SU638260A3 - Способ получени 6-хлор-2-(1"пиперазинил) пиразина - Google Patents

Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Info

Publication number: SU638260A3
Authority: SU; USSR - Soviet Union
Prior art keywords: chlor; pyrazine; piperazinyl; obtaining; temperature
Prior art date: 1975-04-21

Application number

SU762346054A

Other languages

English (en)

Russian (ru)

Inventor

Спенсер Саари Уолфред

Карл Ламма Уильям (Младший)

Original Assignee

Мерк Энд Ко Инк (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-20

Publication date

1978-12-15

1976-04-20 Application filed by Мерк Энд Ко Инк (Фирма) filed Critical Мерк Энд Ко Инк (Фирма)

1978-12-15 Application granted granted Critical

1978-12-15 Publication of SU638260A3 publication Critical patent/SU638260A3/ru

Links

KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SU762346054A 1975-04-21 1976-04-20 Способ получени 6-хлор-2-(1"пиперазинил) пиразина SU638260A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21

Publications (1)

Publication Number	Publication Date
SU638260A3 true SU638260A3 (ru)	1978-12-15

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU762346054A SU638260A3 (ru)	1975-04-21	1976-04-20	Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Country Status (36)

Country	Link
JP (1)	JPS51136688A (2)
AR (1)	AR210349A1 (2)
AT (1)	AT353795B (2)
AU (1)	AU496854B2 (2)
BE (1)	BE840904A (2)
BG (1)	BG34185A3 (2)
CA (1)	CA1059128A (2)
CH (1)	CH619462A5 (2)
CS (1)	CS195726B2 (2)
CY (1)	CY1090A (2)
DD (1)	DD124599A5 (2)
DE (1)	DE2617205C3 (2)
DK (1)	DK143899C (2)
EG (1)	EG12387A (2)
ES (4)	ES447150A1 (2)
FI (1)	FI62666C (2)
FR (1)	FR2308367A1 (2)
GB (1)	GB1492528A (2)
GR (1)	GR59900B (2)
HK (1)	HK60380A (2)
HU (1)	HU172684B (2)
IE (1)	IE42979B1 (2)
IL (1)	IL49391A (2)
KE (1)	KE3088A (2)
LU (1)	LU74795A1 (2)
MY (1)	MY8100225A (2)
NL (1)	NL167692C (2)
NO (1)	NO146599C (2)
PH (1)	PH12274A (2)
PL (1)	PL99664B1 (2)
PT (1)	PT65027B (2)
RO (1)	RO73278A (2)
SE (1)	SE421695B (2)
SU (1)	SU638260A3 (2)
YU (1)	YU100676A (2)
ZA (1)	ZA762320B (2)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
ATE491689T1 (de)	1997-10-27	2011-01-15	Neurosearch As	Heteroaryl diazacycloalkane als cholinergische ligande für nikotin-acetylcholin-rezeptoren
CA2367695A1 (en)	1999-04-26	2000-11-02	Neurosearch A/S	Heteroaryl diazacycloalkanes, their preparation and use
CN1231473C (zh) *	2000-02-16	2005-12-14	神经能质公司	取代的芳基吡嗪
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds
PT1534391E (pt)	2002-07-19	2007-05-31	Biovitrum Ab	Novos derivados e piperazinilo-pirazinona para o tratamento de desordens relacionadas com o receptor 5-ht

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
1977
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
DK143899C (da)	1982-04-13
IL49391A0 (en)	1976-06-30
FR2308367B1 (2)	1979-09-21
JPS51136688A (en)	1976-11-26
SE7604093L (sv)	1976-10-22
FI62666C (fi)	1983-02-10
CA1059128A (en)	1979-07-24
LU74795A1 (2)	1977-02-07
IL49391A (en)	1979-09-30
CY1090A (en)	1980-12-27
DK143899B (da)	1981-10-26
KE3088A (en)	1980-11-07
PT65027B (en)	1978-04-03
DD124599A5 (2)	1977-03-02
AU496854B2 (en)	1978-11-02
AR210349A1 (es)	1977-07-29
YU100676A (en)	1982-08-31
FI760978A7 (2)	1976-10-22
CH619462A5 (en)	1980-09-30
EG12387A (en)	1978-12-31
NO146599B (no)	1982-07-26
MY8100225A (en)	1981-12-31
PL99664B1 (pl)	1978-07-31
HK60380A (en)	1980-11-07
IE42979L (en)	1976-10-21
ES447150A1 (es)	1977-09-16
JPS5522475B2 (2)	1980-06-17
DK164476A (da)	1976-10-22
NL7603800A (nl)	1976-10-25
RO73278A (ro)	1982-09-09
FI62666B (fi)	1982-10-29
DE2617205B2 (de)	1980-05-08
GR59900B (en)	1978-03-16
BE840904A (fr)	1976-08-16
DE2617205A1 (de)	1976-10-28
GB1492528A (en)	1977-11-23
ZA762320B (en)	1977-11-30
ES459405A1 (es)	1978-08-16
NO761207L (2)	1976-10-22
NL167692B (nl)	1981-08-17
SE421695B (sv)	1982-01-25
BG34185A3 (bg)	1983-07-15
HU172684B (hu)	1978-11-28
PT65027A (en)	1976-05-01
FR2308367A1 (fr)	1976-11-19
AU1296676A (en)	1977-10-20
ES459406A1 (es)	1978-08-16
ES459407A1 (es)	1978-08-16
NO146599C (no)	1982-11-03
NL167692C (nl)	1982-01-18
DE2617205C3 (de)	1981-01-29
IE42979B1 (en)	1980-11-19
ATA288376A (de)	1979-05-15
PH12274A (en)	1978-12-12
CS195726B2 (en)	1980-02-29
AT353795B (de)	1979-12-10

Publication	Publication Date	Title
SU645559A3 (ru)	1979-01-30	Способ получени производных оксима или их солей
SU638260A3 (ru)	1978-12-15	Способ получени 6-хлор-2-(1"пиперазинил) пиразина
SE434049B (sv)	1984-07-02	Forfarande for framstellning av 1,4-dihydropyridinderivat
FI781955A7 (fi)	1978-12-21	Foerfarande foer framstaellning av farmakologiskt anvaendbara 1,2,3,6-tetrahydroisonikotinsyraderivater
IT1054791B (it)	1981-11-30	Circuito amplificatore differenziale
SE431456B (sv)	1984-02-06	Analogiforfarande for framstellning av kondenserade kinazolonderivat
SE443981B (sv)	1986-03-17	Analogiforfarande for framstellning av syn-isomerer av 3,7 disubstituerade 3-cefem-4-karboxylsyraforeningar
SE432595B (sv)	1984-04-09	Analogiforfarande for framstellning av piperidyl-indolderivat
NL7613659A (nl)	1977-06-10	Hydroxybenzylmalonzuurderivaten.
DK153150C (da)	1988-10-24	Analogifremgangsmaade til fremstilling af 4-oxo-1,6,7,8-tetrahydro-4h-pyridooe1,2aaapyrimidinderivater
NL7609137A (nl)	1977-02-22	Fenoxyalkylcarbonzuurderivaten.
BG30778A3 (en)	1981-08-14	Method for obtaining of eburnamenine derivatives
SE422462B (sv)	1982-03-08	Analogiforfarande for framstellning av 6-aryl-pyrolo-(1,2-a)imidazol-derivat
NL7714372A (nl)	1978-06-27	Fosfoncarbonzuurderivaten, alsmede werkwijze ter bereiding van dergelijke verbindingen.
SE428017B (sv)	1983-05-30	Forfarande for framstellning av 2,6 - metano - 2h-l- bensoxocinderivat
NL7607483A (nl)	1977-01-11	Werkwijze ter bereiding van nitrilderivaten.
NL7604099A (nl)	1976-10-27	Werkwijze voor het vervaardigen van een condensa- tor.
SU645558A3 (ru)	1979-01-30	Способ получени производных оксима или их солей
SU674671A3 (ru)	1979-07-15	Способ получени производных пирролидина
SU674673A3 (ru)	1979-07-15	Способ получени производных хиноксалина
SE422938B (sv)	1982-04-05	Sett att framstella 2-substituerade 1,4-bensoidazepinderivat
SE423233B (sv)	1982-04-26	Analogiforfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
SU637075A3 (ru)	1978-12-05	Способ получени 2,5-дихлор-п-ксилола
NO143534C (no)	1981-03-04	Analogifremgangsmaate for fremstilling av terapeutisk virksomme derivater av oxatiino(1,4)(2,3-c)pyrrol.
SU647846A1 (ru)	1979-02-15	Усилитель