SK283003B6 - 1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom - Google Patents

1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom Download PDF

Info

Publication number: SK283003B6
Authority: SK; Slovakia
Prior art keywords: ara; elaidate; hydrogen; treatment; cells
Prior art date: 1995-07-25

Application number

SK80-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK8098A3 (en

Inventor

Finn Myhren

Bernt Borretzen

Are Dalen

Kjell Torgeir Stokke

Original Assignee

Conpharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-25

Filing date

1996-07-12

Publication date

2003-01-09

1996-07-12 Application filed by Conpharma As filed Critical Conpharma As

1998-07-08 Publication of SK8098A3 publication Critical patent/SK8098A3/sk

2003-01-09 Publication of SK283003B6 publication Critical patent/SK283003B6/sk

Links

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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 17
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230000001613 neoplastic effect Effects 0.000 description 1
208000020470 nervous system symptom Diseases 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
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238000009097 single-agent therapy Methods 0.000 description 1
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239000003381 stabilizer Substances 0.000 description 1
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230000004936 stimulating effect Effects 0.000 description 1
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210000001541 thymus gland Anatomy 0.000 description 1
235000010384 tocopherol Nutrition 0.000 description 1
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239000011732 tocopherol Substances 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
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239000001226 triphosphate Substances 0.000 description 1
235000011178 triphosphate Nutrition 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
235000021122 unsaturated fatty acids Nutrition 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Hematology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Artificial Filaments (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)

SK80-98A 1995-07-25 1996-07-12 1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom SK283003B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9515279.9A GB9515279D0 (en)	1995-07-25	1995-07-25	Improved therapeutic agents
PCT/NO1996/000179 WO1997005154A1 (en)	1995-07-25	1996-07-12	Improved therapeutic agents

Publications (2)

Publication Number	Publication Date
SK8098A3 SK8098A3 (en)	1998-07-08
SK283003B6 true SK283003B6 (sk)	2003-01-09

Family

ID=10778247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK80-98A SK283003B6 (sk)	1995-07-25	1996-07-12	1-beta-D-Arabinofuranozylcytozínový derivát, jeho použitie a farmaceutický prípravok s jeho obsahom

Country Status (25)

Country	Link
US (2)	US6316425B1 (de)
EP (1)	EP0842185B1 (de)
JP (2)	JP4372227B2 (de)
KR (1)	KR100401909B1 (de)
AT (1)	ATE207076T1 (de)
AU (1)	AU714814B2 (de)
CA (1)	CA2227533C (de)
CZ (1)	CZ291612B6 (de)
DE (1)	DE69616074T2 (de)
DK (1)	DK0842185T3 (de)
ES (1)	ES2166900T3 (de)
GB (1)	GB9515279D0 (de)
HU (1)	HU224839B1 (de)
IL (2)	IL122942A0 (de)
MX (1)	MX9800622A (de)
NO (1)	NO313985B1 (de)
NZ (1)	NZ313790A (de)
PL (1)	PL183601B1 (de)
PT (1)	PT842185E (de)
RU (1)	RU2165260C2 (de)
SK (1)	SK283003B6 (de)
TW (1)	TW434251B (de)
UA (1)	UA55389C2 (de)
WO (1)	WO1997005154A1 (de)
ZA (1)	ZA966047B (de)

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US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
AU735438B2 (en) *	1996-11-12	2001-07-05	Medivir Ab	Nucleosides
JP4352115B2 (ja) *	1997-01-24	2009-10-28	クラヴィス・ファルマ・アーエスアー	ゲムシタビン誘導体
RU2207573C2 (ru) *	2001-08-27	2003-06-27	Новичков Евгений Владимирович	Способ прогнозирования продолжительности жизни больных печеночно-клеточной карциномой
US7393862B2 (en) *	2002-05-17	2008-07-01	Celgene Corporation	Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
WO2005049633A1 (en) *	2003-11-03	2005-06-02	Cognis Ip Management Gmbh	Acyl ribonucleosides and acyl deoxyribonucleosides
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en)	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
BRPI0817234A2 (pt) *	2007-09-26	2014-09-30	Sinai School Medicine	Análogos de azacitidina e seus usos
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
EP2501364A4 (de) *	2009-11-20	2012-10-24	Clavis Pharma Asa	Parenterale formulierungen aus gemcitabinderivaten
CN103108625A (zh)	2010-07-13	2013-05-15	克拉维斯制药股份有限公司	艾西拉滨衍生物的肠胃外制剂
SG10201603288XA (en) *	2012-03-28	2016-05-30	Fujifilm Corp	Salt Of 1-(2-Deoxy-2-Fluoro-4-Thio-beta-D-Arabinofuranosyl)Cytosine
US12059427B2 (en)	2018-01-15	2024-08-13	Yinuoke Medicine Science And Technology Company Ltd.	Treatments for cachexia

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3894000A (en) *	1971-01-27	1975-07-08	Upjohn Co	Ara-cytidine derivatives and process of preparation
US4771056A (en) *	1985-08-29	1988-09-13	Roman Rozencwaig	Method of medical treatment with serotonin antagonists
RU2085557C1 (ru)	1991-09-30	1997-07-27	Санкио Компани Лимитед	Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
GB2266525A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
GB9307043D0 (en) *	1993-04-05	1993-05-26	Norsk Hydro As	Chemical compounds
US5641758A (en)	1993-11-10	1997-06-24	Kluge; Michael	Cytarabine derivatives, the preparation and use thereof

1995
- 1995-07-25 GB GBGB9515279.9A patent/GB9515279D0/en active Pending
1996
- 1996-07-12 WO PCT/NO1996/000179 patent/WO1997005154A1/en not_active Ceased
- 1996-07-12 DK DK96926032T patent/DK0842185T3/da active
- 1996-07-12 NZ NZ313790A patent/NZ313790A/xx not_active IP Right Cessation
- 1996-07-12 CZ CZ1998163A patent/CZ291612B6/cs not_active IP Right Cessation
- 1996-07-12 AT AT96926032T patent/ATE207076T1/de active
- 1996-07-12 EP EP96926032A patent/EP0842185B1/de not_active Expired - Lifetime
- 1996-07-12 JP JP50750497A patent/JP4372227B2/ja not_active Expired - Fee Related
- 1996-07-12 SK SK80-98A patent/SK283003B6/sk not_active IP Right Cessation
- 1996-07-12 RU RU98103238/04A patent/RU2165260C2/ru not_active IP Right Cessation
- 1996-07-12 ES ES96926032T patent/ES2166900T3/es not_active Expired - Lifetime
- 1996-07-12 HU HU9900924A patent/HU224839B1/hu not_active IP Right Cessation
- 1996-07-12 AU AU66335/96A patent/AU714814B2/en not_active Ceased
- 1996-07-12 DE DE69616074T patent/DE69616074T2/de not_active Expired - Lifetime
- 1996-07-12 KR KR10-1998-0700463A patent/KR100401909B1/ko not_active Expired - Fee Related
- 1996-07-12 CA CA002227533A patent/CA2227533C/en not_active Expired - Fee Related
- 1996-07-12 IL IL12294296A patent/IL122942A0/xx active IP Right Grant
- 1996-07-12 PT PT96926032T patent/PT842185E/pt unknown
- 1996-07-12 US US08/983,483 patent/US6316425B1/en not_active Expired - Lifetime
- 1996-07-12 PL PL96324690A patent/PL183601B1/pl not_active IP Right Cessation
- 1996-07-16 ZA ZA9606047A patent/ZA966047B/xx unknown
- 1996-10-02 TW TW085111996A patent/TW434251B/zh not_active IP Right Cessation
- 1996-12-07 UA UA98020922A patent/UA55389C2/uk unknown
1998
- 1998-01-15 IL IL122942A patent/IL122942A/en not_active IP Right Cessation
- 1998-01-21 MX MX9800622A patent/MX9800622A/es not_active IP Right Cessation
- 1998-01-23 NO NO19980296A patent/NO313985B1/no not_active IP Right Cessation
1999
- 1999-11-09 US US09/435,641 patent/US6335322B1/en not_active Expired - Fee Related
2009
- 2009-07-03 JP JP2009159081A patent/JP5087052B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP4372227B2 (ja)	2009-11-25
IL122942A0 (en)	1999-05-09
CZ291612B6 (cs)	2003-04-16
JP2002504068A (ja)	2002-02-05
HUP9900924A2 (hu)	2001-05-28
NO980296D0 (no)	1998-01-23
TW434251B (en)	2001-05-16
DE69616074T2 (de)	2002-06-06
WO1997005154A1 (en)	1997-02-13
US6335322B1 (en)	2002-01-01
JP5087052B2 (ja)	2012-11-28
PL183601B1 (pl)	2002-06-28
PL324690A1 (en)	1998-06-08
HUP9900924A3 (en)	2001-06-28
NO313985B1 (no)	2003-01-13
UA55389C2 (uk)	2003-04-15
NO980296L (no)	1998-01-23
KR100401909B1 (ko)	2004-02-14
CA2227533A1 (en)	1997-02-13
SK8098A3 (en)	1998-07-08
JP2009215326A (ja)	2009-09-24
KR19990035804A (ko)	1999-05-25
ATE207076T1 (de)	2001-11-15
EP0842185A1 (de)	1998-05-20
ZA966047B (en)	1997-02-04
US6316425B1 (en)	2001-11-13
CA2227533C (en)	2007-01-09
RU2165260C2 (ru)	2001-04-20
ES2166900T3 (es)	2002-05-01
MX9800622A (es)	1998-11-30
PT842185E (pt)	2002-04-29
IL122942A (en)	2006-12-10
GB9515279D0 (en)	1995-09-20
DE69616074D1 (de)	2001-11-22
EP0842185B1 (de)	2001-10-17
DK0842185T3 (da)	2002-02-04
AU6633596A (en)	1997-02-26
NZ313790A (en)	1999-07-29
CZ16398A3 (cs)	1998-06-17
HU224839B1 (en)	2006-03-28
AU714814B2 (en)	2000-01-13

Legal Events

Date	Code	Title	Description
2014-04-02	MM4A	Patent lapsed due to non-payment of maintenance fees	Effective date: 20130712

Publication	Publication Date	Title
JP5087052B2 (ja)	2012-11-28	改良された治療剤
KR100483256B1 (ko)	2005-04-15	젬시타빈 유도체
CA2140653A1 (en)	1994-03-03	Protein kinase inhibitors and related compounds combined with taxol
DK166830B1 (da)	1993-07-19	5-fluor-2'-deoxyuridin-3',5'-derivater, hydrater og salte heraf, fremgangsmaade til fremstilling af disse samt antitumorpraeparater indeholdende disse derivater
RU2194711C2 (ru)	2002-12-20	Производные гемцитабина
WO1994021659A1 (fr)	1994-09-29	Nouveau compose de 2'-methylidenenucleotide, procede d'obtention de ce compose et son utilisation pharmaceutique
KR20220039748A (ko)	2022-03-29	암 치료용 디뉴클레오티드 화합물 및 그의 의약 용도
MXPA99006790A (en)	2000-01-21	Gemcitabine derivatives
NO318934B1 (no)	2005-05-30	Gemcitabinderivater