ATE236171T1 - Verfahren zur herstellung von phosphodiestern - Google Patents

Verfahren zur herstellung von phosphodiestern

Info

Publication number: ATE236171T1
Authority: AT; Austria
Prior art keywords: alcohol; reaction; phosphodiesters; producing; phosphorodichlorodite
Prior art date: 1997-04-11

Application number

AT98903734T

Other languages

English (en)

Inventor

John C Amedio

Paul J Bernard

Mark Fountain

Original Assignee

Epix Medical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-11

Filing date

1998-01-27

Publication date

2003-04-15

1998-01-27 Application filed by Epix Medical Inc filed Critical Epix Medical Inc

2003-04-15 Application granted granted Critical

2003-04-15 Publication of ATE236171T1 publication Critical patent/ATE236171T1/de

Links

150000004713 phosphodiesters Chemical class 0.000 title abstract 3
238000004519 manufacturing process Methods 0.000 title abstract 2
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
238000006243 chemical reaction Methods 0.000 abstract 3
108010043958 Peptoids Proteins 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
ZLRAAUUPULJGTL-UHFFFAOYSA-N diaminophosphinous acid Chemical compound NP(N)O ZLRAAUUPULJGTL-UHFFFAOYSA-N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
-1 phosphoramidite diester Chemical class 0.000 abstract 1
150000008300 phosphoramidites Chemical class 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT98903734T 1997-04-11 1998-01-27 Verfahren zur herstellung von phosphodiestern ATE236171T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/833,745 US5919967A (en)	1997-04-11	1997-04-11	Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en)	1997-04-11	1998-01-27	Process for synthesizing phosphodiesters

Publications (1)

Publication Number	Publication Date
ATE236171T1 true ATE236171T1 (de)	2003-04-15

Family

ID=25265165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT98903734T ATE236171T1 (de)	1997-04-11	1998-01-27	Verfahren zur herstellung von phosphodiestern

Country Status (21)

Country	Link
US (1)	US5919967A (de)
EP (1)	EP1021452B1 (de)
JP (2)	JP4014231B2 (de)
KR (2)	KR100593650B1 (de)
AT (1)	ATE236171T1 (de)
AU (1)	AU728902B2 (de)
BR (1)	BR9809084B1 (de)
CA (1)	CA2285417C (de)
CZ (1)	CZ294469B6 (de)
DE (1)	DE69812983T2 (de)
DK (1)	DK1021452T3 (de)
ES (1)	ES2195315T3 (de)
HU (1)	HU224257B1 (de)
IL (1)	IL131964A (de)
IS (1)	IS1994B (de)
NO (1)	NO325619B1 (de)
NZ (1)	NZ337921A (de)
PL (1)	PL188258B1 (de)
PT (1)	PT1021452E (de)
SK (1)	SK283832B6 (de)
WO (1)	WO1998046612A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
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EP1019094B1 (de) *	1997-10-02	2003-11-19	Epix Medical, Inc.	Verfahren für verbesserte kontrast- bilderzeugung zur therapieüberwachung
US20030203879A1 (en) *	1999-09-09	2003-10-30	Schering Ag	Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US6559330B1 (en) *	1999-09-09	2003-05-06	Schering Aktiengesellschaft	Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (de) *	1999-09-09	2005-09-01	Schering Ag	Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
WO2003029257A1 (de) *	2001-09-27	2003-04-10	Schering Aktiengesellschaft	(ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
WO2003074005A2 (en)	2002-03-01	2003-09-12	Dyax Corp.	Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
WO2004065621A1 (en)	2002-03-01	2004-08-05	Dyax Corp.	Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en)	2002-03-01	2014-01-07	Bracco Suisse Sa	KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7261876B2 (en)	2002-03-01	2007-08-28	Bracco International Bv	Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en)	2002-03-01	2010-09-14	Bracco International B.V.	Targeting vector-phospholipid conjugates
US20050214859A1 (en)	2003-03-03	2005-09-29	Dyax Corp.	Peptides that specifically bind HGF receptor (cMet) and uses thereof
KR100585219B1 (ko) *	2004-05-07	2006-06-01	주식회사 태평양	포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) *	2006-03-15	2009-05-13	中国石油化工股份有限公司	一种亚磷酰胺酯类极压抗磨剂及其制备和应用
WO2010121133A2 (en)	2009-04-17	2010-10-21	The General Hospital Corporation	Multimodal imaging of fibrin
WO2010108063A1 (en)	2009-03-19	2010-09-23	Wyeth Llc	Methods for the preparation of [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)ethyl]phosphonic acid and precursors thereof
AU2012282678B2 (en)	2011-07-11	2016-03-03	California Institute Of Technology	Akt-specific capture agents, compositions, and methods of using and making
TW201514188A (zh) *	2013-03-13	2015-04-16	Lantheus Medical Imaging Inc	製備釓磷維塞三鈉單水合物之方法
WO2015171543A1 (en)	2014-05-05	2015-11-12	California Institute Of Technology	Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en)	2014-06-20	2019-11-12	The General Hospital Corporation	Collagen targeted imaging probes
US9913875B2 (en)	2015-03-16	2018-03-13	California Institute Of Technology	Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
WO2017011769A2 (en)	2015-07-15	2017-01-19	California Institute Of Technology	Il-17f-specific capture agents, compositions, and methods of using and making
WO2018064597A1 (en)	2016-09-29	2018-04-05	Indi Molecular, Inc.	Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
WO2018085375A1 (en)	2016-11-01	2018-05-11	Ohio State Innovation Foundation	Methods for the iodination of biomolecules
WO2018232345A1 (en)	2017-06-15	2018-12-20	Indi Molecular, Inc.	Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
WO2020093055A2 (en)	2018-11-02	2020-05-07	Indi Molecular, Inc.	Peptide libraries with non-canonical amino acids
WO2020097531A1 (en)	2018-11-08	2020-05-14	Indi Molecular, Inc.	Theranostic capture agents, compositions, and methods of using and making
US12201679B2 (en)	2019-04-05	2025-01-21	Institute For Systems Biology	Epitope-targeted peptide immunostimulants
US12216122B2 (en)	2019-05-20	2025-02-04	Regeneron Pharmaceuticals, Inc.	Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en)	2019-07-19	2022-08-16	Institute For Systems Biology	KRAS-specific capture agents, compositions, and methods of making and using
IL297806A (en)	2020-04-30	2022-12-01	Sairopa B V	Anti-cd103 antibodies
US12209142B2 (en)	2020-05-29	2025-01-28	Institute For Systems Biology	SARS-CoV-2 epitope-targeted peptide immunostimulants
WO2022098745A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, delivery systems, and methods useful in tumor therapy
WO2022098743A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
EP4303222A4 (de) *	2021-03-03	2025-06-18	Tokyo Institute of Technology	Verfahren zur herstellung von asymmetrischem phosphorsäuretriester, verfahren zur herstellung von symmetrischen phosphorsäuretriestern, verfahren zur herstellung von phosphorsäureester und verfahren zur herstellung einer organophosphorverbindung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
TW319763B (de) *	1995-02-01	1997-11-11	Epix Medical Inc
WO1996027379A1 (en) *	1995-03-08	1996-09-12	The Scripps Research Institute	Carbopeptoids and carbonucleotoids

1997
- 1997-04-11 US US08/833,745 patent/US5919967A/en not_active Expired - Lifetime
1998
- 1998-01-27 JP JP54386798A patent/JP4014231B2/ja not_active Expired - Fee Related
- 1998-01-27 KR KR1019997009256A patent/KR100593650B1/ko not_active Expired - Fee Related
- 1998-01-27 CZ CZ19993559A patent/CZ294469B6/cs not_active IP Right Cessation
- 1998-01-27 ES ES98903734T patent/ES2195315T3/es not_active Expired - Lifetime
- 1998-01-27 NZ NZ337921A patent/NZ337921A/xx not_active IP Right Cessation
- 1998-01-27 DK DK98903734T patent/DK1021452T3/da active
- 1998-01-27 IL IL13196498A patent/IL131964A/en not_active IP Right Cessation
- 1998-01-27 CA CA002285417A patent/CA2285417C/en not_active Expired - Lifetime
- 1998-01-27 WO PCT/US1998/001473 patent/WO1998046612A1/en not_active Ceased
- 1998-01-27 HU HU0004239A patent/HU224257B1/hu not_active IP Right Cessation
- 1998-01-27 AU AU60425/98A patent/AU728902B2/en not_active Ceased
- 1998-01-27 PT PT98903734T patent/PT1021452E/pt unknown
- 1998-01-27 SK SK1382-99A patent/SK283832B6/sk not_active IP Right Cessation
- 1998-01-27 BR BRPI9809084-4A patent/BR9809084B1/pt not_active IP Right Cessation
- 1998-01-27 KR KR1020067007449A patent/KR20060066122A/ko not_active Withdrawn
- 1998-01-27 DE DE69812983T patent/DE69812983T2/de not_active Expired - Lifetime
- 1998-01-27 PL PL98337423A patent/PL188258B1/pl not_active IP Right Cessation
- 1998-01-27 AT AT98903734T patent/ATE236171T1/de active
- 1998-01-27 EP EP98903734A patent/EP1021452B1/de not_active Expired - Lifetime
1999
- 1999-09-24 IS IS5193A patent/IS1994B/is unknown
- 1999-10-08 NO NO19994919A patent/NO325619B1/no not_active IP Right Cessation
2005
- 2005-02-21 JP JP2005044872A patent/JP2005206605A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
DK1021452T3 (da)	2003-08-18
IL131964A (en)	2004-01-04
SK283832B6 (sk)	2004-02-03
ES2195315T3 (es)	2003-12-01
IS1994B (is)	2005-03-15
HU224257B1 (hu)	2005-07-28
BR9809084B1 (pt)	2010-12-14
US5919967A (en)	1999-07-06
NO994919D0 (no)	1999-10-08
SK138299A3 (en)	2000-05-16
AU6042598A (en)	1998-11-11
CA2285417C (en)	2006-01-24
EP1021452A1 (de)	2000-07-26
NZ337921A (en)	2000-09-29
CA2285417A1 (en)	1998-10-22
PL337423A1 (en)	2000-08-14
WO1998046612A1 (en)	1998-10-22
CZ294469B6 (cs)	2005-01-12
CZ355999A3 (cs)	2000-01-12
PT1021452E (pt)	2003-08-29
IL131964A0 (en)	2001-03-19
DE69812983D1 (de)	2003-05-08
JP2002511060A (ja)	2002-04-09
JP4014231B2 (ja)	2007-11-28
AU728902B2 (en)	2001-01-18
KR20010006177A (ko)	2001-01-26
BR9809084A (pt)	2000-08-01
EP1021452B1 (de)	2003-04-02
PL188258B1 (pl)	2005-01-31
KR20060066122A (ko)	2006-06-15
DE69812983T2 (de)	2004-01-08
NO994919L (no)	1999-10-08
KR100593650B1 (ko)	2006-07-03
JP2005206605A (ja)	2005-08-04
IS5193A (is)	1999-09-24
HUP0004239A2 (en)	2001-03-28
HUP0004239A3 (en)	2001-11-28
NO325619B1 (no)	2008-06-30

Legal Events

Date

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Title

Description

2003-11-15

UEP

Publication of translation of european patent specification

Ref document number: 1021452

Country of ref document: EP

2007-04-15

EEFA

Change of the company name

Publication	Publication Date	Title
ATE236171T1 (de)	2003-04-15	Verfahren zur herstellung von phosphodiestern
DE69113325D1 (de)	1995-11-02	Verbessertes Verfahren zur Herstellung von Salzen der 4-Amino-1-hydroxybutyliden-1,1-bisphosphonsäure.
ES2180141T3 (es)	2003-02-01	Procedimiento de produccion de acido 4-amino-1-hidroxibutiliden-1,1-bifosfonico o sus sales.
ATE233775T1 (de)	2003-03-15	Verfahren zur herstellung von phosphinsäureestern
DE69931493D1 (de)	2006-06-29	Verfahren zur herstellung von hydroxymethylthiobuttersäure
DE69535726D1 (de)	2008-04-17	Phosphorylierungsreagens, Verfahren und Verwendung
ATE273316T1 (de)	2004-08-15	Verfahren zur herstellung von alkenylphosphonsäure-derivaten
ATE172464T1 (de)	1998-11-15	Verfahren zur herstellung von n- phosphonomethylamino carboxylsäuren
DE3864927D1 (de)	1991-10-24	Verfahren zur herstellung von aminomethylenphosphonalkylphosphinaten.
ATE388156T1 (de)	2008-03-15	Verfahren zur herstellung von ethylen-1,2- diphosphonsäuren
ATE155789T1 (de)	1997-08-15	Verfahren zur herstellung von aminomethanphosphonsäure
ATE44382T1 (de)	1989-07-15	Verfahren zur herstellung von l-homoalanin-4yl(methyl)-phosphinsaeure sowie ihrer alkylester.
DE69703140D1 (de)	2000-10-26	Verfahren zur Herstellung von seltenem Erdphosphat mit niedrigem überstöchiometrischem Phosphorgehalt
ATE360087T1 (de)	2007-05-15	Verfahren zur racematspaltung von arylalkylcarbonsäureestern
HUT45541A (en)	1988-07-28	Plant protecting compositions containing ester of phosphoric acid as active component and process for producing the active component
ATE235461T1 (de)	2003-04-15	Verfahren zur herstellung von 3-cyano-2,4- dihalogen-5-fluor-benzoesäuren
DE60110019D1 (de)	2005-05-19	Verfahren zur Herstellung von Cyclopropancarboxylaten
DE60035494D1 (de)	2007-08-23	Verfahren zur herstellung von pseudomycin aus pseudomonas syringae
ATE76646T1 (de)	1992-06-15	Verfahren zur herstellung von phosphorthioaten und phosphaten.
ES2127876T3 (es)	1999-05-01	Acidos fosforicos sustituidos.
ATE256689T1 (de)	2004-01-15	Verfahren zur herstellung von ascorbinsaüre-2- monophosphat salz
ATE135692T1 (de)	1996-04-15	Verfahren zur herstellung von dichlormethylpyridinen
ATE217316T1 (de)	2002-05-15	Verfahren zur herstellung von diphosphonat- derivaten
AR011341A1 (es)	2000-08-16	Proceso para preparar derivados de cianofosfonato o aminometilfosfonato a partir de esteres seleccionados entre de pirofosfato o polifosfato y cianuro
ATE78258T1 (de)	1992-08-15	Verfahren zur herstellung von phosphorthioaten und phosphaten und phosphonthioaten und phosphonaten.