SK283346B6 - Kvartérne amóniové zlúčeniny, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické prostriedky na ich báze - Google Patents

Kvartérne amóniové zlúčeniny, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické prostriedky na ich báze Download PDF

Info

Publication number: SK283346B6
Authority: SK; Slovakia
Prior art keywords: phenyl; dichlorophenyl; compound; group; preparation
Prior art date: 1997-06-18

Application number

SK1744-99A

Other languages

English (en)

Slovak (sk)

Other versions

SK174499A3 (en

Inventor

Sandra Marina Monaghan

David Alker

Christopher John Burns

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-06-18

Filing date

1998-06-05

Publication date

2003-06-03

1998-06-05 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2001-05-10 Publication of SK174499A3 publication Critical patent/SK174499A3/sk

2003-06-03 Publication of SK283346B6 publication Critical patent/SK283346B6/sk

Links

238000002360 preparation method Methods 0.000 title claims description 178
238000000034 method Methods 0.000 title claims description 21
239000000543 intermediate Substances 0.000 title claims description 4
239000008194 pharmaceutical composition Substances 0.000 title claims description 3
150000003868 ammonium compounds Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 139
-1 2,3-dihydrobenzo[b]furanyl Chemical group 0.000 claims abstract description 105
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 73
125000004432 carbon atom Chemical group C* 0.000 claims abstract description 27
125000000753 cycloalkyl group Chemical group 0.000 claims abstract description 18
150000001450 anions Chemical class 0.000 claims abstract description 17
125000001424 substituent group Chemical group 0.000 claims abstract description 15
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract description 13
125000001072 heteroaryl group Chemical group 0.000 claims abstract description 13
125000001153 fluoro group Chemical group F* 0.000 claims abstract description 10
125000001624 naphthyl group Chemical group 0.000 claims abstract description 10
125000001544 thienyl group Chemical group 0.000 claims abstract description 10
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims abstract description 9
229910052799 carbon Inorganic materials 0.000 claims abstract description 9
125000004093 cyano group Chemical group *C#N 0.000 claims abstract description 9
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims abstract description 8
125000002947 alkylene group Chemical group 0.000 claims abstract description 7
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract description 5
125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 3
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract description 3
125000003016 chromanyl group Chemical group O1C(CCC2=CC=CC=C12)* 0.000 claims abstract description 3
125000001041 indolyl group Chemical group 0.000 claims abstract description 3
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239000000203 mixture Substances 0.000 claims description 122
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 43
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208000035475 disorder Diseases 0.000 claims description 25
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238000006243 chemical reaction Methods 0.000 claims description 13
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QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 4
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125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 2
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 2
CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims description 2
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical group [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
229910002651 NO3 Inorganic materials 0.000 claims description 2
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
125000003545 alkoxy group Chemical group 0.000 claims description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
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SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 claims description 2
125000005605 benzo group Chemical group 0.000 claims description 2
125000001246 bromo group Chemical group Br* 0.000 claims description 2
239000003085 diluting agent Substances 0.000 claims description 2
125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims description 2
125000002346 iodo group Chemical group I* 0.000 claims description 2
239000001301 oxygen Substances 0.000 claims description 2
206010039083 rhinitis Diseases 0.000 claims description 2
239000002462 tachykinin receptor antagonist Substances 0.000 claims description 2
125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 claims description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-M toluene-4-sulfonate Chemical compound CC1=CC=C(S([O-])(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-M 0.000 claims description 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
WAAMLEYKDDMXCE-LYRHXRSDSA-M [1-[(2s)-2-(3,4-dichlorophenyl)-4-(4-phenyl-1-azoniabicyclo[2.2.2]octan-1-yl)butyl]imidazol-2-yl]-(5,6,7,8-tetrahydronaphthalen-1-yl)methanone;methanesulfonate Chemical compound CS([O-])(=O)=O.C1=C(Cl)C(Cl)=CC=C1[C@@H](CN1C(=NC=C1)C(=O)C=1C=2CCCCC=2C=CC=1)CC[N+]1(CC2)CCC2(C=2C=CC=CC=2)CC1 WAAMLEYKDDMXCE-LYRHXRSDSA-M 0.000 claims 1
SZMUSGRLLRWRIV-UHFFFAOYSA-N [4-methoxy-3-propan-2-yloxy-2-(trifluoromethoxy)phenyl] hypofluorite Chemical group COC1=C(C(=C(OF)C=C1)OC(F)(F)F)OC(C)C SZMUSGRLLRWRIV-UHFFFAOYSA-N 0.000 claims 1
208000015114 central nervous system disease Diseases 0.000 claims 1
230000002496 gastric effect Effects 0.000 claims 1
QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 claims 1
238000004519 manufacturing process Methods 0.000 claims 1
125000005843 halogen group Chemical group 0.000 abstract description 6
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125000002861 (C1-C4) alkanoyl group Chemical group 0.000 abstract description 2
102000003141 Tachykinin Human genes 0.000 abstract description 2
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125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
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239000002904 solvent Substances 0.000 description 134
238000005160 1H NMR spectroscopy Methods 0.000 description 120
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239000012071 phase Substances 0.000 description 13
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230000004048 modification Effects 0.000 description 1
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229920005989 resin Polymers 0.000 description 1
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DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
125000004187 tetrahydropyran-2-yl group Chemical group [H]C1([H])OC([H])(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
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230000001225 therapeutic effect Effects 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
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Classifications

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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Pulmonology (AREA)
Psychiatry (AREA)
Dermatology (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Endocrinology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Ophthalmology & Optometry (AREA)
Orthopedic Medicine & Surgery (AREA)
Gynecology & Obstetrics (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Otolaryngology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)

SK1744-99A 1997-06-18 1998-06-05 Kvartérne amóniové zlúčeniny, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické prostriedky na ich báze SK283346B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9712882.1A GB9712882D0 (en)	1997-06-18	1997-06-18	Quaternary ammonium compounds
PCT/EP1998/003500 WO1998057972A1 (en)	1997-06-18	1998-06-05	Quaternary ammonium compounds as tachykinin antagonists

Publications (2)

Publication Number	Publication Date
SK174499A3 SK174499A3 (en)	2001-05-10
SK283346B6 true SK283346B6 (sk)	2003-06-03

Family

ID=10814535

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1744-99A SK283346B6 (sk)	1997-06-18	1998-06-05	Kvartérne amóniové zlúčeniny, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické prostriedky na ich báze

Country Status (43)

Country	Link
US (2)	US6207678B1 (de)
EP (1)	EP0994876B1 (de)
JP (1)	JP3280993B2 (de)
KR (1)	KR100345389B1 (de)
CN (1)	CN1199971C (de)
AP (1)	AP947A (de)
AR (1)	AR012249A1 (de)
AT (1)	ATE275564T1 (de)
AU (1)	AU726027B2 (de)
BG (1)	BG63341B1 (de)
BR (1)	BR9810619A (de)
CA (1)	CA2291975C (de)
CO (1)	CO4940478A1 (de)
DE (1)	DE69826129T2 (de)
DZ (1)	DZ2524A1 (de)
EA (1)	EA002424B1 (de)
ES (1)	ES2227856T3 (de)
GB (1)	GB9712882D0 (de)
HN (1)	HN1998000087A (de)
HR (1)	HRP980337B1 (de)
HU (1)	HUP0003962A3 (de)
ID (1)	ID23410A (de)
IL (2)	IL133079A (de)
IS (1)	IS5269A (de)
MA (1)	MA26509A1 (de)
MY (1)	MY136376A (de)
NO (1)	NO995782L (de)
NZ (1)	NZ501286A (de)
OA (1)	OA11235A (de)
PA (1)	PA8452501A1 (de)
PE (1)	PE80099A1 (de)
PL (1)	PL189557B1 (de)
PT (1)	PT994876E (de)
SI (1)	SI0994876T1 (de)
SK (1)	SK283346B6 (de)
TN (1)	TNSN98089A1 (de)
TR (1)	TR199903135T2 (de)
TW (1)	TW479055B (de)
UA (1)	UA62966C2 (de)
UY (1)	UY25045A1 (de)
WO (1)	WO1998057972A1 (de)
YU (1)	YU64699A (de)
ZA (1)	ZA985239B (de)

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Publication number	Priority date	Publication date	Assignee	Title
US6919372B1 (en) *	1997-12-26	2005-07-19	Yamanouchi Pharmaceutical Co., Ltd.	Sustained release pharmaceutical compositions
JP4546589B2 (ja) *	1998-04-23	2010-09-15	武田薬品工業株式会社	ナフタレン誘導体
CA2412355A1 (en) *	2000-06-12	2001-12-20	University Of Rochester	Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
WO2002046156A2 (en) *	2000-12-06	2002-06-13	Sepracor, Inc.	4,4-disubstituted piperidines for use as dopamine, serotonin and norepinephrine ligands
US20060205724A1 (en) *	2002-05-29	2006-09-14	The Regents Of The University Of California	Antagonizing nk-1 receptors inhibits consumption of substances of abuse
WO2004091597A2 (en) *	2003-04-15	2004-10-28	Pharmacia & Upjohn Company Llc	Method of treating irritable bowel syndrome (ibs)
CN1980896A (zh) *	2004-05-07	2007-06-13	詹森药业有限公司	咪唑衍生物的可放大合成
EP2117538A1 (de)	2007-01-24	2009-11-18	Glaxo Group Limited	Pharmazeutische zusammensetzungen mit 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-)

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Publication number	Priority date	Publication date	Assignee	Title
US3991201A (en) *	1974-06-27	1976-11-09	Janssen Pharmaceutica N.V.	1-(β-Aryl-β-R-ethyl)imidazoles as antimicrobial agents
US5583134A (en) *	1992-09-30	1996-12-10	Sanofi	1-azoniabicyclo[2.2.2] octanes and pharmaceutical compositions in which they are present
FR2696178B1 (fr) *	1992-09-30	1994-12-30	Sanofi Elf	Amides basiques quaternaires, procédé pour leur préparation et compositions pharmaceutiques en contenant.

1997
- 1997-06-18 GB GBGB9712882.1A patent/GB9712882D0/en active Pending
1998
- 1998-05-06 UA UA99126551A patent/UA62966C2/uk unknown
- 1998-05-19 TW TW087107720A patent/TW479055B/zh not_active IP Right Cessation
- 1998-06-04 PA PA19988452501A patent/PA8452501A1/es unknown
- 1998-06-04 HN HN1998000087A patent/HN1998000087A/es unknown
- 1998-06-05 KR KR1019997011931A patent/KR100345389B1/ko not_active Expired - Fee Related
- 1998-06-05 CN CNB988063425A patent/CN1199971C/zh not_active Expired - Fee Related
- 1998-06-05 WO PCT/EP1998/003500 patent/WO1998057972A1/en not_active Ceased
- 1998-06-05 DE DE69826129T patent/DE69826129T2/de not_active Expired - Fee Related
- 1998-06-05 JP JP50368799A patent/JP3280993B2/ja not_active Expired - Fee Related
- 1998-06-05 YU YU64699A patent/YU64699A/sh unknown
- 1998-06-05 PL PL98337713A patent/PL189557B1/pl not_active IP Right Cessation
- 1998-06-05 ES ES98932148T patent/ES2227856T3/es not_active Expired - Lifetime
- 1998-06-05 IL IL13307998A patent/IL133079A/en not_active IP Right Cessation
- 1998-06-05 EA EA199900986A patent/EA002424B1/ru not_active IP Right Cessation
- 1998-06-05 IL IL15562198A patent/IL155621A0/xx not_active IP Right Cessation
- 1998-06-05 ID IDW991633A patent/ID23410A/id unknown
- 1998-06-05 US US09/380,370 patent/US6207678B1/en not_active Expired - Fee Related
- 1998-06-05 TR TR1999/03135T patent/TR199903135T2/xx unknown
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- 1998-06-05 EP EP98932148A patent/EP0994876B1/de not_active Expired - Lifetime
- 1998-06-05 AU AU82153/98A patent/AU726027B2/en not_active Ceased
- 1998-06-05 AT AT98932148T patent/ATE275564T1/de not_active IP Right Cessation
- 1998-06-05 HU HU0003962A patent/HUP0003962A3/hu unknown
- 1998-06-05 BR BR9810619-8A patent/BR9810619A/pt not_active Application Discontinuation
- 1998-06-05 CA CA002291975A patent/CA2291975C/en not_active Expired - Fee Related
- 1998-06-05 NZ NZ501286A patent/NZ501286A/xx unknown
- 1998-06-05 PT PT98932148T patent/PT994876E/pt unknown
- 1998-06-05 SK SK1744-99A patent/SK283346B6/sk unknown
- 1998-06-08 PE PE1998000468A patent/PE80099A1/es not_active Application Discontinuation
- 1998-06-11 AP APAP/P/1998/001262A patent/AP947A/en active
- 1998-06-15 UY UY25045A patent/UY25045A1/es unknown
- 1998-06-16 MY MYPI98002689A patent/MY136376A/en unknown
- 1998-06-16 AR ARP980102853A patent/AR012249A1/es active IP Right Grant
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- 1998-06-17 DZ DZ980134A patent/DZ2524A1/xx active
- 1998-06-17 MA MA25118A patent/MA26509A1/fr unknown
- 1998-06-17 TN TNTNSN98089A patent/TNSN98089A1/fr unknown
- 1998-06-18 CO CO98034807A patent/CO4940478A1/es unknown
- 1998-06-18 HR HR980337A patent/HRP980337B1/xx not_active IP Right Cessation
1999
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2000
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Also Published As

Publication number	Publication date
CA2291975A1 (en)	1998-12-23
US6207678B1 (en)	2001-03-27
JP3280993B2 (ja)	2002-05-13
HRP980337B1 (en)	2003-02-28
AP9801262A0 (en)	1998-06-30
OA11235A (en)	2003-07-09
PE80099A1 (es)	1999-08-25
MA26509A1 (fr)	2004-12-20
UY25045A1 (es)	2000-09-29
HRP980337A2 (en)	1999-02-28
IS5269A (is)	1999-11-23
DE69826129T2 (de)	2005-09-22
IL155621A0 (en)	2003-11-23
SK174499A3 (en)	2001-05-10
JP2000513030A (ja)	2000-10-03
BG103919A (en)	2001-07-31
SI0994876T1 (en)	2005-02-28
AU726027B2 (en)	2000-10-26
HN1998000087A (es)	1998-10-22
CO4940478A1 (es)	2000-07-24
PL337713A1 (en)	2000-08-28
WO1998057972A1 (en)	1998-12-23
CN1260795A (zh)	2000-07-19
PL189557B1 (pl)	2005-08-31
BR9810619A (pt)	2000-09-12
IL133079A0 (en)	2001-03-19
HUP0003962A2 (hu)	2001-04-28
ZA985239B (en)	1999-12-17
US6380396B1 (en)	2002-04-30
CN1199971C (zh)	2005-05-04
GB9712882D0 (en)	1997-08-20
IL133079A (en)	2004-06-01
HUP0003962A3 (en)	2001-12-28
EA199900986A1 (ru)	2000-06-26
AR012249A1 (es)	2000-09-27
EP0994876B1 (de)	2004-09-08
YU64699A (sh)	2002-06-19
MY136376A (en)	2008-09-30
PT994876E (pt)	2005-01-31
DE69826129D1 (de)	2004-10-14
EA002424B1 (ru)	2002-04-25
TW479055B (en)	2002-03-11
BG63341B1 (bg)	2001-10-31
TR199903135T2 (xx)	2000-04-21
NO995782L (no)	2000-02-16
EP0994876A1 (de)	2000-04-26
ATE275564T1 (de)	2004-09-15
UA62966C2 (en)	2004-01-15
AU8215398A (en)	1999-01-04
TNSN98089A1 (fr)	2005-03-15
NO995782D0 (no)	1999-11-25
ID23410A (id)	2000-04-20
PA8452501A1 (es)	2000-05-24
KR20010013909A (ko)	2001-02-26
ES2227856T3 (es)	2005-04-01
NZ501286A (en)	2000-07-28
CA2291975C (en)	2004-02-10
AP947A (en)	2001-03-08
DZ2524A1 (fr)	2003-02-01
KR100345389B1 (ko)	2002-07-24

Publication	Publication Date	Title
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US5854268A (en)	1998-12-29	Azetidine, pyrrolidine and piperidine derivatives
US20030220495A1 (en)	2003-11-27	Inhibitors of farnesyl protein transferase
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EP0630374A1 (de)	1994-12-28	Imidazol- ,triazol- und tetrazolderivate
SK283346B6 (sk)	2003-06-03	Kvartérne amóniové zlúčeniny, spôsob a medziprodukty na ich prípravu, ich použitie a farmaceutické prostriedky na ich báze
US6462056B1 (en)	2002-10-08	Oxazolidines as 5-HT2A-antagonists
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JP3437819B2 (ja)	2003-08-18	掻痒症の治療用の新規な４−アリールピペリジン誘導体
US4859691A (en)	1989-08-22	Certain 1,2-benzisoxazole derivatives
CZ453499A3 (cs)	2000-08-16	Kvarterní amonné sloučeniny jako antagonisty tachykininu
US5925638A (en)	1999-07-20	Substituted 1-indolylpropyl-4-benzylpiperazine derivatives
AU707750B2 (en)	1999-07-22	Substituted 1-indolylpropyl-4-phenethylpiperazine derivatives
US4758573A (en)	1988-07-19	Heterocyclic group-containing compounds
EP0105575B1 (de)	1987-03-04	1-(1H-Imidazolyl), 1-N-Morpholinyl- und Pyridyl-Verbindungen, ihre Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
US5994374A (en)	1999-11-30	Substituted 1-indolylpropyl-4-benzyl-tetrahydropyridine derivatives
MXPA99012096A (en)	2000-09-04	Quaternary ammonium compounds as tachykinin antagonists
JPH06306025A (ja)	1994-11-01	ジアリールアルカン誘導体
JPH07179337A (ja)	1995-07-18	アルキルーフェノキシアルキルアミン誘導体を有効成分とする抗血栓剤