SK342002A3 - Sustained release compositions, process for producing the same and use thereof - Google Patents

Sustained release compositions, process for producing the same and use thereof Download PDF

Info

Publication number: SK342002A3
Authority: SK; Slovakia
Prior art keywords: salt; acid; sustained release; lactic acid; polymer
Prior art date: 1999-07-15

Application number

SK34-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Yasutaka Igari

Yoshio Hata

Kazumichi Yamamoto

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-15

Filing date

2000-07-13

Publication date

2002-05-09

2000-07-13 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

2002-05-09 Publication of SK342002A3 publication Critical patent/SK342002A3/sk

Links

239000000203 mixture Substances 0.000 title claims abstract description 124
238000013268 sustained release Methods 0.000 title claims abstract description 79
239000012730 sustained-release form Substances 0.000 title claims abstract description 79
238000000034 method Methods 0.000 title claims description 52
230000008569 process Effects 0.000 title claims description 28
229920000642 polymer Polymers 0.000 claims abstract description 182
150000003839 salts Chemical class 0.000 claims abstract description 161
XBBVURRQGJPTHH-UHFFFAOYSA-N 2-hydroxyacetic acid;2-hydroxypropanoic acid Chemical compound OCC(O)=O.CC(O)C(O)=O XBBVURRQGJPTHH-UHFFFAOYSA-N 0.000 claims abstract description 152
239000013543 active substance Substances 0.000 claims abstract description 105
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 97
UPHOPMSGKZNELG-UHFFFAOYSA-N 2-hydroxynaphthalene-1-carboxylic acid Chemical compound C1=CC=C2C(C(=O)O)=C(O)C=CC2=C1 UPHOPMSGKZNELG-UHFFFAOYSA-N 0.000 claims abstract description 65
238000004519 manufacturing process Methods 0.000 claims abstract description 17
239000003814 drug Substances 0.000 claims abstract description 8
239000000243 solution Substances 0.000 claims description 57
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 56
239000003960 organic solvent Substances 0.000 claims description 50
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 41
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238000002372 labelling Methods 0.000 description 6
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125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 6
239000004475 Arginine Substances 0.000 description 5
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 5
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239000002736 nonionic surfactant Substances 0.000 description 1
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239000003791 organic solvent mixture Substances 0.000 description 1
MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
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OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
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MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
238000011946 reduction process Methods 0.000 description 1
238000010992 reflux Methods 0.000 description 1
238000001448 refractive index detection Methods 0.000 description 1
230000004044 response Effects 0.000 description 1
HEBKCHPVOIAQTA-ZXFHETKHSA-N ribitol Chemical compound OC[C@H](O)[C@H](O)[C@H](O)CO HEBKCHPVOIAQTA-ZXFHETKHSA-N 0.000 description 1
238000004626 scanning electron microscopy Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
229920002545 silicone oil Polymers 0.000 description 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
235000010413 sodium alginate Nutrition 0.000 description 1
239000000661 sodium alginate Substances 0.000 description 1
229940005550 sodium alginate Drugs 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
229940010747 sodium hyaluronate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
239000007901 soft capsule Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 description 1
229960000553 somatostatin Drugs 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
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239000003381 stabilizer Substances 0.000 description 1
UQZIYBXSHAGNOE-XNSRJBNMSA-N stachyose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO[C@@H]3[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O3)O)O2)O)O1 UQZIYBXSHAGNOE-XNSRJBNMSA-N 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000007858 starting material Substances 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
YRALAIOMGQZKOW-UHFFFAOYSA-N sulfated caerulein Natural products C=1C=CC=CC=1CC(C(N)=O)NC(=O)C(CC(O)=O)NC(=O)C(CCSC)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)CNC(=O)C(C(C)O)NC(=O)C(NC(=O)C(CC(O)=O)NC(=O)C(CCC(N)=O)NC(=O)C1NC(=O)CC1)CC1=CC=C(OS(O)(=O)=O)C=C1 YRALAIOMGQZKOW-UHFFFAOYSA-N 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
150000004044 tetrasaccharides Chemical class 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
239000005495 thyroid hormone Substances 0.000 description 1
229940036555 thyroid hormone Drugs 0.000 description 1
239000012974 tin catalyst Substances 0.000 description 1
125000003944 tolyl group Chemical group 0.000 description 1
230000007704 transition Effects 0.000 description 1
229910000314 transition metal oxide Inorganic materials 0.000 description 1
VOITXYVAKOUIBA-UHFFFAOYSA-N triethylaluminium Chemical compound CC[Al](CC)CC VOITXYVAKOUIBA-UHFFFAOYSA-N 0.000 description 1
ITMCEJHCFYSIIV-UHFFFAOYSA-N triflic acid Chemical compound OS(=O)(=O)C(F)(F)F ITMCEJHCFYSIIV-UHFFFAOYSA-N 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
PAPBSGBWRJIAAV-UHFFFAOYSA-N ε-Caprolactone Chemical compound O=C1CCCCCO1 PAPBSGBWRJIAAV-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Inorganic Chemistry (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Urology & Nephrology (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Biological Depolymerization Polymers (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Polyesters Or Polycarbonates (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SK34-2002A 1999-07-15 2000-07-13 Sustained release compositions, process for producing the same and use thereof SK342002A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP20188799		1999-07-15
PCT/JP2000/004683 WO2001005380A1 (fr)	1999-07-15	2000-07-13	Compositions a liberation lente, techniques de production et methodes d'utilisation

Publications (1)

Publication Number	Publication Date
SK342002A3 true SK342002A3 (en)	2002-05-09

Family

ID=16448493

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK34-2002A SK342002A3 (en)	1999-07-15	2000-07-13	Sustained release compositions, process for producing the same and use thereof

Country Status (21)

Country	Link
US (2)	US7265157B1 (cs)
EP (1)	EP1197208B1 (cs)
KR (1)	KR20020012312A (cs)
CN (1)	CN1361685A (cs)
AT (1)	ATE360413T1 (cs)
AU (1)	AU5853000A (cs)
BR (1)	BR0012400A (cs)
CA (1)	CA2378714A1 (cs)
CZ (1)	CZ2002114A3 (cs)
DE (1)	DE60034568T2 (cs)
HK (1)	HK1042237A1 (cs)
HU (1)	HUP0202880A3 (cs)
IL (1)	IL147417A0 (cs)
MX (1)	MXPA02000461A (cs)
NO (1)	NO20020084L (cs)
NZ (1)	NZ516466A (cs)
PL (1)	PL352499A1 (cs)
RU (1)	RU2002103718A (cs)
SK (1)	SK342002A3 (cs)
WO (1)	WO2001005380A1 (cs)
ZA (1)	ZA200200347B (cs)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
TR200002059T2 (tr)	1998-01-16	2001-01-22	Takeda Chemical Industries, Ltd.	Devamlı salınan bileşim, üretim yöntemi ve kullanımı.
WO2000035990A1 (fr)	1998-12-15	2000-06-22	Takeda Chemical Industries, Ltd.	Procede de production d'un polymere
CN1269870C (zh)	2000-08-07	2006-08-16	和光纯药工业株式会社	乳酸聚合物及其制备方法
WO2002078669A1 (fr) *	2001-03-30	2002-10-10	Takeda Chemical Industries, Ltd.	Solutions medicinales
EP1382350A4 (en) *	2001-04-25	2006-01-04	Takeda Pharmaceutical	MEANS AGAINST THE PROPHYLAXIS BEFORE POSTOPERATIVE REPEAT OF PREMOPEOPAUSAL BREAST CANCER
US6693134B2 (en)	2001-05-29	2004-02-17	Chemokine Therapeutics Corporation	Bicyclic aromatic chemokine receptor ligands
TWI332407B (en) *	2001-06-29	2010-11-01	Takeda Chemical Industries Ltd	Controlled release composition and method of producting the same
EP1466596B8 (en) *	2001-12-26	2017-01-11	Takeda Pharmaceutical Company Limited	Microsphere and method for production thereof
KR101041767B1 (ko)	2002-06-25	2011-06-17	다케다 야쿠힌 고교 가부시키가이샤	서방성 조성물의 제조 방법
JP5165240B2 (ja) *	2003-07-23	2013-03-21	ピーアールファーマシューティカルズ，インコーポレイテッド	徐放組成物
US20050064045A1 (en) *	2003-09-18	2005-03-24	Sheng-Ping Zhong	Injectable therapeutic formulations
US7906125B2 (en)	2003-09-18	2011-03-15	Boston Scientific Scimed, Inc.	Solid or semi-solid therapeutic formulations
TW200529890A (en)	2004-02-10	2005-09-16	Takeda Pharmaceutical	Sustained-release preparations
EP1679065A1 (en) *	2005-01-07	2006-07-12	OctoPlus Sciences B.V.	Controlled release compositions for interferon based on PEGT/PBT block copolymers
US7862552B2 (en)	2005-05-09	2011-01-04	Boston Scientific Scimed, Inc.	Medical devices for treating urological and uterine conditions
US8263109B2 (en)	2005-05-09	2012-09-11	Boston Scientific Scimed, Inc.	Injectable bulking compositions
WO2007070563A2 (en) *	2005-12-13	2007-06-21	Harkness Pharmaceuticals, Inc.	Stable solid forms of enterostatin
EP1973558A4 (en) *	2005-12-13	2009-12-23	Harkness Pharmaceuticals Inc	METHODS OF TREATING OBESITY WITH ENTEROSTATIN
JP2009542813A (ja) *	2006-07-11	2009-12-03	ハルクネススプハルマセウティカルス，インコーポレイテッド	飽食因子を使用して肥満を治療する方法
US7858663B1 (en) *	2007-10-31	2010-12-28	Pisgah Laboratories, Inc.	Physical and chemical properties of thyroid hormone organic acid addition salts
MX2009006653A (es)	2006-12-18	2009-07-02	Takeda Pharmaceutical	Composicion de liberacion prolongada y metodo para producirla.

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU4459196A (en)	1995-01-23	1996-08-14	Takeda Chemical Industries Ltd.	Sustained-release preparation and use
PT839525E (pt)	1996-10-31	2004-10-29	Takeda Chemical Industries Ltd	Preparacao de libertacao prolongada
WO1998032423A1 (en)	1997-01-29	1998-07-30	Takeda Chemical Industries, Ltd.	Sustained-release microspheres, their production and use
TR200002059T2 (tr)	1998-01-16	2001-01-22	Takeda Chemical Industries, Ltd.	Devamlı salınan bileşim, üretim yöntemi ve kullanımı.
JPH11269094A (ja) *	1998-01-16	1999-10-05	Takeda Chem Ind Ltd	徐放性組成物、その製造法および用途
WO2000035990A1 (fr)	1998-12-15	2000-06-22	Takeda Chemical Industries, Ltd.	Procede de production d'un polymere

2000
- 2000-07-13 PL PL00352499A patent/PL352499A1/xx not_active Application Discontinuation
- 2000-07-13 AT AT00944418T patent/ATE360413T1/de not_active IP Right Cessation
- 2000-07-13 CZ CZ2002114A patent/CZ2002114A3/cs unknown
- 2000-07-13 SK SK34-2002A patent/SK342002A3/sk not_active Application Discontinuation
- 2000-07-13 DE DE60034568T patent/DE60034568T2/de not_active Expired - Fee Related
- 2000-07-13 RU RU2002103718/14A patent/RU2002103718A/ru not_active Application Discontinuation
- 2000-07-13 AU AU58530/00A patent/AU5853000A/en not_active Abandoned
- 2000-07-13 MX MXPA02000461A patent/MXPA02000461A/es not_active Application Discontinuation
- 2000-07-13 HK HK02103567.5A patent/HK1042237A1/en unknown
- 2000-07-13 BR BR0012400-1A patent/BR0012400A/pt not_active IP Right Cessation
- 2000-07-13 US US10/019,786 patent/US7265157B1/en not_active Expired - Fee Related
- 2000-07-13 EP EP00944418A patent/EP1197208B1/en not_active Expired - Lifetime
- 2000-07-13 HU HU0202880A patent/HUP0202880A3/hu unknown
- 2000-07-13 CA CA002378714A patent/CA2378714A1/en not_active Abandoned
- 2000-07-13 CN CN00810405A patent/CN1361685A/zh active Pending
- 2000-07-13 NZ NZ516466A patent/NZ516466A/xx unknown
- 2000-07-13 WO PCT/JP2000/004683 patent/WO2001005380A1/ja not_active Ceased
- 2000-07-13 KR KR1020027000546A patent/KR20020012312A/ko not_active Withdrawn
- 2000-07-13 IL IL14741700A patent/IL147417A0/xx unknown
2002
- 2002-01-08 NO NO20020084A patent/NO20020084L/no not_active Application Discontinuation
- 2002-01-15 ZA ZA200200347A patent/ZA200200347B/en unknown
2007
- 2007-07-25 US US11/782,707 patent/US20080014237A1/en not_active Abandoned

Also Published As

Publication number	Publication date
PL352499A1 (en)	2003-08-25
RU2002103718A (ru)	2003-10-10
CA2378714A1 (en)	2001-01-25
DE60034568D1 (de)	2007-06-06
NZ516466A (en)	2003-02-28
HK1042237A1 (en)	2002-08-09
MXPA02000461A (es)	2002-07-30
HUP0202880A2 (hu)	2003-01-28
US7265157B1 (en)	2007-09-04
EP1197208A4 (en)	2004-06-30
CN1361685A (zh)	2002-07-31
EP1197208A1 (en)	2002-04-17
NO20020084D0 (no)	2002-01-08
HUP0202880A3 (en)	2003-04-28
CZ2002114A3 (cs)	2002-04-17
BR0012400A (pt)	2002-05-21
NO20020084L (no)	2002-03-14
ZA200200347B (en)	2003-03-26
IL147417A0 (en)	2002-08-14
ATE360413T1 (de)	2007-05-15
US20080014237A1 (en)	2008-01-17
KR20020012312A (ko)	2002-02-15
AU5853000A (en)	2001-02-05
WO2001005380A1 (fr)	2001-01-25
DE60034568T2 (de)	2008-01-03
EP1197208B1 (en)	2007-04-25

Legal Events

Date	Code	Title	Description
2010-08-09	FC9A	Refused patent application

Publication	Publication Date	Title
RU2230550C2 (ru)	2004-06-20	Композиции длительного высвобождения, способ их получения и применение
US20080014237A1 (en)	2008-01-17	Sustained release compositions, process for producing the same and use thereof
US8258252B2 (en)	2012-09-04	Sustained-release composition and process for producing the same
US8921326B2 (en)	2014-12-30	Sustained-release composition and method for producing the same
PL204903B1 (pl)	2010-02-26	Kompozycja o kontrolowanym uwalnianiu i metoda jej wytwarzania
JPH11269094A (ja)	1999-10-05	徐放性組成物、その製造法および用途
JP2001081043A (ja)	2001-03-27	徐放性組成物、その製造法および用途
JPWO2001005380A1 (ja)	2003-02-04	徐放性組成物、その製造法および用途
HK1028205A (en)	2001-02-09	Sustained release compositions, process for producing the same and utilization thereof
CZ20002470A3 (cs)	2000-10-11	Prostředek s trvalým uvolňováním, způsob jeho výroby a jeho použití
JPWO1999036099A1 (ja)	2002-09-24	徐放性組成物、その製造法および用途
MXPA00006641A (en)	2001-07-03	Sustained release compositions, process for producing the same and utilization thereof