SK942002A3 - Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise - Google Patents

Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise Download PDF

Info

Publication number: SK942002A3
Authority: SK; Slovakia
Prior art keywords: carnitine; phosphate; muscle; acid; composition
Prior art date: 1999-07-23

Application number

SK94-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Claudio Cavazza

Original Assignee

Sigma Tau Healthscience Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-23

Filing date

2000-07-21

Publication date

2002-05-09

2000-07-21 Application filed by Sigma Tau Healthscience Spa filed Critical Sigma Tau Healthscience Spa

2002-05-09 Publication of SK942002A3 publication Critical patent/SK942002A3/sk

Links

239000000203 mixture Substances 0.000 title claims abstract description 14
206010049565 Muscle fatigue Diseases 0.000 title claims description 5
230000002265 prevention Effects 0.000 title abstract description 5
230000011667 skeletal muscle adaptation Effects 0.000 title 1
PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims abstract description 28
FOIPWTMKYXWFGC-UHFFFAOYSA-N creatinolfosfate Chemical compound NC(=N)N(C)CCOP(O)(O)=O FOIPWTMKYXWFGC-UHFFFAOYSA-N 0.000 claims abstract description 21
229960002956 creatinolfosfate Drugs 0.000 claims abstract description 21
206010003549 asthenia Diseases 0.000 claims abstract description 6
235000015872 dietary supplement Nutrition 0.000 claims abstract description 6
239000003814 drug Substances 0.000 claims abstract description 6
230000003387 muscular Effects 0.000 claims abstract description 6
230000002708 enhancing effect Effects 0.000 claims abstract description 3
230000007812 deficiency Effects 0.000 claims abstract 3
210000003205 muscle Anatomy 0.000 claims description 23
150000003839 salts Chemical class 0.000 claims description 10
MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 8
239000002253 acid Substances 0.000 claims description 7
229910019142 PO4 Inorganic materials 0.000 claims description 6
229960004203 carnitine Drugs 0.000 claims description 6
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 6
239000010452 phosphate Substances 0.000 claims description 6
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 6
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 4
206010061216 Infarction Diseases 0.000 claims description 4
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 4
RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims description 4
UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 claims description 4
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 4
230000000747 cardiac effect Effects 0.000 claims description 4
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims description 4
QWYFHHGCZUCMBN-SECBINFHSA-N O-butanoyl-L-carnitine Chemical compound CCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C QWYFHHGCZUCMBN-SECBINFHSA-N 0.000 claims description 3
VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims description 3
NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims description 2
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KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 2
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DRBBFCLWYRJSJZ-UHFFFAOYSA-N N-phosphocreatine Chemical compound OC(=O)CN(C)C(=N)NP(O)(O)=O DRBBFCLWYRJSJZ-UHFFFAOYSA-N 0.000 description 34
CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 16
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WSMYVTOQOOLQHP-UHFFFAOYSA-N Malondialdehyde Chemical compound O=CCC=O WSMYVTOQOOLQHP-UHFFFAOYSA-N 0.000 description 6
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Epidemiology (AREA)
Nutrition Science (AREA)
Heart & Thoracic Surgery (AREA)
Polymers & Plastics (AREA)
Cardiology (AREA)
Food Science & Technology (AREA)
Mycology (AREA)
Diabetes (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Obesity (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Medicines Containing Plant Substances (AREA)

SK94-2002A 1999-07-23 2000-07-21 Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise SK942002A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999RM000467A IT1306173B1 (it)	1999-07-23	1999-07-23	Composizione per la prevenzione degli affaticamenti muscolari e permigliorare il rendimento energetico muscolare.
PCT/IT2000/000308 WO2001006873A1 (en)	1999-07-23	2000-07-21	Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise

Publications (1)

Publication Number	Publication Date
SK942002A3 true SK942002A3 (en)	2002-05-09

Family

ID=11406897

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK94-2002A SK942002A3 (en)	1999-07-23	2000-07-21	Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise

Country Status (21)

Country	Link
US (1)	US6602512B1 (cs)
EP (1)	EP1196046B1 (cs)
AR (1)	AR024820A1 (cs)
AT (1)	ATE263496T1 (cs)
AU (1)	AU778647B2 (cs)
CA (1)	CA2377128C (cs)
CZ (1)	CZ20023A3 (cs)
DE (1)	DE60009704T2 (cs)
DK (1)	DK1196046T3 (cs)
ES (1)	ES2216931T3 (cs)
HU (1)	HU228838B1 (cs)
IL (1)	IL147408A0 (cs)
IT (1)	IT1306173B1 (cs)
MX (1)	MXPA02000780A (cs)
NO (1)	NO20020337L (cs)
PL (1)	PL204743B1 (cs)
PT (1)	PT1196046E (cs)
SK (1)	SK942002A3 (cs)
TN (1)	TNSN00161A1 (cs)
TR (1)	TR200200179T2 (cs)
WO (1)	WO2001006873A1 (cs)

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IT1316998B1 (it) *	2000-03-02	2003-05-26	Sigma Tau Healthscience Spa	Composizione per la prevenzione e/o il trattamento degli effetticitotossici indotti dall'uso di agenti immunosoppressori.
US7449451B2 (en) *	2001-08-29	2008-11-11	Premier Micronutrient Corporation	Use of multiple antioxidant micronutrients as systemic biological radioprotective agents against potential ionizing radiation risks
US6849613B2 (en)	2001-08-29	2005-02-01	Kedar N. Prasad	Multiple antioxidant micronutrients
DE10160485A1 (de) *	2001-12-08	2003-10-02	Degussa	Verwendung von Kreatin und/oder einem seiner physiologisch geeigneten Derivate zur Prävention oder Linderung von nicht krankheitsbedingten Beeinträchtigungen und/oder Störungen der Muskelfunktion
DE102004009962A1 (de)	2004-03-01	2005-09-22	Degussa Ag	Verwendung von Guanidin-Verbindungen als physiologisches Stärkungsmittel in Form von Nahrungsergänzungsmitteln, Futtermittelzusätzen, in kosmetischen Zubereitungen und als Pflanzenstärkungsmittel
US20060083793A1 (en) *	2004-09-29	2006-04-20	Gardiner Paul T	Nutritional composition for promoting muscle performance and acting as hydrogen (H+) blocker
WO2007006135A1 (en) *	2005-07-07	2007-01-18	H3 Formulations Ltd.	Dietary supplement for enhancing skeletal muscle mass, decreasing muscle protein degradation, downregulation of muscle catabolism pathways, and decreasing catabolism of muscle cells
GB0606864D0 (en) *	2006-04-05	2006-05-17	Univ Nottingham	Increades fatty acid oxidation
WO2008025114A1 (en) *	2006-08-30	2008-03-06	Aplodan Formulations Ltd.	Increasing atp availability by inhibition of creatine kinase (ck) leakage resulting from high-intensity exercise
WO2008025115A1 (en) *	2006-08-30	2008-03-06	Aplodan Formulations Ltd.	Method of increasing intracellular concentrations of phosphate and increasing the force of muscular contractions
US7375097B2 (en) *	2006-08-30	2008-05-20	Aplodan Formulations Ltd.	Increasing ATP availability by inhibition of creatine kinase (CK) leakage resulting from high-intensity exercise
US7368441B2 (en) *	2006-08-30	2008-05-06	Aplodan Formulations Ltd.	Method of increasing intracellular concentrations of phosphate and increasing the force of muscular contractions
US20100124587A1 (en) *	2008-11-17	2010-05-20	Heuer Marvin A	Creatine-containing vitamin and mineral composition
US20110105786A1 (en) *	2009-11-02	2011-05-05	Tianjin Tiancheng Pharmaceutical Co., Ltd.	Creatinol o-phosphate and synthesis method thereof
CN103429234B (zh)	2010-12-10	2016-10-05	布罗迪健康科学有限公司	茉莉酮酸酯治疗膀胱功能障碍的用途
BR112016028654A2 (pt)	2014-06-12	2018-07-10	Lonza Ag	método para diminuição de dano muscular esquelético e / ou estresse oxidativo em mamíferos
US10499682B2 (en)	2014-08-25	2019-12-10	New Age Beverage Corporation	Micronutrient formulation in electronic cigarettes
CN108473384A (zh)	2015-10-27	2018-08-31	细胞酶动物营养品公司	动物营养成分及相关方法
US10674746B2 (en)	2015-10-27	2020-06-09	Cytozyme Animal Nutrition, Inc.	Animal nutrition compositions and related methods
US10888571B2 (en)	2015-12-18	2021-01-12	Lonza Consumer Health Inc.	Method and composition for increasing muscle protein synthesis and/or functional strength in mammals
WO2022215085A1 (en)	2021-04-06	2022-10-13	Celagenex Research (India) Pvt. Ltd.	A synergistic composition for potentiating stabilized atp

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AU518617B2 (en) *	1977-04-29	1981-10-08	Sigma-Tau Industrie Farmaceutiche Riunite S.P.A.	Therapeutic application of acetyl-d, 1-carnitine
IT1124697B (it) *	1979-10-26	1986-05-14	Simes	Derivati di creatinolo o-fosfato ad azione terapeutica,procedimento per la sua preparazione e relativ-e composizioni farmaceutiche
US6080788A (en) *	1997-03-27	2000-06-27	Sole; Michael J.	Composition for improvement of cellular nutrition and mitochondrial energetics
IT1291127B1 (it) *	1997-04-01	1998-12-29	Sigma Tau Ind Farmaceuti	Integratore alimentare per soggetti dediti ad intensa e prolungata attivita' fisica
EP0891719A1 (en) *	1997-07-14	1999-01-20	N.V. Nutricia	Nutritional composition containing methionine
EP1065931A4 (en)	1998-04-02	2006-10-11	Avicena Group Inc	COMPOSITIONS CONTAINING CREATINE COMBINED WITH A SECOND AGENT
ES2146555B1 (es) *	1999-01-22	2001-03-01	Helsint S A L	Empleo de formulaciones a base de fracciones hidrosolubles de phlebodium decumanum (exply-37) y/o polypodium leucotomos como complemento nutricional en la prevencion y reversion del sindrome de sobresfuerzo fisico.

1999
- 1999-07-23 IT IT1999RM000467A patent/IT1306173B1/it active
2000
- 2000-07-21 IL IL14740800A patent/IL147408A0/xx unknown
- 2000-07-21 TN TNTNSN00161A patent/TNSN00161A1/fr unknown
- 2000-07-21 CA CA002377128A patent/CA2377128C/en not_active Expired - Lifetime
- 2000-07-21 PL PL352683A patent/PL204743B1/pl unknown
- 2000-07-21 CZ CZ20023A patent/CZ20023A3/cs unknown
- 2000-07-21 US US10/019,546 patent/US6602512B1/en not_active Expired - Lifetime
- 2000-07-21 DK DK00951844T patent/DK1196046T3/da active
- 2000-07-21 DE DE60009704T patent/DE60009704T2/de not_active Expired - Lifetime
- 2000-07-21 WO PCT/IT2000/000308 patent/WO2001006873A1/en not_active Ceased
- 2000-07-21 HU HU0202298A patent/HU228838B1/hu not_active IP Right Cessation
- 2000-07-21 MX MXPA02000780A patent/MXPA02000780A/es active IP Right Grant
- 2000-07-21 AU AU64687/00A patent/AU778647B2/en not_active Ceased
- 2000-07-21 ES ES00951844T patent/ES2216931T3/es not_active Expired - Lifetime
- 2000-07-21 SK SK94-2002A patent/SK942002A3/sk unknown
- 2000-07-21 EP EP00951844A patent/EP1196046B1/en not_active Expired - Lifetime
- 2000-07-21 AT AT00951844T patent/ATE263496T1/de active
- 2000-07-21 TR TR2002/00179T patent/TR200200179T2/xx unknown
- 2000-07-21 PT PT00951844T patent/PT1196046E/pt unknown
- 2000-07-21 AR ARP000103777A patent/AR024820A1/es unknown
2002
- 2002-01-22 NO NO20020337A patent/NO20020337L/no unknown

Also Published As

Publication number	Publication date
EP1196046A1 (en)	2002-04-17
CA2377128A1 (en)	2001-02-01
MXPA02000780A (es)	2002-08-20
ES2216931T3 (es)	2004-11-01
ITRM990467A0 (it)	1999-07-23
IL147408A0 (en)	2002-08-14
WO2001006873A1 (en)	2001-02-01
HUP0202298A3 (en)	2005-07-28
EP1196046B1 (en)	2004-04-07
PL352683A1 (en)	2003-09-08
ITRM990467A1 (it)	2001-01-23
NO20020337L (no)	2002-03-22
ATE263496T1 (de)	2004-04-15
PL204743B1 (pl)	2010-02-26
DK1196046T3 (da)	2004-08-02
DE60009704T2 (de)	2005-04-14
CA2377128C (en)	2009-09-22
PT1196046E (pt)	2004-08-31
TNSN00161A1 (fr)	2005-11-10
HUP0202298A2 (en)	2002-10-28
AR024820A1 (es)	2002-10-23
DE60009704D1 (de)	2004-05-13
NO20020337D0 (no)	2002-01-22
IT1306173B1 (it)	2001-05-30
US6602512B1 (en)	2003-08-05
TR200200179T2 (tr)	2002-06-21
HU228838B1 (en)	2013-06-28
AU778647B2 (en)	2004-12-16
AU6468700A (en)	2001-02-13
CZ20023A3 (cs)	2002-06-12

Publication	Publication Date	Title
CA2377128C (en)	2009-09-22	Composition for the prevention of muscle fatigue and skeletal muscle adaptation to strenuous exercise
US8747906B2 (en)	2014-06-10	Dietary supplement enhancing the muscular energy metabolism, comprising an alkanoyl carnitine and ribose
AU767492B2 (en)	2003-11-13	Combination of carnitines and resveratrol for prevention or treatment of cerebral and ageing disorders
SK282907B6 (sk)	2003-01-09	Potravinový doplnok a jeho použitie
US8207109B2 (en)	2012-06-26	Food supplement with a slimming effect
AU2001270980A1 (en)	2003-02-20	Food supplement with a slimming effect
KR100556237B1 (ko)	2006-03-03	Ｌ-카르니틴 및 알카노일-ｌ-카르니틴 마그네슘 타르트레이트를 함유하는 경구 투여용 고체 조성물
CA2400959C (en)	2011-01-04	Composition for the prevention and/or treatment of vascular diseases, comprising propionyl l-carnitine and coenzyme q10
RU2001101529A (ru)	2002-12-20	Композиция, включающая карнитин и глутатион, пригодная для повышения всасывания глутатиона и усиливающая его эффекты
MXPA01003569A (es)	2002-05-09	Combinacion de carnitinas y resveratrol para prevenir o tratar enfermedades cerebrales y del envejecimiento