SU1366042A3 - Способ получения гепарина - Google Patents

Способ получения гепарина Download PDF

Info

Publication number: SU1366042A3
Authority: SU; USSR - Soviet Union
Prior art keywords: heparin; dry matter; sample; content; temperature
Prior art date: 1979-03-21

Application number

SU802897057A

Other languages

English (en)

Russian (ru)

Inventor

Ishtvan Takach

Derd Kerej

Yanosh Illesh

Peter Rudolf

Pal Gere

Laslo Chebe

Erzhebet Nesmeli

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1979-03-21

Filing date

1980-03-20

Publication date

1988-01-07

1980-03-20 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1988-01-07 Application granted granted Critical

1988-01-07 Publication of SU1366042A3 publication Critical patent/SU1366042A3/ru

1993-01-18 Priority to LV930043A priority Critical patent/LV5184A3/xx

1993-07-01 Priority to LTRP750A priority patent/LT2279B/xx

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title claims abstract description 35
229960002897 heparin Drugs 0.000 title claims abstract description 35
229920000669 heparin Polymers 0.000 title claims abstract description 35
238000000034 method Methods 0.000 title abstract description 8
210000000056 organ Anatomy 0.000 claims abstract description 15
239000002994 raw material Substances 0.000 claims abstract description 9
239000000725 suspension Substances 0.000 claims description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 9
208000035404 Autolysis Diseases 0.000 claims description 6
206010057248 Cell death Diseases 0.000 claims description 6
230000028043 self proteolysis Effects 0.000 claims description 6
230000004071 biological effect Effects 0.000 claims description 3
239000002244 precipitate Substances 0.000 claims description 3
241001465754 Metazoa Species 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims 1
239000000126 substance Substances 0.000 abstract description 15
210000001557 animal structure Anatomy 0.000 abstract description 3
150000003839 salts Chemical class 0.000 abstract description 2
239000007864 aqueous solution Substances 0.000 abstract 1
239000007788 liquid Substances 0.000 abstract 1
239000012266 salt solution Substances 0.000 abstract 1
239000000706 filtrate Substances 0.000 description 12
210000000813 small intestine Anatomy 0.000 description 8
239000012141 concentrate Substances 0.000 description 7
239000000463 material Substances 0.000 description 7
238000001035 drying Methods 0.000 description 6
230000000694 effects Effects 0.000 description 6
239000000047 product Substances 0.000 description 6
208000031888 Mycoses Diseases 0.000 description 5
239000003925 fat Substances 0.000 description 5
239000000203 mixture Substances 0.000 description 5
210000004400 mucous membrane Anatomy 0.000 description 5
239000007900 aqueous suspension Substances 0.000 description 4
238000000605 extraction Methods 0.000 description 4
244000005700 microbiome Species 0.000 description 4
239000002245 particle Substances 0.000 description 4
239000013049 sediment Substances 0.000 description 4
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
238000004925 denaturation Methods 0.000 description 3
230000036425 denaturation Effects 0.000 description 3
229940079593 drug Drugs 0.000 description 3
239000003814 drug Substances 0.000 description 3
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
102000004190 Enzymes Human genes 0.000 description 2
108090000790 Enzymes Proteins 0.000 description 2
238000001914 filtration Methods 0.000 description 2
238000010438 heat treatment Methods 0.000 description 2
230000002452 interceptive effect Effects 0.000 description 2
239000007791 liquid phase Substances 0.000 description 2
102000004196 processed proteins & peptides Human genes 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
238000003756 stirring Methods 0.000 description 2
239000008399 tap water Substances 0.000 description 2
235000020679 tap water Nutrition 0.000 description 2
238000010793 Steam injection (oil industry) Methods 0.000 description 1
239000013543 active substance Substances 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
238000009835 boiling Methods 0.000 description 1
238000004140 cleaning Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
235000013861 fat-free Nutrition 0.000 description 1
238000007710 freezing Methods 0.000 description 1
230000008014 freezing Effects 0.000 description 1
230000005484 gravity Effects 0.000 description 1
238000000227 grinding Methods 0.000 description 1
102000022382 heparin binding proteins Human genes 0.000 description 1
108091012216 heparin binding proteins Proteins 0.000 description 1
229940060367 inert ingredients Drugs 0.000 description 1
238000002347 injection Methods 0.000 description 1
239000007924 injection Substances 0.000 description 1
230000000968 intestinal effect Effects 0.000 description 1
210000000936 intestine Anatomy 0.000 description 1
238000005259 measurement Methods 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
210000004379 membrane Anatomy 0.000 description 1
239000012528 membrane Substances 0.000 description 1
229910052751 metal Inorganic materials 0.000 description 1
239000002184 metal Substances 0.000 description 1
238000002156 mixing Methods 0.000 description 1
XULSCZPZVQIMFM-IPZQJPLYSA-N odevixibat Chemical compound C12=CC(SC)=C(OCC(=O)N[C@@H](C(=O)N[C@@H](CC)C(O)=O)C=3C=CC(O)=CC=3)C=C2S(=O)(=O)NC(CCCC)(CCCC)CN1C1=CC=CC=C1 XULSCZPZVQIMFM-IPZQJPLYSA-N 0.000 description 1
230000000737 periodic effect Effects 0.000 description 1
229920001184 polypeptide Polymers 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
238000005057 refrigeration Methods 0.000 description 1
230000001105 regulatory effect Effects 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Polymers & Plastics (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Materials Engineering (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Extraction Or Liquid Replacement (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SU802897057A 1979-03-21 1980-03-20 Способ получения гепарина SU1366042A3 (ru)

Priority Applications (2)

Application Number	Priority Date	Filing Date	Title
LV930043A LV5184A3 (lv)	1979-03-21	1993-01-18	Heparina iegusanas panemiens
LTRP750A LT2279B (lt)	1979-03-21	1993-07-01	Geparino gavimo budas

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU79RI705A HU177887B (en)	1979-03-21	1979-03-21	Process for preparing a raw material containing heparin

Publications (1)

Publication Number	Publication Date
SU1366042A3 true SU1366042A3 (ru)	1988-01-07

Family

ID=11001090

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU802897057A SU1366042A3 (ru)	1979-03-21	1980-03-20	Способ получения гепарина
SU802897802A SU1375115A3 (ru)	1979-03-21	1980-03-20	Способ получени гепарина

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU802897802A SU1375115A3 (ru)	1979-03-21	1980-03-20	Способ получени гепарина

Country Status (26)

Country	Link
US (1)	US4315923A (2)
JP (2)	JPS55164202A (2)
AR (2)	AR222215A1 (2)
AT (2)	AT368004B (2)
AU (2)	AU529809B2 (2)
BE (2)	BE882369A (2)
BR (2)	BR8001711A (2)
CA (2)	CA1137081A (2)
CS (2)	CS248011B2 (2)
DD (2)	DD149532A5 (2)
DE (2)	DE3011062A1 (2)
DK (2)	DK166504C (2)
ES (2)	ES8102581A1 (2)
FR (2)	FR2451743A1 (2)
GB (2)	GB2045272B (2)
GR (2)	GR67682B (2)
HU (1)	HU177887B (2)
IN (1)	IN153527B (2)
IT (2)	IT1133068B (2)
NL (2)	NL8001695A (2)
NZ (2)	NZ193188A (2)
PL (2)	PL134709B1 (2)
SE (2)	SE453725B (2)
SU (2)	SU1366042A3 (2)
YU (2)	YU76580A (2)
ZA (2)	ZA801480B (2)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4692435A (en) *	1978-11-06	1987-09-08	Choay, S.A.	Mucopolysaccharide composition having a regulatory action on coagulation, medicament containing same and process of preparation
SE449753B (sv) *	1978-11-06	1987-05-18	Choay Sa	Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
US4826600A (en) *	1987-06-24	1989-05-02	Amoco Corporation	Process for treatment of wastewater
FR2704226B1 (fr) *	1993-04-22	1995-07-21	Sanofi Elf	3-desoxy oligosaccharides, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
BR9810881B1 (pt) *	1997-07-16	2009-01-13		mÉtodo para produzir heparina a partir do tecido da mucosa de mamÍferos.
CA2489662C (en) *	2002-06-19	2011-04-12	Can Technologies, Inc.	Animal feed composition comprising mucosa byproduct
ES3041746T3 (en) *	2022-03-08	2025-11-14	Horizon Ip S L	Heparin and mixtures of native proteins and peptides from waste tissue of slaughtered animals

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2410084A (en) *	1943-12-09	1946-10-29	Upjohn Co	Recovery of heparin
US2587924A (en) *	1948-05-27	1952-03-04	Univ Alberta	Methods of producing heparin
US2571679A (en) *	1948-07-08	1951-10-16	Carlo Erba S A	Process for preparing purified heparin
DE950594C (de) *	1953-07-01	1956-10-11	Upjohn Co	Verfahren zur Gewinnung von Heparin
GB872214A (en) *	1957-09-23	1961-07-05	Upjohn Co	Extraction process for the recovery of heparin
US2989438A (en) *	1958-12-29	1961-06-20	Roussel Uclaf	Process of purifying heparin, and product produced therefrom
GB1221784A (en) *	1967-04-07	1971-02-10	John Ernest Scott	Precipitation of heparin from aqueous solution
US3451996A (en) *	1968-02-12	1969-06-24	Thompson Farms Co	Method for the preparation of heparin
IT1019525B (it) *	1972-03-21	1977-11-30	Ferdinando D	Metodo apparecchio e prodotto per formare complessi stabili di polia nioni
US4188467A (en) *	1975-10-31	1980-02-12	A. H. Robins Company, Incorporated	Process for tempering tissue for heparin production
US4192916A (en) *	1975-10-31	1980-03-11	A. H. Robins Company, Incorporated	Process for producing defatted heparin tissue for heparin production
DE2646678C2 (de) *	1975-10-31	1985-11-28	A. H. Robins Co. Inc., Richmond, Va.	Verfahren zur Herstellung eines entfetteten Heparin-Gewebes
DE2646677C2 (de) *	1975-10-31	1985-11-07	A. H. Robins Co. Inc., Richmond, Va.	Verfahren zum Tempern von gefrorenem, Heparin führendem tierischem Gewebe
DE2660052A1 (de) *	1976-11-12	1979-01-25	Schering Ag	Verfahren zur herstellung von heparin
DE2652272C2 (de) *	1976-11-12	1979-02-15	Schering Ag, 1000 Berlin Und 4619 Bergkamen	Verfahren zur Herstellung von Heparin
US4175182A (en) *	1978-07-03	1979-11-20	Research Corporation	Separation of high-activity heparin by affinity chromatography on supported protamine

1979
- 1979-03-21 HU HU79RI705A patent/HU177887B/hu unknown
1980
- 1980-03-11 AT AT0134880A patent/AT368004B/de not_active IP Right Cessation
- 1980-03-13 ZA ZA00801480A patent/ZA801480B/xx unknown
- 1980-03-17 AT AT0144280A patent/AT365927B/de not_active IP Right Cessation
- 1980-03-18 ZA ZA00801564A patent/ZA801564B/xx unknown
- 1980-03-18 SE SE8002126A patent/SE453725B/sv not_active IP Right Cessation
- 1980-03-18 SE SE8002125A patent/SE451297B/sv not_active IP Right Cessation
- 1980-03-18 PL PL1980222794A patent/PL134709B1/pl unknown
- 1980-03-19 GR GR61493A patent/GR67682B/el unknown
- 1980-03-19 US US06/131,824 patent/US4315923A/en not_active Expired - Lifetime
- 1980-03-19 CS CS801897A patent/CS248011B2/cs unknown
- 1980-03-19 GR GR61492A patent/GR67681B/el unknown
- 1980-03-19 YU YU00765/80A patent/YU76580A/xx unknown
- 1980-03-19 CS CS801898A patent/CS248012B2/cs unknown
- 1980-03-20 DK DK119780A patent/DK166504C/da not_active IP Right Cessation
- 1980-03-20 SU SU802897057A patent/SU1366042A3/ru active
- 1980-03-20 SU SU802897802A patent/SU1375115A3/ru active
- 1980-03-20 CA CA000348224A patent/CA1137081A/en not_active Expired
- 1980-03-20 YU YU00769/80A patent/YU76980A/xx unknown
- 1980-03-20 DD DD80219786A patent/DD149532A5/de not_active IP Right Cessation
- 1980-03-20 CA CA000348222A patent/CA1152894A/en not_active Expired
- 1980-03-20 AU AU56637/80A patent/AU529809B2/en not_active Ceased
- 1980-03-20 NZ NZ193188A patent/NZ193188A/en unknown
- 1980-03-20 FR FR8006266A patent/FR2451743A1/fr active Granted
- 1980-03-20 DK DK119480A patent/DK166393C/da not_active IP Right Cessation
- 1980-03-20 FR FR8006267A patent/FR2451744A1/fr active Granted
- 1980-03-20 DD DD80219787A patent/DD149467A5/de unknown
- 1980-03-20 AU AU56636/80A patent/AU533021B2/en not_active Ceased
- 1980-03-21 DE DE19803011062 patent/DE3011062A1/de not_active Withdrawn
- 1980-03-21 GB GB8009611A patent/GB2045272B/en not_active Expired
- 1980-03-21 GB GB8009608A patent/GB2045271B/en not_active Expired
- 1980-03-21 AR AR280393A patent/AR222215A1/es active
- 1980-03-21 ES ES490538A patent/ES8102581A1/es not_active Expired
- 1980-03-21 BR BR8001711A patent/BR8001711A/pt unknown
- 1980-03-21 NL NL8001695A patent/NL8001695A/nl not_active Application Discontinuation
- 1980-03-21 IT IT67438/80A patent/IT1133068B/it active
- 1980-03-21 JP JP3601280A patent/JPS55164202A/ja active Granted
- 1980-03-21 DE DE19803010972 patent/DE3010972A1/de active Granted
- 1980-03-21 BE BE0/199894A patent/BE882369A/fr not_active IP Right Cessation
- 1980-03-21 PL PL1980222906A patent/PL128250B1/pl unknown
- 1980-03-21 IT IT67444/80A patent/IT1133074B/it active
- 1980-03-21 ES ES490537A patent/ES490537A0/es active Granted
- 1980-03-21 NL NL8001693A patent/NL8001693A/nl not_active Application Discontinuation
- 1980-03-21 BR BR8001717A patent/BR8001717A/pt unknown
- 1980-03-21 AR AR280392A patent/AR219226A1/es active
- 1980-03-21 NZ NZ193215A patent/NZ193215A/en unknown
- 1980-03-21 JP JP3600680A patent/JPS55164201A/ja active Granted
- 1980-03-21 BE BE0/199895A patent/BE882370A/fr not_active IP Right Cessation
- 1980-08-21 IN IN952/CAL/80A patent/IN153527B/en unknown

Also Published As

Publication number	Publication date
ZA801564B (en)	1981-03-25
CS248012B2 (en)	1987-01-15
AR222215A1 (es)	1981-04-30
GB2045272A (en)	1980-10-29
CA1137081A (en)	1982-12-07
ES490538A0 (es)	1981-02-16
AR219226A1 (es)	1980-07-31
AU5663780A (en)	1980-09-25
BE882370A (fr)	1980-09-22
GB2045271B (en)	1983-04-20
ES8102580A1 (es)	1981-02-16
JPH039121B2 (2)	1991-02-07
SU1375115A3 (ru)	1988-02-15
YU76580A (en)	1983-10-31
GR67681B (2)	1981-09-04
NL8001695A (nl)	1980-09-23
US4315923A (en)	1982-02-16
FR2451744A1 (fr)	1980-10-17
HU177887B (en)	1982-01-28
DK166504C (da)	1993-10-18
DD149467A5 (de)	1981-07-15
AU529809B2 (en)	1983-06-23
PL222906A1 (2)	1981-01-02
DK119480A (da)	1980-09-22
CS248011B2 (en)	1987-01-15
BR8001717A (pt)	1980-11-18
AU533021B2 (en)	1983-10-27
SE451297B (sv)	1987-09-28
NZ193188A (en)	1984-11-09
SE8002126L (sv)	1980-09-22
IT8067444A0 (it)	1980-03-21
PL222794A1 (2)	1981-01-02
NL8001693A (nl)	1980-09-23
SE453725B (sv)	1988-02-29
DE3011062A1 (de)	1980-10-02
CA1152894A (en)	1983-08-30
DK166393C (da)	1993-09-27
GB2045271A (en)	1980-10-29
FR2451743B1 (2)	1983-05-27
IT1133074B (it)	1986-07-09
GR67682B (2)	1981-09-04
ES490537A0 (es)	1981-02-16
ATA134880A (de)	1982-01-15
IT8067438A0 (it)	1980-03-21
AT365927B (de)	1982-02-25
ZA801480B (en)	1981-03-25
DK166504B (da)	1993-06-01
PL134709B1 (en)	1985-09-30
DE3010972C2 (2)	1989-08-31
ATA144280A (de)	1981-07-15
BR8001711A (pt)	1980-11-18
DE3010972A1 (de)	1980-10-02
DK119780A (da)	1980-09-22
SE8002125L (sv)	1980-09-22
JPS55164202A (en)	1980-12-20
DD149532A5 (de)	1981-07-15
FR2451744B1 (2)	1983-07-29
JPH0232282B2 (2)	1990-07-19
AU5663680A (en)	1980-09-25
FR2451743A1 (fr)	1980-10-17
AT368004B (de)	1982-08-25
NZ193215A (en)	1984-11-09
PL128250B1 (en)	1984-01-31
ES8102581A1 (es)	1981-02-16
IT1133068B (it)	1986-07-09
JPS55164201A (en)	1980-12-20
DK166393B (da)	1993-05-10
IN153527B (2)	1984-07-21
YU76980A (en)	1984-02-29
GB2045272B (en)	1983-03-30
BE882369A (fr)	1980-09-22

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US4347259A (en)	1982-08-31	Method for reducing the bacterial population of blood powder
NZ262775A (en)	1996-10-28	Gelatin production; collagen-containing slurry heated and treated with acid
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US2328361A (en)	1943-08-31	Method of conditioning sludge
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