SK283832B6 - Spôsob prípravy fosfodiesterových zlúčenín - Google Patents

Spôsob prípravy fosfodiesterových zlúčenín Download PDF

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Publication number
SK283832B6
SK283832B6 SK1382-99A SK138299A SK283832B6 SK 283832 B6 SK283832 B6 SK 283832B6 SK 138299 A SK138299 A SK 138299A SK 283832 B6 SK283832 B6 SK 283832B6
Authority
SK
Slovakia
Prior art keywords
formula
amino
prepared
solvent
penta
Prior art date
Application number
SK1382-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK138299A3 (en
Inventor
John C. Amedio
Paul J. Bernard
Mark Fountain
Original Assignee
Epix Medical, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epix Medical, Inc. filed Critical Epix Medical, Inc.
Publication of SK138299A3 publication Critical patent/SK138299A3/sk
Publication of SK283832B6 publication Critical patent/SK283832B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SK1382-99A 1997-04-11 1998-01-27 Spôsob prípravy fosfodiesterových zlúčenín SK283832B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/833,745 US5919967A (en) 1997-04-11 1997-04-11 Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en) 1997-04-11 1998-01-27 Process for synthesizing phosphodiesters

Publications (2)

Publication Number Publication Date
SK138299A3 SK138299A3 (en) 2000-05-16
SK283832B6 true SK283832B6 (sk) 2004-02-03

Family

ID=25265165

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1382-99A SK283832B6 (sk) 1997-04-11 1998-01-27 Spôsob prípravy fosfodiesterových zlúčenín

Country Status (21)

Country Link
US (1) US5919967A (de)
EP (1) EP1021452B1 (de)
JP (2) JP4014231B2 (de)
KR (2) KR100593650B1 (de)
AT (1) ATE236171T1 (de)
AU (1) AU728902B2 (de)
BR (1) BR9809084B1 (de)
CA (1) CA2285417C (de)
CZ (1) CZ294469B6 (de)
DE (1) DE69812983T2 (de)
DK (1) DK1021452T3 (de)
ES (1) ES2195315T3 (de)
HU (1) HU224257B1 (de)
IL (1) IL131964A (de)
IS (1) IS1994B (de)
NO (1) NO325619B1 (de)
NZ (1) NZ337921A (de)
PL (1) PL188258B1 (de)
PT (1) PT1021452E (de)
SK (1) SK283832B6 (de)
WO (1) WO1998046612A1 (de)

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KR20010030854A (ko) 1997-10-02 2001-04-16 로퍼, 랜달 비. 인터벤셔날 요법을 모니터하기 위한 콘트라스트 강화된진단 영상화 방법
US6559330B1 (en) * 1999-09-09 2003-05-06 Schering Aktiengesellschaft Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US20030203879A1 (en) * 1999-09-09 2003-10-30 Schering Ag Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (de) * 1999-09-09 2005-09-01 Schering Ag Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
WO2003029257A1 (de) * 2001-09-27 2003-04-10 Schering Aktiengesellschaft (ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
CA2666005C (en) 2002-03-01 2016-01-19 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US20050100963A1 (en) 2002-03-01 2005-05-12 Dyax Corporation KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
PT2949658T (pt) 2003-03-03 2018-10-18 Bracco Suisse Sa Péptidos que ligam especificamente o recetor de hgf (cmet) e utilizações dos mesmos
KR100585219B1 (ko) * 2004-05-07 2006-06-01 주식회사 태평양 포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) * 2006-03-15 2009-05-13 中国石油化工股份有限公司 一种亚磷酰胺酯类极压抗磨剂及其制备和应用
WO2010121133A2 (en) 2009-04-17 2010-10-21 The General Hospital Corporation Multimodal imaging of fibrin
EP2408790A1 (de) 2009-03-19 2012-01-25 Wyeth LLC Verfahren zur herstellung von [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1-(7)- en-2-yl)ethyl]phosphonsäure und vorstufen davon
AU2012282678B2 (en) 2011-07-11 2016-03-03 California Institute Of Technology Akt-specific capture agents, compositions, and methods of using and making
TW201514188A (zh) * 2013-03-13 2015-04-16 Lantheus Medical Imaging Inc 製備釓磷維塞三鈉單水合物之方法
WO2015171543A1 (en) 2014-05-05 2015-11-12 California Institute Of Technology Mutant akt-specific capture agents, compositions, and methods of using and making
WO2015196208A2 (en) 2014-06-20 2015-12-23 The General Hospital Corporation Collagen targeted imaging probes
EP3270951B1 (de) 2015-03-16 2020-09-09 California Institute of Technology Botulinum-neurotoxin-spezifische abscheidungsmittel, zusammensetzungen und verfahren zur verwendung und herstellung
CN115112898B (zh) 2015-07-15 2026-03-24 加州理工学院 Il-17f-特异性捕获剂、组合物以及使用和制造的方法
CN115109120A (zh) 2016-04-04 2022-09-27 英蒂分子公司 Cd8-特异性捕获剂、组合物及使用和制备方法
US11884707B2 (en) 2016-09-29 2024-01-30 Regeneron Pharmaceuticals, Inc. Compositions for detection, inhibition and imaging of indoleamine 2, 3-dioxygenase 1 (IDO1) and methods of making and using same
EP3535278A4 (de) 2016-11-01 2020-06-24 Ohio State Innovation Foundation Verfahren zur jodierung von biomolekülen
EP3638687A1 (de) 2017-06-15 2020-04-22 Indi Molecular, Inc. Il-17f- und il-17a-spezifische fänger, zusammensetzungen und verfahren zur verwendung und herstellung davon
WO2020093055A2 (en) 2018-11-02 2020-05-07 Indi Molecular, Inc. Peptide libraries with non-canonical amino acids
US11638764B2 (en) 2018-11-08 2023-05-02 Indi Molecular, Inc. Theranostic capture agents, compositions, and methods of using and making
US12201679B2 (en) 2019-04-05 2025-01-21 Institute For Systems Biology Epitope-targeted peptide immunostimulants
WO2020236969A1 (en) 2019-05-20 2020-11-26 Indi Molecular, Inc. Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1)
US11414460B2 (en) 2019-07-19 2022-08-16 Institute For Systems Biology KRAS-specific capture agents, compositions, and methods of making and using
EP4143227A2 (de) 2020-04-30 2023-03-08 Sairopa B.V. Anti-cd103 antikörper
US12209142B2 (en) 2020-05-29 2025-01-28 Institute For Systems Biology SARS-CoV-2 epitope-targeted peptide immunostimulants
WO2022098743A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en) 2020-11-03 2022-05-12 Indi Molecular, Inc. Compositions, delivery systems, and methods useful in tumor therapy
WO2022185843A1 (ja) * 2021-03-03 2022-09-09 国立大学法人東京工業大学 非対称型リン酸トリエステルの製造方法、対称型リン酸トリエステルの製造方法、リン酸エステルの製造方法、及び、有機リン化合物の製造方法

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US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
US4880008A (en) * 1985-05-08 1989-11-14 The General Hospital Corporation Vivo enhancement of NMR relaxivity
TW319763B (de) * 1995-02-01 1997-11-11 Epix Medical Inc
EP0827406A1 (de) * 1995-03-08 1998-03-11 The Scripps Research Institute Carbopeptoide und carbonukleotoide

Also Published As

Publication number Publication date
ATE236171T1 (de) 2003-04-15
ES2195315T3 (es) 2003-12-01
IS1994B (is) 2005-03-15
JP4014231B2 (ja) 2007-11-28
EP1021452B1 (de) 2003-04-02
SK138299A3 (en) 2000-05-16
NO325619B1 (no) 2008-06-30
AU6042598A (en) 1998-11-11
PL337423A1 (en) 2000-08-14
KR20010006177A (ko) 2001-01-26
CZ294469B6 (cs) 2005-01-12
BR9809084B1 (pt) 2010-12-14
DK1021452T3 (da) 2003-08-18
JP2005206605A (ja) 2005-08-04
CZ355999A3 (cs) 2000-01-12
HU224257B1 (hu) 2005-07-28
NZ337921A (en) 2000-09-29
PL188258B1 (pl) 2005-01-31
AU728902B2 (en) 2001-01-18
BR9809084A (pt) 2000-08-01
WO1998046612A1 (en) 1998-10-22
NO994919D0 (no) 1999-10-08
IS5193A (is) 1999-09-24
IL131964A0 (en) 2001-03-19
EP1021452A1 (de) 2000-07-26
HUP0004239A2 (en) 2001-03-28
HUP0004239A3 (en) 2001-11-28
NO994919L (no) 1999-10-08
IL131964A (en) 2004-01-04
US5919967A (en) 1999-07-06
DE69812983D1 (de) 2003-05-08
KR20060066122A (ko) 2006-06-15
CA2285417A1 (en) 1998-10-22
PT1021452E (pt) 2003-08-29
CA2285417C (en) 2006-01-24
KR100593650B1 (ko) 2006-07-03
JP2002511060A (ja) 2002-04-09
DE69812983T2 (de) 2004-01-08

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100127