NO994919L - FremgangsmÕte ved syntetisering av fosfidiesterforbindelser - Google Patents

FremgangsmÕte ved syntetisering av fosfidiesterforbindelser

Info

Publication number: NO994919L
Authority: NO; Norway
Prior art keywords: phosphidic; synthesis; alcohol; reaction; ester compounds
Prior art date: 1997-04-11

Application number

NO994919A

Other languages

English (en)

Other versions

NO994919D0 (no

NO325619B1 (no

Inventor

John C Amedio

Paul J Bernard

Mark Fountain

Original Assignee

Epix Medical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-11

Filing date

1999-10-08

Publication date

1999-10-08

1999-10-08 Application filed by Epix Medical Inc filed Critical Epix Medical Inc

1999-10-08 Publication of NO994919L publication Critical patent/NO994919L/no

1999-10-08 Publication of NO994919D0 publication Critical patent/NO994919D0/no

2008-06-30 Publication of NO325619B1 publication Critical patent/NO325619B1/no

Links

-1 ester compounds Chemical class 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
238000000034 method Methods 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
238000006243 chemical reaction Methods 0.000 abstract 3
150000004713 phosphodiesters Chemical class 0.000 abstract 2
108010043958 Peptoids Proteins 0.000 abstract 1
125000001931 aliphatic group Chemical group 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
ZLRAAUUPULJGTL-UHFFFAOYSA-N diaminophosphinous acid Chemical compound NP(N)O ZLRAAUUPULJGTL-UHFFFAOYSA-N 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
230000003647 oxidation Effects 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1
150000008300 phosphoramidites Chemical class 0.000 abstract 1
FAIAAWCVCHQXDN-UHFFFAOYSA-N phosphorus trichloride Chemical compound ClP(Cl)Cl FAIAAWCVCHQXDN-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/117—Esters of phosphoric acids with cycloaliphatic alcohols
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

NO19994919A 1997-04-11 1999-10-08 Fremgangsmate ved syntetisering av fosfodiesterforbindelser NO325619B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/833,745 US5919967A (en)	1997-04-11	1997-04-11	Process for synthesizing phosphodiesters
PCT/US1998/001473 WO1998046612A1 (en)	1997-04-11	1998-01-27	Process for synthesizing phosphodiesters

Publications (3)

Publication Number	Publication Date
NO994919L true NO994919L (no)	1999-10-08
NO994919D0 NO994919D0 (no)	1999-10-08
NO325619B1 NO325619B1 (no)	2008-06-30

Family

ID=25265165

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO19994919A NO325619B1 (no)	1997-04-11	1999-10-08	Fremgangsmate ved syntetisering av fosfodiesterforbindelser

Country Status (21)

Country	Link
US (1)	US5919967A (no)
EP (1)	EP1021452B1 (no)
JP (2)	JP4014231B2 (no)
KR (2)	KR100593650B1 (no)
AT (1)	ATE236171T1 (no)
AU (1)	AU728902B2 (no)
BR (1)	BR9809084B1 (no)
CA (1)	CA2285417C (no)
CZ (1)	CZ294469B6 (no)
DE (1)	DE69812983T2 (no)
DK (1)	DK1021452T3 (no)
ES (1)	ES2195315T3 (no)
HU (1)	HU224257B1 (no)
IL (1)	IL131964A (no)
IS (1)	IS1994B (no)
NO (1)	NO325619B1 (no)
NZ (1)	NZ337921A (no)
PL (1)	PL188258B1 (no)
PT (1)	PT1021452E (no)
SK (1)	SK283832B6 (no)
WO (1)	WO1998046612A1 (no)

Families Citing this family (35)

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ES2206996T3 (es) *	1997-10-02	2004-05-16	Epix Medical Inc	Metodo de formacion de imagenes para diagnostico con contraste mejorado para monitorizar terapias de intervencion.
US6559330B1 (en) *	1999-09-09	2003-05-06	Schering Aktiengesellschaft	Calcium complex of [[(4r)-4-[bis{carboxy-.kappa.o)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.o)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.n6,.kappa.n9,.kappa.011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
US20030203879A1 (en) *	1999-09-09	2003-10-30	Schering Ag	Calcium complex of [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.n]-6,9-bis[(carboxy.kappa.O)methyl]-1-[(4,4-diphenylcyclohexy)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-ylic-acid-.kappa.N6,.Kappa.N9,.Kappa 011]1-oxidato(6-)]-, hexahydrogen, its salts, pharmaceutical agents that contain these complexes, their use in treatment and as additives in diagnosis, as well as processes for the production of the complexes and agents
DE19964224B4 (de) *	1999-09-09	2005-09-01	Schering Ag	Pharmazeutische Mittel enthaltend Calcium-Komplex von [[(4R)-4-[bis[(carboxy-.kappa.O)methyl]amino-.kappa.N]-6,9-bis[(carboxy-.kappa.O)methyl]-1-[(4,4-diphenylcyclohexyl)oxy]-1-hydroxy-2-oxa-6,9-diaza-1-phosphaundecan-11-yl-säure-.kappa.N6,.kappa.N9,.kappa.011]1-oxidato(6-)]-, tetrahydrogen (MS-325) und dessen Salze sowie Verfahren zur Herstellung der Mittel
WO2003029257A1 (de) *	2001-09-27	2003-04-10	Schering Aktiengesellschaft	(ethylen)-(propylen/butylen)-phosphodiester-triaminpentaessigsäure-derivate
WO2004065621A1 (en)	2002-03-01	2004-08-05	Dyax Corp.	Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7261876B2 (en)	2002-03-01	2007-08-28	Bracco International Bv	Multivalent constructs for therapeutic and diagnostic applications
US7794693B2 (en)	2002-03-01	2010-09-14	Bracco International B.V.	Targeting vector-phospholipid conjugates
US8623822B2 (en)	2002-03-01	2014-01-07	Bracco Suisse Sa	KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
SI2301587T1 (sl)	2002-03-01	2014-11-28	Dyax Corp.	KDR in VEGF/KDR vezavni peptidi in njihova uporaba pri diagnozi
ES2557286T3 (es)	2003-03-03	2016-01-25	Dyax Corp.	Usos de péptidos que se unen específicamente al receptor del HGF (cMet)
KR100585219B1 (ko) *	2004-05-07	2006-06-01	주식회사 태평양	포스페이트 유도체 및 이의 제조방법
CN100487093C (zh) *	2006-03-15	2009-05-13	中国石油化工股份有限公司	一种亚磷酰胺酯类极压抗磨剂及其制备和应用
BRPI1009900A2 (pt)	2009-03-19	2016-03-15	Wyeth Llc	métodos para a preparação de ácido [2-(8,9-dioxo-2,6-diazabiciclo[5.2.0]non-1(7)-en-2-il)etil]fosfônico e seus precursores
WO2010121133A2 (en)	2009-04-17	2010-10-21	The General Hospital Corporation	Multimodal imaging of fibrin
US9239332B2 (en)	2011-07-11	2016-01-19	Indi Molecular, Inc.	Akt-specific capture agents, compositions, and methods of using and making
TW201514188A (zh) *	2013-03-13	2015-04-16	Lantheus Medical Imaging Inc	製備釓磷維塞三鈉單水合物之方法
US20150344523A1 (en)	2014-05-05	2015-12-03	California Institute Of Technology	Mutant akt-specific capture agents, compositions, and methods of using and making
US10471162B2 (en)	2014-06-20	2019-11-12	The General Hospital Corporation	Collagen targeted imaging probes
US9913875B2 (en)	2015-03-16	2018-03-13	California Institute Of Technology	Botulinum neurotoxin-specific capture agents, compositions, and methods of using and making
IL256833B2 (en)	2015-07-15	2025-07-01	California Inst Of Techn	IL-17F-specific binding agents, compositions and methods of use and preparation
WO2017176769A1 (en)	2016-04-04	2017-10-12	Indi Molecular, Inc.	Cd8-specific capture agents, compositions, and methods of using and making
EP3519425B1 (en)	2016-09-29	2024-02-28	Indi Molecular, Inc.	Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same
US11358982B2 (en)	2016-11-01	2022-06-14	Ohio State Innovation Foundation	Methods for the iodination of biomolecules
EP3638687A1 (en)	2017-06-15	2020-04-22	Indi Molecular, Inc.	Il-17f and il-17a-specific capture agents, compositions, and methods of using and making
WO2020093055A2 (en)	2018-11-02	2020-05-07	Indi Molecular, Inc.	Peptide libraries with non-canonical amino acids
US11638764B2 (en)	2018-11-08	2023-05-02	Indi Molecular, Inc.	Theranostic capture agents, compositions, and methods of using and making
US12201679B2 (en)	2019-04-05	2025-01-21	Institute For Systems Biology	Epitope-targeted peptide immunostimulants
US12216122B2 (en)	2019-05-20	2025-02-04	Regeneron Pharmaceuticals, Inc.	Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (IDO1)
US11414460B2 (en)	2019-07-19	2022-08-16	Institute For Systems Biology	KRAS-specific capture agents, compositions, and methods of making and using
JP2023524464A (ja)	2020-04-30	2023-06-12	サイロパビー．ブイ．	抗ｃｄ１０３抗体
US12209142B2 (en)	2020-05-29	2025-01-28	Institute For Systems Biology	SARS-CoV-2 epitope-targeted peptide immunostimulants
WO2022098743A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1)
WO2022098745A1 (en)	2020-11-03	2022-05-12	Indi Molecular, Inc.	Compositions, delivery systems, and methods useful in tumor therapy
EP4303222A4 (en)	2021-03-03	2025-06-18	Tokyo Institute of Technology	Method for producing asymmetric phosphoric acid triester, method for producing symmetric phosphoric acid triester, method for producing phosphoric acid ester, and method for producing organophosphorus compound

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4647447A (en) *	1981-07-24	1987-03-03	Schering Aktiengesellschaft	Diagnostic media
US4880008A (en) *	1985-05-08	1989-11-14	The General Hospital Corporation	Vivo enhancement of NMR relaxivity
TW319763B (no) *	1995-02-01	1997-11-11	Epix Medical Inc
WO1996027379A1 (en) *	1995-03-08	1996-09-12	The Scripps Research Institute	Carbopeptoids and carbonucleotoids

1997
- 1997-04-11 US US08/833,745 patent/US5919967A/en not_active Expired - Lifetime
1998
- 1998-01-27 JP JP54386798A patent/JP4014231B2/ja not_active Expired - Fee Related
- 1998-01-27 DE DE69812983T patent/DE69812983T2/de not_active Expired - Lifetime
- 1998-01-27 AU AU60425/98A patent/AU728902B2/en not_active Ceased
- 1998-01-27 CZ CZ19993559A patent/CZ294469B6/cs not_active IP Right Cessation
- 1998-01-27 CA CA002285417A patent/CA2285417C/en not_active Expired - Lifetime
- 1998-01-27 BR BRPI9809084-4A patent/BR9809084B1/pt not_active IP Right Cessation
- 1998-01-27 KR KR1019997009256A patent/KR100593650B1/ko not_active Expired - Fee Related
- 1998-01-27 EP EP98903734A patent/EP1021452B1/en not_active Expired - Lifetime
- 1998-01-27 ES ES98903734T patent/ES2195315T3/es not_active Expired - Lifetime
- 1998-01-27 HU HU0004239A patent/HU224257B1/hu not_active IP Right Cessation
- 1998-01-27 WO PCT/US1998/001473 patent/WO1998046612A1/en not_active Ceased
- 1998-01-27 SK SK1382-99A patent/SK283832B6/sk not_active IP Right Cessation
- 1998-01-27 DK DK98903734T patent/DK1021452T3/da active
- 1998-01-27 KR KR1020067007449A patent/KR20060066122A/ko not_active Withdrawn
- 1998-01-27 AT AT98903734T patent/ATE236171T1/de active
- 1998-01-27 NZ NZ337921A patent/NZ337921A/xx not_active IP Right Cessation
- 1998-01-27 PL PL98337423A patent/PL188258B1/pl not_active IP Right Cessation
- 1998-01-27 IL IL13196498A patent/IL131964A/en not_active IP Right Cessation
- 1998-01-27 PT PT98903734T patent/PT1021452E/pt unknown
1999
- 1999-09-24 IS IS5193A patent/IS1994B/is unknown
- 1999-10-08 NO NO19994919A patent/NO325619B1/no not_active IP Right Cessation
2005
- 2005-02-21 JP JP2005044872A patent/JP2005206605A/ja not_active Withdrawn

Also Published As

Publication number	Publication date
IL131964A (en)	2004-01-04
WO1998046612A1 (en)	1998-10-22
BR9809084A (pt)	2000-08-01
ATE236171T1 (de)	2003-04-15
ES2195315T3 (es)	2003-12-01
IS1994B (is)	2005-03-15
KR100593650B1 (ko)	2006-07-03
HU224257B1 (hu)	2005-07-28
SK283832B6 (sk)	2004-02-03
PT1021452E (pt)	2003-08-29
HUP0004239A2 (en)	2001-03-28
HUP0004239A3 (en)	2001-11-28
SK138299A3 (en)	2000-05-16
BR9809084B1 (pt)	2010-12-14
KR20060066122A (ko)	2006-06-15
AU728902B2 (en)	2001-01-18
NZ337921A (en)	2000-09-29
JP2002511060A (ja)	2002-04-09
IS5193A (is)	1999-09-24
DK1021452T3 (da)	2003-08-18
PL188258B1 (pl)	2005-01-31
AU6042598A (en)	1998-11-11
CA2285417A1 (en)	1998-10-22
US5919967A (en)	1999-07-06
EP1021452A1 (en)	2000-07-26
PL337423A1 (en)	2000-08-14
NO994919D0 (no)	1999-10-08
CZ294469B6 (cs)	2005-01-12
IL131964A0 (en)	2001-03-19
DE69812983D1 (de)	2003-05-08
NO325619B1 (no)	2008-06-30
CZ355999A3 (cs)	2000-01-12
JP4014231B2 (ja)	2007-11-28
CA2285417C (en)	2006-01-24
EP1021452B1 (en)	2003-04-02
JP2005206605A (ja)	2005-08-04
KR20010006177A (ko)	2001-01-26
DE69812983T2 (de)	2004-01-08

Legal Events

Date	Code	Title	Description
2014-08-25	MM1K	Lapsed by not paying the annual fees

Publication	Publication Date	Title
NO994919D0 (no)	1999-10-08	Fremgangsmaate ved syntetisering av fosfidiesterforbindelser
DE69711391D1 (de)	2002-05-02	Verbessertes verfahren zum herstellen von geschützten 3,4-dihydroxybuttersäure estern
WO2002006279A3 (en)	2002-04-18	Efficient method of synthesizing combretastatin a-4 prodrugs
DE59206900D1 (de)	1996-09-19	Diphosphonsaurederivate als zwischenprodukte zur herstellung von diphosphinliganden
ATE77626T1 (de)	1992-07-15	Organische phosphinsaeureverbindungen.
FI883207A0 (fi)	1988-07-05	Foerfarande foer framstaellning av aminometylenfosfonoalkylfosfinater.
HUT45541A (en)	1988-07-28	Plant protecting compositions containing ester of phosphoric acid as active component and process for producing the active component
FI921057A0 (fi)	1992-03-11	Process foer framstaellningen av peroxykarboxylsyror med anvaendning av en enzymkatalysator.
DE50113691D1 (de)	2008-04-17	Verfahren zur Herstellung von Ethylen-1,2-diphosphonsäuren
NO953992D0 (no)	1995-10-06	Fremgangsmåte for fremstilling av aminometanfosforsyre
EP0997534A3 (de)	2003-09-03	Verfahren zur Racematspaltung von Arylalkylcarbonsäureestern
MY101645A (en)	1991-12-31	Phosphoric esters and process for preparing the same.
DE3868207D1 (en)	1992-03-12	O-(o-ethyl-s-alkylphosphoryl)-o-(carbamoyl)-brenzkatechinderivate.
ES2003066A4 (es)	1988-10-16	Obtencion de acidos 2-amino-4-fosfinilbutanoico.
ES2079852T3 (es)	1996-01-16	Derivados de tritianos y acido de fosforo y/o acido de tiofosforo.
JPS57183796A (en)	1982-11-12	Preparation of organophosphoric acid ester substituted with alkylsulfinyl group
NO180378C (no)	1997-04-09	Fremgangsmåte ved fremstilling av metylenbisfosfonsyrer
ES484569A1 (es)	1980-10-01	Procedimiento para preparar una composicion insecticida a base de fosfatos y fosfanatos de pirazol.
GB9424356D0 (en)	1995-01-18	Substituted phosphonic acids
ATE135692T1 (de)	1996-04-15	Verfahren zur herstellung von dichlormethylpyridinen
JPS53144558A (en)	1978-12-15	Color protection of beta-naphthol
ES463860A1 (es)	1979-01-01	Procedimiento para preparar anhidridos de acidos organofos- foricos
JPS5553274A (en)	1980-04-18	Preparation of n-substituted imidazole
JPS56166197A (en)	1981-12-21	O-alkyl s-alkyl or -aryl thiophosphoric chloride