MA38193B1 - Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives - Google Patents

Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives

Info

Publication number
MA38193B1
MA38193B1 MA38193A MA38193A MA38193B1 MA 38193 B1 MA38193 B1 MA 38193B1 MA 38193 A MA38193 A MA 38193A MA 38193 A MA38193 A MA 38193A MA 38193 B1 MA38193 B1 MA 38193B1
Authority
MA
Morocco
Prior art keywords
myeloproliferative
telomerase inhibitors
treatment
myeloproliferative disorders
disorders
Prior art date
Application number
MA38193A
Other languages
English (en)
Other versions
MA38193A1 (fr
Inventor
Monic Stuart
Stephen Kelsey
Original Assignee
Geron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US13/841,711 external-priority patent/US9375485B2/en
Application filed by Geron Corp filed Critical Geron Corp
Publication of MA38193A1 publication Critical patent/MA38193A1/fr
Publication of MA38193B1 publication Critical patent/MA38193B1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/314—Phosphoramidates
    • C12N2310/3145—Phosphoramidates with the nitrogen in 3' or 5'-position
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07049—RNA-directed DNA polymerase (2.7.7.49), i.e. telomerase or reverse-transcriptase

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Physiology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés pour réduire la prolifération de cellules progénitrices néoplasiques et soulager des symptômes associés chez des individus diagnostiqués avec ou suspectés d'avoir des troubles myéloprolifératifs, tels que la thrombocytémie essentielle (te). La présente invention concerne en outre des procédés d'utilisation d'inhibiteurs de télomérase pour maintenir les numérations plaquettaires sanguines dans des plages relativement normales dans le sang d'individus diagnostiqués avec ou suspectés d'avoir des troubles myéloprolifératifs, tels que te.
MA38193A 2012-12-07 2013-11-15 Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives MA38193B1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261734941P 2012-12-07 2012-12-07
US201361799069P 2013-03-15 2013-03-15
US13/841,711 US9375485B2 (en) 2012-12-07 2013-03-15 Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
US201361900347P 2013-11-05 2013-11-05
PCT/US2013/070437 WO2014088785A1 (fr) 2012-12-07 2013-11-15 Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives

Publications (2)

Publication Number Publication Date
MA38193A1 MA38193A1 (fr) 2017-12-29
MA38193B1 true MA38193B1 (fr) 2018-12-31

Family

ID=50883867

Family Applications (2)

Application Number Title Priority Date Filing Date
MA38193A MA38193B1 (fr) 2012-12-07 2013-11-15 Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives
MA45504A MA45504B1 (fr) 2012-12-07 2013-11-15 Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA45504A MA45504B1 (fr) 2012-12-07 2013-11-15 Utilisation d'inhibiteurs de télomérase pour le traitement de troubles myéloprolifératifs et de néoplasies myéloprolifératives

Country Status (37)

Country Link
EP (3) EP3646876B1 (fr)
JP (6) JP6433911B2 (fr)
KR (4) KR102662590B1 (fr)
CN (2) CN111617252A (fr)
AP (1) AP2015008504A0 (fr)
AU (4) AU2013356533B2 (fr)
BR (1) BR112015013260A2 (fr)
CA (2) CA3188494A1 (fr)
CL (2) CL2015001530A1 (fr)
CY (3) CY1122169T1 (fr)
DK (3) DK2928477T3 (fr)
EA (1) EA032973B1 (fr)
ES (3) ES2982897T3 (fr)
FI (2) FI3646876T3 (fr)
FR (1) FR25C1016I2 (fr)
HK (1) HK1210940A1 (fr)
HR (3) HRP20191784T1 (fr)
HU (4) HUE066402T2 (fr)
IL (3) IL317233A (fr)
LT (4) LT3456333T (fr)
MA (2) MA38193B1 (fr)
ME (1) ME03538B (fr)
MX (3) MX372753B (fr)
MY (2) MY200076A (fr)
NL (1) NL301326I2 (fr)
NZ (1) NZ708920A (fr)
PH (2) PH12019501008A1 (fr)
PL (3) PL2928477T3 (fr)
PT (3) PT2928477T (fr)
RS (2) RS59363B1 (fr)
SG (3) SG10201802926XA (fr)
SI (3) SI3456333T1 (fr)
SM (2) SMT202000328T1 (fr)
TN (1) TN2015000249A1 (fr)
UA (3) UA128370C2 (fr)
WO (1) WO2014088785A1 (fr)
ZA (3) ZA201504124B (fr)

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HRP20171705T1 (hr) 2004-07-02 2017-12-15 Geron Corporation Sinteza zaštićenih 3’-amino-nukleozidnih monomera
US9375485B2 (en) 2012-12-07 2016-06-28 Geron Corporation Use of telomerase inhibitors for the treatment of myeloproliferative disorders and myeloproliferative neoplasms
SMT202000315T1 (it) 2013-08-07 2020-07-08 Incyte Corp Forme di dosaggio a rilascio prolungato per un inibitore di jak1
HUE042792T2 (hu) * 2013-11-06 2019-07-29 Mayo Found Medical Education & Res Eljárások és anyagok hematológiai, rosszindulatú betegségek kezelésére
MA42157A (fr) * 2015-04-23 2018-02-28 Geron Corp Procédés de préparation de polynucléotides à l'aide de compositions de sel cationique multivalent
EP3318276A1 (fr) * 2016-11-04 2018-05-09 Janssen Biotech, Inc. Combinaisons d'un inhibiteur de la télomérase et d'un inhibiteur du bcl-2 destinées au traitement des cancers hématologiques
JP7316261B2 (ja) 2017-07-28 2023-07-27 ジェロン・コーポレーション 骨髄異形成症候群の治療方法
IL319432A (en) * 2018-04-30 2025-05-01 Kartos Therapeutics Inc Methods of treating cancer
MX2020012503A (es) * 2018-05-25 2021-08-11 Kartos Therapeutics Inc Métodos de tratamiento de neoplasias mieloproliferativas.
UA129979C2 (uk) * 2018-07-31 2025-10-01 Джерон Корпорейшн Способи ідентифікації пацієнтів з мієлофіброзом, що мають підвищену ймовірність отримати користь від лікування іметелстатом
KR20250074692A (ko) 2018-11-29 2025-05-27 제론 코포레이션 골수이형성 증후군을 치료하는 방법
CN115666588A (zh) 2019-11-04 2023-01-31 美国杰龙生物医药公司 Janus激酶抑制剂和端粒酶抑制剂用于治疗骨髓增殖性肿瘤的用途
JP2021157248A (ja) * 2020-03-25 2021-10-07 パイオニア株式会社 状況出力装置
IL299205A (en) * 2020-07-17 2023-02-01 Geron Corp Subcutaneous telomerase inhibitor preparations and methods of using them
WO2022159760A1 (fr) * 2021-01-22 2022-07-28 The Regents Of The University Of California Méthodes de traitement et d'atténuation d'un cancer
WO2024259369A1 (fr) * 2023-06-14 2024-12-19 Rarecells Inc. Compositions ciblant des cellules géantes dans des troubles sanguins

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MY200076A (en) 2023-12-06
EP3646876B1 (fr) 2024-02-14
HRP20240624T1 (hr) 2024-08-02
SG10201802926XA (en) 2018-05-30
EP3646876A1 (fr) 2020-05-06
CN111617252A (zh) 2020-09-04
JP2022179684A (ja) 2022-12-02
ES2789176T3 (es) 2020-10-26
CA2892907C (fr) 2023-03-21
EP3456333B1 (fr) 2020-04-01
EA201590878A1 (ru) 2016-04-29
PH12019501008A1 (en) 2022-11-14
FIC20250019I1 (fi) 2025-05-07
JP2025109842A (ja) 2025-07-25
PT3456333T (pt) 2020-06-01
MX2022015437A (es) 2023-01-11
PL3646876T3 (pl) 2024-07-22
AU2013356533B2 (en) 2018-09-27
MX2020003276A (es) 2020-07-20
RS60401B1 (sr) 2020-07-31
PH12015501282B1 (en) 2015-08-24
CY1123206T1 (el) 2021-10-29
HUE066402T2 (hu) 2024-07-28
WO2014088785A8 (fr) 2015-07-16
DK3456333T3 (da) 2020-05-18
CY1122169T1 (el) 2020-11-25
CN104936602B (zh) 2020-07-17
AU2020267142A1 (en) 2020-12-03
FR25C1016I1 (fr) 2025-06-20
ZA201504124B (en) 2017-05-31
MA38193A1 (fr) 2017-12-29
EP2928477B1 (fr) 2019-07-24
UA128370C2 (uk) 2024-06-26
SMT201900567T1 (it) 2019-11-13
KR20230028590A (ko) 2023-02-28
LTPA2025517I1 (fr) 2025-05-26
PT2928477T (pt) 2019-10-25
HK1212226A1 (en) 2016-06-10
LT3456333T (lt) 2020-06-25
IL280144B1 (en) 2025-01-01
AU2020267142B2 (en) 2024-05-16
JP6433911B2 (ja) 2018-12-05
MX2015007169A (es) 2016-03-31
EP3456333A1 (fr) 2019-03-20
KR102662590B1 (ko) 2024-05-03
SI3646876T1 (sl) 2024-07-31
FI3646876T3 (fi) 2024-05-14
IL239266A0 (en) 2015-07-30
PL2928477T3 (pl) 2020-03-31
UA126015C2 (uk) 2022-08-03
DK3646876T3 (da) 2024-05-06
HRP20191784T1 (hr) 2019-12-27
NZ708920A (en) 2020-08-28
AP2015008504A0 (en) 2015-06-30
PL3456333T3 (pl) 2020-09-21
MY180634A (en) 2020-12-03
CL2015001530A1 (es) 2016-03-28
AU2018282364A1 (en) 2019-05-23
WO2014088785A1 (fr) 2014-06-12
NZ748134A (en) 2020-10-30
ES2982897T3 (es) 2024-10-18
CL2017002156A1 (es) 2018-05-04
KR20150091130A (ko) 2015-08-07
IL239266B (en) 2019-11-28
SG10202103341SA (en) 2021-05-28
IL280144B2 (en) 2025-05-01
HUS2500019I1 (hu) 2025-05-28
HUE049858T2 (hu) 2020-11-30
CN104936602A (zh) 2015-09-23
JP7288098B2 (ja) 2023-06-06
IL280144A (en) 2021-03-01
EP2928477A4 (fr) 2016-09-21
EP2928477A1 (fr) 2015-10-14
AU2020267142C1 (en) 2024-08-08
HK1210940A1 (zh) 2016-05-13
UA117116C2 (uk) 2018-06-25
CA2892907A1 (fr) 2014-06-12
JP2016504307A (ja) 2016-02-12
SI2928477T1 (sl) 2019-11-29
HRP20200993T1 (hr) 2020-11-27
HUE045098T2 (hu) 2019-12-30
ZA202108991B (en) 2023-05-31
KR102294819B1 (ko) 2021-09-01
JP6998191B2 (ja) 2022-02-04
KR20210107906A (ko) 2021-09-01
AU2024203138A1 (en) 2024-07-25
PT3646876T (pt) 2024-05-15
SG11201504383TA (en) 2015-07-30
MA45504A1 (fr) 2020-05-29
MA45504B1 (fr) 2021-10-29
EA032973B1 (ru) 2019-08-30
TN2015000249A1 (en) 2016-10-03
AU2013356533A1 (en) 2014-06-12
JP2022050537A (ja) 2022-03-30
NL301326I2 (nl) 2025-07-31
ME03538B (fr) 2020-07-20
JP2018035196A (ja) 2018-03-08
BR112015013260A2 (pt) 2018-02-06
EP3456333B8 (fr) 2020-05-13
PH12015501282A1 (en) 2015-08-24
JP2020041001A (ja) 2020-03-19
IL317233A (en) 2025-01-01
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CY2025015I1 (el) 2026-02-25
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MX372753B (es) 2020-06-26
SMT202000328T1 (it) 2020-07-08
SI3456333T1 (sl) 2020-10-30
CY2025015I2 (el) 2026-02-25
CA3188494A1 (fr) 2014-06-12
RS59363B1 (sr) 2019-11-29
LT3646876T (lt) 2024-05-10
DK2928477T3 (da) 2019-10-07
ES2744790T3 (es) 2020-02-26
LT2928477T (lt) 2019-10-10

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