DK3646876T3 - Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer - Google Patents

Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer Download PDF

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Publication number
DK3646876T3
DK3646876T3 DK19187756.2T DK19187756T DK3646876T3 DK 3646876 T3 DK3646876 T3 DK 3646876T3 DK 19187756 T DK19187756 T DK 19187756T DK 3646876 T3 DK3646876 T3 DK 3646876T3
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Denmark
Prior art keywords
myeloproliferative
treatment
telomerase inhibitor
neoplasms
disorders
Prior art date
Application number
DK19187756.2T
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English (en)
Inventor
Monic J Stuart
Stephen Kelsey
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50883867&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3646876(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Application granted granted Critical
Publication of DK3646876T3 publication Critical patent/DK3646876T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
DK19187756.2T 2012-12-07 2013-11-15 Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer DK3646876T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
EP13861008.4A EP2928477B1 (en) 2012-12-07 2013-11-15 Use of the telomerase inhibitor imetelstat for the treatment of myelofibrosis

Publications (1)

Publication Number Publication Date
DK3646876T3 true DK3646876T3 (da) 2024-05-06

Family

ID=50883867

Family Applications (3)

Application Number Title Priority Date Filing Date
DK18196690.4T DK3456333T3 (da) 2012-12-07 2013-11-15 Anvendelse af telomeraseinhibitor imetelstat til behandling af myelodysplastisk syndrom
DK13861008.4T DK2928477T3 (da) 2012-12-07 2013-11-15 Anvendelse af telomeraseinhibitor imetelstat til behandling af myelofibrosis
DK19187756.2T DK3646876T3 (da) 2012-12-07 2013-11-15 Telomeraseinhibitoren imetelstat til behandling af myeloproliferative lidelser og myeloproliferative neoplasmer

Family Applications Before (2)

Application Number Title Priority Date Filing Date
DK18196690.4T DK3456333T3 (da) 2012-12-07 2013-11-15 Anvendelse af telomeraseinhibitor imetelstat til behandling af myelodysplastisk syndrom
DK13861008.4T DK2928477T3 (da) 2012-12-07 2013-11-15 Anvendelse af telomeraseinhibitor imetelstat til behandling af myelofibrosis

Country Status (36)

Country Link
EP (5) EP3646876B1 (da)
JP (6) JP6433911B2 (da)
KR (4) KR20230028590A (da)
CN (2) CN111617252A (da)
AP (1) AP2015008504A0 (da)
AU (4) AU2013356533B2 (da)
CA (2) CA3188494A1 (da)
CL (2) CL2015001530A1 (da)
CY (3) CY1122169T1 (da)
DK (3) DK3456333T3 (da)
EA (1) EA032973B1 (da)
ES (3) ES2982897T3 (da)
FI (2) FI3646876T3 (da)
FR (1) FR25C1016I2 (da)
HK (1) HK1210940A1 (da)
HR (3) HRP20240624T1 (da)
HU (4) HUE066402T2 (da)
IL (3) IL280144B2 (da)
LT (4) LT3646876T (da)
MA (2) MA38193B1 (da)
ME (1) ME03538B (da)
MX (3) MX372753B (da)
MY (2) MY180634A (da)
NL (1) NL301326I2 (da)
NZ (1) NZ708920A (da)
PH (2) PH12019501008A1 (da)
PL (3) PL2928477T3 (da)
PT (3) PT3456333T (da)
RS (2) RS60401B1 (da)
SG (3) SG11201504383TA (da)
SI (3) SI3456333T1 (da)
SM (2) SMT201900567T1 (da)
TN (1) TN2015000249A1 (da)
UA (3) UA126015C2 (da)
WO (1) WO2014088785A1 (da)
ZA (3) ZA201504124B (da)

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RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
MX376856B (es) 2013-08-07 2025-03-07 Incyte Holdings Corp Formas de dosificacion de liberacion prolongada para un inhibidor de jak 1 (cinasa de janus 1).
US11123359B2 (en) * 2013-11-06 2021-09-21 Mayo Foundation For Medical Education And Research Methods and materials for treating hematological malignancies
JP2018513127A (ja) 2015-04-23 2018-05-24 ジェロン・コーポレーションＧｅｒｏｎ Ｃｏｒｐｏｒａｔｉｏｎ 多価カチオン塩組成物を用いたポリヌクレオチド調製方法
EP3318276A1 (en) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers
EP3658156B1 (en) * 2017-07-28 2026-03-25 Geron Corporation Telomerase inhibitor for use in treating a myelodysplastic syndrome
IL319432A (en) * 2018-04-30 2025-05-01 Kartos Therapeutics Inc Methods of treating cancer
US12268681B2 (en) 2018-05-25 2025-04-08 Kartos Therapeutics, Inc. Methods of treating myeloproliferative neoplasms
CN112770783B (zh) * 2018-07-31 2025-02-25 美国杰龙生物医药公司 鉴定可能从端粒酶抑制剂治疗中受益的患者的方法
CN113631719A (zh) 2018-11-29 2021-11-09 美国杰龙生物医药公司 治疗骨髓增生异常综合征的方法
JP7767279B2 (ja) 2019-11-04 2025-11-11 ジェロン・コーポレーション 骨髄増殖性腫瘍の治療のためのヤヌスキナーゼ阻害剤およびテロメラーゼ阻害剤の使用
JP2021157248A (ja) * 2020-03-25 2021-10-07 パイオニア株式会社 状況出力装置
CA3181682A1 (en) * 2020-07-17 2022-01-20 Anil Kapur Subcutaneous telomerase inhibitor compositions and methods for using same
JP2024504367A (ja) * 2021-01-22 2024-01-31 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア がんを治療及び改善するための方法
WO2024259369A1 (en) * 2023-06-14 2024-12-19 Rarecells Inc. Compositions targeting giant cells in blood disorders

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US5489508A (en) 1992-05-13 1996-02-06 University Of Texas System Board Of Regents Therapy and diagnosis of conditions related to telomere length and/or telomerase activity
US5958680A (en) 1994-07-07 1999-09-28 Geron Corporation Mammalian telomerase
US5583016A (en) 1994-07-07 1996-12-10 Geron Corporation Mammalian telomerase
US5760062A (en) 1995-04-18 1998-06-02 Geron Corporation Telomerase inhibitors
US5863936A (en) 1995-04-18 1999-01-26 Geron Corporation Telomerase inhibitors
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WO2004070008A2 (en) * 2003-01-31 2004-08-19 Au Jessie L-S Methods and compositions for using suramin, pentosan polysulfate, telomerase antisense, and telomerase inhibitors
CN1244592C (zh) * 2003-07-11 2006-03-08 暨南大学 抑制白血病细胞端粒酶活性的反义核酸及其应用
DK3342425T3 (da) 2003-09-09 2020-03-16 Geron Corp Modificerede oligonukleotider til inhibering af telomerase
US20050282893A1 (en) * 2004-01-30 2005-12-22 Au Jessie L Methods and compositions for using suramin, pentosan, polysulfate, telomerase antisense and telomerase inhibitors
RS61840B1 (sr) 2004-07-02 2021-06-30 Geron Corp Sinteza zaštićenih 3'-amino 5'-fosforamidit nukleozidnih monomera
FR2877013A1 (fr) 2004-10-27 2006-04-28 Assist Publ Hopitaux De Paris Indentification d'une mutation de jak2 impliquee dans la polyglobulie de vaquez
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Also Published As

Publication number Publication date
ES2744790T3 (es) 2020-02-26
AU2020267142C1 (en) 2024-08-08
ES2982897T3 (es) 2024-10-18
FIC20250019I1 (fi) 2025-05-07
JP2016504307A (ja) 2016-02-12
MY200076A (en) 2023-12-06
RS59363B1 (sr) 2019-11-29
HRP20191784T1 (hr) 2019-12-27
PH12015501282B1 (en) 2015-08-24
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
PH12015501282A1 (en) 2015-08-24
ZA201504124B (en) 2017-05-31
NL301326I2 (nl) 2025-07-31
CA3188494A1 (en) 2014-06-12
SMT201900567T1 (it) 2019-11-13
SI3456333T1 (sl) 2020-10-30
JP6998191B2 (ja) 2022-02-04
CY1123206T1 (el) 2021-10-29
IL239266A0 (en) 2015-07-30
LT3456333T (lt) 2020-06-25
SG10201802926XA (en) 2018-05-30
JP2022050537A (ja) 2022-03-30
IL239266B (en) 2019-11-28
DK3456333T3 (da) 2020-05-18
EP3456333B8 (en) 2020-05-13
HK1212226A1 (en) 2016-06-10
CA2892907C (en) 2023-03-21
LTPA2025517I1 (da) 2025-05-26
IL280144B2 (en) 2025-05-01
MX372753B (es) 2020-06-26
AU2013356533A1 (en) 2014-06-12
EP2928477A4 (en) 2016-09-21
PT3456333T (pt) 2020-06-01
JP2020041001A (ja) 2020-03-19
HRP20240624T1 (hr) 2024-08-02
NZ748134A (en) 2020-10-30
JP7288098B2 (ja) 2023-06-06
TN2015000249A1 (en) 2016-10-03
SI3646876T1 (sl) 2024-07-31
PT2928477T (pt) 2019-10-25
NZ708920A (en) 2020-08-28
IL317233A (en) 2025-01-01
ES2789176T3 (es) 2020-10-26
PL2928477T3 (pl) 2020-03-31
EA201590878A1 (ru) 2016-04-29
CY2025015I2 (el) 2026-02-25
IL280144A (en) 2021-03-01
JP2018035196A (ja) 2018-03-08
PL3456333T3 (pl) 2020-09-21
MY180634A (en) 2020-12-03
MA38193B1 (fr) 2018-12-31
AP2015008504A0 (en) 2015-06-30
LT2928477T (lt) 2019-10-10
EP3646876B1 (en) 2024-02-14
AU2018282364A1 (en) 2019-05-23
SMT202000328T1 (it) 2020-07-08
AU2020267142B2 (en) 2024-05-16
EP3456333B1 (en) 2020-04-01
FI3646876T3 (fi) 2024-05-14
RS60401B1 (sr) 2020-07-31
CN104936602B (zh) 2020-07-17
UA126015C2 (uk) 2022-08-03
MA45504A1 (fr) 2020-05-29
KR20230028590A (ko) 2023-02-28
WO2014088785A1 (en) 2014-06-12
DK2928477T3 (da) 2019-10-07
EP3646876A1 (en) 2020-05-06
SG10202103341SA (en) 2021-05-28
EP4751723A2 (en) 2026-06-03
JP6433911B2 (ja) 2018-12-05
HK1210940A1 (zh) 2016-05-13
CN104936602A (zh) 2015-09-23
KR102294819B1 (ko) 2021-09-01
FR25C1016I1 (fr) 2025-06-20
KR20210107906A (ko) 2021-09-01
HUS2500019I1 (hu) 2025-05-28
JP2022179684A (ja) 2022-12-02
JP2025109842A (ja) 2025-07-25
IL280144B1 (en) 2025-01-01
EP2928477B1 (en) 2019-07-24
AU2013356533B2 (en) 2018-09-27
CY1122169T1 (el) 2020-11-25
PT3646876T (pt) 2024-05-15
SG11201504383TA (en) 2015-07-30
MA38193A1 (fr) 2017-12-29
KR20250114449A (ko) 2025-07-29
SI2928477T1 (sl) 2019-11-29
LT3646876T (lt) 2024-05-10
CY2025015I1 (el) 2026-02-25
PH12019501008A1 (en) 2022-11-14
MX2020003276A (es) 2020-07-20
EP2928477A1 (en) 2015-10-14
BR112015013260A2 (pt) 2018-02-06
UA128370C2 (uk) 2024-06-26
HUE049858T2 (hu) 2020-11-30
EP4789716A2 (en) 2026-08-12
EA032973B1 (ru) 2019-08-30
WO2014088785A8 (en) 2015-07-16
ME03538B (me) 2020-07-20
UA117116C2 (uk) 2018-06-25
FR25C1016I2 (fr) 2026-04-17
HUE066402T2 (hu) 2024-07-28
CN111617252A (zh) 2020-09-04
MX2015007169A (es) 2016-03-31
AU2024203138A1 (en) 2024-07-25
KR20150091130A (ko) 2015-08-07
KR102662590B1 (ko) 2024-05-03
EP3456333A1 (en) 2019-03-20
CA2892907A1 (en) 2014-06-12
ZA202212327B (en) 2025-03-26
PL3646876T3 (pl) 2024-07-22
AU2020267142A1 (en) 2020-12-03
MX2022015437A (es) 2023-01-11
ZA202108991B (en) 2023-05-31
CL2015001530A1 (es) 2016-03-28
CL2017002156A1 (es) 2018-05-04
MA45504B1 (fr) 2021-10-29

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