SU971103A3 - Способ получени гемисукцинатов ситостерилгликозидов или их щелочных,щелочноземельных или аммониевых солей - Google Patents
Способ получени гемисукцинатов ситостерилгликозидов или их щелочных,щелочноземельных или аммониевых солей Download PDFInfo
- Publication number
- SU971103A3 SU971103A3 SU792788551A SU2788551A SU971103A3 SU 971103 A3 SU971103 A3 SU 971103A3 SU 792788551 A SU792788551 A SU 792788551A SU 2788551 A SU2788551 A SU 2788551A SU 971103 A3 SU971103 A3 SU 971103A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- alkali
- sitosteryl
- glycosides
- hemisuccinates
- alkaline
- Prior art date
Links
- 229930182470 glycoside Natural products 0.000 title claims abstract description 7
- 150000002338 glycosides Chemical class 0.000 title claims abstract description 7
- 238000000034 method Methods 0.000 title claims abstract description 6
- 150000003863 ammonium salts Chemical class 0.000 title claims description 6
- 239000003513 alkali Substances 0.000 title description 2
- FALRKNHUBBKYCC-UHFFFAOYSA-N 2-(chloromethyl)pyridine-3-carbonitrile Chemical compound ClCC1=NC=CC=C1C#N FALRKNHUBBKYCC-UHFFFAOYSA-N 0.000 claims description 5
- 238000002360 preparation method Methods 0.000 claims description 5
- 229940014800 succinic anhydride Drugs 0.000 claims description 5
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 4
- 238000000354 decomposition reaction Methods 0.000 claims description 3
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 2
- 238000002955 isolation Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 claims 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000006188 syrup Substances 0.000 claims 1
- 235000020357 syrup Nutrition 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 abstract description 7
- 239000000203 mixture Substances 0.000 abstract description 3
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 2
- 150000005690 diesters Chemical class 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000027796 Blood pressure disease Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- OFOBLEOULBTSOW-UHFFFAOYSA-N Malonic acid Chemical compound OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
- 208000025747 Rheumatic disease Diseases 0.000 description 1
- NPJICTMALKLTFW-NEOYQNEMSA-N Sitosteryl glucoside Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1OC(CO)[C@@H](O)C(O)C1O NPJICTMALKLTFW-NEOYQNEMSA-N 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000002686 anti-diuretic effect Effects 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- NPJICTMALKLTFW-OFUAXYCQSA-N daucosterol Chemical compound O([C@@H]1CC2=CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CC[C@@H](CC)C(C)C)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O NPJICTMALKLTFW-OFUAXYCQSA-N 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 150000002016 disaccharides Chemical class 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 239000005457 ice water Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 150000005691 triesters Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J17/005—Glycosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Rheumatology (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB7828833 | 1978-07-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU971103A3 true SU971103A3 (ru) | 1982-10-30 |
Family
ID=10498259
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU792788551A SU971103A3 (ru) | 1978-07-05 | 1979-07-04 | Способ получени гемисукцинатов ситостерилгликозидов или их щелочных,щелочноземельных или аммониевых солей |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4254111A (de) |
| EP (1) | EP0007474B1 (de) |
| JP (1) | JPS5942680B2 (de) |
| AT (1) | ATE11417T1 (de) |
| AU (1) | AU521669B2 (de) |
| CA (1) | CA1142510A (de) |
| DE (1) | DE2967364D1 (de) |
| DK (1) | DK285679A (de) |
| ES (1) | ES482241A1 (de) |
| IE (1) | IE49728B1 (de) |
| IL (1) | IL57728A (de) |
| IN (1) | IN152550B (de) |
| NZ (1) | NZ190914A (de) |
| PT (1) | PT69874A (de) |
| SU (1) | SU971103A3 (de) |
| YU (1) | YU41651B (de) |
| ZA (1) | ZA793321B (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS56113799A (en) * | 1980-02-08 | 1981-09-07 | Nippon Shinyaku Co Ltd | Glucoside derivative |
| JPS5874619A (ja) * | 1981-10-29 | 1983-05-06 | Nippon Shinyaku Co Ltd | リポソ−ム及びその製法 |
| US4602003A (en) * | 1982-05-17 | 1986-07-22 | Medical Research Foundation Of Oregon | Synthetic compounds to inhibit intestinal absorption of cholesterol in the treatment of hypercholesterolemia |
| JPS5948414A (ja) * | 1982-09-10 | 1984-03-19 | Asahi Denka Kogyo Kk | ビタミンｅの水溶性製剤 |
| CA1229636A (en) * | 1983-04-14 | 1987-11-24 | Richard S. Antoszewski | Radial-theta manipulator apparatus |
| DE3401178A1 (de) * | 1984-01-14 | 1985-07-18 | Roecar Holdings (Netherlands Antilles) N.V., Willemstad, Curacao, Niederländische Antillen | Verwendung von phytosterolglykosiden zur behandlung erhoehter 5(6)(alpha)-epoxicholesterolspiegel |
| DE3416112A1 (de) * | 1984-04-30 | 1985-10-31 | Roecar Holdings (Netherlands Antilles) N.V., Willemstad, Curacao, Niederländische Antillen | Verwendung von sterolinen und spiroketalinen als lipoxygenaseregulatoren |
| JPS62180694A (ja) * | 1986-01-27 | 1987-08-07 | ドナルド・ジエイ・イムサンド | ３次元テレビジヨン方式 |
| DE3829641A1 (de) * | 1988-09-01 | 1990-03-15 | Roecar Holdings Nv | Transdermal anwendbare pharmazeutische zubereitungen mit sterolinen und/oder spiroketalinen |
| ATE142883T1 (de) * | 1991-03-28 | 1996-10-15 | Rooperol Na Nv | Zusammensetzungen von phytosterolen mit phytosterolinen als immunmodulatoren |
| DK0647235T3 (da) * | 1992-06-26 | 1997-10-27 | Pfizer | Fremgangsmåde til steroide peracylglycosider |
| AUPN029994A0 (en) * | 1994-12-23 | 1995-01-27 | Ici Australia Operations Proprietary Limited | Alkypolysaccharide derivatives & compositions |
| DE19701264A1 (de) * | 1997-01-16 | 1998-07-23 | Kief Lizenz Verwertungsgesells | Heilmittel, enthaltend Betasitosterin und/oder Phytosterol/Betasitosteringemische |
| WO2001032679A2 (en) * | 1999-11-01 | 2001-05-10 | Forbes Medi-Tech Inc. | Novel glycosides comprising pentose mono-, di-, tri-, or oligosaccharides and phytosterols and/or phytostanols |
| WO2002037122A2 (en) | 2000-11-03 | 2002-05-10 | The University Of British Columbia | Sterol glucoside toxins |
| WO2004089969A2 (en) * | 2003-04-02 | 2004-10-21 | The Government Of The United States Of America As Represented By The Secretary, Department Of Healthand Human Services | Cholesterol-containing compounds and their use as immunogens against borrelia burgdorferi |
| WO2008150487A2 (en) * | 2007-05-31 | 2008-12-11 | Texas Tech University | Synthesis of half esters |
| US20090011060A1 (en) * | 2007-07-06 | 2009-01-08 | Peter Koepke | Campsiandra angustifolia extract and methods of extracting and using such extract |
| US20090017140A1 (en) * | 2007-07-09 | 2009-01-15 | Peter Koepke | Maytenus abenfolia extract and methods of extracting and using such extract |
| KR101038022B1 (ko) | 2007-07-25 | 2011-05-30 | 주식회사 알엔에이 | 신규 당 화합물 |
| US20090035395A1 (en) * | 2007-08-01 | 2009-02-05 | Peter Koepke | Spondias mombin l. extract and methods of extracting and using such extract |
| US7879369B2 (en) * | 2007-09-18 | 2011-02-01 | Selvamedica, Llc | Combretum laurifolium Mart. extract and methods of extracting and using such extract |
| US9573972B2 (en) | 2008-10-31 | 2017-02-21 | Neurodyn, Inc. | Nurotoxic sterol glycosides |
| CN103732608A (zh) * | 2011-05-20 | 2014-04-16 | 马来西亚博特拉大学 | 一种包含酰化固醇糖苷的组成物在用于制备一产物中的用途 |
| JP5953490B2 (ja) * | 2012-05-10 | 2016-07-20 | 株式会社タニタ | 浮腫評価装置 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE35018B1 (en) * | 1970-03-18 | 1975-10-15 | Liebenberg R W | Therapeutic agent |
| GB1390683A (en) * | 1972-12-18 | 1975-04-16 | Biorex Laboratories Ltd | Pharmaceutical composition |
| JPS5123254A (en) * | 1974-08-14 | 1976-02-24 | Nippon Shinyaku Co Ltd | Suteriru beetaa dd gurukoshidono parumichinsanesuteruno seizohoho |
| US3963697A (en) * | 1974-08-29 | 1976-06-15 | Curtis Nuclear Corporation | Labelled cardiotonic glycosides for use in radioimmunoassay |
| US4021535A (en) * | 1975-01-14 | 1977-05-03 | Beckman Instruments, Inc. | Reagents used in the radioimmunoassay of digoxin |
| JPS51118817A (en) * | 1975-04-08 | 1976-10-19 | Nippon Shinyaku Co Ltd | A process for preparing absorbable steroid glycoside pharmaceutical |
| FR2312257A1 (fr) * | 1975-05-28 | 1976-12-24 | Nippon Shinyaku Co Ltd | Produits pharmaceutiques a action hemostatique comprenant des steryl-b-d-glucosides et leurs monopalmitates |
-
1979
- 1979-07-02 US US06/053,735 patent/US4254111A/en not_active Expired - Lifetime
- 1979-07-03 ZA ZA793321A patent/ZA793321B/xx unknown
- 1979-07-03 DE DE7979102235T patent/DE2967364D1/de not_active Expired
- 1979-07-03 AT AT79102235T patent/ATE11417T1/de not_active IP Right Cessation
- 1979-07-03 EP EP79102235A patent/EP0007474B1/de not_active Expired
- 1979-07-04 SU SU792788551A patent/SU971103A3/ru active
- 1979-07-04 CA CA000331143A patent/CA1142510A/en not_active Expired
- 1979-07-04 IL IL57728A patent/IL57728A/xx not_active IP Right Cessation
- 1979-07-04 NZ NZ190914A patent/NZ190914A/xx unknown
- 1979-07-04 PT PT69874A patent/PT69874A/pt unknown
- 1979-07-05 YU YU1639/79A patent/YU41651B/xx unknown
- 1979-07-05 DK DK285679A patent/DK285679A/da unknown
- 1979-07-05 AU AU48667/79A patent/AU521669B2/en not_active Ceased
- 1979-07-05 ES ES482241A patent/ES482241A1/es not_active Expired
- 1979-07-05 JP JP54085498A patent/JPS5942680B2/ja not_active Expired
- 1979-07-16 IN IN510/DEL/79A patent/IN152550B/en unknown
- 1979-08-08 IE IE1238/79A patent/IE49728B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL57728A0 (en) | 1979-11-30 |
| ZA793321B (en) | 1981-03-25 |
| EP0007474B1 (de) | 1985-01-23 |
| YU163979A (en) | 1983-04-30 |
| IL57728A (en) | 1983-06-15 |
| AU521669B2 (en) | 1982-04-22 |
| IN152550B (de) | 1984-02-11 |
| PT69874A (en) | 1979-08-01 |
| CA1142510A (en) | 1983-03-08 |
| AU4866779A (en) | 1980-01-10 |
| ES482241A1 (es) | 1980-04-01 |
| ATE11417T1 (de) | 1985-02-15 |
| YU41651B (en) | 1987-12-31 |
| DE2967364D1 (en) | 1985-03-07 |
| JPS5942680B2 (ja) | 1984-10-16 |
| EP0007474A1 (de) | 1980-02-06 |
| NZ190914A (en) | 1981-05-01 |
| JPS5536472A (en) | 1980-03-14 |
| IE49728B1 (en) | 1985-12-11 |
| DK285679A (da) | 1980-01-06 |
| US4254111A (en) | 1981-03-03 |
| IE791238L (en) | 1980-01-05 |
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