SMT202000328T1 - Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica - Google Patents

Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica

Info

Publication number
SMT202000328T1
SMT202000328T1 SM20200328T SMT202000328T SMT202000328T1 SM T202000328 T1 SMT202000328 T1 SM T202000328T1 SM 20200328 T SM20200328 T SM 20200328T SM T202000328 T SMT202000328 T SM T202000328T SM T202000328 T1 SMT202000328 T1 SM T202000328T1
Authority
SM
San Marino
Prior art keywords
treatment
myelodysplastic syndrome
telomerase inhibitor
imetelstat
inhibitor imetelstat
Prior art date
Application number
SM20200328T
Other languages
English (en)
Inventor
Monic J Stuart
Stephen Kelsey
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50883867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT202000328(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Publication of SMT202000328T1 publication Critical patent/SMT202000328T1/it

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
SM20200328T 2012-12-07 2013-11-15 Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica SMT202000328T1 (it)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
EP18196690.4A EP3456333B8 (en) 2012-12-07 2013-11-15 Use of the telomerase inhibitor imetelstat for the treatment of myelodysplastic syndrome

Publications (1)

Publication Number Publication Date
SMT202000328T1 true SMT202000328T1 (it) 2020-07-08

Family

ID=50883867

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20190567T SMT201900567T1 (it) 2012-12-07 2013-11-15 Uso dell’inibitore di telomerasi imetelstat per il trattamento di mielofibrosi
SM20200328T SMT202000328T1 (it) 2012-12-07 2013-11-15 Uso dell'inibitore di telomelstat per il trattamento di sindrome mielodisplastica

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SM20190567T SMT201900567T1 (it) 2012-12-07 2013-11-15 Uso dell’inibitore di telomerasi imetelstat per il trattamento di mielofibrosi

Country Status (36)

Country Link
EP (5) EP3646876B1 (it)
JP (6) JP6433911B2 (it)
KR (4) KR20230028590A (it)
CN (2) CN111617252A (it)
AP (1) AP2015008504A0 (it)
AU (4) AU2013356533B2 (it)
CA (2) CA3188494A1 (it)
CL (2) CL2015001530A1 (it)
CY (3) CY1122169T1 (it)
DK (3) DK3456333T3 (it)
EA (1) EA032973B1 (it)
ES (3) ES2982897T3 (it)
FI (2) FI3646876T3 (it)
FR (1) FR25C1016I2 (it)
HK (1) HK1210940A1 (it)
HR (3) HRP20240624T1 (it)
HU (4) HUE066402T2 (it)
IL (3) IL280144B2 (it)
LT (4) LT3646876T (it)
MA (2) MA38193B1 (it)
ME (1) ME03538B (it)
MX (3) MX372753B (it)
MY (2) MY180634A (it)
NL (1) NL301326I2 (it)
NZ (1) NZ708920A (it)
PH (2) PH12019501008A1 (it)
PL (3) PL2928477T3 (it)
PT (3) PT3456333T (it)
RS (2) RS60401B1 (it)
SG (3) SG11201504383TA (it)
SI (3) SI3456333T1 (it)
SM (2) SMT201900567T1 (it)
TN (1) TN2015000249A1 (it)
UA (3) UA126015C2 (it)
WO (1) WO2014088785A1 (it)
ZA (3) ZA201504124B (it)

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RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
MX376856B (es) 2013-08-07 2025-03-07 Incyte Holdings Corp Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
US11123359B2 (en) * 2013-11-06 2021-09-21 Mayo Foundation For Medical Education And Research Methods and materials for treating hematological malignancies
JP2018513127A (ja) 2015-04-23 2018-05-24 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ 多価カチオン塩組成物を用いたポリヌクレオチド調製方法
EP3318276A1 (en) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
EP3658156B1 (en) * 2017-07-28 2026-03-25 Geron Corporation Telomerase inhibitor for use in treating a myelodysplastic syndrome
IL319432A (en) * 2018-04-30 2025-05-01 Kartos Therapeutics Inc Methods of treating cancer
US12268681B2 (en) 2018-05-25 2025-04-08 Kartos Therapeutics, Inc. Methods of treating myeloproliferative neoplasms
CN112770783B (zh) * 2018-07-31 2025-02-25 美国杰龙生物医药公司 鉴定可能从端粒酶抑制剂治疗中受益的患者的方法
CN113631719A (zh) 2018-11-29 2021-11-09 美国杰龙生物医药公司 治疗骨髓增生异常综合征的方法
JP7767279B2 (ja) 2019-11-04 2025-11-11 ジェロン・コーポレーション 骨髄増殖性腫瘍の治療のためのヤヌスキナーゼ阻害剤およびテロメラーゼ阻害剤の使用
JP2021157248A (ja) * 2020-03-25 2021-10-07 パイオニア株式会社 状況出力装置
CA3181682A1 (en) * 2020-07-17 2022-01-20 Anil Kapur Subcutaneous telomerase inhibitor compositions and methods for using same
JP2024504367A (ja) * 2021-01-22 2024-01-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア がんを治療及び改善するための方法
WO2024259369A1 (en) * 2023-06-14 2024-12-19 Rarecells Inc. Compositions targeting giant cells in blood disorders

Family Cites Families (25)

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US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
US5656638A (en) 1995-04-18 1997-08-12 Geron Corporation Telomerase inhibitors
US5770613A (en) 1995-09-29 1998-06-23 Geron Corporation Telomerase inhibitors
US5767278A (en) 1995-10-06 1998-06-16 Geron Corporation Telomerase inhibitors
US6261836B1 (en) 1996-10-01 2001-07-17 Geron Corporation Telomerase
US6444650B1 (en) 1996-10-01 2002-09-03 Geron Corporation Antisense compositions for detecting and inhibiting telomerase reverse transcriptase
EP0951568A1 (en) 1996-12-20 1999-10-27 Geron Corporation Methods for detecting and inhibiting the rna component of telomerase
US6331399B1 (en) 2000-05-16 2001-12-18 Isis Pharmaceuticals, Inc. Antisense inhibition of tert expression
WO2004070008A2 (en) * 2003-01-31 2004-08-19 Au Jessie L-S Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (zh) * 2003-07-11 2006-03-08 暨南大学 抑制白血病细胞端粒酶活性的反义核酸及其应用
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
US20050282893A1 (en) * 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
FR2877013A1 (fr) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
US20060166221A1 (en) 2005-01-21 2006-07-27 Bahou Wadie F Methods of diagnosing essential thrombocythemia
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US20070224598A1 (en) 2006-03-15 2007-09-27 The Methodist Hospital Research Institute System and method for detection of mutations in JAK2 polynucleotides
US20080021013A1 (en) 2006-07-21 2008-01-24 Cephalon, Inc. JAK inhibitors for treatment of myeloproliferative disorders
EP4600359A2 (en) 2006-10-30 2025-08-13 Geron Corporation Combined telomerase inhibitor and gemcitabine for the treatment of cancer
CN101220044B (zh) * 2008-01-21 2010-06-02 中国药科大学 端粒酶抑制剂及其制备方法和用途

Also Published As

Publication number Publication date
ES2744790T3 (es) 2020-02-26
AU2020267142C1 (en) 2024-08-08
ES2982897T3 (es) 2024-10-18
FIC20250019I1 (fi) 2025-05-07
JP2016504307A (ja) 2016-02-12
MY200076A (en) 2023-12-06
RS59363B1 (sr) 2019-11-29
HRP20191784T1 (hr) 2019-12-27
PH12015501282B1 (en) 2015-08-24
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
PH12015501282A1 (en) 2015-08-24
ZA201504124B (en) 2017-05-31
NL301326I2 (nl) 2025-07-31
CA3188494A1 (en) 2014-06-12
SMT201900567T1 (it) 2019-11-13
SI3456333T1 (sl) 2020-10-30
JP6998191B2 (ja) 2022-02-04
CY1123206T1 (el) 2021-10-29
IL239266A0 (en) 2015-07-30
LT3456333T (lt) 2020-06-25
SG10201802926XA (en) 2018-05-30
JP2022050537A (ja) 2022-03-30
IL239266B (en) 2019-11-28
DK3456333T3 (da) 2020-05-18
EP3456333B8 (en) 2020-05-13
HK1212226A1 (en) 2016-06-10
CA2892907C (en) 2023-03-21
LTPA2025517I1 (it) 2025-05-26
IL280144B2 (en) 2025-05-01
MX372753B (es) 2020-06-26
AU2013356533A1 (en) 2014-06-12
EP2928477A4 (en) 2016-09-21
PT3456333T (pt) 2020-06-01
JP2020041001A (ja) 2020-03-19
HRP20240624T1 (hr) 2024-08-02
NZ748134A (en) 2020-10-30
JP7288098B2 (ja) 2023-06-06
TN2015000249A1 (en) 2016-10-03
SI3646876T1 (sl) 2024-07-31
PT2928477T (pt) 2019-10-25
NZ708920A (en) 2020-08-28
IL317233A (en) 2025-01-01
ES2789176T3 (es) 2020-10-26
PL2928477T3 (pl) 2020-03-31
EA201590878A1 (ru) 2016-04-29
CY2025015I2 (el) 2026-02-25
IL280144A (en) 2021-03-01
JP2018035196A (ja) 2018-03-08
PL3456333T3 (pl) 2020-09-21
MY180634A (en) 2020-12-03
MA38193B1 (fr) 2018-12-31
AP2015008504A0 (en) 2015-06-30
LT2928477T (lt) 2019-10-10
EP3646876B1 (en) 2024-02-14
AU2018282364A1 (en) 2019-05-23
AU2020267142B2 (en) 2024-05-16
EP3456333B1 (en) 2020-04-01
FI3646876T3 (fi) 2024-05-14
RS60401B1 (sr) 2020-07-31
CN104936602B (zh) 2020-07-17
UA126015C2 (uk) 2022-08-03
MA45504A1 (fr) 2020-05-29
KR20230028590A (ko) 2023-02-28
WO2014088785A1 (en) 2014-06-12
DK2928477T3 (da) 2019-10-07
EP3646876A1 (en) 2020-05-06
SG10202103341SA (en) 2021-05-28
EP4751723A2 (en) 2026-06-03
JP6433911B2 (ja) 2018-12-05
HK1210940A1 (zh) 2016-05-13
CN104936602A (zh) 2015-09-23
KR102294819B1 (ko) 2021-09-01
FR25C1016I1 (fr) 2025-06-20
KR20210107906A (ko) 2021-09-01
HUS2500019I1 (hu) 2025-05-28
JP2022179684A (ja) 2022-12-02
JP2025109842A (ja) 2025-07-25
IL280144B1 (en) 2025-01-01
EP2928477B1 (en) 2019-07-24
AU2013356533B2 (en) 2018-09-27
CY1122169T1 (el) 2020-11-25
PT3646876T (pt) 2024-05-15
SG11201504383TA (en) 2015-07-30
MA38193A1 (fr) 2017-12-29
KR20250114449A (ko) 2025-07-29
SI2928477T1 (sl) 2019-11-29
LT3646876T (lt) 2024-05-10
CY2025015I1 (el) 2026-02-25
PH12019501008A1 (en) 2022-11-14
MX2020003276A (es) 2020-07-20
DK3646876T3 (da) 2024-05-06
EP2928477A1 (en) 2015-10-14
BR112015013260A2 (pt) 2018-02-06
UA128370C2 (uk) 2024-06-26
HUE049858T2 (hu) 2020-11-30
EP4789716A2 (en) 2026-08-12
EA032973B1 (ru) 2019-08-30
WO2014088785A8 (en) 2015-07-16
ME03538B (me) 2020-07-20
UA117116C2 (uk) 2018-06-25
FR25C1016I2 (fr) 2026-04-17
HUE066402T2 (hu) 2024-07-28
CN111617252A (zh) 2020-09-04
MX2015007169A (es) 2016-03-31
AU2024203138A1 (en) 2024-07-25
KR20150091130A (ko) 2015-08-07
KR102662590B1 (ko) 2024-05-03
EP3456333A1 (en) 2019-03-20
CA2892907A1 (en) 2014-06-12
ZA202212327B (en) 2025-03-26
PL3646876T3 (pl) 2024-07-22
AU2020267142A1 (en) 2020-12-03
MX2022015437A (es) 2023-01-11
ZA202108991B (en) 2023-05-31
CL2015001530A1 (es) 2016-03-28
CL2017002156A1 (es) 2018-05-04
MA45504B1 (fr) 2021-10-29

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