SU741804A3 - Способ получени антибиотика - Google Patents

Способ получени антибиотика Download PDF

Info

Publication number: SU741804A3
Authority: SU; USSR - Soviet Union
Prior art keywords: vol; ethyl acetate; antibiotic; water; methanol
Prior art date: 1977-03-31

Application number

SU772529301A

Other languages

English (en)

Russian (ru)

Inventor

Хигасиде Эйдзи

Асаи Мицуко

Танида Сеиити

Original Assignee

Такеда Кемикал Индастриз Инк. (Фирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-31

Filing date

1977-10-07

Publication date

1980-06-15

1977-10-07 Application filed by Такеда Кемикал Индастриз Инк. (Фирма) filed Critical Такеда Кемикал Индастриз Инк. (Фирма)

1980-06-15 Application granted granted Critical

1980-06-15 Publication of SU741804A3 publication Critical patent/SU741804A3/ru

Links

230000003115 biocidal effect Effects 0.000 title claims abstract description 26
238000000034 method Methods 0.000 title claims description 11
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 8
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 6
239000003242 anti bacterial agent Substances 0.000 claims description 4
229910052799 carbon Inorganic materials 0.000 claims description 4
229910052757 nitrogen Inorganic materials 0.000 claims description 4
239000000126 substance Substances 0.000 abstract description 5
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 94
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 39
239000000203 mixture Substances 0.000 description 26
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 15
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 14
239000013078 crystal Substances 0.000 description 14
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239000000047 product Substances 0.000 description 11
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
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239000000758 substrate Substances 0.000 description 10
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YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
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240000004808 Saccharomyces cerevisiae Species 0.000 description 2
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
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238000011081 inoculation Methods 0.000 description 1
239000002054 inoculum Substances 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
239000007928 intraperitoneal injection Substances 0.000 description 1
229960001375 lactose Drugs 0.000 description 1
239000012280 lithium aluminium hydride Substances 0.000 description 1
239000011777 magnesium Chemical class 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
235000009973 maize Nutrition 0.000 description 1
WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical class [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
235000013372 meat Nutrition 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
238000002156 mixing Methods 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
150000004682 monohydrates Chemical class 0.000 description 1
230000000877 morphologic effect Effects 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
230000007935 neutral effect Effects 0.000 description 1
229910052759 nickel Inorganic materials 0.000 description 1
229960003512 nicotinic acid Drugs 0.000 description 1
235000001968 nicotinic acid Nutrition 0.000 description 1
239000011664 nicotinic acid Substances 0.000 description 1
150000002823 nitrates Chemical class 0.000 description 1
OTKCDFNVBPBSNB-UHFFFAOYSA-N nitric acid;propane-1,2,3-triol Chemical compound O[N+]([O-])=O.OCC(O)CO OTKCDFNVBPBSNB-UHFFFAOYSA-N 0.000 description 1
239000012454 non-polar solvent Substances 0.000 description 1
238000010899 nucleation Methods 0.000 description 1
150000007523 nucleic acids Chemical class 0.000 description 1
102000039446 nucleic acids Human genes 0.000 description 1
108020004707 nucleic acids Proteins 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
235000012771 pancakes Nutrition 0.000 description 1
235000011007 phosphoric acid Nutrition 0.000 description 1
DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 description 1
239000011591 potassium Chemical class 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
208000019585 progressive encephalomyelitis with rigidity and myoclonus Diseases 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
230000001007 puffing effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
238000005070 sampling Methods 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
238000000926 separation method Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
LNDCCSBWZAQAAW-UHFFFAOYSA-M sodium hydrogen sulfate sulfuric acid Chemical compound [Na+].OS(O)(=O)=O.OS([O-])(=O)=O LNDCCSBWZAQAAW-UHFFFAOYSA-M 0.000 description 1
239000002689 soil Substances 0.000 description 1
238000000638 solvent extraction Methods 0.000 description 1
239000002594 sorbent Substances 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
238000009331 sowing Methods 0.000 description 1
235000013322 soy milk Nutrition 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
238000001228 spectrum Methods 0.000 description 1
229910021653 sulphate ion Inorganic materials 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
238000005406 washing Methods 0.000 description 1
229940075420 xanthine Drugs 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Wood Science & Technology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Zoology (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Microbiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

SU772529301A 1977-03-31 1977-10-07 Способ получени антибиотика SU741804A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP52037166A JPS6034556B2 (ja)	1977-03-31	1977-03-31	抗生物質ｃ−１５００３

Publications (1)

Publication Number	Publication Date
SU741804A3 true SU741804A3 (ru)	1980-06-15

Family

ID=12490004

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
SU772529301A SU741804A3 (ru)	1977-03-31	1977-10-07	Способ получени антибиотика
SU782627804A SU890978A3 (ru)	1977-03-31	1978-06-20	Способ получени антибиотика с-1500зр-0

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
SU782627804A SU890978A3 (ru)	1977-03-31	1978-06-20	Способ получени антибиотика с-1500зр-0

Country Status (6)

Country	Link
JP (1)	JPS6034556B2 (de)
AT (1)	AT364081B (de)
BE (2)	BE865590A (de)
HU (1)	HU187372B (de)
SU (2)	SU741804A3 (de)
ZA (2)	ZA781863B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7432088B2 (en) *	2003-05-08	2008-10-07	Immunogen Inc.	Methods for the production of ansamitocins
LT2900676T (lt) *	2012-09-26	2019-03-25	Immunogen, Inc.	Maitanzinolio acilinimo patobulintas būdas
CN116421733B (zh) *	2023-06-08	2023-09-12	金宇保灵生物药品有限公司	可用于猪多杀性巴氏杆菌病活疫苗的疫苗耐热保护剂

1977
- 1977-03-31 JP JP52037166A patent/JPS6034556B2/ja not_active Expired
- 1977-10-07 SU SU772529301A patent/SU741804A3/ru active
- 1977-10-13 HU HU802440A patent/HU187372B/hu unknown
- 1977-10-14 AT AT0736277A patent/AT364081B/de not_active IP Right Cessation
1978
- 1978-03-31 BE BE186487A patent/BE865590A/fr not_active IP Right Cessation
- 1978-03-31 ZA ZA00781863A patent/ZA781863B/xx unknown
- 1978-03-31 BE BE186486A patent/BE865589A/fr not_active IP Right Cessation
- 1978-03-31 ZA ZA00781862A patent/ZA781862B/xx unknown
- 1978-06-20 SU SU782627804A patent/SU890978A3/ru active

Also Published As

Publication number	Publication date
ATA736277A (de)	1981-02-15
BE865590A (fr)	1978-10-02
JPS53130693A (en)	1978-11-14
SU890978A3 (ru)	1981-12-15
BE865589A (fr)	1978-10-02
AT364081B (de)	1981-09-25
ZA781862B (en)	1979-03-28
HU187372B (en)	1985-12-28
JPS6034556B2 (ja)	1985-08-09
ZA781863B (en)	1979-03-28

Publication	Publication Date	Title
US4151042A (en)	1979-04-24	Method for producing maytansinol and its derivatives
CA1131144A (en)	1982-09-07	Antibiotic c-15003 pnd
US4225494A (en)	1980-09-30	Maytansinol esters
JPS6253158B2 (de)	1987-11-09
JPH0341475B2 (de)	1991-06-24
SU741804A3 (ru)	1980-06-15	Способ получени антибиотика
SU938746A3 (ru)	1982-06-23	Способ получени алкалоидов метанзинола, метанацина и пропионата метанзинола
KR920001366B1 (ko)	1992-02-11	새로운 항암 항생복합체 bbm-1675의 제조방법
SU751332A3 (ru)	1980-07-23	Способ получени антибиотического комплекса а-35512
SU882414A3 (ru)	1981-11-15	Способ получени антибиотика с-15003 р-4
US4550021A (en)	1985-10-29	Antitumor antibiotic 81-484 and process for its production
US4843008A (en)	1989-06-27	Novel microorganisms and a novel process for producing antibiotics
EP0213320B1 (de)	1988-09-28	Physiologisch aktive Formamide
SU1296009A3 (ru)	1987-03-07	Штамм @ @ 15118-продуцент антибиотического комплекса и способ получени антибиотического комплекса
CA1107212A (en)	1981-08-18	Antibiotic c-15003
RU2089614C1 (ru)	1997-09-10	Противоопухолевый антибиотик вму-46164 и способ его получения
US4994271A (en)	1991-02-19	BMY-40800 antitumor antibiotics
CA1220746A (en)	1987-04-21	Luzopeptin e.sub.2
EP0191399B1 (de)	1991-09-18	Benz(a)anthrachinonverbindungen, mikrobielles Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
US5036010A (en)	1991-07-30	BMY-40800 antitumor antibiotics
KR810001056B1 (ko)	1981-09-07	항생물질 c-15003의 제조법
KR810000510B1 (ko)	1981-05-25	메이탄시노올 유도체의 제조방법
GB1592264A (en)	1981-07-01	Treatment of tumor-carrying animal with antibiotic c-15003
RU2120997C1 (ru)	1998-10-27	Способ получения 2-амино-4(гидроксиметил)-3а,5,6,6а-тетрагидро-4h-циклопент-[d]-оксазол-4, 5,6-триола и продуцирующие его штаммы актиномицета micromonospora и актиномицета amycolatopsis
KR820001433B1 (ko)	1982-08-14	항생물질 c-15003 p-4의 제조법