publication Date
SK90898A3 SK90898A3 (en)	1999-01-11
SK282984B6 true SK282984B6 (sk)	2003-01-09

Family

ID=7782261

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK908-98A SK282984B6 (sk)	1996-01-08	1996-12-23	Na kožu priľnavý farmaceutický prípravok a spôsob jeho prípravy

Country Status (21)

Country	Link
US (1)	US6267982B1 (fr)
EP (1)	EP0880366B1 (fr)
JP (1)	JP2000505071A (fr)
KR (1)	KR100476579B1 (fr)
CN (1)	CN1107525C (fr)
AT (1)	ATE205406T1 (fr)
AU (1)	AU721677B2 (fr)
CA (1)	CA2242577C (fr)
CZ (1)	CZ289291B6 (fr)
DE (2)	DE19600347A1 (fr)
DK (1)	DK0880366T3 (fr)
ES (1)	ES2164270T3 (fr)
HU (1)	HUP9901102A3 (fr)
IL (1)	IL125160A (fr)
MY (1)	MY129733A (fr)
NO (1)	NO312878B1 (fr)
NZ (1)	NZ325817A (fr)
PL (1)	PL187275B1 (fr)
SK (1)	SK282984B6 (fr)
WO (1)	WO1997025077A1 (fr)
ZA (1)	ZA97111B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6623763B2 (en) *	1996-01-08	2003-09-23	Lts Lohmann Therape-System Ag	Pharmaceutical preparation adhering to the skin, in particular a transdermal therapeutic system for the release of 17-β-estradiol to the human organism
ES2373864T3 (es) *	1998-04-20	2012-02-09	Eisai R&D Management Co., Ltd.	Composición estabilizada que contiene un compuesto de tipo bencimidazol.
DE19827732A1 (de) *	1998-06-22	1999-12-23	Rottapharm Bv	Transdermales System vom Matrix-Typ zur Abgabe von Wirkstoffen mit einer hohen Abgaberate von Steroid-Hormonen und die Verwendung eines derartigen Systems zur Hormonersatztherapie
CA2401606A1 (fr) *	2000-03-02	2001-09-07	Mcgill University	Facteur inhibiteur de caspase et utilisations correspondantes
JP4989892B2 (ja) *	2004-01-30	2012-08-01	久光製薬株式会社	貼付剤入り包装袋

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4863738A (en) *	1987-11-23	1989-09-05	Alza Corporation	Skin permeation enhancer compositions using glycerol monooleate
ATE95059T1 (de) *	1989-02-28	1993-10-15	Teijin Ltd	Pflaster sowie dessen herstellung.
IT1253265B (it) *	1991-11-25	1995-07-14	Rotta Research Lab	Preparato a matrice copolimerica adesiva a base acrilica per il rilascio transdermico dell'estradiolo.
DE4223360C1 (fr) *	1992-07-16	1993-04-08	Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4237453C1 (fr) *	1992-11-06	1993-08-19	Lts Lohmann Therapie-Systeme Gmbh & Co Kg, 5450 Neuwied, De
DE4405899A1 (de) *	1994-02-18	1995-08-24	Schering Ag	Mittel zur transdermalen Applikation enthaltend Desogestrel
DE4429664C2 (de) *	1994-08-20	1997-09-11	Lohmann Therapie Syst Lts	Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung
DE4429667C2 (de) *	1994-08-20	1996-07-11	Lohmann Therapie Syst Lts	Estradiol-TTS mit wasserbindenden Zusätzen und Verfahren zu seiner Herstellung

1996
- 1996-01-08 DE DE19600347A patent/DE19600347A1/de not_active Withdrawn
- 1996-12-23 JP JP9524813A patent/JP2000505071A/ja active Pending
- 1996-12-23 NZ NZ325817A patent/NZ325817A/xx not_active IP Right Cessation
- 1996-12-23 US US09/101,720 patent/US6267982B1/en not_active Expired - Lifetime
- 1996-12-23 HU HU9901102A patent/HUP9901102A3/hu unknown
- 1996-12-23 WO PCT/EP1996/005822 patent/WO1997025077A1/fr not_active Ceased
- 1996-12-23 CZ CZ19982140A patent/CZ289291B6/cs not_active IP Right Cessation
- 1996-12-23 DK DK96944648T patent/DK0880366T3/da active
- 1996-12-23 PL PL96327940A patent/PL187275B1/pl not_active IP Right Cessation
- 1996-12-23 AU AU13057/97A patent/AU721677B2/en not_active Ceased
- 1996-12-23 AT AT96944648T patent/ATE205406T1/de active
- 1996-12-23 CA CA002242577A patent/CA2242577C/fr not_active Expired - Fee Related
- 1996-12-23 ES ES96944648T patent/ES2164270T3/es not_active Expired - Lifetime
- 1996-12-23 CN CN96199544A patent/CN1107525C/zh not_active Expired - Fee Related
- 1996-12-23 SK SK908-98A patent/SK282984B6/sk unknown
- 1996-12-23 KR KR10-1998-0705246A patent/KR100476579B1/ko not_active Expired - Fee Related
- 1996-12-23 EP EP96944648A patent/EP0880366B1/fr not_active Expired - Lifetime
- 1996-12-23 IL IL12516096A patent/IL125160A/xx not_active IP Right Cessation
- 1996-12-23 DE DE59607696T patent/DE59607696D1/de not_active Expired - Lifetime
1997
- 1997-01-06 MY MYPI97000032A patent/MY129733A/en unknown
- 1997-01-07 ZA ZA9700111A patent/ZA97111B/xx unknown
1998
- 1998-07-03 NO NO19983098A patent/NO312878B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
ES2164270T3 (es)	2002-02-16
PL327940A1 (en)	1999-01-04
CN1207049A (zh)	1999-02-03
HUP9901102A3 (en)	1999-11-29
WO1997025077A1 (fr)	1997-07-17
ZA97111B (en)	1997-08-18
AU1305797A (en)	1997-08-01
CA2242577C (fr)	2006-06-06
PL187275B1 (pl)	2004-06-30
NO983098L (no)	1998-07-03
KR100476579B1 (ko)	2005-09-26
NZ325817A (en)	1999-01-28
NO983098D0 (no)	1998-07-03
CA2242577A1 (fr)	1997-07-17
KR19990077110A (ko)	1999-10-25
JP2000505071A (ja)	2000-04-25
US6267982B1 (en)	2001-07-31
AU721677B2 (en)	2000-07-13
CZ214098A3 (cs)	1998-11-11
MY129733A (en)	2007-04-30
IL125160A (en)	2003-01-12
ATE205406T1 (de)	2001-09-15
CZ289291B6 (cs)	2001-12-12
EP0880366B1 (fr)	2001-09-12
DE19600347A1 (de)	1997-07-10
SK90898A3 (en)	1999-01-11
NO312878B1 (no)	2002-07-15
EP0880366A1 (fr)	1998-12-02
DK0880366T3 (da)	2001-12-27
IL125160A0 (en)	1999-01-26
HUP9901102A2 (hu)	1999-08-30
CN1107525C (zh)	2003-05-07
DE59607696D1 (de)	2001-10-18

Publication	Publication Date	Title
JP3489831B2 (ja)	2004-01-26	活性成分パッチ
KR100507266B1 (ko)	2005-08-10	퍼골라이드 함유 경피 흡수 치료 시스템
US4719226A (en)	1988-01-12	Percutaneous absorption type preparation and process for preparing the same
EP0413034B1 (fr)	1993-09-29	Cataplasme et sa preparation
US20040028726A1 (en)	2004-02-12	Transdermal systems for the delivery of clonidine
JP3731016B2 (ja)	2006-01-05	化学的に塩基性の揮発性医療用活性物質の経皮的投与のためのプラスタおよびその製造方法
EA030797B1 (ru)	2018-09-28	Система трансдермальной доставки гормонов (варианты) и способы ее применения
US20060088580A1 (en)	2006-04-27	Hormone-containing transdermal therapeutic system with an active substance reservoir based on vinylacetate-vinylpyrrolidone copolymer with improved cohesion
JP2002536403A (ja)	2002-10-29	経皮系のための作用物質含有ラミネート
SK146894A3 (en)	1996-01-10	Transdermal therapeutic system containing the active substance 17-beta-oestradiol anhydrous form
JPH066534B2 (ja)	1994-01-26	経皮吸収貼付剤
CN112915071A (zh)	2021-06-08	一种含有美金刚的透皮贴剂
SK90898A3 (en)	1999-01-11	Skin-adhering pharmaceutical preparation, in particular transdermal therapeutic system for the release of 17-'beta'-estradiol to the human organism
EP1865931B1 (fr)	2011-09-14	Timbre transdermique
CN1187042C (zh)	2005-02-02	含甾族化合物的硬膏剂,其制备方法及其应用
SK281626B6 (sk)	2001-05-10	Transdermálny terapeutický systém s obsahom estradiolu
JPH078785B2 (ja)	1995-02-01	経皮吸収性製剤の製造方法
JPH0753671B2 (ja)	1995-06-07	経皮・経粘膜製剤
EP1547600A1 (fr)	2005-06-29	Timbre adhesif contenant une hormone femelle
JPH0699299B2 (ja)	1994-12-07	経皮吸収性製剤の製造方法
JPH0840910A (ja)	1996-02-13	安定なエストラジオール含有貼付剤の製造法
JPS6393715A (ja)	1988-04-25	経皮吸収貼付剤
JPH0825881B2 (ja)	1996-03-13	エストラジオール含有貼付剤