SK287397B6 - Analógy paratyroidného hormónu na liečenie osteoporózy - Google Patents

Analógy paratyroidného hormónu na liečenie osteoporózy Download PDF

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Publication number
SK287397B6
SK287397B6 SK132-99A SK13299A SK287397B6 SK 287397 B6 SK287397 B6 SK 287397B6 SK 13299 A SK13299 A SK 13299A SK 287397 B6 SK287397 B6 SK 287397B6
Authority
SK
Slovakia
Prior art keywords
hpth
leu
lys
glu
seq
Prior art date
Application number
SK132-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK13299A3 (en
Inventor
Jean-Ren Barbier
Paul Morley
Witold Neugebauer
Virginia Ross
James Whitfield
Gordon E. Willick
Original Assignee
National Research Council Of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/691,647 external-priority patent/US5955425A/en
Application filed by National Research Council Of Canada filed Critical National Research Council Of Canada
Publication of SK13299A3 publication Critical patent/SK13299A3/sk
Publication of SK287397B6 publication Critical patent/SK287397B6/sk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/29—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
    • A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measurement Of Radiation (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SK132-99A 1996-08-02 1997-08-01 Analógy paratyroidného hormónu na liečenie osteoporózy SK287397B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/691,647 US5955425A (en) 1996-08-02 1996-08-02 Parathyroid hormone analogues for the treatment of osteoporosis
US4056097P 1997-03-14 1997-03-14
PCT/CA1997/000547 WO1998005683A1 (en) 1996-08-02 1997-08-01 Parathyroid hormone analogues for the treatment of osteoporosis

Publications (2)

Publication Number Publication Date
SK13299A3 SK13299A3 (en) 1999-10-08
SK287397B6 true SK287397B6 (sk) 2010-08-09

Family

ID=26717175

Family Applications (1)

Application Number Title Priority Date Filing Date
SK132-99A SK287397B6 (sk) 1996-08-02 1997-08-01 Analógy paratyroidného hormónu na liečenie osteoporózy

Country Status (24)

Country Link
EP (1) EP0915911B1 (de)
JP (3) JP4122061B2 (de)
KR (1) KR100500859B1 (de)
CN (1) CN1176947C (de)
AT (1) ATE253078T1 (de)
AU (1) AU723728B2 (de)
BG (1) BG103128A (de)
BR (1) BR9711002B1 (de)
CA (1) CA2261564C (de)
CZ (1) CZ34799A3 (de)
DE (1) DE69725850T2 (de)
DK (1) DK0915911T3 (de)
EE (1) EE9900039A (de)
ES (1) ES2207740T3 (de)
FI (1) FI990126A7 (de)
GE (1) GEP20033095B (de)
IS (1) IS4962A (de)
LV (1) LV12293B (de)
NZ (1) NZ333809A (de)
PT (1) PT915911E (de)
RU (1) RU2203286C2 (de)
SI (1) SI9720057A (de)
SK (1) SK287397B6 (de)
WO (1) WO1998005683A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP9901686A0 (en) * 1997-05-14 1999-12-31 Rhone Poulenc Rorer Pharma Peptide parathyroid hormone analogs.
EP1123401A1 (de) 1998-10-22 2001-08-16 The General Hospital Corporation Bioaktive peptide und peptid-derivate von parathyroidhormon (pth) und parathyroidhormon verwandte peptide (pthrp)
AU1633200A (en) 1998-11-25 2000-06-13 General Hospital Corporation, The Human parathyroid hormone modifications, preparation and use
US7169567B1 (en) 1998-12-31 2007-01-30 The General Hospital Corporation Screening assay utilizing the PTH receptor
EP1221963A4 (de) * 1999-07-28 2006-03-22 Univ Pennsylvania Methoden zur hemmung der osteoclastogenese
US6316410B1 (en) 1999-09-22 2001-11-13 National Research Council Of Canada Parathyroid hormone analogues for the treatment of osteoporosis
AU2002339843B2 (en) 2001-07-23 2007-12-06 The General Hospital Corporation Conformationally constrained parathyroid hormone (PTH) analogs
CA2453646C (en) * 2001-08-17 2008-09-30 Novartis Ag 5-cnac as oral delivery agent for parathyroid hormone fragments
AU2003207512B2 (en) 2002-01-10 2008-06-12 Osteotrophin Llc Treatment of bone disorders with skeletal anabolic drugs
EP1567178A4 (de) * 2002-11-01 2009-07-15 Amgen Inc Modulatoren von rezeptoren für nebenschilddrüsenhormon- und nebenschildsrüsenhormonbezogene proteine
US8088734B2 (en) * 2003-01-21 2012-01-03 Unigene Laboratories Inc. Oral delivery of peptides
CN100508957C (zh) * 2003-01-21 2009-07-08 尤尼金实验室股份有限公司 肽经口输递的改进
CA2621264A1 (en) * 2005-09-06 2007-11-15 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
CA2659846A1 (en) * 2006-07-31 2008-02-07 Zelos Therapeutics, Inc. Parathyroid hormone analogues and methods of use
CA2672907C (en) 2006-10-13 2013-08-06 Eli Lilly And Company Pegylated pth as pth receptor modulators and uses thereof
MX346714B (es) 2007-08-01 2017-03-24 The General Hospital Corp * Metodos de analisis y seleccion usando receptores acoplados a proteina g y composiciones relacionadas.
CN103002906B (zh) * 2010-05-13 2017-12-29 总医院有限公司 甲状旁腺激素类似物及其应用
CN105440126B (zh) * 2015-12-31 2019-10-25 南京工业大学 治疗骨质疏松的α-螺旋多肽及其制备方法与应用
US11219697B2 (en) 2017-07-15 2022-01-11 The Regents Of The University Of California Osteoadsorptive fluorogenic substrate of cathepsin k for imaging osteoclast activity and migration
US12404393B2 (en) 2018-09-26 2025-09-02 Borealis Ag Propylene copolymer composition with excellent optical and mechanical properties
CN113549144A (zh) * 2021-06-30 2021-10-26 华南理工大学 一种特立帕肽hPTH(1-34)的生产和纯化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0532696A (ja) * 1990-09-28 1993-02-09 Takeda Chem Ind Ltd 副甲状腺ホルモン誘導体
US5317010A (en) * 1991-10-10 1994-05-31 Peter K. T. Pang Parathyroid hormone analogues substituted at AA 25, 26, 27, and use in osteoporosis treatment
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5589452A (en) * 1992-07-14 1996-12-31 Syntex (U.S.A.) Inc. Analogs of parathyroid hormone and parathyroid hormone related peptide: synthesis and use for the treatment of osteoporosis
AU672790B2 (en) * 1992-07-15 1996-10-17 Novartis Ag Variants of parathyroid hormone and its fragments
CA2126299C (en) * 1994-06-20 2000-12-12 Gordon E. Willick Parathyroid hormone analogues for the treatment of osteoporosis

Also Published As

Publication number Publication date
DE69725850T2 (de) 2004-08-19
JP4224111B2 (ja) 2009-02-12
EP0915911A1 (de) 1999-05-19
GEP20033095B (en) 2003-10-27
AU723728B2 (en) 2000-09-07
CN1176947C (zh) 2004-11-24
FI990126L (fi) 1999-03-31
LV12293A (lv) 1999-06-20
LV12293B (en) 2000-11-20
KR20000029783A (ko) 2000-05-25
FI990126A0 (fi) 1999-01-22
NZ333809A (en) 2000-07-28
CZ34799A3 (cs) 1999-07-14
FI990126A7 (fi) 1999-03-31
BR9711002A (pt) 2002-01-15
BR9711002B1 (pt) 2011-09-06
KR100500859B1 (ko) 2005-07-14
DK0915911T3 (da) 2004-03-08
CA2261564A1 (en) 1998-02-12
ES2207740T3 (es) 2004-06-01
SI9720057A (sl) 1999-12-31
IS4962A (is) 1999-01-29
RU2203286C2 (ru) 2003-04-27
CN1231676A (zh) 1999-10-13
BG103128A (bg) 2000-05-31
ATE253078T1 (de) 2003-11-15
WO1998005683A1 (en) 1998-02-12
PT915911E (pt) 2004-03-31
AU3690597A (en) 1998-02-25
JP2009057386A (ja) 2009-03-19
DE69725850D1 (de) 2003-12-04
JP4122061B2 (ja) 2008-07-23
JP2001500845A (ja) 2001-01-23
CA2261564C (en) 2007-10-30
EP0915911B1 (de) 2003-10-29
EE9900039A (et) 1999-08-16
JP2007254480A (ja) 2007-10-04
SK13299A3 (en) 1999-10-08

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20120801