SK9132000A3 - Pharmaceutical compositions containing micronized bicyclic drugs - Google Patents
Pharmaceutical compositions containing micronized bicyclic drugs Download PDFInfo
- Publication number
- SK9132000A3 SK9132000A3 SK913-2000A SK9132000A SK9132000A3 SK 9132000 A3 SK9132000 A3 SK 9132000A3 SK 9132000 A SK9132000 A SK 9132000A SK 9132000 A3 SK9132000 A3 SK 9132000A3
- Authority
- SK
- Slovakia
- Prior art keywords
- alkyl
- hydrogen
- composition
- formula
- alkoxy
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 6
- 239000003814 drug Substances 0.000 title claims description 17
- 229940079593 drug Drugs 0.000 title description 11
- 125000002619 bicyclic group Chemical group 0.000 title 1
- 239000000203 mixture Substances 0.000 claims abstract description 65
- 239000002245 particle Substances 0.000 claims abstract description 37
- 150000001875 compounds Chemical class 0.000 claims abstract description 33
- 238000009826 distribution Methods 0.000 claims abstract description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 59
- 239000001257 hydrogen Substances 0.000 claims description 38
- 229910052739 hydrogen Inorganic materials 0.000 claims description 38
- 238000000034 method Methods 0.000 claims description 29
- 239000000725 suspension Substances 0.000 claims description 29
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 28
- -1 -C 1-6 Chemical group 0.000 claims description 23
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 23
- 238000000227 grinding Methods 0.000 claims description 23
- 239000011324 bead Substances 0.000 claims description 18
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 16
- 125000003545 alkoxy group Chemical group 0.000 claims description 14
- 208000035475 disorder Diseases 0.000 claims description 14
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 12
- 239000006185 dispersion Substances 0.000 claims description 11
- 125000003118 aryl group Chemical group 0.000 claims description 10
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 10
- 230000000694 effects Effects 0.000 claims description 10
- 150000002431 hydrogen Chemical class 0.000 claims description 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 10
- 208000004296 neuralgia Diseases 0.000 claims description 10
- 229910052760 oxygen Inorganic materials 0.000 claims description 10
- 239000001301 oxygen Substances 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 9
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 9
- 238000001694 spray drying Methods 0.000 claims description 9
- 238000001238 wet grinding Methods 0.000 claims description 9
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims description 8
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims description 8
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 8
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 claims description 8
- 125000001072 heteroaryl group Chemical group 0.000 claims description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
- 201000006417 multiple sclerosis Diseases 0.000 claims description 8
- 230000001537 neural effect Effects 0.000 claims description 8
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 239000008186 active pharmaceutical agent Substances 0.000 claims description 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims description 7
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 229940088679 drug related substance Drugs 0.000 claims description 7
- 239000004094 surface-active agent Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 claims description 6
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 6
- 230000035939 shock Effects 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 5
- 229930195725 Mannitol Natural products 0.000 claims description 5
- 239000001961 anticonvulsive agent Substances 0.000 claims description 5
- 125000001589 carboacyl group Chemical group 0.000 claims description 5
- 239000000594 mannitol Substances 0.000 claims description 5
- 235000010355 mannitol Nutrition 0.000 claims description 5
- 208000021722 neuropathic pain Diseases 0.000 claims description 5
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims description 4
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- 208000018737 Parkinson disease Diseases 0.000 claims description 4
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- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 claims description 4
- 208000030886 Traumatic Brain injury Diseases 0.000 claims description 4
- 230000016571 aggressive behavior Effects 0.000 claims description 4
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 4
- 125000004685 alkoxythiocarbonyl group Chemical group 0.000 claims description 4
- 125000004691 alkyl thio carbonyl group Chemical group 0.000 claims description 4
- 239000003006 anti-agglomeration agent Substances 0.000 claims description 4
- 229940125681 anticonvulsant agent Drugs 0.000 claims description 4
- 230000036506 anxiety Effects 0.000 claims description 4
- 125000005129 aryl carbonyl group Chemical group 0.000 claims description 4
- 125000004391 aryl sulfonyl group Chemical group 0.000 claims description 4
- 229940049706 benzodiazepine Drugs 0.000 claims description 4
- 150000001557 benzodiazepines Chemical class 0.000 claims description 4
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims description 4
- 206010008118 cerebral infarction Diseases 0.000 claims description 4
- 229960003920 cocaine Drugs 0.000 claims description 4
- 206010012601 diabetes mellitus Diseases 0.000 claims description 4
- 206010015037 epilepsy Diseases 0.000 claims description 4
- 125000005469 ethylenyl group Chemical group 0.000 claims description 4
- 125000005223 heteroarylcarbonyl group Chemical group 0.000 claims description 4
- 206010022437 insomnia Diseases 0.000 claims description 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
- 206010027599 migraine Diseases 0.000 claims description 4
- 201000003631 narcolepsy Diseases 0.000 claims description 4
- 210000005036 nerve Anatomy 0.000 claims description 4
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 4
- 230000007971 neurological deficit Effects 0.000 claims description 4
- 229960002715 nicotine Drugs 0.000 claims description 4
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims description 4
- 208000019906 panic disease Diseases 0.000 claims description 4
- 230000033764 rhythmic process Effects 0.000 claims description 4
- 208000019116 sleep disease Diseases 0.000 claims description 4
- 230000009529 traumatic brain injury Effects 0.000 claims description 4
- 206010044652 trigeminal neuralgia Diseases 0.000 claims description 4
- 208000023105 Huntington disease Diseases 0.000 claims description 3
- 208000032851 Subarachnoid Hemorrhage Diseases 0.000 claims description 3
- 208000000323 Tourette Syndrome Diseases 0.000 claims description 3
- 208000016620 Tourette disease Diseases 0.000 claims description 3
- 125000005138 alkoxysulfonyl group Chemical group 0.000 claims description 3
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 claims description 3
- 125000005135 aryl sulfinyl group Chemical group 0.000 claims description 3
- 230000004064 dysfunction Effects 0.000 claims description 3
- 210000005069 ears Anatomy 0.000 claims description 3
- CHNUOJQWGUIOLD-NFZZJPOKSA-N epalrestat Chemical compound C=1C=CC=CC=1\C=C(/C)\C=C1/SC(=S)N(CC(O)=O)C1=O CHNUOJQWGUIOLD-NFZZJPOKSA-N 0.000 claims description 3
- 229910052736 halogen Inorganic materials 0.000 claims description 3
- 150000002367 halogens Chemical class 0.000 claims description 3
- 125000005150 heteroarylsulfinyl group Chemical group 0.000 claims description 3
- 125000005143 heteroarylsulfonyl group Chemical group 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 201000000980 schizophrenia Diseases 0.000 claims description 3
- 230000002123 temporal effect Effects 0.000 claims description 3
- 208000004371 toothache Diseases 0.000 claims description 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 2
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 2
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims description 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 2
- 125000004656 alkyl sulfonylamino group Chemical group 0.000 claims description 2
- 125000003435 aroyl group Chemical group 0.000 claims description 2
- 125000005199 aryl carbonyloxy group Chemical group 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims description 2
- 239000000460 chlorine Substances 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 239000011737 fluorine Substances 0.000 claims description 2
- 125000001153 fluoro group Chemical group F* 0.000 claims description 2
- 125000001207 fluorophenyl group Chemical group 0.000 claims description 2
- 125000005204 heteroarylcarbonyloxy group Chemical group 0.000 claims description 2
- WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical class C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 claims description 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 claims description 2
- 229910001404 rare earth metal oxide Inorganic materials 0.000 claims description 2
- 208000011117 substance-related disease Diseases 0.000 claims description 2
- 239000011593 sulfur Substances 0.000 claims description 2
- 230000017105 transposition Effects 0.000 claims description 2
- 150000003852 triazoles Chemical class 0.000 claims description 2
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000004738 (C1-C6) alkyl sulfinyl group Chemical group 0.000 claims 2
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 2
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 125000001091 aminosulfinyl group Chemical group [H]N([H])S(*)=O 0.000 claims 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
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- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 125000006620 amino-(C1-C6) alkyl group Chemical group 0.000 claims 1
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- RUDFQVOCFDJEEF-UHFFFAOYSA-N yttrium(III) oxide Inorganic materials [O-2].[O-2].[O-2].[Y+3].[Y+3] RUDFQVOCFDJEEF-UHFFFAOYSA-N 0.000 description 3
- FEAVXMPFTQROEI-UHFFFAOYSA-N 2h-pyrano[3,2-b]pyridine Chemical class C1=CN=C2C=CCOC2=C1 FEAVXMPFTQROEI-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
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Classifications
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- B02—CRUSHING, PULVERISING, OR DISINTEGRATING; PREPARATORY TREATMENT OF GRAIN FOR MILLING
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
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- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9726543.3A GB9726543D0 (en) | 1997-12-16 | 1997-12-16 | Novel compositions |
| PCT/EP1998/008156 WO1999030687A1 (fr) | 1997-12-16 | 1998-12-14 | Preparations pharmaceutiques contenant des medicaments bicycliques micronises |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK9132000A3 true SK9132000A3 (en) | 2001-01-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK913-2000A SK9132000A3 (en) | 1997-12-16 | 1998-12-14 | Pharmaceutical compositions containing micronized bicyclic drugs |
Country Status (32)
| Country | Link |
|---|---|
| EP (2) | EP1338274A1 (fr) |
| JP (1) | JP2002508310A (fr) |
| KR (1) | KR20010033149A (fr) |
| CN (2) | CN1284865A (fr) |
| AP (1) | AP2000001837A0 (fr) |
| AR (1) | AR017212A1 (fr) |
| AT (1) | ATE260094T1 (fr) |
| AU (1) | AU743155B2 (fr) |
| BG (1) | BG104596A (fr) |
| BR (1) | BR9813602A (fr) |
| CA (1) | CA2314968A1 (fr) |
| DE (1) | DE69821978T2 (fr) |
| DZ (1) | DZ2677A1 (fr) |
| EA (1) | EA003732B1 (fr) |
| ES (1) | ES2216350T3 (fr) |
| GB (1) | GB9726543D0 (fr) |
| HU (1) | HUP0100384A3 (fr) |
| ID (1) | ID24930A (fr) |
| IL (1) | IL136664A0 (fr) |
| MA (1) | MA24721A1 (fr) |
| MY (1) | MY132978A (fr) |
| NO (1) | NO20003073L (fr) |
| NZ (1) | NZ504991A (fr) |
| OA (1) | OA11429A (fr) |
| PE (1) | PE20000114A1 (fr) |
| PL (1) | PL341339A1 (fr) |
| SK (1) | SK9132000A3 (fr) |
| TR (1) | TR200001792T2 (fr) |
| TW (1) | TW200305442A (fr) |
| UY (1) | UY25307A1 (fr) |
| WO (1) | WO1999030687A1 (fr) |
| ZA (1) | ZA9811502B (fr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4990696A (en) | 1995-02-24 | 1996-09-11 | Nanosystems L.L.C. | Aerosols containing nanoparticle dispersions |
| US7521068B2 (en) | 1998-11-12 | 2009-04-21 | Elan Pharma International Ltd. | Dry powder aerosols of nanoparticulate drugs |
| EP1294358B1 (fr) * | 2000-06-28 | 2004-08-18 | Smithkline Beecham Plc | Procede de broyage par voie humide |
| GB0112497D0 (en) * | 2001-05-22 | 2001-07-11 | Smithkline Beecham Plc | Formulation |
| GB0127805D0 (en) | 2001-11-20 | 2002-01-09 | Smithkline Beecham Plc | Pharmaceutical composition |
| KR20080066977A (ko) | 2005-11-10 | 2008-07-17 | 더루우브리졸코오포레이션 | 분산체의 제조방법 |
| CA2726878A1 (fr) * | 2008-06-05 | 2009-12-10 | Minster Research Limited | Nouveaux traitements |
| WO2009147441A2 (fr) * | 2008-06-05 | 2009-12-10 | Minster Research Limited | Nouveaux traitements |
| WO2011067607A1 (fr) * | 2009-12-03 | 2011-06-09 | Minster Research Ltd | Traitement de maladies infectieuses |
| EP2506846A1 (fr) * | 2009-12-03 | 2012-10-10 | Proximagen Limited | Traitement de l'allodynie et de l'hyperalgésie |
| EP2471513B1 (fr) * | 2010-12-28 | 2015-06-10 | LEK Pharmaceuticals d.d. | Procédé de production d'ingrédients pharmaceutique actif et préparation sous la forme de billes |
| WO2016157061A1 (fr) * | 2015-03-31 | 2016-10-06 | Wockhardt Limited | Procédé de broyage humide aseptique pour le palmitate de palipéridone |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5065946A (en) * | 1988-07-21 | 1991-11-19 | Matsushita Electric Industrial Co., Ltd. | Media agitating mill and method for milling ceramic powder |
| US5145684A (en) * | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| NZ248813A (en) * | 1992-11-25 | 1995-06-27 | Eastman Kodak Co | Polymeric grinding media used in grinding pharmaceutical substances |
| DE69327965T2 (de) * | 1992-12-11 | 2000-10-19 | Smithkline Beecham Corp., Philadelphia | Pharmazeutische zusammenstellung enthaltende bizyklisch typ verbindungen |
| DE69524871T2 (de) * | 1994-06-10 | 2002-08-22 | Smithkline Beecham P.L.C., Brentford | Benzopyrans und deren verwendung als therapeutische mittel |
| US5534270A (en) * | 1995-02-09 | 1996-07-09 | Nanosystems Llc | Method of preparing stable drug nanoparticles |
| US5518738A (en) * | 1995-02-09 | 1996-05-21 | Nanosystem L.L.C. | Nanoparticulate nsaid compositions |
| DE19614295A1 (de) * | 1995-04-21 | 1996-10-24 | Friedrich Dr Ing Vock | Verfahren und Vorrichtung zum Nassmahlen und Dispergieren von Feststoffpartikeln in Flüssigkeiten |
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1997
- 1997-12-16 GB GBGB9726543.3A patent/GB9726543D0/en not_active Ceased
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1998
- 1998-11-22 TW TW092109280A patent/TW200305442A/zh unknown
- 1998-12-14 EA EA200000664A patent/EA003732B1/ru not_active IP Right Cessation
- 1998-12-14 HU HU0100384A patent/HUP0100384A3/hu unknown
- 1998-12-14 PL PL98341339A patent/PL341339A1/xx unknown
- 1998-12-14 ID IDW20001124A patent/ID24930A/id unknown
- 1998-12-14 AU AU22724/99A patent/AU743155B2/en not_active Ceased
- 1998-12-14 EP EP03076016A patent/EP1338274A1/fr not_active Withdrawn
- 1998-12-14 CA CA002314968A patent/CA2314968A1/fr not_active Abandoned
- 1998-12-14 AP APAP/P/2000/001837A patent/AP2000001837A0/en unknown
- 1998-12-14 JP JP2000538670A patent/JP2002508310A/ja active Pending
- 1998-12-14 CN CN98813568A patent/CN1284865A/zh active Pending
- 1998-12-14 MA MA25390A patent/MA24721A1/fr unknown
- 1998-12-14 CN CNA031787088A patent/CN1475206A/zh active Pending
- 1998-12-14 WO PCT/EP1998/008156 patent/WO1999030687A1/fr not_active Ceased
- 1998-12-14 TR TR2000/01792T patent/TR200001792T2/xx unknown
- 1998-12-14 NZ NZ504991A patent/NZ504991A/xx unknown
- 1998-12-14 BR BR9813602-0A patent/BR9813602A/pt not_active IP Right Cessation
- 1998-12-14 ES ES98966322T patent/ES2216350T3/es not_active Expired - Lifetime
- 1998-12-14 AT AT98966322T patent/ATE260094T1/de not_active IP Right Cessation
- 1998-12-14 DE DE69821978T patent/DE69821978T2/de not_active Expired - Fee Related
- 1998-12-14 KR KR1020007006525A patent/KR20010033149A/ko not_active Ceased
- 1998-12-14 SK SK913-2000A patent/SK9132000A3/sk unknown
- 1998-12-14 EP EP98966322A patent/EP1037612B1/fr not_active Expired - Lifetime
- 1998-12-14 IL IL13666498A patent/IL136664A0/xx unknown
- 1998-12-15 ZA ZA9811502A patent/ZA9811502B/xx unknown
- 1998-12-15 UY UY25307A patent/UY25307A1/es not_active Application Discontinuation
- 1998-12-15 DZ DZ980287A patent/DZ2677A1/fr active
- 1998-12-15 MY MYPI98005667A patent/MY132978A/en unknown
- 1998-12-15 AR ARP980106367A patent/AR017212A1/es not_active Application Discontinuation
- 1998-12-16 PE PE1998001230A patent/PE20000114A1/es not_active Application Discontinuation
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2000
- 2000-06-15 NO NO20003073A patent/NO20003073L/no not_active Application Discontinuation
- 2000-06-16 OA OA1200000176A patent/OA11429A/en unknown
- 2000-07-11 BG BG104596A patent/BG104596A/xx unknown
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