SK69799A3 - Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists - Google Patents

Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists Download PDF

Info

Publication number: SK69799A3
Authority: SK; Slovakia
Prior art keywords: gndnl; nothing; compounds; guanidine; unsubstituted
Prior art date: 1996-11-25

Application number

SK697-99A

Other languages

English (en)

Slovak (sk)

Inventor

Thomas Lee Cupps

Sophie Eva Bogdan

Raymond Todd Henry

Russell James Sheldon

William Lee Seibel

Jeffrey Joseph Ares

Original Assignee

Procter & Gamble

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-11-25

Filing date

1997-11-21

Publication date

2000-06-12

1997-11-21 Application filed by Procter & Gamble filed Critical Procter & Gamble

2000-06-12 Publication of SK69799A3 publication Critical patent/SK69799A3/sk

Links

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108020004101 alpha-2 Adrenergic Receptor Proteins 0.000 title claims description 24
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150000003839 salts Chemical class 0.000 claims abstract description 55
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HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims abstract description 5
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Classifications

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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
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Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
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Public Health (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Cardiology (AREA)
Biomedical Technology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Addiction (AREA)
Ophthalmology & Optometry (AREA)
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Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Otolaryngology (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Quinoline Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

SK697-99A 1996-11-25 1997-11-21 Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists SK69799A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3202396P	1996-11-25	1996-11-25
PCT/US1997/020802 WO1998023596A1 (fr)	1996-11-25	1997-11-21	Composes guanidinyl heterocycles convenant comme agonistes de l'adrenorecepteur alpha-2

Publications (1)

Publication Number	Publication Date
SK69799A3 true SK69799A3 (en)	2000-06-12

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ID=21862692

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK697-99A SK69799A3 (en)	1996-11-25	1997-11-21	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists

Country Status (25)

Country	Link
US (3)	US6225331B1 (fr)
EP (1)	EP0944604B1 (fr)
JP (1)	JP2001506600A (fr)
KR (1)	KR20000069131A (fr)
CN (1)	CN1104422C (fr)
AR (1)	AR009145A1 (fr)
AT (1)	ATE286885T1 (fr)
AU (1)	AU730369B2 (fr)
BR (1)	BR9713536A (fr)
CA (1)	CA2272640C (fr)
CO (1)	CO4910148A1 (fr)
CZ (1)	CZ184099A3 (fr)
DE (1)	DE69732244T2 (fr)
ES (1)	ES2236833T3 (fr)
HU (1)	HUP0000312A3 (fr)
ID (1)	ID23857A (fr)
IL (1)	IL130077A0 (fr)
NO (1)	NO313912B1 (fr)
NZ (1)	NZ336010A (fr)
PE (1)	PE16399A1 (fr)
RU (1)	RU2194700C2 (fr)
SK (1)	SK69799A3 (fr)
TR (1)	TR199901468T2 (fr)
WO (1)	WO1998023596A1 (fr)
ZA (1)	ZA9710578B (fr)

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US6291514B1 (en) *	1998-02-09	2001-09-18	3-Dimensional Pharmaceuticals, Inc.	Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
DZ3415A1 (fr) *	2000-08-31	2002-03-07	Chiron Corp	Guanidinobenzamides comme mc4-r agonistes.
CA2419653A1 (fr) *	2000-09-08	2002-03-14	Warner-Lambert Company	Prevention de sinusite aigue et d'attaque aux sinus
WO2002081443A1 (fr)	2001-04-09	2002-10-17	Chiron Corporation	Nouveaux composes guanidino
US20050124652A1 (en) *	2002-02-04	2005-06-09	Rustum Boyce	Guanidino compounds
US20030195187A1 (en) *	2002-02-04	2003-10-16	Chiron Corporation	Guanidino compounds
US20030207814A1 (en) *	2002-02-04	2003-11-06	Chiron Corporation	Novel guanidinyl derivatives
US20070004743A1 (en) *	2002-02-25	2007-01-04	Xiao Linda L	Intranasal administration of mc4-r agonists
PT1551834E (pt)	2002-05-23	2010-09-30	Novartis Vaccines & Diagnostic	Compostos de quinazolinona substituídos
EP1651229A1 (fr) *	2003-05-23	2006-05-03	Chiron Corporation	Composes de quinazoline substitues par guanidino constituant des agonistes de mc4-r
RU2254855C2 (ru) *	2003-09-10	2005-06-27	Открытое акционерное общество "Акционерное курганское общество медицинских препаратов и изделий "Синтез"	Противовирусное средство и способ его получения
US7368453B2 (en) *	2003-11-19	2008-05-06	Chiron Corporation	Quinazolinone compounds with reduced bioaccumulation
ATE489138T1 (de) *	2005-04-13	2010-12-15	Neuraxon Inc	Substituierte indolverbindungen mit nos-hemmender aktivität
US8067433B2 (en)	2005-11-09	2011-11-29	Zalicus Inc.	Methods, compositions, and kits for the treatment of ophthalmic disorders
US8173813B2 (en) *	2007-03-23	2012-05-08	Neuraxon, Inc.	Quinolone and tetrahydroquinolone and related compounds having NOS inhibitory activity
WO2009062318A1 (fr) *	2007-11-16	2009-05-22	Neuraxon, Inc.	Composés d'indole 3,5-substitués ayant une activité d'inhibition de la réabsorption de la nos et de la noradrénaline
US20100196286A1 (en) *	2008-12-01	2010-08-05	Armer Thomas A	Inhalation delivery methods and devices
US8555875B2 (en) *	2008-12-23	2013-10-15	Map Pharmaceuticals, Inc.	Inhalation devices and related methods for administration of sedative hypnotic compounds
GB0919889D0 (en) *	2009-11-13	2009-12-30	Biocopea Ltd	Drug composition and its use in therapy
EP2668177B1 (fr) *	2011-01-28	2014-10-22	Boehringer Ingelheim International GmbH	Pyridinyl-pyrimidines substituées et leur utilisation en tant que médicaments
CN112047947A (zh) *	2020-10-13	2020-12-08	石药集团新诺威制药股份有限公司	一种茶碱的合成方法

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1997
- 1997-11-21 BR BR9713536-4A patent/BR9713536A/pt not_active IP Right Cessation
- 1997-11-21 EP EP97948290A patent/EP0944604B1/fr not_active Expired - Lifetime
- 1997-11-21 NZ NZ336010A patent/NZ336010A/en unknown
- 1997-11-21 AT AT97948290T patent/ATE286885T1/de not_active IP Right Cessation
- 1997-11-21 IL IL13007797A patent/IL130077A0/xx unknown
- 1997-11-21 HU HU0000312A patent/HUP0000312A3/hu unknown
- 1997-11-21 ID IDW990410A patent/ID23857A/id unknown
- 1997-11-21 US US09/308,788 patent/US6225331B1/en not_active Expired - Lifetime
- 1997-11-21 ES ES97948290T patent/ES2236833T3/es not_active Expired - Lifetime
- 1997-11-21 WO PCT/US1997/020802 patent/WO1998023596A1/fr not_active Ceased
- 1997-11-21 AU AU54381/98A patent/AU730369B2/en not_active Ceased
- 1997-11-21 CN CN97181078A patent/CN1104422C/zh not_active Expired - Fee Related
- 1997-11-21 KR KR1019997004619A patent/KR20000069131A/ko not_active Ceased
- 1997-11-21 DE DE69732244T patent/DE69732244T2/de not_active Expired - Lifetime
- 1997-11-21 SK SK697-99A patent/SK69799A3/sk unknown
- 1997-11-21 CZ CZ991840A patent/CZ184099A3/cs unknown
- 1997-11-21 TR TR1999/01468T patent/TR199901468T2/xx unknown
- 1997-11-21 RU RU99113446/04A patent/RU2194700C2/ru not_active IP Right Cessation
- 1997-11-21 CA CA002272640A patent/CA2272640C/fr not_active Expired - Fee Related
- 1997-11-21 JP JP52469498A patent/JP2001506600A/ja active Pending
- 1997-11-24 CO CO97068606A patent/CO4910148A1/es unknown
- 1997-11-25 ZA ZA9710578A patent/ZA9710578B/xx unknown
- 1997-11-25 AR ARP970105530A patent/AR009145A1/es unknown
- 1997-11-25 PE PE1997001070A patent/PE16399A1/es not_active Application Discontinuation
1999
- 1999-05-25 NO NO19992498A patent/NO313912B1/no unknown
2000
- 2000-12-01 US US09/727,900 patent/US6391878B2/en not_active Expired - Lifetime
2002
- 2002-02-08 US US10/071,284 patent/US20020128481A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CZ184099A3 (cs)	1999-11-17
ES2236833T3 (es)	2005-07-16
US20010000345A1 (en)	2001-04-19
NO313912B1 (no)	2002-12-23
ATE286885T1 (de)	2005-01-15
CO4910148A1 (es)	2000-04-24
AU730369B2 (en)	2001-03-08
US6225331B1 (en)	2001-05-01
ZA9710578B (en)	1998-06-25
JP2001506600A (ja)	2001-05-22
TR199901468T2 (xx)	1999-10-21
RU2194700C2 (ru)	2002-12-20
ID23857A (id)	2000-05-25
US20020128481A1 (en)	2002-09-12
NO992498D0 (no)	1999-05-25
AU5438198A (en)	1998-06-22
PE16399A1 (es)	1999-03-12
CA2272640C (fr)	2003-07-08
WO1998023596A1 (fr)	1998-06-04
KR20000069131A (ko)	2000-11-25
BR9713536A (pt)	2000-11-07
DE69732244T2 (de)	2006-06-29
EP0944604B1 (fr)	2005-01-12
US6391878B2 (en)	2002-05-21
CN1242006A (zh)	2000-01-19
NZ336010A (en)	2001-05-25
HUP0000312A3 (en)	2001-12-28
NO992498L (no)	1999-07-26
IL130077A0 (en)	2000-02-29
AR009145A1 (es)	2000-03-08
EP0944604A1 (fr)	1999-09-29
HUP0000312A2 (hu)	2000-09-28
CN1104422C (zh)	2003-04-02
CA2272640A1 (fr)	1998-06-04
DE69732244D1 (de)	2005-02-17

Publication	Publication Date	Title
US6225331B1 (en)	2001-05-01	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists
KR100395356B1 (ko)	2003-08-21	알파-2 아드레날린수용체 아고니스트로서 유용한 2-이미다졸리닐아미노인돌 화합물
US5916900A (en)	1999-06-29	7-(2-imidazolinylamino)quinoline compounds useful as alpha-2 adrenoceptor agonists
US6110952A (en)	2000-08-29	2-imidazolinylaminobenzoxazole compounds useful as alpha-2 adrenoceptor agonists
US6306877B1 (en)	2001-10-23	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
EP0944601B1 (fr)	2003-02-12	Composes heterocycliques guanidinylamino utiles en tant qu'agonistes de l'adrenorecepteur alpha-2
US6172095B1 (en)	2001-01-09	Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists
SK69699A3 (en)	2000-06-12	2-imidazolinylaminoindazole compounds useful as alpha-2 adrenoceptor agonists
CA2285610A1 (fr)	1998-10-22	Composes de 5-(2-imidazolinylamino)benzimidazole utiles en tant qu'agonistes de l'adrenorecepteur alpha-2
MXPA99004843A (en)	2000-04-24	Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists