SU638260A3 - Способ получени 6-хлор-2-(1"пиперазинил) пиразина - Google Patents

Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Info

Publication number: SU638260A3
Authority: SU; USSR - Soviet Union
Prior art keywords: chlor; pyrazine; piperazinyl; obtaining; temperature
Prior art date: 1975-04-21

Application number

SU762346054A

Other languages

English (en)

Russian (ru)

Inventor

Спенсер Саари Уолфред

Карл Ламма Уильям (Младший)

Original Assignee

Мерк Энд Ко Инк (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1975-04-21

Filing date

1976-04-20

Publication date

1978-12-15

1976-04-20 Application filed by Мерк Энд Ко Инк (Фирма) filed Critical Мерк Энд Ко Инк (Фирма)

1978-12-15 Application granted granted Critical

1978-12-15 Publication of SU638260A3 publication Critical patent/SU638260A3/ru

Links

KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 title 2
PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 title 1
GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
229910052736 halogen Inorganic materials 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Child & Adolescent Psychology (AREA)
Hematology (AREA)
Obesity (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

SU762346054A 1975-04-21 1976-04-20 Способ получени 6-хлор-2-(1"пиперазинил) пиразина SU638260A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US57005275A	1975-04-21	1975-04-21

Publications (1)

Publication Number	Publication Date
SU638260A3 true SU638260A3 (ru)	1978-12-15

Family

ID=24277994

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU762346054A SU638260A3 (ru)	1975-04-21	1976-04-20	Способ получени 6-хлор-2-(1"пиперазинил) пиразина

Country Status (36)

Country	Link
JP (1)	JPS51136688A (da)
AR (1)	AR210349A1 (da)
AT (1)	AT353795B (da)
AU (1)	AU496854B2 (da)
BE (1)	BE840904A (da)
BG (1)	BG34185A3 (da)
CA (1)	CA1059128A (da)
CH (1)	CH619462A5 (da)
CS (1)	CS195726B2 (da)
CY (1)	CY1090A (da)
DD (1)	DD124599A5 (da)
DE (1)	DE2617205C3 (da)
DK (1)	DK143899C (da)
EG (1)	EG12387A (da)
ES (4)	ES447150A1 (da)
FI (1)	FI62666C (da)
FR (1)	FR2308367A1 (da)
GB (1)	GB1492528A (da)
GR (1)	GR59900B (da)
HK (1)	HK60380A (da)
HU (1)	HU172684B (da)
IE (1)	IE42979B1 (da)
IL (1)	IL49391A (da)
KE (1)	KE3088A (da)
LU (1)	LU74795A1 (da)
MY (1)	MY8100225A (da)
NL (1)	NL167692C (da)
NO (1)	NO146599C (da)
PH (1)	PH12274A (da)
PL (1)	PL99664B1 (da)
PT (1)	PT65027B (da)
RO (1)	RO73278A (da)
SE (1)	SE421695B (da)
SU (1)	SU638260A3 (da)
YU (1)	YU100676A (da)
ZA (1)	ZA762320B (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4091098A (en) *	1977-04-25	1978-05-23	Merck & Co., Inc.	3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
US4163849A (en)	1978-03-17	1979-08-07	Merck & Co., Inc.	Piperazinylpyrazines
US4252816A (en) *	1979-12-03	1981-02-24	Merck & Co., Inc.	Tetrahydro-1H-1,4-diazepino(1,7-a)benzimidazoles useful as analgesic agents
US4339579A (en)	1980-12-29	1982-07-13	American Home Products Corporation	2,6-Bis-(pyrrolopyrazinyl)pyrazines
EP0094498A3 (en) *	1982-05-06	1985-04-03	American Cyanamid Company	Antiatherosclerotic 1-piperazine derivatives
US4547505A (en) *	1983-03-25	1985-10-15	Degussa Aktiengesellschaft	N-Phenyl-N-'-cycloalkylalkanoylpiperazine useful as analgetics and process for its production
US4788290A (en) *	1987-12-11	1988-11-29	American Home Products Corporation	Serotonergic pyrazine derivatives
EP0580465A1 (fr) *	1992-06-25	1994-01-26	Sanofi	Nouvelle utilisation thérapeutique d'hétérocyclyl-pipérazines comme 5-HT3 agonistes et nouveaux dérivés
AU744539B2 (en) *	1997-10-27	2002-02-28	Neurosearch A/S	Heteroaryl diazacycloalkanes as cholinergic ligands at nicotinic acetylcholine receptors
WO2000064885A1 (en) *	1999-04-26	2000-11-02	Neurosearch A/S	Heteroaryl diazacycloalkanes, their preparation and use
CN1231473C (zh) *	2000-02-16	2005-12-14	神经能质公司	取代的芳基吡嗪
US6825198B2 (en) *	2001-06-21	2004-11-30	Pfizer Inc	5-HT receptor ligands and uses thereof
MXPA05000784A (es)	2002-07-19	2005-06-17	Biovitrum Ab	Derivados de piperazinil-pirazinona novedosos para el tratamiento de los trastornos relacionados con el receptor 5-ht2a.
SE0202287D0 (sv) *	2002-07-19	2002-07-19	Biovitrum Ab	New compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2606906A (en) *	1948-10-14	1952-08-12	American Cyanamid Co	1-(2-pyridyl) piperazine and process of preparing same

1976
- 1976-04-07 DK DK164476A patent/DK143899C/da not_active IP Right Cessation
- 1976-04-07 SE SE7604093A patent/SE421695B/xx not_active IP Right Cessation
- 1976-04-07 EG EG76205A patent/EG12387A/xx active
- 1976-04-08 NO NO761207A patent/NO146599C/no unknown
- 1976-04-09 NL NL7603800A patent/NL167692C/xx not_active IP Right Cessation
- 1976-04-09 FI FI760978A patent/FI62666C/fi not_active IP Right Cessation
- 1976-04-12 IL IL49391A patent/IL49391A/xx unknown
- 1976-04-13 AU AU12966/76A patent/AU496854B2/en not_active Expired
- 1976-04-13 PH PH18329A patent/PH12274A/en unknown
- 1976-04-13 GR GR50538A patent/GR59900B/el unknown
- 1976-04-14 CA CA250,732A patent/CA1059128A/en not_active Expired
- 1976-04-14 FR FR7610958A patent/FR2308367A1/fr active Granted
- 1976-04-15 GB GB15644/76A patent/GB1492528A/en not_active Expired
- 1976-04-15 CY CY1090A patent/CY1090A/xx unknown
- 1976-04-15 DD DD192399A patent/DD124599A5/xx unknown
- 1976-04-16 CS CS762549A patent/CS195726B2/cs unknown
- 1976-04-19 ES ES447150A patent/ES447150A1/es not_active Expired
- 1976-04-19 JP JP51043763A patent/JPS51136688A/ja active Granted
- 1976-04-20 BE BE166282A patent/BE840904A/xx not_active IP Right Cessation
- 1976-04-20 SU SU762346054A patent/SU638260A3/ru active
- 1976-04-20 ZA ZA762320A patent/ZA762320B/xx unknown
- 1976-04-20 CH CH492676A patent/CH619462A5/de not_active IP Right Cessation
- 1976-04-20 YU YU01006/76A patent/YU100676A/xx unknown
- 1976-04-20 DE DE2617205A patent/DE2617205C3/de not_active Expired
- 1976-04-20 BG BG032968A patent/BG34185A3/xx unknown
- 1976-04-20 LU LU74795A patent/LU74795A1/xx unknown
- 1976-04-20 AT AT288376A patent/AT353795B/de not_active IP Right Cessation
- 1976-04-20 RO RO7685688A patent/RO73278A/ro unknown
- 1976-04-20 AR AR262930A patent/AR210349A1/es active
- 1976-04-20 PL PL1976188912A patent/PL99664B1/pl unknown
- 1976-04-21 PT PT65027A patent/PT65027B/pt unknown
- 1976-04-21 IE IE828/76A patent/IE42979B1/en unknown
- 1976-04-21 HU HU76ME00001967A patent/HU172684B/hu unknown
1977
- 1977-06-01 ES ES459406A patent/ES459406A1/es not_active Expired
- 1977-06-01 ES ES459407A patent/ES459407A1/es not_active Expired
- 1977-06-01 ES ES459405A patent/ES459405A1/es not_active Expired
1980
- 1980-10-02 KE KE3088A patent/KE3088A/xx unknown
- 1980-10-30 HK HK603/80A patent/HK60380A/xx unknown
1981
- 1981-12-30 MY MY225/81A patent/MY8100225A/xx unknown

Also Published As

Publication number	Publication date
AU496854B2 (en)	1978-11-02
EG12387A (en)	1978-12-31
NL167692B (nl)	1981-08-17
SE421695B (sv)	1982-01-25
NL167692C (nl)	1982-01-18
FI760978A7 (da)	1976-10-22
CY1090A (en)	1980-12-27
CH619462A5 (en)	1980-09-30
IL49391A (en)	1979-09-30
DK143899B (da)	1981-10-26
SE7604093L (sv)	1976-10-22
PL99664B1 (pl)	1978-07-31
JPS51136688A (en)	1976-11-26
AT353795B (de)	1979-12-10
DE2617205C3 (de)	1981-01-29
DD124599A5 (da)	1977-03-02
DK143899C (da)	1982-04-13
ES459405A1 (es)	1978-08-16
NO761207L (da)	1976-10-22
GB1492528A (en)	1977-11-23
ES459407A1 (es)	1978-08-16
ES459406A1 (es)	1978-08-16
FI62666C (fi)	1983-02-10
PH12274A (en)	1978-12-12
AU1296676A (en)	1977-10-20
DE2617205B2 (de)	1980-05-08
NO146599B (no)	1982-07-26
PT65027A (en)	1976-05-01
MY8100225A (en)	1981-12-31
NO146599C (no)	1982-11-03
HK60380A (en)	1980-11-07
BE840904A (fr)	1976-08-16
PT65027B (en)	1978-04-03
FR2308367A1 (fr)	1976-11-19
FI62666B (fi)	1982-10-29
KE3088A (en)	1980-11-07
ZA762320B (en)	1977-11-30
JPS5522475B2 (da)	1980-06-17
HU172684B (hu)	1978-11-28
RO73278A (ro)	1982-09-09
IE42979L (en)	1976-10-21
FR2308367B1 (da)	1979-09-21
IE42979B1 (en)	1980-11-19
GR59900B (en)	1978-03-16
CA1059128A (en)	1979-07-24
DK164476A (da)	1976-10-22
DE2617205A1 (de)	1976-10-28
CS195726B2 (en)	1980-02-29
YU100676A (en)	1982-08-31
ES447150A1 (es)	1977-09-16
ATA288376A (de)	1979-05-15
AR210349A1 (es)	1977-07-29
NL7603800A (nl)	1976-10-25
LU74795A1 (da)	1977-02-07
BG34185A3 (bg)	1983-07-15
IL49391A0 (en)	1976-06-30

Publication	Publication Date	Title
SU645559A3 (ru)	1979-01-30	Способ получени производных оксима или их солей
AU510353B2 (en)	1980-06-19	1, 4-dihydro-pyridine derivatives
FI781955A7 (fi)	1978-12-21	Foerfarande foer framstaellning av farmakologiskt anvaendbara 1,2,3,6-tetrahydroisonikotinsyraderivater
SE434394B (sv)	1984-07-23	Analogiforfarande for framstellning av kinolonalkansyraderivat
IT1054791B (it)	1981-11-30	Circuito amplificatore differenziale
SE443981B (sv)	1986-03-17	Analogiforfarande for framstellning av syn-isomerer av 3,7 disubstituerade 3-cefem-4-karboxylsyraforeningar
SE432595B (sv)	1984-04-09	Analogiforfarande for framstellning av piperidyl-indolderivat
NL7613659A (nl)	1977-06-10	Hydroxybenzylmalonzuurderivaten.
NL7601806A (nl)	1976-08-26	Differentiaalversterker.
BG30778A3 (en)	1981-08-14	Method for obtaining of eburnamenine derivatives
SE422462B (sv)	1982-03-08	Analogiforfarande for framstellning av 6-aryl-pyrolo-(1,2-a)imidazol-derivat
SE428017B (sv)	1983-05-30	Forfarande for framstellning av 2,6 - metano - 2h-l- bensoxocinderivat
NL7607483A (nl)	1977-01-11	Werkwijze ter bereiding van nitrilderivaten.
SU674671A3 (ru)	1979-07-15	Способ получени производных пирролидина
SU674673A3 (ru)	1979-07-15	Способ получени производных хиноксалина
NO141295C (no)	1980-02-06	Fremkoblet forsterker.
SE422938B (sv)	1982-04-05	Sett att framstella 2-substituerade 1,4-bensoidazepinderivat
SE423233B (sv)	1982-04-26	Analogiforfarande for framstellning av 1,2,3,4-tetrahydroisokinoliner
SU637075A3 (ru)	1978-12-05	Способ получени 2,5-дихлор-п-ксилола
NO143534C (no)	1981-03-04	Analogifremgangsmaate for fremstilling av terapeutisk virksomme derivater av oxatiino(1,4)(2,3-c)pyrrol.
SU647846A1 (ru)	1979-02-15	Усилитель
JPS5239674A (en)	1977-03-28	Imidazole derivatives and agricultural bactericides therefrom
FI773711A7 (fi)	1978-06-12	Foerfarande foer framstaellning av 1-aziridin-karbonsyraderivat
NL7608936A (nl)	1977-02-15	Pyridylderivaten.
BG28044A3 (bg)	1980-02-25	Метод за получаване на производни на 2-(фенилалкилхидразоно)- пропионовата киселина