SU923366A3 - Способ получени N,N-диметил-3-(4-бромфенил)-3-(3-пиридил) аллиламина или его дигидрохлорида или @ изомера - Google Patents

Способ получени N,N-диметил-3-(4-бромфенил)-3-(3-пиридил) аллиламина или его дигидрохлорида или @ изомера Download PDF

Info

Publication number: SU923366A3
Authority: SU; USSR - Soviet Union
Prior art keywords: pyridyl; isomer; bromophenyl; dimethyl; allylamine
Prior art date: 1977-07-04

Application number

SU792798502A

Other languages

English (en)

Russian (ru)

Inventor

Бамберг Петер

Original Assignee

Астра Лэкемедель Аб (Инофирма)

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-07-04

Filing date

1979-08-03

Publication date

1982-04-23

1979-08-03 Application filed by Астра Лэкемедель Аб (Инофирма) filed Critical Астра Лэкемедель Аб (Инофирма)

1982-04-23 Application granted granted Critical

1982-04-23 Publication of SU923366A3 publication Critical patent/SU923366A3/ru

Links

238000000034 method Methods 0.000 title claims description 6
WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 claims abstract description 7
150000001875 compounds Chemical class 0.000 claims abstract description 3
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 14
VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 claims description 12
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims description 9
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 8
MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 claims description 8
125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 5
QYRFJLLXPINATB-UHFFFAOYSA-N hydron;2,4,5,6-tetrafluorobenzene-1,3-diamine;dichloride Chemical compound Cl.Cl.NC1=C(F)C(N)=C(F)C(F)=C1F QYRFJLLXPINATB-UHFFFAOYSA-N 0.000 claims description 3
238000002955 isolation Methods 0.000 claims description 3
YIIHEMGEQQWSMA-UHFFFAOYSA-M 2-(dimethylamino)ethyl-triphenylphosphanium;bromide Chemical compound [Br-].C=1C=CC=CC=1[P+](C=1C=CC=CC=1)(CCN(C)C)C1=CC=CC=C1 YIIHEMGEQQWSMA-UHFFFAOYSA-M 0.000 claims description 2
238000001816 cooling Methods 0.000 claims description 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 2
239000011541 reaction mixture Substances 0.000 claims description 2
238000003756 stirring Methods 0.000 claims description 2
239000000725 suspension Substances 0.000 claims description 2
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 6
YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 3
WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
239000008346 aqueous phase Substances 0.000 claims 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
WLNKGGRXEOAKBY-UHFFFAOYSA-N bis(4-bromo-2-pyridin-3-ylphenyl)methanone Chemical compound C=1C=CN=CC=1C1=CC(Br)=CC=C1C(=O)C1=CC=C(Br)C=C1C1=CC=CN=C1 WLNKGGRXEOAKBY-UHFFFAOYSA-N 0.000 claims 1
238000001035 drying Methods 0.000 claims 1
238000004519 manufacturing process Methods 0.000 abstract description 2
239000003153 chemical reaction reagent Substances 0.000 abstract 1
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 9
239000000047 product Substances 0.000 description 8
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 4
239000000203 mixture Substances 0.000 description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
230000003993 interaction Effects 0.000 description 2
IMRWILPUOVGIMU-UHFFFAOYSA-N 2-bromopyridine Chemical compound BrC1=CC=CC=N1 IMRWILPUOVGIMU-UHFFFAOYSA-N 0.000 description 1
NYPYPOZNGOXYSU-UHFFFAOYSA-N 3-bromopyridine Chemical compound BrC1=CC=CN=C1 NYPYPOZNGOXYSU-UHFFFAOYSA-N 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000006356 dehydrogenation reaction Methods 0.000 description 1
KYCIUIVANPKXLW-UHFFFAOYSA-N dimethyl-(2-phenoxyethyl)-(thiophen-2-ylmethyl)azanium Chemical compound C=1C=CSC=1C[N+](C)(C)CCOC1=CC=CC=C1 KYCIUIVANPKXLW-UHFFFAOYSA-N 0.000 description 1
238000001704 evaporation Methods 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
QMEZUZOCLYUADC-UHFFFAOYSA-N hydrate;dihydrochloride Chemical compound O.Cl.Cl QMEZUZOCLYUADC-UHFFFAOYSA-N 0.000 description 1
239000005457 ice water Substances 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
JDOZOOBCADNBIJ-UHFFFAOYSA-N lithium;2h-pyridin-2-ide Chemical compound [Li+].C1=CC=N[C-]=C1 JDOZOOBCADNBIJ-UHFFFAOYSA-N 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000012452 mother liquor Substances 0.000 description 1
239000003208 petroleum Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000007858 starting material Substances 0.000 description 1
FIQMHBFVRAXMOP-UHFFFAOYSA-N triphenylphosphane oxide Chemical compound C=1C=CC=CC=1P(C=1C=CC=CC=1)(=O)C1=CC=CC=C1 FIQMHBFVRAXMOP-UHFFFAOYSA-N 0.000 description 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pyridine Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SU792798502A 1977-07-04 1979-08-03 Способ получени N,N-диметил-3-(4-бромфенил)-3-(3-пиридил) аллиламина или его дигидрохлорида или @ изомера SU923366A3 (ru)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE7707707A SE409861B (sv)	1977-07-04	1977-07-04	Ett nytt forfarande for framstellning av en terapeutisk aktiv pyridinforening

Publications (1)

Publication Number	Publication Date
SU923366A3 true SU923366A3 (ru)	1982-04-23

Family

ID=20331764

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SU792798502A SU923366A3 (ru)	1977-07-04	1979-08-03	Способ получени N,N-диметил-3-(4-бромфенил)-3-(3-пиридил) аллиламина или его дигидрохлорида или @ изомера

Country Status (13)

Country	Link
JP (1)	JPS5414976A (da)
AT (1)	AT365171B (da)
CA (1)	CA1082198A (da)
CH (1)	CH641163A5 (da)
DK (1)	DK295378A (da)
ES (1)	ES471302A1 (da)
FI (1)	FI64581C (da)
IT (1)	IT1105226B (da)
NL (1)	NL7807246A (da)
NO (1)	NO782304L (da)
SE (1)	SE409861B (da)
SU (1)	SU923366A3 (da)
WO (1)	WO1979000023A1 (da)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7909514L (sv) *	1979-11-16	1981-05-17	Astra Laekemedel Ab	Nya halofenyl-pyridyl-allylaminderivat
FI20090389L (fi) *	2009-10-23	2011-04-24	Kone Corp	Menetelmä hissin valmistamisessa
FI122066B (fi) *	2009-12-31	2011-08-15	Kone Corp	Menetelmä hissin valmistamisessa
FI20100223A0 (fi) *	2010-05-28	2010-05-28	Kone Corp	Menetelmä ja hissijärjestely
FI20106273A7 (fi) *	2010-12-01	2012-06-02	Kone Corp	Hissijärjestely ja menetelmä
EP2636629B1 (en) *	2012-03-06	2015-05-06	KONE Corporation	A method and an elevator arrangement
US9388020B2 (en) *	2012-03-06	2016-07-12	Kone Corporation	Method and an elevator arrangement

1977
- 1977-07-04 SE SE7707707A patent/SE409861B/sv unknown
1978
- 1978-06-26 WO PCT/SE1978/000009 patent/WO1979000023A1/en not_active Ceased
- 1978-06-26 CH CH329979A patent/CH641163A5/de not_active IP Right Cessation
- 1978-06-27 CA CA306,260A patent/CA1082198A/en not_active Expired
- 1978-06-29 DK DK782953A patent/DK295378A/da not_active Application Discontinuation
- 1978-06-30 IT IT50123/78A patent/IT1105226B/it active
- 1978-06-30 ES ES471302A patent/ES471302A1/es not_active Expired
- 1978-06-30 FI FI782115A patent/FI64581C/fi not_active IP Right Cessation
- 1978-07-03 NO NO782304A patent/NO782304L/no unknown
- 1978-07-04 JP JP8182078A patent/JPS5414976A/ja active Pending
- 1978-07-04 NL NL7807246A patent/NL7807246A/xx not_active Application Discontinuation
- 1978-07-04 AT AT0483778A patent/AT365171B/de not_active IP Right Cessation
1979
- 1979-08-03 SU SU792798502A patent/SU923366A3/ru active

Also Published As

Publication number	Publication date
IT1105226B (it)	1985-10-28
NO782304L (no)	1979-01-05
CH641163A5 (de)	1984-02-15
ES471302A1 (es)	1979-09-01
IT7850123A0 (it)	1978-06-30
CA1082198A (en)	1980-07-22
DK295378A (da)	1979-01-05
SE409861B (sv)	1979-09-10
AT365171B (de)	1981-12-28
JPS5414976A (en)	1979-02-03
FI64581B (fi)	1983-08-31
WO1979000023A1 (en)	1979-01-25
ATA483778A (de)	1981-05-15
FI782115A7 (fi)	1979-01-05
FI64581C (fi)	1983-12-12
NL7807246A (nl)	1979-01-08
SE7707707L (sv)	1979-01-05

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