SK65598A3 - Antiglucocorticoid drug - Google Patents

Antiglucocorticoid drug Download PDF

Info

Publication number: SK65598A3
Authority: SK; Slovakia
Prior art keywords: pheromones; glucocorticoid; carbon atoms; aliphatic; chain length
Prior art date: 1996-01-31

Application number

SK655-98A

Other languages

English (en)

Slovak (sk)

Inventor

Sergei Dmitrievich Burlakov

Dmitry Dmitrievich Genkin

Kirill Gennadievich Surkov

Viktor Veniaminovich Tets

Original Assignee

Sergei Dmitrievich Burlakov

Dmitry Dmitrievich Genkin

Kirill Gennadievich Surkov

Viktor Veniaminovich Tets

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-01-31

Filing date

1996-02-01

Publication date

1998-09-09

1996-02-01 Application filed by Sergei Dmitrievich Burlakov, Dmitry Dmitrievich Genkin, Kirill Gennadievich Surkov, Viktor Veniaminovich Tets filed Critical Sergei Dmitrievich Burlakov

1998-09-09 Publication of SK65598A3 publication Critical patent/SK65598A3/sk

Links

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Classifications

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- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Emergency Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Securing Of Glass Panes Or The Like (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SK655-98A 1996-01-31 1996-02-01 Antiglucocorticoid drug SK65598A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
RU96101194/14A RU2125446C1 (ru)	1996-01-31	1996-01-31	Антиглюкокортикоидное лекарственное средство
PCT/RU1996/000028 WO1997027845A1 (en)	1996-01-31	1996-02-01	Antiglucocorticoid drug

Publications (1)

Publication Number	Publication Date
SK65598A3 true SK65598A3 (en)	1998-09-09

Family

ID=20175968

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK655-98A SK65598A3 (en)	1996-01-31	1996-02-01	Antiglucocorticoid drug

Country Status (24)

Country	Link
US (1)	US5965623A (lt)
EP (1)	EP0896819A4 (lt)
JP (1)	JPH11504946A (lt)
KR (1)	KR100347862B1 (lt)
CN (1)	CN1213964A (lt)
AU (1)	AU710479B2 (lt)
BG (1)	BG102709A (lt)
BR (1)	BR9612470A (lt)
CA (1)	CA2244985A1 (lt)
CZ (1)	CZ160598A3 (lt)
EE (1)	EE9800209A (lt)
GE (1)	GEP20001955B (lt)
HU (1)	HUP9900504A2 (lt)
LT (1)	LT4441B (lt)
LV (1)	LV12177B (lt)
MD (1)	MD1430B1 (lt)
MX (1)	MX9806182A (lt)
NO (1)	NO983508L (lt)
PL (1)	PL187564B1 (lt)
RU (1)	RU2125446C1 (lt)
SI (1)	SI9620053A (lt)
SK (1)	SK65598A3 (lt)
UA (1)	UA48212C2 (lt)
WO (1)	WO1997027845A1 (lt)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2001039766A2 (en) *	1999-12-01	2001-06-07	Alydar Pharmaceuticals Ltd.	Screening invertebrate pheromones for therapeutic activity
US6548706B2 (en) *	1999-12-23	2003-04-15	Aerojet Fine Chemicals Llc	Preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl) -p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines
US6806293B1 (en)	2001-03-12	2004-10-19	Darley Pharmaceuticals Ltd	Use of pheromone compounds having MAP kinase modulating activity
WO2002072809A1 (en) *	2001-03-12	2002-09-19	Alydar Pharmaceuticals, Inc.	Screening non-peptide, non-steroid invertebrate pheromone compounds for mitogen-activated protein kinase modulating activity
RU2211213C2 (ru) *	2001-05-16	2003-08-27	Закрытое Акционерное Общество "Асгл - Исследовательские Лаборатории"	Лекарственное средство, обладающее противоязвенным, кардиопротективным и противошоковым действием
AU2003225277A1 (en) *	2002-05-02	2003-11-17	Robert Harris	Lipid removal from the body
RU2222326C1 (ru) *	2002-10-09	2004-01-27	Российский онкологический научный центр им. Н.Н.Блохина РАМН	Способ лечения саркомы юинга
US6752649B2 (en) *	2002-11-07	2004-06-22	Xentris, Llc	Illuminated indicia power supply apparatus and method of manufacture
DE10335845B4 (de) *	2003-05-09	2006-08-31	Müller, Martina, Dr.med.	Pheromone als Antikrebsmittel
KR100556335B1 (ko) *	2004-02-05	2006-03-03	정만길	6알-(3,6-디데옥시-엘-아라비노-헥소피라노실옥시)헵타노익산, 그 제조방법 및 그를 포함하는 장기휴면 유발효과
US20110195501A1 (en) *	2008-08-06	2011-08-11	Pangu Gautam D	Ultrasonically induced release from polymer vesicles

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US161926A (en)		1875-04-13		Improvement in ink-wells
US2900756A (en) *	1958-12-09	1959-08-25	Jacobson Martin	Attractants for the gypsy moth
EP0149847A3 (en) *	1983-12-26	1989-11-08	Eisai Co., Ltd.	Therapeutic and preventive agent containing dolichol
JPH0759504B2 (ja) *	1986-01-23	1995-06-28	エーザイ株式会社	ポリプレニルアルコ−ル含有注射剤
US5019569A (en) *	1986-11-03	1991-05-28	Ortho Pharmaceutical Corporation	Reversal of glucocorticoid-induced skin atrophy
US4740627A (en) *	1987-05-21	1988-04-26	Phillips Petroleum Company	Synthesis of E,Z-11-tetradecen-1-al
ES2051998T3 (es)	1988-02-29	1994-07-01	Pfizer	Composiciones aumentadoras del flujo transdermal.
US5190978A (en) *	1989-09-29	1993-03-02	Dai-Ichi Kogyo Seiyaku Co. Ltd.	Carcinostatic compositions and methods
FR2718354B1 (fr) *	1994-04-08	1996-05-03	Roussel Uclaf	Application des composés antiglucocorticoïde pour la préparation de médicaments destinés à la prévention ou au traitement des manifestations liées au syndrome de sevrage des narcotiques et les compositions les renfermant.

1996
- 1996-01-02 UA UA98074187A patent/UA48212C2/uk unknown
- 1996-01-31 RU RU96101194/14A patent/RU2125446C1/ru not_active IP Right Cessation
- 1996-02-01 AU AU46363/96A patent/AU710479B2/en not_active Ceased
- 1996-02-01 US US08/930,733 patent/US5965623A/en not_active Expired - Fee Related
- 1996-02-01 KR KR10-1998-0705074A patent/KR100347862B1/ko not_active Expired - Fee Related
- 1996-02-01 BR BR9612470A patent/BR9612470A/pt not_active Application Discontinuation
- 1996-02-01 SK SK655-98A patent/SK65598A3/sk unknown
- 1996-02-01 JP JP9527525A patent/JPH11504946A/ja active Pending
- 1996-02-01 MD MD98-0171A patent/MD1430B1/ro unknown
- 1996-02-01 CN CN96180161A patent/CN1213964A/zh active Pending
- 1996-02-01 HU HU9900504A patent/HUP9900504A2/hu unknown
- 1996-02-01 GE GEAP19964288A patent/GEP20001955B/en unknown
- 1996-02-01 CA CA002244985A patent/CA2244985A1/en not_active Abandoned
- 1996-02-01 PL PL96322596A patent/PL187564B1/pl unknown
- 1996-02-01 CZ CZ981605A patent/CZ160598A3/cs unknown
- 1996-02-01 EP EP96902026A patent/EP0896819A4/en not_active Withdrawn
- 1996-02-01 EE EE9800209A patent/EE9800209A/xx unknown
- 1996-02-01 SI SI9620053A patent/SI9620053A/sl not_active IP Right Cessation
- 1996-02-01 WO PCT/RU1996/000028 patent/WO1997027845A1/ru not_active Ceased
1998
- 1998-04-21 LT LT98-054A patent/LT4441B/lt not_active IP Right Cessation
- 1998-05-28 LV LVP-98-126A patent/LV12177B/lv unknown
- 1998-07-30 NO NO983508A patent/NO983508L/no unknown
- 1998-07-31 MX MX9806182A patent/MX9806182A/es unknown
- 1998-08-20 BG BG102709A patent/BG102709A/xx unknown

Also Published As

Publication number	Publication date
CN1213964A (zh)	1999-04-14
AU710479B2 (en)	1999-09-23
LV12177A (lv)	1998-12-20
PL187564B1 (pl)	2004-08-31
EE9800209A (et)	1998-12-15
GEP20001955B (en)	2000-03-05
MD1430B1 (ro)	2000-03-31
KR100347862B1 (ko)	2003-01-24
EP0896819A1 (en)	1999-02-17
HUP9900504A2 (en)	1999-09-28
CZ160598A3 (cs)	1998-08-12
CA2244985A1 (en)	1997-08-07
LT98054A (lt)	1998-10-26
SI9620053A (sl)	1998-04-30
UA48212C2 (uk)	2002-08-15
PL322596A1 (en)	1998-02-02
LV12177B (lv)	1999-06-20
EP0896819A4 (en)	2001-11-07
US5965623A (en)	1999-10-12
JPH11504946A (ja)	1999-05-11
MX9806182A (es)	1998-10-31
NO983508D0 (no)	1998-07-30
BR9612470A (pt)	1999-07-13
WO1997027845A1 (en)	1997-08-07
BG102709A (bg)	1999-06-30
NO983508L (no)	1998-07-30
AU4636396A (en)	1997-08-22
KR19990076946A (ko)	1999-10-25
RU2125446C1 (ru)	1999-01-27
LT4441B (lt)	1999-01-25

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HU203201B (en)	1991-06-28	Process for producing antitumoural pharmaceutical composition having synergetic effect
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US6306383B1 (en)	2001-10-23	Method for topical treatment of scars with protein kinase C inhibitors
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