SK288131B6 - CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method - Google Patents

CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method Download PDF

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Publication number
SK288131B6
SK288131B6 SK1570-2002A SK15702002A SK288131B6 SK 288131 B6 SK288131 B6 SK 288131B6 SK 15702002 A SK15702002 A SK 15702002A SK 288131 B6 SK288131 B6 SK 288131B6
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SK
Slovakia
Prior art keywords
ctla4
ctla4 mutant
molecule
mutant molecule
cell
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Application number
SK1570-2002A
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English (en)
Slovak (sk)
Other versions
SK15702002A3 (sk
Inventor
Robert J. Peach
Joseph R. Naemura
Peter S. Linsley
Jurgen Bajorath
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of SK15702002A3 publication Critical patent/SK15702002A3/sk
Publication of SK288131B6 publication Critical patent/SK288131B6/sk

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503Immunoglobulin superfamily
    • C07K14/70521CD28, CD152
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047Cells of the immune system
    • G01N33/505Cells of the immune system involving T-cells
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SK1570-2002A 2000-05-26 2001-05-23 CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method SK288131B6 (sk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US57992700A 2000-05-26 2000-05-26
US21406500P 2000-06-26 2000-06-26
PCT/US2001/017139 WO2001092337A2 (fr) 2000-05-26 2001-05-23 Molecules ctla4 mutantes solubles et leurs utilisations

Publications (2)

Publication Number Publication Date
SK15702002A3 SK15702002A3 (sk) 2004-01-08
SK288131B6 true SK288131B6 (sk) 2013-10-02

Family

ID=26908652

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1570-2002A SK288131B6 (sk) 2000-05-26 2001-05-23 CTLA4 mutant molecule or nucleic acid molecule, vector and host vector system, host cell, CTLA4 mutant protein, method for producing and use thereof, pharmaceutical composition and regulation method

Country Status (41)

Country Link
EP (3) EP3029062A1 (fr)
JP (1) JP4328525B2 (fr)
KR (2) KR100895134B1 (fr)
CN (2) CN101255192A (fr)
AR (1) AR031699A1 (fr)
AT (1) ATE271066T1 (fr)
AU (2) AU2001263466C1 (fr)
BE (1) BE2011C041I2 (fr)
BR (1) BRPI0111191B8 (fr)
CA (1) CA2409748C (fr)
CY (2) CY2011019I1 (fr)
CZ (1) CZ304451B6 (fr)
DE (2) DE60104282T2 (fr)
DK (1) DK1248802T3 (fr)
EC (1) ECSP024365A (fr)
EE (2) EE05458B1 (fr)
EG (1) EG24459A (fr)
ES (2) ES2225549T3 (fr)
FR (1) FR11C0053I2 (fr)
GE (1) GEP20053658B (fr)
HK (1) HK1048126B (fr)
HU (2) HU228137B1 (fr)
IL (1) IL152315A (fr)
LT (1) LT5133B (fr)
LU (1) LU91902I2 (fr)
LV (1) LV12994B (fr)
MX (1) MXPA02011534A (fr)
MY (1) MY136113A (fr)
NO (2) NO330797B1 (fr)
PE (1) PE20011338A1 (fr)
PL (1) PL206267B1 (fr)
PT (1) PT1248802E (fr)
RU (1) RU2283847C2 (fr)
SI (1) SI1248802T1 (fr)
SK (1) SK288131B6 (fr)
TR (1) TR200402703T4 (fr)
TW (2) TWI314933B (fr)
UA (1) UA87432C2 (fr)
UY (1) UY26723A1 (fr)
WO (1) WO2001092337A2 (fr)
ZA (1) ZA200208944B (fr)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6887471B1 (en) 1991-06-27 2005-05-03 Bristol-Myers Squibb Company Method to inhibit T cell interactions with soluble B7
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US20040022787A1 (en) 2000-07-03 2004-02-05 Robert Cohen Methods for treating an autoimmune disease using a soluble CTLA4 molecule and a DMARD or NSAID
EP1935427B1 (fr) * 2000-07-03 2018-03-07 Bristol-Myers Squibb Company Utilisations des molécules mutantes solubles CTLA4
US7304033B2 (en) 2001-05-23 2007-12-04 Bristol-Myers Squibb Company Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules
CA2482042A1 (fr) * 2002-04-19 2003-10-30 Bristol-Myers Squibb Company Methodes de traitement d'une maladie auto-immune au moyen d'une molecule ctla4 soluble et d'un armm ou d'un ains
DE10232697A1 (de) * 2002-07-15 2004-02-05 Universitätsklinikum Charité, Medizinische Fakultät der Humboldt-Universität zu Berlin Verwendung von CD152 zur Behandlung von Autoimmunkrankheiten und Entzündungen
MXPA05006522A (es) * 2002-12-23 2006-02-17 Bristol Myers Squibb Co Mejora en la calidad de producto en procesos de cultivo en celulas de mamiferos para la produccion de proteina.
MXPA05006523A (es) 2002-12-23 2005-08-26 Squibb Bristol Myers Co Procesos de cultivo de celulas de mamiferos para la produccion de proteinas.
WO2004060911A2 (fr) 2002-12-30 2004-07-22 Amgen Inc. Polytherapie a facteurs costimulants
AU2004287431B2 (en) 2003-10-27 2010-03-11 Amgen Inc. Compositions and methods to modulate an immune response to an immunogenic therapeutic agent
DK1969007T3 (da) * 2005-12-20 2013-11-25 Bristol Myers Squibb Co Sammensætninger og fremgangsmåder til fremstilling af en sammensætning
AR058568A1 (es) 2005-12-20 2008-02-13 Bristol Myers Squibb Co Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
US7510844B2 (en) 2006-01-24 2009-03-31 Bristol-Myers Squibb Company CD86 and CD80 receptor competition assays
WO2008005290A2 (fr) 2006-06-29 2008-01-10 The Trustees Of Columbia University In The City Of New York Procédés de test d'agents anti-thrombotiques
GB0620934D0 (en) * 2006-10-20 2006-11-29 Cambridge Antibody Tech Protein variants
EP2121756A4 (fr) 2006-12-20 2011-08-31 Mmrglobal Inc Anticorps et procedes de fabrication et d'utilisation de ceux-ci
EP2612867A1 (fr) * 2007-11-01 2013-07-10 Perseid Therapeutics LLC Acides nucléiques et polypeptides immunosuppresseurs
NO2344540T3 (fr) 2008-10-02 2018-04-28
US9540426B2 (en) 2009-10-06 2017-01-10 Bristol-Myers Squibb Company Mammalian cell culture processes for protein production
CN106432474A (zh) * 2010-03-12 2017-02-22 艾伯维生物医疗股份有限公司 Ctla4蛋白和其用途
EA201370187A1 (ru) 2011-02-23 2013-12-30 Амген Инк. Клеточная культуральная среда для уфс воздействия и относящиеся к ней способы
WO2013010537A1 (fr) 2011-07-20 2013-01-24 Aarhus Universitet Procédé de traitement de la morphée
US9758566B2 (en) 2012-03-29 2017-09-12 The General Hospital Corporation Recombinant cytotoxic T-lymphocyte-associated protein 4 (CTLA4)
WO2013169338A1 (fr) 2012-05-11 2013-11-14 Medimmune, Llc Variants de ctla-4
US8735359B2 (en) 2012-05-24 2014-05-27 Orban Biotech Llc Combinations of modalities for the treatment of diabetes
KR20150033703A (ko) * 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20140112958A1 (en) 2012-10-24 2014-04-24 Mwm Biomodels Gmbh Pancreatic islets of transgenic LEA29Y animals for treating diabetes
CN104740608A (zh) * 2013-12-30 2015-07-01 上海中信国健药业股份有限公司 可溶性ctla4分子用于制备治疗类风湿性关节炎药物的用途
BR122020004385B1 (pt) 2014-01-13 2022-10-04 Amgen Inc Método para aumentar o teor de glicoforma de alta manose de uma glicoproteína recombinante e método de produção de uma glicoproteína recombinante
GB2523399B (en) 2014-02-25 2019-03-13 Orban Tihamer A composition comprising ten overlapping peptide fragments of the entire preproinsulin sequence
AU2015269365A1 (en) 2014-06-04 2016-12-15 Amgen Inc. Methods for harvesting mammalian cell cultures
CA2969225C (fr) 2014-12-01 2023-08-22 Amgen Inc. Procede de manipulation du taux de contenu de glycane d'une glycoproteine
WO2016130734A1 (fr) 2015-02-11 2016-08-18 Bristol-Myers Squibb Company Utilisation d'antioxydants phénoliques dans la culture cellulaire pour la production de protéines
CN121159719A (zh) 2015-04-17 2025-12-19 高山免疫科学股份有限公司 具有可调的亲和力的免疫调节蛋白
AU2016321298A1 (en) 2015-09-09 2018-03-29 The Trustees Of Columbia University In The City Of New York Reduction of ER-MAM localized APP-C99 and methods of treating Alzheimer's Disease
WO2017083224A1 (fr) 2015-11-09 2017-05-18 Bristol-Myers Squibb Company Procédés pour manipuler des attributs de qualité de polypeptides produits dans des cellules cho
ES3059995T3 (en) * 2016-09-19 2026-03-24 Oncoc4 Inc Cd80 and cd86 binding protein compositions and uses thereof
CN107987153A (zh) * 2016-10-27 2018-05-04 广东香雪精准医疗技术有限公司 高亲和力的可溶性pd-1分子
KR102746223B1 (ko) 2017-04-20 2024-12-27 이제네시스, 인크. 유전자 변형 동물의 생성 방법
JP7749319B2 (ja) 2017-10-10 2025-10-06 アルパイン イミューン サイエンシズ インコーポレイテッド Ctla-4変異型免疫調節タンパク質およびそれらの使用
AU2019205273B2 (en) 2018-01-03 2024-04-04 Alpine Immune Sciences, Inc. Multi-domain immunomodulatory proteins and methods of use thereof
CN115227824A (zh) * 2018-11-12 2022-10-25 中南大学湘雅二医院 免疫检查点的抑制剂在制备治疗青光眼和其他眼部免疫损伤机制相关疾病药物中的应用
CA3120868A1 (fr) 2018-11-30 2020-06-04 Alpine Immune Sciences, Inc. Proteines immunomodulatrices a variants cd86 et leurs utilisations
AU2020338947A1 (en) 2019-08-27 2022-03-31 Tonix Pharma Limited Modified TFF2 polypeptides
SG11202110968VA (en) 2019-12-06 2021-10-28 Regeneron Pharma Anti-vegf protein compositions and methods for producing the same
AU2021268026A1 (en) 2020-05-08 2023-01-19 Regeneron Pharmaceuticals, Inc. VEGF traps and mini-traps and methods for treating ocular disorders and cancer
EP4146684A2 (fr) 2020-05-08 2023-03-15 Alpine Immune Sciences, Inc. Protéines immunomodulatrices inhibitrices de baff et april avec et sans protéine inhibitrice des lymphocytes t et leurs procédés d'utilisation
MX2022016104A (es) 2020-06-18 2023-02-01 Regeneron Pharma Enfoque de peptidos pesados para medir con precision lisina de extremo c-terminal sin procesar.
CN116601279A (zh) 2020-07-28 2023-08-15 思进股份有限公司 用于生产多肽的方法和系统
KR20240125949A (ko) 2021-12-16 2024-08-20 브리스톨-마이어스 스큅 컴퍼니 바이러스 불활성화를 위한 세제
CN119301236A (zh) 2022-03-02 2025-01-10 瑞泽恩制药公司 用于抗体生产的生物反应器

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US5637481A (en) 1993-02-01 1997-06-10 Bristol-Myers Squibb Company Expression vectors encoding bispecific fusion proteins and methods of producing biologically active bispecific fusion proteins in a mammalian cell
CA2580812A1 (fr) * 1991-06-27 1993-01-07 Bristol-Myers Squibb Company Recepteur ctla, proteines hybrides qui le contiennent et ses applications
US5844095A (en) 1991-06-27 1998-12-01 Bristol-Myers Squibb Company CTLA4 Ig fusion proteins
US5851795A (en) * 1991-06-27 1998-12-22 Bristol-Myers Squibb Company Soluble CTLA4 molecules and uses thereof
ZA98533B (en) * 1997-01-31 1999-07-22 Bristol Myers Squibb Co Soluble CTLA4 mutant molecules and uses thereof.
JP3521382B2 (ja) * 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
GB9809280D0 (en) * 1998-04-30 1998-07-01 Rpms Technology Ltd Immunosupression
EP1119253A4 (fr) * 1998-10-07 2005-12-21 Millennium Pharm Inc NOUVELLES MOLECULES SPECIFIQUES DE Th2 ET LEURS UTILISATIONS
EP1935427B1 (fr) * 2000-07-03 2018-03-07 Bristol-Myers Squibb Company Utilisations des molécules mutantes solubles CTLA4

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NO20025656L (no) 2002-11-25
EP1536234A3 (fr) 2009-06-03
RU2283847C2 (ru) 2006-09-20
IL152315A (en) 2010-04-15
EP1248802B9 (fr) 2005-05-11
NO330797B1 (no) 2011-07-18
UA87432C2 (uk) 2009-07-27
AR031699A1 (es) 2003-10-01
AU6346601A (en) 2001-12-11
EE05557B1 (et) 2012-08-15
AU2001263466C1 (en) 2006-10-26
NO2011027I1 (no) 2012-01-09
EP3029062A1 (fr) 2016-06-08
ECSP024365A (es) 2003-03-31
CN1309735C (zh) 2007-04-11
BE2011C041I2 (fr) 2020-08-20
BR0111191A (pt) 2004-07-06
EG24459A (en) 2009-07-16
ZA200208944B (en) 2004-02-13
HUS1300012I1 (hu) 2016-08-29
CY2011019I2 (el) 2016-12-14
EP1248802A2 (fr) 2002-10-16
SK15702002A3 (sk) 2004-01-08
EE05458B1 (et) 2011-08-15
KR20070094019A (ko) 2007-09-19
LU91902I2 (fr) 2012-01-16
LT2002114A (en) 2003-12-29
EE201100050A (et) 2011-10-17
CY2011019I1 (el) 2016-12-14
KR100889887B1 (ko) 2009-03-24
FR11C0053I2 (fr) 2013-01-11
GEP20053658B (en) 2005-11-10
PT1248802E (pt) 2004-11-30
EP1536234A2 (fr) 2005-06-01
CZ304451B6 (cs) 2014-05-14
FR11C0053I1 (fr) 2012-01-13
NO20025656D0 (no) 2002-11-25
LT5133B (lt) 2004-05-25
CZ20023892A3 (cs) 2003-09-17
JP4328525B2 (ja) 2009-09-09
DE60104282T2 (de) 2005-10-13
MY136113A (en) 2008-08-29
EE200200659A (et) 2004-06-15
IL152315A0 (en) 2003-05-29
DK1248802T3 (da) 2004-11-15
WO2001092337A2 (fr) 2001-12-06
HK1071931A1 (en) 2005-08-05
TW200906857A (en) 2009-02-16
DE122011100063I1 (de) 2012-06-14
TR200402703T4 (tr) 2004-11-22
ATE271066T1 (de) 2004-07-15
PE20011338A1 (es) 2002-01-13
EP1536234B1 (fr) 2016-03-16
ES2225549T3 (es) 2005-03-16
HUP0302201A3 (en) 2010-01-28
ES2571852T3 (es) 2016-05-27
CN101255192A (zh) 2008-09-03
TWI314933B (en) 2009-09-21
HK1048126A1 (en) 2003-03-21
KR20030009502A (ko) 2003-01-29
HU228137B1 (en) 2012-12-28
AU2001263466B2 (en) 2006-04-27
EP1248802B1 (fr) 2004-07-14
WO2001092337A3 (fr) 2002-05-10
SI1248802T1 (en) 2005-02-28
CY1117625T1 (el) 2017-04-26
CA2409748C (fr) 2008-09-16
CN1441810A (zh) 2003-09-10
PL366231A1 (en) 2005-01-24
JP2004511213A (ja) 2004-04-15
KR100895134B1 (ko) 2009-05-04
HK1048126B (en) 2005-03-04
UY26723A1 (es) 2001-12-28
HUP0302201A2 (hu) 2003-10-28
BRPI0111191B8 (pt) 2021-05-25
BRPI0111191B1 (pt) 2019-12-31
TWI319405B (en) 2010-01-11
DE60104282D1 (de) 2004-08-19
LV12994B (en) 2003-08-20
NO2011027I2 (fr) 2011-12-15
CA2409748A1 (fr) 2001-12-06
PL206267B1 (pl) 2010-07-30
MXPA02011534A (es) 2004-08-12

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