ATE207076T1 - Ara-c derivate - Google Patents

Ara-c derivate

Info

Publication number: ATE207076T1
Authority: AT; Austria
Prior art keywords: ara; derivatives; eicosenoyl; elaidoyl; cis
Prior art date: 1995-07-25

Application number

AT96926032T

Other languages

English (en)

Inventor

Finn Myhren

Bernt Boerretzen

Are Dalen

Kjell Torgeir Stokke

Original Assignee

Norsk Hydro As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-07-25

Filing date

1996-07-12

Publication date

2001-11-15

1996-07-12 Application filed by Norsk Hydro As filed Critical Norsk Hydro As

2001-11-15 Application granted granted Critical

2001-11-15 Publication of ATE207076T1 publication Critical patent/ATE207076T1/de

Links

UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical class O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 title abstract 2
125000004016 elaidoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])/C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 trans-eicosenoyl Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Hematology (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Polyamides (AREA)
Artificial Filaments (AREA)

AT96926032T 1995-07-25 1996-07-12 Ara-c derivate ATE207076T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9515279.9A GB9515279D0 (en)	1995-07-25	1995-07-25	Improved therapeutic agents
PCT/NO1996/000179 WO1997005154A1 (en)	1995-07-25	1996-07-12	Improved therapeutic agents

Publications (1)

Publication Number	Publication Date
ATE207076T1 true ATE207076T1 (de)	2001-11-15

Family

ID=10778247

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT96926032T ATE207076T1 (de)	1995-07-25	1996-07-12	Ara-c derivate

Country Status (25)

Country	Link
US (2)	US6316425B1 (de)
EP (1)	EP0842185B1 (de)
JP (2)	JP4372227B2 (de)
KR (1)	KR100401909B1 (de)
AT (1)	ATE207076T1 (de)
AU (1)	AU714814B2 (de)
CA (1)	CA2227533C (de)
CZ (1)	CZ291612B6 (de)
DE (1)	DE69616074T2 (de)
DK (1)	DK0842185T3 (de)
ES (1)	ES2166900T3 (de)
GB (1)	GB9515279D0 (de)
HU (1)	HU224839B1 (de)
IL (2)	IL122942A0 (de)
MX (1)	MX9800622A (de)
NO (1)	NO313985B1 (de)
NZ (1)	NZ313790A (de)
PL (1)	PL183601B1 (de)
PT (1)	PT842185E (de)
RU (1)	RU2165260C2 (de)
SK (1)	SK283003B6 (de)
TW (1)	TW434251B (de)
UA (1)	UA55389C2 (de)
WO (1)	WO1997005154A1 (de)
ZA (1)	ZA966047B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6458772B1 (en)	1909-10-07	2002-10-01	Medivir Ab	Prodrugs
WO1998021223A1 (en) *	1996-11-12	1998-05-22	Medivir Ab	Nucleosides
NZ336676A (en) *	1997-01-24	2000-01-28	Norsk Hydro As	Gemcitabine esters or amides useful as anti-cancer and anti-viral agents
RU2207573C2 (ru) *	2001-08-27	2003-06-27	Новичков Евгений Владимирович	Способ прогнозирования продолжительности жизни больных печеночно-клеточной карциномой
US7393862B2 (en) *	2002-05-17	2008-07-01	Celgene Corporation	Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias
WO2005049633A1 (en) *	2003-11-03	2005-06-02	Cognis Ip Management Gmbh	Acyl ribonucleosides and acyl deoxyribonucleosides
NO324263B1 (no) *	2005-12-08	2007-09-17	Clavis Pharma Asa	Kjemiske forbindelser, anvendelse derav ved behandling av kreft, samt farmasoytiske preparater som omfatter slike forbindelser
US8497292B2 (en) *	2005-12-28	2013-07-30	Translational Therapeutics, Inc.	Translational dysfunction based therapeutics
UA99308C2 (ru) *	2007-09-26	2012-08-10	Маунт Синай Скул Оф Медсин	Аналог азацитидина и его применение
GB0808357D0 (en) *	2008-05-08	2008-06-18	Cyclacel Ltd	Process
CA2778432A1 (en) *	2009-11-20	2011-05-26	Clavis Pharma Asa	Parenteral formulations of gemcitabine derivatives
WO2012008845A1 (en) *	2010-07-13	2012-01-19	Clavis Pharma Asa	Parenteral formulations of elacytarabine derivatives
KR20170082650A (ko) *	2012-03-28	2017-07-14	후지필름 가부시키가이샤	1-(2-디옥시-2-플루오로-4-티오-β-D-아라비노푸라노실)시토신의 염
US12059427B2 (en)	2018-01-15	2024-08-13	Yinuoke Medicine Science And Technology Company Ltd.	Treatments for cachexia

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3894000A (en) *	1971-01-27	1975-07-08	Upjohn Co	Ara-cytidine derivatives and process of preparation
US4771056A (en) *	1985-08-29	1988-09-13	Roman Rozencwaig	Method of medical treatment with serotonin antagonists
RU2085557C1 (ru)	1991-09-30	1997-07-27	Санкио Компани Лимитед	Производные нуклеозидов пиримидина или их фармацевтически приемлемые соли и способ их получения
GB2266525A (en) *	1992-03-17	1993-11-03	Merck & Co Inc	Substituted cephalosporin sulfone compositions useful in the treatment of leukemia
GB9307043D0 (en) *	1993-04-05	1993-05-26	Norsk Hydro As	Chemical compounds
US5641758A (en)	1993-11-10	1997-06-24	Kluge; Michael	Cytarabine derivatives, the preparation and use thereof

1995
- 1995-07-25 GB GBGB9515279.9A patent/GB9515279D0/en active Pending
1996
- 1996-07-12 WO PCT/NO1996/000179 patent/WO1997005154A1/en not_active Ceased
- 1996-07-12 NZ NZ313790A patent/NZ313790A/xx not_active IP Right Cessation
- 1996-07-12 SK SK80-98A patent/SK283003B6/sk not_active IP Right Cessation
- 1996-07-12 DK DK96926032T patent/DK0842185T3/da active
- 1996-07-12 RU RU98103238/04A patent/RU2165260C2/ru not_active IP Right Cessation
- 1996-07-12 ES ES96926032T patent/ES2166900T3/es not_active Expired - Lifetime
- 1996-07-12 HU HU9900924A patent/HU224839B1/hu not_active IP Right Cessation
- 1996-07-12 AU AU66335/96A patent/AU714814B2/en not_active Ceased
- 1996-07-12 EP EP96926032A patent/EP0842185B1/de not_active Expired - Lifetime
- 1996-07-12 AT AT96926032T patent/ATE207076T1/de active
- 1996-07-12 US US08/983,483 patent/US6316425B1/en not_active Expired - Lifetime
- 1996-07-12 CZ CZ1998163A patent/CZ291612B6/cs not_active IP Right Cessation
- 1996-07-12 PL PL96324690A patent/PL183601B1/pl not_active IP Right Cessation
- 1996-07-12 KR KR10-1998-0700463A patent/KR100401909B1/ko not_active Expired - Fee Related
- 1996-07-12 DE DE69616074T patent/DE69616074T2/de not_active Expired - Lifetime
- 1996-07-12 IL IL12294296A patent/IL122942A0/xx active IP Right Grant
- 1996-07-12 PT PT96926032T patent/PT842185E/pt unknown
- 1996-07-12 JP JP50750497A patent/JP4372227B2/ja not_active Expired - Fee Related
- 1996-07-12 CA CA002227533A patent/CA2227533C/en not_active Expired - Fee Related
- 1996-07-16 ZA ZA9606047A patent/ZA966047B/xx unknown
- 1996-10-02 TW TW085111996A patent/TW434251B/zh not_active IP Right Cessation
- 1996-12-07 UA UA98020922A patent/UA55389C2/uk unknown
1998
- 1998-01-15 IL IL122942A patent/IL122942A/en not_active IP Right Cessation
- 1998-01-21 MX MX9800622A patent/MX9800622A/es not_active IP Right Cessation
- 1998-01-23 NO NO19980296A patent/NO313985B1/no not_active IP Right Cessation
1999
- 1999-11-09 US US09/435,641 patent/US6335322B1/en not_active Expired - Fee Related
2009
- 2009-07-03 JP JP2009159081A patent/JP5087052B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
HUP9900924A3 (en)	2001-06-28
CZ291612B6 (cs)	2003-04-16
JP5087052B2 (ja)	2012-11-28
UA55389C2 (uk)	2003-04-15
EP0842185B1 (de)	2001-10-17
DE69616074D1 (de)	2001-11-22
KR100401909B1 (ko)	2004-02-14
ZA966047B (en)	1997-02-04
GB9515279D0 (en)	1995-09-20
EP0842185A1 (de)	1998-05-20
IL122942A (en)	2006-12-10
NO980296D0 (no)	1998-01-23
IL122942A0 (en)	1999-05-09
AU6633596A (en)	1997-02-26
CA2227533A1 (en)	1997-02-13
US6335322B1 (en)	2002-01-01
NO313985B1 (no)	2003-01-13
WO1997005154A1 (en)	1997-02-13
JP2009215326A (ja)	2009-09-24
JP2002504068A (ja)	2002-02-05
KR19990035804A (ko)	1999-05-25
DE69616074T2 (de)	2002-06-06
PL324690A1 (en)	1998-06-08
DK0842185T3 (da)	2002-02-04
SK283003B6 (sk)	2003-01-09
JP4372227B2 (ja)	2009-11-25
HU224839B1 (en)	2006-03-28
CZ16398A3 (cs)	1998-06-17
HUP9900924A2 (hu)	2001-05-28
NO980296L (no)	1998-01-23
TW434251B (en)	2001-05-16
PT842185E (pt)	2002-04-29
MX9800622A (es)	1998-11-30
ES2166900T3 (es)	2002-05-01
US6316425B1 (en)	2001-11-13
RU2165260C2 (ru)	2001-04-20
SK8098A3 (en)	1998-07-08
PL183601B1 (pl)	2002-06-28
CA2227533C (en)	2007-01-09
AU714814B2 (en)	2000-01-13
NZ313790A (en)	1999-07-29

Legal Events

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2003-02-15

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